Cited by 285Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchDementia and Cognitive Impairment Research

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Alzheimer’s disease-related alterations in synaptic density: neocortex and hippocampus.

Scheff, Stephen W., Price, Douglas A.·2006·Journal of Alzheimer's Disease

DOI 10.3233/jad-2006-9s312

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Abstract

Alzheimer's disease (AD) is a progressive disorder that is characterized by the accumulation of neuropathologic lesions and neurochemical alterations. Ultrastructural investigations in many association regions of the neocortex and the hippocampal dentate gyrus have demonstrated a disease-related decline in numerical synaptic density. This decline in brain connectivity occurs early in the disease process and strongly correlates with the cognitive decline observed in AD. The synapse loss does not appear to be an inevitable consequence of the aging process. This article reviews the ultrastructural studies assessing AD-related synaptic loss and the possible compensatory changes in the synaptic complex that occur as a result of the loss in brain connectivity.

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Authors: Scheff, S. W., & Price, D. A.
Affiliations: University of Kentucky (US)
Corresponding author: Scheff, Stephen W.
ORCID: Price, Douglas A.
Venue: Journal of Alzheimer's Disease
Publisher: SAGE Publications
Published: 2006-07-27
Volume: 9
Issue: s3
Pages: 101-115
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-2006-9s312
OpenAlex: W1694984064
Cited by: 284
References: 99
Citations by year: 2026: 9 · 2025: 5 · 2024: 22 · 2023: 15 · 2022: 10 · 2021: 14 · 2020: 19 · 2019: 12 · 2018: 17 · 2017: 15 · 2016: 16 · 2015: 18 · 2014: 15 · 2013: 20 · 2012: 22
FWCI: 5.09
Type: journal article
Language: en
Open access: closed
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r37ag012138-05, 5r01ag012986-03)
National Institute on Aging (P50AG005144, AG-14449, AG-05144, P01AG005119, P01AG014449, AG0 5119, AG12986, AG12138)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, synaptic density
MeSH terms: Age Factors, Aged, Aging, Alzheimer Disease, Cell Count, Cerebral Cortex, Hippocampus, Humans, Nerve Net, Synapses, Ultrasonography

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Alzheimer’s disease-related alterations in synaptic density: neocortex and hippocampus.

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