Cited by 315Immune cells in cancerPhagocytosis and Immune RegulationImmune Response and Inflammation

The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.

Revisiting Mouse Peritoneal Macrophages: Heterogeneity, Development, and Function

Open access

Cassado, Alexandra dos Anjos, Dâ€™ImpÃ©rio Lima, Maria Regina, Bortoluci, Karina Ramalho·2015·Frontiers in Immunology

DOI 10.3389/fimmu.2015.00225PMC PMC4437037

Open this paper in CoChat — free account Open PDF

Abstract

Tissue macrophages play a crucial role in the maintenance of tissue homeostasis and also contribute to inflammatory and reparatory responses during pathogenic infection and tissue injury. The high heterogeneity of these macrophages is consistent with their adaptation to distinct tissue environments and specialization to develop niche-specific functions. Although peritoneal macrophages are one of the best-studied macrophage populations, recently it was demonstrated the co-existence of two subsets in mouse peritoneal cavity (PerC), which exhibit distinct phenotypes, functions, and origins. These macrophage subsets have been classified, according to their morphology, as large peritoneal macrophages (LPMs) and small peritoneal macrophages (SPMs). LPMs, the most abundant subset under steady state conditions, express high levels of F4/80 and low levels of class II molecules of the major histocompatibility complex (MHC). LPMs appear to be originated from embryogenic precursors, and their maintenance in PerC is regulated by expression of specific transcription factors and tissue-derived signals. Conversely, SPMs, a minor subset in unstimulated PerC, have a F4/80(low)MHC-II(high) phenotype and are generated from bone-marrow-derived myeloid precursors. In response to infectious or inflammatory stimuli, the cellular composition of PerC is dramatically altered, where LPMs disappear and SPMs become the prevalent population together with their precursor, the inflammatory monocyte. SPMs appear to be the major source of inflammatory mediators in PerC during infection, whereas LPMs contribute for gut-associated lymphoid tissue-independent and retinoic acid-dependent IgA production by peritoneal B-1 cells. In the previous years, considerable efforts have been made to broaden our understanding of LPM and SPM origin, transcriptional regulation, and functional profile. This review addresses these issues, focusing on the impact of tissue-derived signals and external stimulation in the complex dynamics of peritoneal macrophage populations.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fimmu.2015.00225

Cites

97 of 97 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Distinct origin of peritoneal macrophage subsets. SPMs are generated from hematopoietic stem cells (HSC) in the bone marrow (BM) by differentiation of inflammatory blood monocytes (31, 40). However, LPMs appear to be originated from progenitors from yolk sac and independent of hematopoietic progenitors (69). Local proliferation of LPMs ensures homeostatic maintenance by self-renewal (36).CC BY · PubMed Central

