The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Is There a Physiologic Basis for Creatine Use in Children and Adolescents?
Abstract
The purported ergogenic benefits of creatine for the adult population have been well documented. In able-bodied children and adolescents, there is a paucity of data on creatine use and the purported ergogenic effects of creatine. Only 1 study to date has investigated the ergogenic properties of creatine in the adolescent population. The purpose of this review was to try to establish a rationale for creatine use in the child and adolescent population. The limited literature available in this area did not provide a strong enough rationale from either a physiologic or performance perspective for creatine supplementation in these populations. However, significantly more research is required before definitive conclusions can be made.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“While the physiological rationale regarding an ergogenic benefit in adolescents is similar to that seen in adults [8], the lack of randomized controlled trials and clinical data supporting the safety of creatine supplementation protocols among adolescent populations has resulted in hesitation regarding its widespread recommendation by some practitioners.”
From Creatine Supplementation in Children and Adolescents (2021) · cites this paper as [8]
In the citing paper
“Unnithan et al. (88) eloquently described the physiological basis for creatine use in adolescents and came to the conclusion that in anaerobic athletes, there exists a metabolic rationale as to how and why creatine may provide an ergogenic benefit.”
From Safety of Creatine Supplementation in Active Adolescents and Youth: A Brief Review (2018) · cites this paper as [88]
Citations
Cites
Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation
Harris, R. C., Söderlund, K., & Hultman, E. (1992) · Clinical Science · doi:10.1042/cs0830367 · Cited by 1,168
Muscle function after exercise-induced muscle damage and rapid adaptation
CLARKSON, P. M., NOSAKA, K., & BRAUN, B. (1992) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199205000-00004 · Cited by 970
Self-citationMuscle Metabolism and Enzyme Activities after Training in Boys 11–13 Years Old
Eriksson, B. O., Gollnick, P. D., & Saltin, B. (1973) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1973.tb05415.x · Cited by 326
Birch, R., Noble, D., & Greenhaff, P. L. (1994) · European Journal of Applied Physiology · doi:10.1007/bf01094800 · Cited by 251
Stöckler, S., Hanefeld, F., & Frahm, J. (1996) · The Lancet · doi:10.1016/s0140-6736(96)04116-5 · Cited by 240
Creatine Supplementation Enhances Muscular Performance During High-Intensity Resistance Exercise
VOLEK, J. S., KRAEMER, W. J., BUSH, J. A., BOETES, M., INCLEDON, T., CLARK, K. L., & LYNCH, J. M. (1997) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(97)00189-2 · Cited by 219
Schulze, A., Hess, T., Wevers, R. A., Mayatepek, E., Bachert, P., Marescau, B., Knopp, M. V., Deyn, P. P. D., Bremer, H. J., & Rating, D. (1997) · The Journal of Pediatrics · doi:10.1016/s0022-3476(97)70075-1 · Cited by 170
Comparison of two regimens of concurrent strength and endurance training.
SALE, D. G., JACOBS, I., MACDOUGALL, J. D., & GARNER, S. (1990) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199006000-00012 · Cited by 161
31P-magnetic resonance spectroscopy of leg muscle metabolism during exercise in children and adults
Zanconato, S., Buchthal, S. D., Barstow, T. J., & Cooper, D. M. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.74.5.2214 · Cited by 143
MUSCLE METABOLITES DURING EXERCISE IN PUBERTAL BOYS
