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Alzheimer’s disease-related alterations in synaptic density: neocortex and hippocampus.
Abstract
Alzheimer's disease (AD) is a progressive disorder that is characterized by the accumulation of neuropathologic lesions and neurochemical alterations. Ultrastructural investigations in many association regions of the neocortex and the hippocampal dentate gyrus have demonstrated a disease-related decline in numerical synaptic density. This decline in brain connectivity occurs early in the disease process and strongly correlates with the cognitive decline observed in AD. The synapse loss does not appear to be an inevitable consequence of the aging process. This article reviews the ultrastructural studies assessing AD-related synaptic loss and the possible compensatory changes in the synaptic complex that occur as a result of the loss in brain connectivity.
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“Synapse loss, as occurs in Alzheimer’s patients, is intimately associated with cognitive decline”
From Human Brain/Cloud Interface (2019) · cites this paper as Scheff and Price, 2006
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“The loss of synapses, as occurs in Alzheimer’s patients, is intimately related to cognitive decline (Dekosky and Scheff, 1990; Terry et al., 1991; Scheff and Price, 2006).”
From Human Brain/Cloud Interface (2019) · cites this paper as Scheff and Price, 2006
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Metadata
- Authors
- Scheff, S. W., & Price, D. A.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Scheff, Stephen W.
- ORCID
- Price, Douglas A.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2006-07-27
- Volume
- 9
- Issue
- s3
- Pages
- 101-115
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1694984064
- Cited by
- 284
- References
- 99
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 22 · 2023: 15 · 2022: 10 · 2021: 14 · 2020: 19 · 2019: 12 · 2018: 17 · 2017: 15 · 2016: 16 · 2015: 18 · 2014: 15 · 2013: 20 · 2012: 22
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r37ag012138-05, 5r01ag012986-03)
- National Institute on Aging (P50AG005144, AG-14449, AG-05144, P01AG005119, P01AG014449, AG0 5119, AG12986, AG12138)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, synaptic density
- MeSH terms
- Age Factors, Aged, Aging, Alzheimer Disease, Cell Count, Cerebral Cortex, Hippocampus, Humans, Nerve Net, Synapses, Ultrasonography
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