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Cited by 369

The DOI matches its Crossref record; 233 of the 233 references it cites were found in a registry or an index.

Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions

Open access
Megyesfalvi, Zsolt, Gay, Carl M., Popper, Helmut, Pirker, Robert, Ostoros, Gyula, Heeke, Simon, Lang, Christian, Hoetzenecker, Konrad, Schwendenwein, Anna, Boettiger, Kristiina, Bunn, Paul A., Renyi‐Vamos, Ferenc, Schelch, Karin, Prosch, Helmut, Byers, Lauren A., Hirsch, Fred R., Dome, Balazs·2023·CA: A Cancer Journal for Clinicians
DOI 10.3322/caac.21785
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Abstract

Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity. It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority of SCLCs exhibit neuroendocrine features, an important subset of tumors lacks these properties. Genomic profiling of SCLC reveals genetic instability, almost universal inactivation of the tumor suppressor genes TP53 and RB1 , and a high mutation burden. Because of early metastasis, only a small fraction of patients are amenable to curative‐intent lung resection, and these individuals require adjuvant platinum‐etoposide chemotherapy. Therefore, the vast majority of patients are currently being treated with chemoradiation with or without immunotherapy. In patients with disease confined to the chest, standard therapy includes thoracic radiotherapy and concurrent platinum‐etoposide chemotherapy. Patients with metastatic (extensive‐stage) disease are treated with a combination of platinum‐etoposide chemotherapy plus immunotherapy with an anti‐programmed death‐ligand 1 monoclonal antibody. Although SCLC is initially very responsive to platinum‐based chemotherapy, these responses are transient because of the development of drug resistance. In recent years, the authors have witnessed an accelerating pace of biologic insights into the disease, leading to the redefinition of the SCLC classification scheme. This emerging knowledge of SCLC molecular subtypes has the potential to define unique therapeutic vulnerabilities. Synthesizing these new discoveries with the current knowledge of SCLC biology and clinical management may lead to unprecedented advances in SCLC patient care. Here, the authors present an overview of multimodal clinical approaches in SCLC, with a special focus on illuminating how recent advancements in SCLC research could accelerate clinical development.

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Metadata

Authors
Megyesfalvi, Z., Gay, C. M., Popper, H., Pirker, R., Ostoros, G., Heeke, S., Lang, C., Hoetzenecker, K., Schwendenwein, A., Boettiger, K., Bunn, P. A., Renyi‐Vamos, F., Schelch, K., Prosch, H., Byers, L. A., Hirsch, F. R., & Dome, B.
Venue
CA: A Cancer Journal for Clinicians
Publisher
Wiley
Published
2023-06-17
Volume
73
Issue
6
Pages
620-652
ISSN
  • 0007-9235 (ISSN-L)
  • 1542-4863
DOI
10.3322/caac.21785
OpenAlex
W4381094907
Cited by
369
References
233
FWCI
38.20
Type
journal article
Language
en
Open access
gold

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