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Loss of ERβ expression as a common step in estrogen-dependent tumor progression
Open accessAbstract
The characterization of estrogen receptor beta (ERβ) brought new insight into the mechanisms underlying estrogen signaling. Estrogen induction of cell proliferation is a crucial step in carcinogenesis of gynecologic target tissues, and the mitogenic effects of estrogen in these tissues (such as breast, endometrium and ovary) are well documented both in vitro and in vivo. There is also an emerging body of evidence that colon and prostate cancer growth is influenced by estrogens. In all of these tissues, most studies have shown decreased ERβ expression in cancer as compared with benign tumors or normal tissues, whereas ERα expression persists. The loss of ERβ expression in cancer cells could reflect tumor cell dedifferentiation but may also represent a critical stage in estrogen-dependent tumor progression. Modulation of the expression of ERα target genes by ERβ or ERβ-specific gene induction could explain that ERβ has a differential effect on proliferation as compared with ERα. ERβ may exert a protective effect and thus constitute a new target for hormone therapy, such as ligand specific activation. The potential distinct roles of ERα and ERβ expression in carcinogenesis, as suggested by experimental and clinical data, are discussed in this review.
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Quantitative analysis of estrogen receptor-? mRNA and its variants in human breast cancers
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Choi, K., Kang, S. K., Tai, C., Auersperg, N., & Leung, P. C. K. (2001) · Endocrinology · doi:10.1210/endo.142.6.8144 · Cited by 122
Bollig-Fischer, A. B., & Miksicek, R. J. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.5.0460 · Cited by 122
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A meta-analysis of estrogen replacement therapy and risk of epithelial ovarian cancer
Coughlin, S. S., Giustozzi, A. G., Smith, S. J., & Lee, N. C. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00179-1 · Cited by 119
Evidence That Estrogens Directly Alter Androgen-Regulated Prostate Development
Jarred, R. A., Cancilla, B., Prins, G. S., Thayer, K. A., Cunha, G. R., & Risbridger, G. P. (2000) · Endocrinology · doi:10.1210/en.141.9.3471 · Cited by 103
The role of tamoxifen in the treatment and prevention of breast cancer
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Signaling through estrogen receptors modulates telomerase activity in human prostate cancer
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Estrogen receptor β expression in human prostate tissue
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ERβ Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus
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Signaling through estrogen receptors modulates telomerase activity in human prostate cancer
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Cited by
Risks and benefits of dietary isoflavones for cancer
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AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer
Rižner, T. L., Šmuc, T., Rupreht, R., Šinkovec, J., & Penning, T. M. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.10.009 · Cited by 159
Metadata
- Authors
- Bardin, A., Boulle, N., Lazennec, G., Vignon, F., & Pujol, P.
- Venue
- Endocrine-Related Cancer
- Publisher
- Bioscientifica
- Published
- 2004-09
- Volume
- 11
- Issue
- 3
- Pages
- 537-551
- ISSN
- 1351-0088 (ISSN-L)
- 1479-6821
- OpenAlex
- W2100323988
- Cited by
- 417
- References
- 127
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.