Eriksson, B. O., Karlsson, J., & Saltin, B. (1971) · Acta Paediatrica · doi:10.1111/j.1651-2227.1971.tb05717.x · Cited by 139
Cited by
Sorted by citations
Items 101–161 of 161
Behm, D. G., Alizadeh, S., Anvar, S. H., Drury, B., Granacher, U., & Moran, J. (2021) · Sports Medicine · doi:10.1007/s40279-020-01422-5 · Cited by 66
β-hydroxy-β-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans
Vukovich, M. D., Slater, G., Macchi, M. B., Turner, M. J., Fallon, K., Boston, T., & Rathmacher, J. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00182-6 · Cited by 66
Traditional and Nontraditional Supplement Use by Collegiate Female Varsity Athletes
Herbold, N. H., Visconti, B. K., Frates, S., & Bandini, L. (2004) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.14.5.586 · Cited by 63
Lowery, R. P., Joy, J. M., Rathmacher, J. A., Baier, S. M., Fuller, J. C., Shelley, M. C., Jäger, R., Purpura, M., Wilson, S. M. C., & Wilson, J. M. (2016) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000482 · Cited by 62
Safety of Creatine Supplementation
Persky, A. M., & Rawson, E. S. (2007) · Subcellular Biochemistry · doi:10.1007/978-1-4020-6486-9_14 · Cited by 60
Goulet, E. D. B., Aubertin-Leheudre, M., Plante, G. E., & Dionne, I. J. (2007) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.17.4.391 · Cited by 60
Wirth, K., Keiner, M., Hartmann, H., Sander, A., & Mickel, C. (2016) · Journal of Human Kinetics · doi:10.1515/hukin-2016-0023 · Cited by 61
Tawfik, S., Koofy, N. E., & Moawad, E. M. I. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161252 · Cited by 63
Teo, S. Y. M., Newton, M. J., Newton, R. U., Dempsey, A. R., & Fairchild, T. J. (2016) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001379 · Cited by 54
Nuzzo, J. L., Pinto, M. D., Kirk, B. J. C., & Nosaka, K. (2024) · Sports Medicine · doi:10.1007/s40279-024-02009-0 · Cited by 56
McCartney, D., Desbrow, B., & Irwin, C. (2017) · Sports Medicine - Open · doi:10.1186/s40798-017-0079-y · Cited by 54
Laurent, C. M., Vervaecke, L. S., Kutz, M. R., & Green, J. M. (2014) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3182a1f574 · Cited by 53
Refalo, M. C., Hamilton, D. L., Paval, D. R., Gallagher, I. J., Feros, S. A., & Fyfe, J. J. (2021) · Journal of Sports Sciences · doi:10.1080/02640414.2021.1898094 · Cited by 45
Chilibeck, P. D., Magnus, C., & Anderson, M. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-072 · Cited by 50
Lamboley, C. R. H., Royer, D., & Dionne, I. J. (2007) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.17.1.56 · Cited by 49
Novakova, K., Kummer, O., Bouitbir, J., Stoffel, S. D., Hoerler-Koerner, U., Bodmer, M., Roberts, P., Urwyler, A., Ehrsam, R., & Krähenbühl, S. (2016) · European Journal of Nutrition · doi:10.1007/s00394-015-0838-9 · Cited by 51
Creatine Supplementation in Children and Adolescents
Jagim, A. R., & Kerksick, C. M. (2021) · Nutrients · doi:10.3390/nu13020664 · Cited by 61
“the physiological rationale regarding an ergogenic benefit in adolescents is similar to that seen in adults [8], the lack of randomized controlled trials and clinical data supporting the safety of creatine supplementation protocols among adolescent populations has resulted in hesitation regarding its widespread recomm…”
ResultDurkalec-Michalski, K., & Jeszka, J. (2015) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0092-9 · Cited by 48
Oliynyk, S., & Oh, S.-K. (2012) · Biomolecules and Therapeutics · doi:10.4062/biomolther.2012.20.5.446 · Cited by 47
Protein Supplement Users Among High School Athletes Have Misconceptions About Effectiveness
Duellman, M. C., Lukaszuk, J. M., Prawitz, A. D., & Brandenburg, J. P. (2008) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31817394b9 · Cited by 47