Figure 2 Summary of the dynamic of peritoneal macrophage subsets. (A) Under homeostatic conditions, peritoneal macrophages comprise two subsets LPMs and SPMs (31). LPMs, which are the major peritoneal macrophage population, appear to be responsible for phagocytosis of apoptotic cell and tissue repair (36). (B) At the outset of inflammation, the myeloid compartment is modified in general by disappearance of LPMs, increase of SPMs numbers, and monocytes influx (31, 35, 36, 40). The changes in the myeloid cells from zymosan, T. cruzi, and LPS stimulated or thioglicollate-elicited PerC result in the gain of immune state (35, 36). SPMs from zymosan and T. cruzi stimulated mice contribute to effector function of PerC through secretion of high levels of NO and presence of IL-12-producing cells (35). In response to LPS in vivo, SPMs produce several inflammatory cytokines, such as IL-12, MIP-1α, TNF-α, and RANTES, whereas LPMs produce enhanced amounts of G-CSF, GM-CSF, and KC (36). LPMs, which migrate to omentum by a retinoic acid and GATA-6-dependent way in response to in vivo LPS stimulation or vitamin-A deprivation, return to PerC and appear to be correlated with GALT-independent and TGF-β2-dependent IgA production by B-1 cells in the intestine (40).CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · cited 2×
“Currently, it is accepted that inflammatory macrophages and tissue-resident macrophages comprise developmentally and functionally distinct populations (3, 14, 17, 18, 29).”
Background
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543
Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311
Mouse and human dendritic cell subtypes
Shortman, K., & Liu, Y.-J. (2002) · Nature reviews. Immunology · doi:10.1038/nri746 · Cited by 2,289
Tissue-resident macrophages
Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
Guilliams, M., Ginhoux, F., Jakubzick, C., Naik, S. H., Onai, N., Schraml, B. U., Segura, É., Tussiwand, R., & Yona, S. (2014) · Nature reviews. Immunology · doi:10.1038/nri3712 · Cited by 1,923
The many faces of macrophage activation
Mosser, D. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0602325 · Cited by 1,902
Monocytes and macrophages: developmental pathways and tissue homeostasis
Ginhoux, F., & Jung, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3671 · Cited by 1,840
Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells
Auffray, C., Sieweke, M. H., & Geissmann, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132557 · Cited by 1,745
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643
F4/80, a monoclonal antibody directed specifically against the mouse macrophage
Austyn, J. M., & Gordon, S. (1981) · European Journal of Immunology · doi:10.1002/eji.1830111013 · Cited by 1,596
THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES
van Furth, R., & Cohn, Z. A. (1968) · The Journal of Experimental Medicine · doi:10.1084/jem.128.3.415 · Cited by 1,564
MACROPHAGE RECEPTORS AND IMMUNE RECOGNITION
Taylor, P. R., Martínez‐Pomares, L., Stacey, M. A., Lin, H.-H., Brown, G. D., & Gordon, S. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115816 · Cited by 1,366
Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF
Guilliams, M., de Kleer, I., Henri, S., Post, S., Vanhoutte, L., Prijck, S. D., Deswarte, K., MALISSEN, B., Hammad, H., & Lambrecht, B. N. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131199 · Cited by 1,342
C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages
Hoeffel, G., Chen, J., Lavin, Y., Low, D., Almeida, F. F., See, P., Beaudin, A. E., Lum, J., Low, I., Forsberg, E. C., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.011 · Cited by 1,135
The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells.
van Furth, R., Cohn, Z. A., Jg, H., Humphrey, J., Spector, W. G., & Langevoort, H. L. (1972) · PubMed Central · Cited by 1,133
A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells
Fogg, D. K., Sibon, C., Miled, C., Jung, S., Aucouturier, P., Littman, D. R., Cumano, A., & Geissmann, F. (2005) · Science · doi:10.1126/science.1117729 · Cited by 1,050
The double life of a B-1 cell: self-reactivity selects for protective effector functions
Baumgarth, N. (2011) · Nature Reviews Immunology · doi:10.1038/nri2901 · Cited by 969
Tissue-specific signals control reversible program of localization and functional polarization of macrophages
Okabe, Y., & Medzhitov, R. (2014) · Cell · doi:10.1016/j.cell.2014.04.016 · Cited by 884
Two physically, functionally, and developmentally distinct peritoneal macrophage subsets
Ghosn, E. E. B., Cassado, A. A., Govoni, G. R., Fukuhara, T., Yang, Y., Monack, D. M., Bortoluci, K. R., Almeida, S. R., Herzenberg, L. A., & Herzenberg, L. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915000107 · Cited by 689
Self-citation
The mononuclear phagocyte system
Hume, D. A. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.11.008 · Cited by 654
The macrophage: Past, present and future
Gordon, S. (2007) · European Journal of Immunology · doi:10.1002/eji.200737638 · Cited by 640
The Activation of Mononuclear Phagocytes: Fact, Fancy, and Future
Cohn, Z. A. (1978) · The Journal of Immunology · doi:10.4049/jimmunol.121.3.813 · Cited by 602
Unravelling mononuclear phagocyte heterogeneity
Geissmann, F., Gordon, S., Hume, D. A., Mowat, A. M., & Randolph, G. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2784 · Cited by 554
Beyond stem cells: self-renewal of differentiated macrophages
Sieweke, M. H., & Allen, J. E. (2013) · Science · doi:10.1126/science.1242974 · Cited by 503
Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis
Kohyama, M., Ise, W., Edelson, B. T., Wilker, P. R., Hildner, K., Mejia, C., Frazier, W. A., Murphy, T. L., & Murphy, K. M. (2009) · Nature · doi:10.1038/nature07472 · Cited by 479
Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers.
Hume, D. A., Perry, V. H., & Gordon, S. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.1.253 · Cited by 447
