Cited by 134Advanced Neuroimaging Techniques and ApplicationsDementia and Cognitive Impairment ResearchFunctional Brain Connectivity Studies

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DTI analyses and clinical applications in Alzheimer’s disease

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Oishi, Kenichi, Mielke, Michelle M., Albert, Marilyn, Lyketsos, Constantine G., Mori, Susumu·2011·Journal of Alzheimer's Disease

DOI 10.3233/jad-2011-0007PMC PMC3294372

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Abstract

DTI is one of the most effective MR tools for the investigation of the brain anatomy. In addition to the gray matter, histopathological studies indicate that white matter is also a good target for both the early diagnosis of AD and for monitoring disease progression, which motivates us to use DTI to study AD patients in vivo. There are already a large amount of studies reporting significant differences between AD patients and controls, as well as to predict progression of disease in symptomatic non-demented individuals. Application of these findings in clinical practice remains to be demonstrated.

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“DTI is widely recognized as a useful tool for studying neurodegenerative disorders such as AD (Oishi et al., 2011; Müller and Kassubek, 2013; Abhinav et al., 2014; Acosta-Cabronero and Nestor, 2014; Maggipinto et al., 2017).”

See all 134

Authors: Oishi, K., Mielke, M. M., Albert, M., Lyketsos, C. G., & Mori, S.
Affiliations: Johns Hopkins University (US)
Kennedy Krieger Institute (US)
Corresponding author: Oishi, Kenichi
ORCID: Oishi, Kenichi
Mielke, Michelle M.
Albert, Marilyn
Lyketsos, Constantine G.
Mori, Susumu
Venue: Journal of Alzheimer's Disease
Publisher: SAGE Publications
Published: 2011-10-04
Volume: 26
Issue: s3
Pages: 287-296
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-2011-0007
PMC: PMC3294372
OpenAlex: W1556823089
Cited by: 134
References: 103
Citations by year: 2026: 14 · 2025: 8 · 2024: 12 · 2023: 9 · 2022: 8 · 2021: 10 · 2020: 9 · 2019: 11 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 14 · 2014: 6 · 2013: 14 · 2012: 7
FWCI: 6.86
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Johns Hopkins University
National Institutes of Health
National Institute on Aging (R01AG020012, R21AG033774, R01-AG20012, P50AG005146)
National Institute of Biomedical Imaging and Bioengineering (P01EB00195)
National Center for Research Resources (P41RR015241, U24RR021382)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: diffusion tensor imaging, Alzheimer's disease
MeSH terms: Aged, Alzheimer Disease, Brain, Brain Mapping, Cognition Disorders, Female, Humans, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Diffusion Magnetic Resonance Imaging

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DTI analyses and clinical applications in Alzheimer’s disease

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