Cited by 186Neural and Behavioral Psychology StudiesMemory and Neural MechanismsPrimate Behavior and Ecology

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Comparison of the Effects of Bilateral Orbital Prefrontal Cortex Lesions and Amygdala Lesions on Emotional Responses in Rhesus Monkeys

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Izquierdo, Alicia, Suda, Robin K., Murray, Elisabeth A.·2005·The Journal of Neuroscience

DOI 10.1523/jneurosci.1232-05.2005PMC PMC6725674

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Abstract

The present study examines the effects of bilateral orbital prefrontal cortex (PFo) lesions on monkeys' emotional responses in two different contexts: in the presence of a rubber snake and in the presence of a human intruder. For comparison, we also assessed the responses of rhesus monkeys with selective amygdala lesions on these same tasks. Monkeys with PFo lesions, like those with amygdala lesions, displayed blunted emotional responses to the fake snake. Unlike monkeys with amygdala lesions, however, monkeys with PFo lesions displayed more mild aggression than controls in the presence of a human intruder. The findings support the idea that the PFo helps integrate sensory signals in the service of choosing among competing responses. In addition, they point to a divergence of the roles of the PFo and amygdala in responding to a social stimulus, the human intruder.

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Limbic lesions and the problem of stimulus--reinforcement associations.
Jones, B., & Mishkin, M. (1972) · Experimental Neurology · doi:10.1016/0014-4886(72)90030-1 · Cited by 864
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Walker, A. E. (1940) · The Journal of Comparative Neurology · doi:10.1002/cne.900730106 · Cited by 803
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Frontal lobe injuries, violence, and aggression: A report of the Vietnam Head Injury Study
Grafman, J., Schwab, K., Warden, D., Pridgen, A., Brown, H. R., & Salazar, A. M. (1996) · Neurology · doi:10.1212/wnl.46.5.1231 · Cited by 696
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Winstanley, C. A., Theobald, D. E. H., Cardinal, R. N., & Robbins, T. W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5606-03.2004 · Cited by 675
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Show all 43 references

Research works printed but not linked: 7

1972, Acta Neurobiol Exp (Wars), 32, 525
1995, J Cereb Blood Flow Metab, 15, S856
2004, PLoS Biol, 2, 1919
1997, J Clin Psychiatry, 58, 4
1997, J Neurosci, 17, 4828
1977, J Physiol (Lond), 266, 98
2004, J Neurosci, 19, 4718

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Authors: Izquierdo, A., Suda, R. K., & Murray, E. A.
Affiliations: National Institutes of Health (US)
ORCID: Izquierdo, Alicia
Murray, Elisabeth A.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2005-09-14
Volume: 25
Issue: 37
Pages: 8534-8542
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1232-05.2005
PMC: PMC6725674
OpenAlex: W2097004047
Cited by: 186
References: 43
Citations by year: 2026: 2 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 12 · 2016: 10 · 2015: 5 · 2014: 9 · 2013: 9 · 2012: 11
FWCI: 6.45
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
Keywords: orbitofrontal cortex, amygdala, emotional responses, rhesus monkeys, aggression, fear, threat detection, lesion studies, sensory integration, competing responses
MeSH terms: Amygdala, Animals, Animal Feed, Emotions, Functional Laterality, Macaca mulatta, Reaction Time, Reward, Visual Cortex, Prefrontal Cortex

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Comparison of the Effects of Bilateral Orbital Prefrontal Cortex Lesions and Amygdala Lesions on Emotional Responses in Rhesus Monkeys

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