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages
Haldar, M., Kohyama, M., So, A. Y.-L., KC, W., Wu, X., Briseño, C. G., Satpathy, A. T., Kretzer, N. M., Arase, H., Rajasekaran, N. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.069 · Cited by 431 · cited 1×
“Heme has been shown to induce Spi-c, a transcription factor important for red pulp macrophage development (81, 82).”
Background
The mononuclear phagocyte system revisited
Hume, D. A., Ross, I. L., Himes, S. R., Sasmono, R. T., Wells, C. A., & Ravasi, T. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.4.621 · Cited by 423
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation
Auffray, C., Fogg, D. K., Narni-Mancinelli, E., Senechal, B., Trouillet, C., Saederup, N., Leemput, J., Bigot, K., Campisi, L., Abitbol, M., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081385 · Cited by 422
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice
Bedoret, D., Wallemacq, H., Marichal, T., Desmet, C., Quesada Calvo, F., Henry, E., Closset, R., Dewals, B., Thielen, C., Gustin, P., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39717 · Cited by 399
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network
Chorro, L., Sarde, A., Li, M., Woollard, K. J., Chambon, P., MALISSEN, B., Kissenpfennig, A., Barbaroux, J.-B., Groves, R. W., & Geissmann, F. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091586 · Cited by 395
The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal
Rosas, M., Davies, L. C., Giles, P. J., Liao, C., Kharfan, B., Stone, T., O’Donnell, V. B., Fraser, D. J., Jones, S. A., & Taylor, P. R. (2014) · Science · doi:10.1126/science.1251414 · Cited by 393
The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs.
Hume, D. A., Robinson, A. P., MacPherson, G. G., & Gordon, S. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.158.5.1522 · Cited by 390
Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation
Davies, L. C., Rosas, M., Jenkins, S. J., Liao, C., Scurr, M. J., Brombacher, F., Fraser, D. J., Allen, J. E., Jones, S. A., & Taylor, P. R. (2013) · Nature Communications · doi:10.1038/ncomms2877 · Cited by 349
Flow cytometric identification of murine neutrophils and monocytes
Lagasse, E., & Weissman, I. L. (1996) · Journal of Immunological Methods · doi:10.1016/0022-1759(96)00138-x · Cited by 334
Das reticulo-endotheliale System
Aschoff, L. (1924) · Springer eBooks · doi:10.1007/978-3-642-90639-8_1 · Cited by 332
Distinct Differentiation Potential of Blood Monocyte Subsets in the Lung
Landsman, L., Varol, C., & Jung, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2000 · Cited by 322
Differential development of progenitor activity for three B-cell lineages.
Kantor, A. B., Stall, A. M., Adams, S. D., Herzenberg, L. A., & Herzenberg, L. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3320 · Cited by 314
The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of endocrine organs.
Hume, D. A., Halpin, D., Charlton, H. M., & Gordon, S. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.13.4174 · Cited by 283
Current View on the Mononuclear Phagocyte System
van Furth, R. (1982) · Immunobiology · doi:10.1016/s0171-2985(82)80072-7 · Cited by 246
A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation
Davies, L. C., Rosas, M., Smith, P. J., Fraser, D. J., Jones, S. A., & Taylor, P. R. (2011) · European Journal of Immunology · doi:10.1002/eji.201141817 · Cited by 245
Origin and kinetics of monocytes and macrophages.
van Furth, R. (1970) · PubMed · Cited by 226
Characterization of murine macrophages from bone marrow, spleen and peritoneum
Wang, C., Yu, X., Cao, Q., Wang, Y., Zheng, G., Tan, T. K., Zhao, H., Zhao, Y., Wang, Y., & Harris, D. C. (2013) · BMC Immunology · doi:10.1186/1471-2172-14-6 · Cited by 225
Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival
Gautier, E. L., Ivanov, S., Williams, J. W., Huang, S. C., Marcelin, G., Fairfax, K. C., Wang, P. L., Francis, J. S., Leone, P., Wilson, D. B., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140570 · Cited by 210
Intestinal macrophages: well educated exceptions from the rule
Zigmond, E., & Jung, S. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.02.001 · Cited by 207
Review of the macrophage disappearance reaction
Barth, M. W., Hendrzak, J. A., Melnicoff, M. J., & Morahan, P. S. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.57.3.361 · Cited by 197
Mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex
Hume, D., & Gordon, S. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.157.5.1704 · Cited by 192
Identification of a Tissue-Specific, C/EBPβ-Dependent Pathway of Differentiation for Murine Peritoneal Macrophages
Cain, D. W., O’Koren, E. G., Kan, M. J., Womble, M. A., Sempowski, G. D., Hopper, K., Gunn, M. D., & Kelsoe, G. H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300581 · Cited by 189
The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: Macrophages associated with epithelia
Hume, D., Perry, V. H., & Gordon, S. (1984) · The Anatomical Record · doi:10.1002/ar.1092100311 · Cited by 180
Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis
Dahdah, A., Gautier, G., Attout, T., FIORE, F., Lebourdais, E., Msallam, R., Daëron, M., Monteiro, R. C., Benhamou, M., Charles, N., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75212 · Cited by 147
Immunosenescence of macrophages: reduced MHC class II gene expression
Herrero, C., Sebastián, C., Marqués, L., Comalada, M., Xaus, J., Valledor, A. F., Lloberas, J., & Celada, A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00205-4 · Cited by 139
Effect of aging on macrophage function
Lloberas, J., & Celada, A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00125-0 · Cited by 136
Monocyte Heterogeneity and Innate Immunity
Taylor, P. R., & Gordon, S. (2003) · Immunity · doi:10.1016/s1074-7613(03)00178-x · Cited by 135
Ontogeny and homeostasis of Langerhans cells