Santos, W. D. N. D., Vieira, C. A., Bottaro, M., Nunes, V. A., Ramirez-Campillo, R., Steele, J., Fisher, J. P., & Gentil, P. (2021) · Journal of Strength & Conditioning Research · doi:10.1519/jsc.0000000000002915 · Cited by 42
de Oliveira, L. F., Dolan, E., Swinton, P. A., Durkalec-Michalski, K., Artioli, G. G., McNaughton, L. R., & Saunders, B. (2022) · Sports Medicine · doi:10.1007/s40279-021-01575-x · Cited by 46
Behm, D. G., Granacher, U., Warneke, K., Aragão-Santos, J. C., Da Silva-Grigoletto, M. E., & Konrad, A. (2024) · Sports Medicine · doi:10.1007/s40279-023-01949-3 · Cited by 45
Sports Drinks, Exercise Training, and Competition
von Duvillard, S. P., Arciero, P. J., Tietjen-Smith, T., & Alford, K. (2008) · Current Sports Medicine Reports · doi:10.1249/jsr.0b013e31817ffa37 · Cited by 41
Effects of different lifting cadences on ground reaction forces during the squat exercise
Bentley, J. R., Amonette, W. E., De Witt, J. K., & Hagan, R. D. (2010) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181cb27e7 · Cited by 38
The Effects of Short-Cycle Sprints on Power, Strength, and Salivary Hormones in Elite Rugby Players
Crewther, B. T., Cook, C. J., Lowe, T. E., Weatherby, R. P., & Gill, N. (2011) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181b6045c · Cited by 38
ISSN Exercise & Sport Nutrition Review: Research & Recommendations
Kreider, R. B., Almada, A. L., Antonio, J., Broeder, C., Earnest, C., Greenwood, M., Incledon, T., Kalman, D. S., Kleiner, S. M., Leutholtz, B., et al. (2004) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-1-1-1 · Cited by 38
Creatine supplementation improves the anaerobic performance of elite junior fin swimmers
Juhász, I., Györe, I., Csende, Z., Rácz, L., & Tihanyi, J. (2009) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.96.2009.3.6 · Cited by 36
Fleming, J., & James, L. J. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0044 · Cited by 36
Kim, E., Dear, A., Ferguson, S. L., Seo, D., & Bemben, M. G. (2011) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318212e3a2 · Cited by 36
Maté-Muñoz, J. L., Lougedo, J. H., Garnacho-Castaño, M. V., Veiga-Herreros, P., Lozano-Estevan, M. D. C., García-Fernández, P., de Jesús, F., Guodemar-Pérez, J., San Juan, A. F., & Domínguez, R. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0224-0 · Cited by 36
Role of creatine supplementation in exercise-induced muscle damage: A mini review
Kim, J., Lee, J., Kim, S., Yoon, D., Kim, J., & Sung, D. J. (2015) · Journal of Exercise Rehabilitation · doi:10.12965/jer.150237 · Cited by 35
Safety of Creatine Supplementation in Active Adolescents and Youth: A Brief Review
Jagim, A. R., Stecker, R. A., Harty, P. S., Erickson, J. L., & Kerksick, C. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00115 · Cited by 35
San Juan, A. F., Dominguez, R., Lago-Rodríguez, Á., Montoya, J. J., Tan, R., & Bailey, S. J. (2020) · Nutrients · doi:10.3390/nu12082227 · Cited by 36
Escalante, G., Alencar, M., Haddock, B., & Harvey, P. (2016) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-016-0135-x · Cited by 32
Durkalec-Michalski, K., & Jeszka, J. (2016) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001361 · Cited by 31
Oral Creatine Supplementation Augments the Repeated Bout Effect
Veggi, K. F. T., Machado, M., Koch, A. J., Santana, S. C., Oliveira, S. S., & Stec, M. J. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.4.378 · Cited by 27
Haug, W. B., Drinkwater, E. J., & Chapman, D. W. (2015) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000826 · Cited by 26
Repeated sets or single set of resistance training—a systematic review.
