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Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease
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“miR-16-5p mimics induced a reduction in AD-related genes, including APP, BACE1 and Tau, in AD mice [101] (as listed in Table 6).”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [101]
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“miR-9-5p [42,43], miR-16-5p [101], miR-29b [47], miR-124 [59] and miR-206-3p [105] were related to the generation of Aβ.”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [101]
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The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941
Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14103 · Cited by 943
Campion, D., Dumanchin, C., Hannequin, D., Dubois, B., Belliard, S., Puel, M., Thomas-Anterion, C., Michon, A., Martin, C., Charbonnier, F., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302553 · Cited by 785
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O’Leary, J. C., Fontaine, S. N., Breydo, L., Zhang, B., Li, P., Wang, L., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69003 · Cited by 322
Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
Koval, E. D., Shaner, C., Zhang, P., du Maine, X., Fischer, K., Tay, J., Chau, B. N., Wu, G. F., & Miller, T. M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt261 · Cited by 236
MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms
Delay, C., Dorval, V., Fok, A., Grenier-Boley, B., Lambert, J.-C., Hsiung, G.-Y., & Hébert, S. S. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00067 · Cited by 28
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Research works printed but not linked: 86
- Sperling, 2011, Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease, Alzheimers Dement, 7, 280, 10.1016/j.jalz.2011.03.003 · DOI · Paper page
- De Strooper, 2012, Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease, Cold Spring Harb Perspect Med, 2, a006304, 10.1101/cshperspect.a006304 · DOI
- Hardy, 2002, The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science, 297, 353, 10.1126/science.1072994 · DOI · Paper page
- Jia, 2014, Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials, Biomed Res Int, 2014, 837157, 10.1155/2014/837157 · DOI
- Boutajangout, 2014, Tau-based therapeutic approaches for Alzheimer's disease - a mini-review, Gerontology, 60, 381, 10.1159/000358875 · DOI
- Rosenblum, 2014, Why Alzheimer trials fail: removing soluble oligomeric beta amyloid is essential, inconsistent, and difficult, Neurobiol Aging, 35, 969, 10.1016/j.neurobiolaging.2013.10.085 · DOI
- Jaturapatporn, 2012, Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease, Cochrane Database Syst Rev, 2, CD006378
- Carreiras, 2013, The multifactorial nature of Alzheimer's disease for developing potential therapeutics, Curr Top Med Chem, 13, 1745, 10.2174/15680266113139990135 · DOI
- Hébert, 2013, A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls, J Alzheimers Dis, 35, 335, 10.3233/JAD-122350 · DOI · Paper page
- Ambros, 2004, The functions of animal microRNAs, Nature, 431, 350, 10.1038/nature02871 · DOI · Paper page
- He, 2004, MicroRNAs: small RNAs with a big role in gene regulation, Nat Rev Genet, 5, 522, 10.1038/nrg1379 · DOI · Paper page
- Bartel, 2004, MicroRNAs: genomics, biogenesis, mechanism, and function, Cell, 116, 281, 10.1016/S0092-8674(04)00045-5 · DOI
- van Rooij, 2014, Development of microRNA therapeutics is coming of age, EMBO Mol Med, 6, 851, 10.15252/emmm.201100899 · DOI · Paper page