Ginhoux, F., & Mérad, M. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.38 · Cited by 132
TGF‐β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment
Abutbul, S., Shapiro, J., Szaingurten‐Solodkin, I., Levy, N., Carmy, Y., Baron, R., Jung, S., & Monsonego, A. (2012) · Glia · doi:10.1002/glia.22343 · Cited by 122
The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen f4/80: Macrophages of bone and associated connective tissue
Hume, D., Loutit, J. F., & Gordon, S. (1984) · Journal of Cell Science · doi:10.1242/jcs.66.1.189 · Cited by 121
Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo
Taylor, P. R., Brown, G. D., Geldhof, A. B., Martínez‐Pomares, L., & Gordon, S. (2003) · European Journal of Immunology · doi:10.1002/eji.200324003 · Cited by 114
Endogenous Transforming Growth Factor β1 Suppresses Inflammation and Promotes Survival in Adult CNS
Makwana, M., Jones, L. L., Cuthill, D., Heuer, H., Bohatschek, M., Hristova, M., Friedrichsen, S., Ormsby, I., Büringer, D., Koppius, A., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2255-07.2007 · Cited by 112
CD11b expression distinguishes sequential stages of peritoneal B-1 development
Ghosn, E., Yang, Y., Tung, J. W., Herzenberg, L. A., & Herzenberg, L. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712350105 · Cited by 107
The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B
Rosas, M., Thomas, B., Stacey, M. A., Gordon, S., & Taylor, P. R. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809548 · Cited by 105
Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile
Bastos, K. R. B., Álvarez, J. M., Marinho, C. R. F., Rizzo, L. V., & Lima, M. R. D. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.2.271 · Cited by 100
Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-γ in IL-12/IL-18-stimulated mouse macrophage populations
Schleicher, U., Hesse, A., & Bogdan, C. (2004) · Blood · doi:10.1182/blood-2004-05-1749 · Cited by 93
Cells of the Mononuclear Phagocyte System
van Furth, R. (1980) · Springer eBooks · doi:10.1007/978-94-009-8793-7_1 · Cited by 91
12/15-Lipoxygenase Regulates the Inflammatory Response to Bacterial Products In Vivo
Dioszeghy, V., Rosas, M., Maskrey, B. H., Colmont, C. S., Topley, N., Chaitidis, P., Kühn, H., Jones, S. A., Taylor, P. R., & O’Donnell, V. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6514 · Cited by 90
Monocyte Chemoattractant Protein-1 (MCP-1), Not MCP-3, Is the Primary Chemokine Required for Monocyte Recruitment in Mouse Peritonitis Induced with Thioglycollate or Zymosan A
Takahashi, M., Galligan, C. L., Tessarollo, L., & Yoshimura, T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802812 · Cited by 86
Milky spots in the mouse omentum may play an important role in the origin of peritoneal macrophages
Wijffels, J. F. A. M., Hendrickx, R. J. B. M., Steenbergen, J. J. E., Eestermans, I. L., & Beelen, R. H. J. (1992) · Research in Immunology · doi:10.1016/s0923-2494(05)80072-0 · Cited by 83
Effect of thioglycolate on phagocytic and microbicidal activities of peritoneal macrophages
Leijh, P. C. J., van Zwet, T. L., ter Kuile, M. N., & van Furth, R. (1984) · Infection and Immunity · doi:10.1128/iai.46.2.448-452.1984 · Cited by 81
Cellular Renewal and Improvement of Local Cell Effector Activity in Peritoneal Cavity in Response to Infectious Stimuli
Cassado, A. D. A., de Albuquerque, J. A. T., Sardinha, L. R., Buzzo, C. D. L., Faustino, L., Nascimento, R., Ghosn, E., Lima, M. R. D., Álvarez, J. M., & Bortoluci, K. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022141 · Cited by 76
Self-citation
Determinants of infection in the peritoneal cavity. I. Response to and fate of Staphylococcus aureus and Staphylococcus albus in the mouse.
Cohn, Z. A. (1962) · PubMed · Cited by 70
Origin and Kinetics of Resident Tissue Macrophages
Parwaresch, M. R., & Wacker, H.-H. (1984) · Cell Proliferation · doi:10.1111/j.1365-2184.1984.tb00565.x · Cited by 66
Receptor-receptor interactions of complement receptor type 3 in neutrophil membranes
Petty, H. R., & Todd, R. R. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.5.492 · Cited by 66
Development and homeostasis of ‘resident’ myeloid cells: the case of the Langerhans cell
Chorro, L., & Geissmann, F. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.09.003 · Cited by 64
Maintenance of Peritoneal Macrophages in the Steady State
Melnicoff, M. J., Horan, P. K., Breslin, E. W., & Morahan, P. S. (1988) · Journal of Leukocyte Biology · doi:10.1002/jlb.44.5.367 · Cited by 63
Do Resident Macrophages Proliferate?
Daems, W., & Bakker, J. M. D. (1982) · Immunobiology · doi:10.1016/s0171-2985(82)80075-2 · Cited by 57
Isolation and characterization of the receptor on human neutrophils that mediates cellular adherence.
Hickstein, D., Ozols, J., Williams, S. A., Baenziger, J., Locksley, R. M., & Roth, G. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45611-6 · Cited by 53
Zanvil Alexander Cohn 1926-1993.
Steinman, R. M., & Moberg, C. L. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.1.1 · Cited by 42
Determinants of infection in the peritoneal cavity. II. Factors influencing the fate of Staphylococcus aureus in the mouse.
Cohn, Z. A. (1962) · PubMed · Cited by 39
Mononuclear phagocyte system
(2004) · Springer eBooks · doi:10.1007/3-540-29662-x_1888 · Cited by 39
Current View of the Mononuclear Phagocyte System
van Furth, R. (1981) · Hämatologie und Bluttransfusion · doi:10.1007/978-3-642-81696-3_1 · Cited by 32
Determinants of infection in the peritoneal cavity. III. The action of selected inhibitors on the fate of Staphylococcus aureus in the mouse.
Cohn, Z. A. (1962) · PubMed Central · Cited by 18
Role of Peritoneal Macrophages on Local and Systemic Inflammatory Response in Acute Pancreatitis
Machado, M. C. C., & Coelho, A. M. M. (2012) · InTech eBooks · doi:10.5772/25639 · Cited by 6
[ELIE METCHNIKOFF, 1845-1916].
Meursg, V. (1964) · PubMed · Cited by 3
[The origin of mononuclear phagocytes].
van Furth, R. (1967) · PubMed · Cited by 2

