Cited by 173Antifungal resistance and susceptibilityFungal Infections and StudiesFungal and yeast genetics research

Antifungal therapy with an emphasis on biofilms

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Pierce, Christopher G, Srinivasan, Anand, Uppuluri, Priya, Ramasubramanian, Anand K, López-Ribot, José L·2013·Current Opinion in Pharmacology

Abstract

Fungal infections are on the rise as advances in modern medicine prolong the lives of severely ill patients. Fungi are eukaryotic organisms and there are a limited number of targets for antifungal drug development; as a result the antifungal arsenal is exceedingly limited. Azoles, polyenes and echinocandins constitute the mainstay of antifungal therapy for patients with life-threatening mycoses. One of the main factors complicating antifungal therapy is the formation of fungal biofilms, microbial communities displaying resistance to most antifungal agents. A better understanding of fungal biofilms provides for new opportunities for the development of urgently needed novel antifungal agents and strategies.

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Crossref · 10.1016/j.coph.2013.08.008

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  • Sessile Candida cells show high levels of tolerance to antifungal therapy as compared to their planktonic counterparts.

    “sessile cells show high levels of tolerance to antifungal therapy as compared to their planktonic counterparts [21,22].”

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Authors
Pierce, C. G., Srinivasan, A., Uppuluri, P., Ramasubramanian, A. K., & López-Ribot, J. L.
Affiliations
The University of Texas at San Antonio (US)
Venue
Current Opinion in Pharmacology
Publisher
Elsevier BV
Published
2013-10
Volume
13
Issue
5
Pages
726-730
ISSN
1471-4892 (ISSN-L)
OpenAlex
W2076025899
Cited by
173
References
64
Citations by year
2026: 9 · 2025: 22 · 2024: 7 · 2023: 12 · 2022: 16 · 2021: 7 · 2020: 19 · 2019: 18 · 2018: 14 · 2017: 11 · 2016: 15 · 2015: 13 · 2014: 9 · 2013: 1
FWCI
1.64
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Dental and Craniofacial Research (R01DE023510)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
antifungal therapy, fungal biofilms, antifungal resistance, azoles, polyenes, echinocandins, fungal infection, antifungal drug development
MeSH terms
Animals, Antifungal Agents, Fungi, Humans, Mycoses, Biofilms, Drug Resistance, Fungal

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