- Ling, 2013, MicroRNAs and other non-coding RNAs as targets for anticancer drug development, Nat Rev Drug Discov, 12, 847, 10.1038/nrd4140 · DOI
- Jackson, 2012, Developing microRNA therapeutics: approaching the unique complexities, Nucleic Acid Ther, 22, 213, 10.1089/nat.2012.0356 · DOI
- Hammond, 2007, MicroRNAs as tumor suppressors, Nat Genet, 39, 582, 10.1038/ng0507-582 · DOI
- Bader, 2010, The promise of microRNA replacement therapy, Cancer Res, 70, 7027, 10.1158/0008-5472.CAN-10-2010 · DOI
- Simonson, 2015, MicroRNA Therapeutics: the Next Magic Bullet?, Mini Rev Med Chem, 15, 467, 10.2174/1389557515666150324123208 · DOI
- Bader, 2012, miR-34 - a microRNA replacement therapy is headed to the clinic, Front Genet, 3, 120, 10.3389/fgene.2012.00120 · DOI
- Pasquinelli, 2012, MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship, Nat Rev Genet, 13, 271, 10.1038/nrg3162 · DOI
- Finnerty, 2010, The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases, J Mol Biol, 402, 491, 10.1016/j.jmb.2010.07.051 · DOI · Paper page
- Linsley, 2007, Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression, Mol Cell Biol, 27, 2240, 10.1128/MCB.02005-06 · DOI · Paper page
- Müller, 2014, MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid, Neurobiol Aging, 35, 152, 10.1016/j.neurobiolaging.2013.07.005 · DOI · Paper page
- Liu, 2012, MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice, Neurobiol Aging, 33, 522, 10.1016/j.neurobiolaging.2010.04.034 · DOI
- Wang, 2011, Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter, Acta Neuropathol, 121, 193, 10.1007/s00401-010-0756-0 · DOI · Paper page
- Hébert, 2008, Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression, Proc Natl Acad Sci USA, 105, 6415, 10.1073/pnas.0710263105 · DOI · Paper page
- Shioya, 2010, Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3, Neuropathol Appl Neurobiol, 36, 320, 10.1111/j.1365-2990.2010.01076.x · DOI · Paper page
- Nunez-Iglesias, 2010, Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation, PLoS One, 5, e8898, 10.1371/journal.pone.0008898 · DOI
- Hébert, 2010, Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration, Hum Mol Genet, 19, 3959, 10.1093/hmg/ddq311 · DOI
- Ai, 2013, MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats, J Neurosci, 33, 3989, 10.1523/JNEUROSCI.1997-12.2013 · DOI
- Wang, 2008, The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1, J Neurosci, 28, 1213, 10.1523/JNEUROSCI.5065-07.2008 · DOI · Paper page
- Nelson, 2010, MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study, J Alzheimers Dis, 21, 75, 10.3233/JAD-2010-091603 · DOI · Paper page
- Smith, 2011, In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs, J Neurochem, 116, 240, 10.1111/j.1471-4159.2010.07097.x · DOI · Paper page
- Zhu, 2012, MicroRNA-195 downregulates Alzheimer's disease amyloid-β production by targeting BACE1, Brain Res Bull, 88, 596, 10.1016/j.brainresbull.2012.05.018 · DOI · Paper page
- van Rooij, 2012, Developing microRNA therapeutics, Circ Res, 110, 496, 10.1161/CIRCRESAHA.111.247916 · DOI · Paper page
- Jopling, 2010, Targeting microRNA-122 to Treat Hepatitis C Virus Infection, Viruses, 2, 1382, 10.3390/v2071382 · DOI
- Patel, 2008, MicroRNAs can regulate human APP levels, Mol Neurodegener, 3, 10, 10.1186/1750-1326-3-10 · DOI
- Absalon, 2013, MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons, J Neurosci, 33, 14645, 10.1523/JNEUROSCI.1327-13.2013 · DOI · Paper page
- Ancolio, 1999, Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 –> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease, Proc Natl Acad Sci USA, 96, 4119, 10.1073/pnas.96.7.4119 · DOI
