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β1-Integrins Are Required for Hippocampal AMPA Receptor-Dependent Synaptic Transmission, Synaptic Plasticity, and Working Memory
Open accessAbstract
Integrins comprise a large family of cell adhesion receptors that mediate diverse biological events through cell–cell and cell–extracellular matrix interactions. Recent studies have shown that several integrins are localized to synapses with suggested roles in synaptic plasticity and memory formation. We generated a postnatal forebrain and excitatory neuron-specific knock-out of β1-integrin in the mouse. Electrophysiological studies demonstrated that these mutants have impaired synaptic transmission through AMPA receptors and diminished NMDA receptor-dependent long-term potentiation. Despite the impairment in hippocampal synaptic transmission, the mutants displayed normal hippocampal-dependent spatial and contextual memory but were impaired in a hippocampal-dependent, nonmatching-to-place working memory task. These phenotypes parallel those observed in animals carrying knock-outs of the GluR1 (glutamate receptor subunit 1) subunit of the AMPA receptor. These observations suggest a new function of β1-integrins as regulators of synaptic glutamate receptor function and working memory.
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“and have been firmly implicated in neuronal development and plasticity (Wiera et al. 2022; Chan et al. 2006).”
From The Serine/Threonine Kinase NDR2 Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Chan et al. 2006
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“It localizes to postsynaptic sites in hippocampal neurons and influences cytoskeletal organization, dendritic spine maturation, and synaptic transmission”
From PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity (2025) · cites this paper as Chan et al., 2006
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“A postnatal forebrain and excitatory neuron-specific knockout of β1-integrin in the mouse showed impaired synaptic transmission through AMPA-type glutamate receptors (AMPARs) as well as decreased N-methyl-D-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP), even though the steady-state expression of AMPAR subunits are not regulated by β1-integrin (Chan et al., 2006).”
From Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity (2023) · cites this paper as Chan et al., 2006
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“Previous studies show that β1-integrin plays key roles in the regulation of synaptic function and plasticity.”
From Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity (2023) · cites this paper as Chan et al., 2006
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Metadata
- Authors
- Chan, C.-S., Weeber, E. J., Zong, L., Fuchs, E., Sweatt, J. D., & Davis, R. L.
- Affiliations
- Baylor College of Medicine (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Davis, Ronald L.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-01-04
- Volume
- 26
- Issue
- 1
- Pages
- 223-232
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2408376
- OpenAlex
- W2082833517
- Cited by
- 165
- References
- 48
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 3 · 2019: 10 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 4 · 2014: 7 · 2013: 7 · 2012: 18
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons-TMC (Texas Medical Center) (submittedVersion)
- Funders
- University of Oxford
- National Institute of Mental Health (R01MH060420, MH60420)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR027883)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 24064, P30HD024064)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- beta1 integrin, AMPA receptors, synaptic transmission, synaptic plasticity, working memory, hippocampus, long-term potentiation, NMDA receptor, GluR1, excitatory neurons, spatial memory, contextual memory, cell adhesion receptors
- MeSH terms
- Animals, Hippocampus, Memory, Mice, Inbred C57BL, Synaptic Transmission, Neuronal Plasticity, Receptors, AMPA, Mice, Knockout, Integrin beta1, Mice
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