Bågenhammar, S., & Ekvall Hansson, E. (2007) · Advances in Physiotherapy · doi:10.1080/14038190701554277 · Cited by 17
Cotter, J. A., Garver, M. J., Dinyer, T. K., Fairman, C. M., & Focht, B. C. (2017) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001782 · Cited by 22
Ralston, G. W., Kilgore, L., Wyatt, F. B., Dutheil, F., Jaekel, P., Buchan, D. S., & Baker, J. S. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00864 · Cited by 15
Hsu, T.-H., Chiu, C.-C., Wang, Y.-C., Chen, T.-H., Chen, Y.-H., Lee, Y.-P., Hung, S.-W., Wu, C.-P., & Chuang, H.-L. (2018) · Nutrients · doi:10.3390/nu10111740 · Cited by 20
Additive benefits of β-alanine supplementation and sprint-interval training
BELLINGER, P. M., & MINAHAN, C. L. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001050 · Cited by 21
Shaw, P., Zhang, V., & Metallinos‐Katsaras, E. S. (2009) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2008.0323 · Cited by 20
Kalhan, S. C., Gruca, L., Marczewski, S., Bennett, C., & Kummitha, C. (2016) · Amino Acids · doi:10.1007/s00726-015-2111-1 · Cited by 19
Wang, C.-C., Lin, S.-C., Hsu, S.-C., Yang, M.-T., & Chan, K.-H. (2017) · Nutrients · doi:10.3390/nu9111169 · Cited by 16
The Physiological Effects of Creatine Supplementation on Hydration: A Review
Sobolewski, E. J., Thompson, B. J., Smith, A. E., & Ryan, E. D. (2011) · American Journal of Lifestyle Medicine · doi:10.1177/1559827611406071 · Cited by 16
(2018) · Europe PMC (PubMed Central) · Cited by 16
Arazi, H., Asadi, A., Nasehi, M., & Delpasand, A. (2012) · Sport Sciences for Health · doi:10.1007/s11332-012-0123-8 · Cited by 15
Obrusníková, I., Bibik, J. M., Cavalier, A. R., & Manley, K. (2012) · Journal of Physical Education Recreation & Dance · doi:10.1080/07303084.2012.10598794 · Cited by 15
Trybulski, R., Gepfert, M., Gawel, D., Bichowska, M., Fostiak, K., Wojdala, G., Trybek, G., Krzysztofik, M., & Wilk, M. (2022) · Biology of Sport · doi:10.5114/biolsport.2022.106160 · Cited by 9
Creatine supplementation does not alter neuromuscular recovery after eccentric exercise
Boychuk, K. E., Lanovaz, J. L., Krentz, J. R., Lishchynsky, J. T., Candow, D. G., & Farthing, J. P. (2016) · Muscle & Nerve · doi:10.1002/mus.25091 · Cited by 9
Movement velocity during high- and low-velocity resistance exercise protocols in older adults.
Richardson, D. L., Duncan, M. J., Jimenez, A., Jones, V. M., Juris, P. M., & Clarke, N. D. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.09.020 · Cited by 5
Zan, D. D., Eletti, F., Fiore, G., Girolamo, E. D., Bozzini, G. G. M., Perico, V., Tosi, M., Norsa, L., Zuccotti, G., & Verduci, E. (2025) · Nutrients · doi:10.3390/nu17132194 · Cited by 11
Tambalis, K. D., & Arnaoutis, G. (2022) · Journal of Sports Science and Nutrition · doi:10.33545/27077012.2022.v3.i1a.57 · Cited by 2
Acute Effects of Different Creatine Supplementation Methods on Anaerobic Performance
Yapıcı, A. (2023) · Akdeniz Spor Bilimleri Dergisi · doi:10.38021/asbid.1249053 · Cited by 3
Moraes, M. R., Simões, H. G., Campbell, C. S. G., & Baldissera, V. (2004) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 2
Günay, E., & Yıldız, G. (2016) · Spor Bilimleri Araştırmaları Dergisi · doi:10.25307/jssr.277954 · Cited by 2
Creatine and the Male Adolescent Athlete
Schumaker, S., Eyers, C. M., & Cappaert, T. A. (2012) · Journal of Physical Education Recreation & Dance · doi:10.1080/07303084.2012.10598795 · Cited by 1
Supplementation for athletes – part 1 – creatine
Szewczyk, P. B., Osowski, M., Dorożyński, B., & Szura, E. (2023) · Farmacja Polska · doi:10.32383/farmpol/166058 · Cited by 1
Metadata
- Authors
- UNNITHAN, V. B., VEEHOF, S. H. E., VELLA, C. A., & KERN, M.
- Affiliations
- Syracuse University (US)
- University of San Francisco (US)
- San Francisco State University (US)
- Venue
- Journal of Strength and Conditioning Research
- Published
- 2001-11
- Volume
- 15
- Issue
- 4
- Pages
- 524-528
- ISSN
- 1064-8011 (ISSN-L)
- OpenAlex
- W1993077130
- Cited by
- 18
- References
- 18
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2018: 2 · 2016: 2 · 2012: 3
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Strength and Conditioning Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- San Francisco State University
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
- Keywords
- creatine supplementation, children, adolescents, ergogenic aids, performance improvement, exercise performance
- MeSH terms
- Contraindications, Adaptation, Physiological, Adolescent, Adult, Child, Child Development, Creatine, Female, Humans, Health Knowledge, Attitudes, Practice, Male, Physical Education and Training, Sports, Task Performance and Analysis, Anaerobic Threshold, Muscle, Skeletal, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review