Cited by 205Attention Deficit Hyperactivity DisorderBehavioral and Psychological StudiesDevelopmental and Educational Neuropsychology

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Time-Response Analysis of the Effect of Stimulant Medication on the Learning Ability of Children Referred for Hyperactivity

Swanson, James, Kinsbourne, Marcel, Roberts, Wendy, Zucker, Kenneth·1978·PEDIATRICS

DOI 10.1542/peds.61.1.21

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Abstract

This report introduces a method for obtaining behavioral time-response information for a short-acting psychotropic drug (methylphenidate [Ritalin]) that is widely used to treat behaviorally hyperactive children. We used a laboratory learning task to document that between one and two hours after the administration of a single dose of methylphenidate, the drug exerts its maximum effect on performance in a learning task in the laboratory. This effect on cognitive performance dissipates within the same day. This rapid and transient effect of methylphenidate makes it possible to classify patients in a single day into those who respond favorably and those who respond adversely to the drug in terms of its effect on cognitive behavior.

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Authors: Swanson, J., Kinsbourne, M., Roberts, W., & Zucker, K.
Affiliations: Hospital for Sick Children (CA)
ORCID: Swanson, James
Zucker, Kenneth
Venue: PEDIATRICS
Publisher: American Academy of Pediatrics (AAP)
Published: 1978-01-01
Volume: 61
Issue: 1
Pages: 21-29
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.61.1.21
OpenAlex: W1512135897
Cited by: 205
References: 18
Citations by year: 2022: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2012: 5
FWCI: 10.31
Type: journal article
Language: en
Open access: closed
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
Keywords: methylphenidate, hyperactivity, stimulant medication, time response analysis, cognitive performance, learning ability, children, drug response variability, pharmacokinetics
MeSH terms: Association Learning, Attention Deficit Disorder with Hyperactivity, Child, Clinical Trials as Topic, Cognition, Female, Humans, Learning, Male, Methylphenidate, Prognosis, Psychomotor Performance, Time Factors

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Time-Response Analysis of the Effect of Stimulant Medication on the Learning Ability of Children Referred for Hyperactivity

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