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Evidence for Enhanced Neurobehavioral Vulnerability to Nicotine during Periadolescence in Rats
Open accessAbstract
Epidemiological studies indicate that there is an increased likelihood for the development of nicotine addiction when cigarette smoking starts early during adolescence. These observations suggest that adolescence could be a “critical” ontogenetic period, during which drugs of abuse have distinct effects responsible for the development of dependence later in life. We compared the long-term behavioral and molecular effects of repeated nicotine treatment during either periadolescence or postadolescence in rats. It was found that exposure to nicotine during periadolescence, but not a similar exposure in the postadolescent period, increased the intravenous self-administration of nicotine and the expression of distinct subunits of the ligand-gated acetylcholine receptor in adult animals. Both these changes indicated an increased sensitivity to the addictive properties of nicotine. In conclusion, adolescence seems to be a critical developmental period, characterized by enhanced neurobehavioral vulnerability to nicotine.
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“Adolescent nicotine treatment increases subsequent nicotine reward and decreases aversion in adults”
From Unique, long-term effects of nicotine on adolescent brain. (2020) · cites this paper as Adriani et al., 2003
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Nicotine administration during, but not following, adolescence has long-lasting effects on cognitive, addictive, and emotional behavior in rats (Adriani et al. 2003; Iniguez et al. 2008; Counotte et al. 2009, 2011).”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Adriani et al. 2003
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Adolescents are more vulnerable than adults to nicotine’s long-term effects on addictive and cognitive behavior.”
From Adolescent nicotine exposure transiently increases high-affinity nicotinic receptors and modulates inhibitory synaptic transmission in rat medial prefrontal cortex (2012) · cites this paper as [16]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Nicotine administration during, but not following, adolescence has long-lasting effects on cognitive, addictive, and emotional behavior in rats (16–19).”
From Adolescent nicotine exposure transiently increases high-affinity nicotinic receptors and modulates inhibitory synaptic transmission in rat medial prefrontal cortex (2012) · cites this paper as [16]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“α4β2 and α7 nAchR expression and binding are higher in adolescents than adults [187, 188].”
From Consequences of adolescent drug use (2023) · cites this paper as [187]
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“A similar mid-adolescent exposure regimen (PND 34–43) lead to an increased expression of α5, α6, β2, and β3 nAChR subunits in the adult VTA –– while the same exposure, given instead during adulthood, only increased the β3 subunit [117].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [117]
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“The difference in sensitivity to nicotine between adolescents and adults is also reported for laboratory animals (Slotkin 2002; Adriani et al. 2003).”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Adriani et al. 2003
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“there are alterations in both right dorsal and left ventral frontostriatal tracts in young adult male smokers, which corresponded with poorer performance in cognitive tasks [187, 188].”
From Consequences of adolescent drug use (2023) · cites this paper as [187]
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Metadata
- Authors
- Adriani, W., Spijker, S., Deroche-Gamonet, V., Laviola, G., Le Moal, M., Smit, A. B., & Piazza, P. V.
- Affiliations
- Inserm (FR)
- Vrije Universiteit Amsterdam (NL)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-06-01
- Volume
- 23
- Issue
- 11
- Pages
- 4712-4716
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6740776
- OpenAlex
- W2159655610
- Cited by
- 257
- References
- 41
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 1 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 11 · 2015: 16 · 2014: 15 · 2013: 18 · 2012: 14
- FWCI
- 10.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotine, adolescence, periadolescence, nicotine dependence, nicotine self-administration, acetylcholine receptor subunits, ligand-gated receptors, developmental vulnerability
- MeSH terms
- Animals, Behavior, Animal, Critical Period, Psychological, Injections, Intravenous, Male, Mesencephalon, Motor Activity, Nervous System, Nicotine, Receptors, Nicotinic, Reinforcement, Psychology, RNA, Messenger, Self Administration, Sexual Maturation, Substantia Nigra, Time, Tobacco Use Disorder, Gene Expression, Rats, Sprague-Dawley, Ventral Tegmental Area, Protein Subunits, Rats
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