- Planel, 2008, Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo, J Neurosci, 28, 12798, 10.1523/JNEUROSCI.4101-08.2008 · DOI · Paper page
- Calin, 2002, Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia, Proc Natl Acad Sci USA, 99, 15524, 10.1073/pnas.242606799 · DOI · Paper page
- Wilkes, 2014, Programmable intrathecal pumps for the management of chronic pain: recommendations for improved efficiency, J Pain Res, 7, 571, 10.2147/JPR.S46929 · DOI
- Grondin, 2015, Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA, Mol Ther Nucleic Acids, 4, e245, 10.1038/mtna.2015.20 · DOI
- Wesemann, 2014, Clinical accuracy and safety using the SynchroMed II intrathecal drug infusion pump, Reg Anesth Pain Med, 39, 341, 10.1097/AAP.0000000000000107 · DOI
- Dweep, 2011, miRWalk–database: prediction of possible miRNA binding sites by “walking” the genes of three genomes, J Biomed Inform, 44, 839, 10.1016/j.jbi.2011.05.002 · DOI
- Zhou, 2012, miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene, PLoS One, 7, e30772, 10.1371/journal.pone.0030772 · DOI
- Frasca, 2015, MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals, J Immunol, 195, 2134, 10.4049/jimmunol.1500520 · DOI · Paper page
- Padurariu, 2012, Hippocampal neuronal loss in the CA1 and CA3 areas of Alzheimer's disease patients, Psychiatr Danub, 24, 152
- Grinberg, 2011, Brainstem: neglected locus in neurodegenerative diseases, Front Neurol, 2, 42, 10.3389/fneur.2011.00042 · DOI
- Simic, 2009, Does Alzheimer's disease begin in the brainstem?, Neuropathol Appl Neurobiol, 35, 532, 10.1111/j.1365-2990.2009.01038.x · DOI · Paper page
- Wiese, 2007, Protein labeling by iTRAQ: a new tool for quantitative mass spectrometry in proteome research, Proteomics, 7, 340, 10.1002/pmic.200600422 · DOI
- Warde-Farley, 2010, The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function, Nucleic Acids Res, 38, W214, 10.1093/nar/gkq537 · DOI · Paper page
- Huang, 2009, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat Protoc, 4, 44, 10.1038/nprot.2008.211 · DOI · Paper page
- Wang, 2010, miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease, Am J Pathol, 177, 334, 10.2353/ajpath.2010.091202 · DOI
- Ren, 2012, Identification and characterization of receptor-specific peptides for siRNA delivery, ACS Nano, 6, 8620, 10.1021/nn301975s · DOI
- Trang, 2011, Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice, Mol Ther, 19, 1116, 10.1038/mt.2011.48 · DOI
- Di Martino, 2014, In vivo activity of miR-34a mimics delivered by stable nucleic acid lipid particles (SNALPs) against multiple myeloma, PLoS One, 9, e90005, 10.1371/journal.pone.0090005 · DOI
- Thomson, 2013, On measuring miRNAs after transient transfection of mimics or antisense inhibitors, PLoS One, 8, e55214, 10.1371/journal.pone.0055214 · DOI
- Zhang, 2013, Progress in microRNA delivery, J Control Release, 172, 962, 10.1016/j.jconrel.2013.09.015 · DOI · Paper page
- Robakis, 2014, Cell signaling abnormalities may drive neurodegeneration in familial Alzheimer disease, Neurochem Res, 39, 570, 10.1007/s11064-013-1003-6 · DOI
- Magen, 2014, Oligonucleotide-based therapy for neurodegenerative diseases, Brain Res, 1584, 116, 10.1016/j.brainres.2014.04.005 · DOI
- Hanbury, 2003, GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insults, J Comp Neurol, 461, 307, 10.1002/cne.10667 · DOI
- Furman, 2012, Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease, J Neurosci, 32, 16129, 10.1523/JNEUROSCI.2323-12.2012 · DOI · Paper page
- Hol, 2003, Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms, Mol Psychiatry, 8, 786, 10.1038/sj.mp.4001379 · DOI
- Meraz-Ríos, 2013, Inflammatory process in Alzheimer's Disease, Front Integr Neurosci, 7, 59, 10.3389/fnint.2013.00059 · DOI · Paper page
- An, 2012, miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure, Apoptosis, 17, 702, 10.1007/s10495-012-0704-7 · DOI
- Spillantini, 1997, Alpha-synuclein in Lewy bodies, Nature, 388, 839, 10.1038/42166 · DOI · Paper page
- Nonaka, 2010, Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases, J Biol Chem, 285, 34885, 10.1074/jbc.M110.148460 · DOI
- Raven, 2013, Increased iron levels and decreased tissue integrity in hippocampus of Alzheimer's disease detected in vivo with magnetic resonance imaging, J Alzheimers Dis, 37, 127, 10.3233/JAD-130209 · DOI · Paper page
- Huang, 2014, Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease, Neurobiol Aging, 35, 1045, 10.1016/j.neurobiolaging.2013.11.004 · DOI
- Hunker, 2006, Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis, Biochem Biophys Res Commun, 340, 967, 10.1016/j.bbrc.2005.12.099 · DOI
- Leto, 2012, Regulation of glucose transport by insulin: traffic control of GLUT4, Nat Rev Mol Cell Biol, 13, 383, 10.1038/nrm3351 · DOI · Paper page
- Blencowe, 1998, A coactivator of pre-mRNA splicing, Genes Dev, 12, 996, 10.1101/gad.12.7.996 · DOI
- Shehadeh, 2010, SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinson's disease, PLoS One, 5, e9104, 10.1371/journal.pone.0009104 · DOI
- Liang, 2007, Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain, Physiol Genomics, 28, 311, 10.1152/physiolgenomics.00208.2006 · DOI
- Baskerville, 2008, Aging elevates metabolic gene expression in brain cholinergic neurons, Neurobiol Aging, 29, 1874, 10.1016/j.neurobiolaging.2007.04.024 · DOI
- Junn, 2012, MicroRNAs in neurodegenerative diseases and their therapeutic potential, Pharmacol Ther, 133, 142, 10.1016/j.pharmthera.2011.10.002 · DOI · Paper page
- Park, 2010, Analysis of microRNA knockouts in mice, Hum Mol Genet, 19, R169, 10.1093/hmg/ddq367 · DOI
- Vidigal, 2015, The biological functions of miRNAs: lessons from in vivo studies, Trends Cell Biol, 25, 137, 10.1016/j.tcb.2014.11.004 · DOI
- Aqeilan, 2010, miR-15a and miR-16-1 in cancer: discovery, function and future perspectives, Cell Death Differ, 17, 215, 10.1038/cdd.2009.69 · DOI
- Yang, 2014, MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathway, Cancer Sci, 105, 265, 10.1111/cas.12351 · DOI
- Chen, 2013, miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma, FEBS Lett, 587, 1366, 10.1016/j.febslet.2013.03.007 · DOI
- Calin, 2008, MiR-15a and miR-16-1 cluster functions in human leukemia, Proc Natl Acad Sci USA, 105, 5166, 10.1073/pnas.0800121105 · DOI
- Hébert, 2009, MicroRNA regulation of Alzheimer's Amyloid precursor protein expression, Neurobiol Dis, 33, 422, 10.1016/j.nbd.2008.11.009 · DOI · Paper page
- Dorval, 2014, Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models, PLoS One, 9, e85510, 10.1371/journal.pone.0085510 · DOI
- Wang, 2010, Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes, RNA, 16, 394, 10.1261/rna.1905910 · DOI
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Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases
Wu, Y.-Y., & Kuo, H.-C. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00636-z · Cited by 213
MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease
Li, W., & Zheng, Y. (2023) · Cells · doi:10.3390/cells12101378 · Cited by 43
Metadata
- Authors
- Parsi, S., Smith, P. Y., Goupil, C., Dorval, V., & Hébert, S. S.
- Venue
- Molecular Therapy - Nucleic Acids
- Publisher
- Elsevier BV
- Published
- 2015
- Volume
- 4
- Pages
- e256
- ISSN
- 2162-2531
- PMC
- PMC4881761
- Cited by
- 83
- References
- 6
- Language
- en
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