Research works printed but not linked: 3

Aschoff, 1924, Das reticuloendotheliale system, Ergeb Inn Med Kinderheilkd, 26, 1
Ghosn, 2008, CD11b expression distinguishes sequential stages of peritoneal B-1 development, Proc Natl Acad Sci U S A, 105, 5195, 10.1073/pnas.0712350105 · DOI

Sorted by citations

Targeting macrophages in cancer immunotherapy
Duan, Z., & Luo, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00506-6 · Cited by 656
Metabolism of tissue macrophages in homeostasis and pathology
Wculek, S. K., Dunphy, G., Heras-Murillo, I., Mastrangelo, A., & Sancho, D. (2022) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00791-9 · Cited by 501
Macrophages During the Fibrotic Process: M2 as Friend and Foe
Braga, T. T., Agudelo, J. S. H., & Câmara, N. O. S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00602 · Cited by 481
Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis
Corliss, B. A., Azimi, M. S., Munson, J. M., Peirce, S. M., & Murfee, W. L. (2016) · Microcirculation · doi:10.1111/micc.12259 · Cited by 356
Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355

See all 315

Affiliations: Universidade de São Paulo (BR)
Universidade Federal de São Paulo (BR)
Corresponding author: Cassado, Alexandra dos Anjos
ORCID: Cassado, Alexandra dos Anjos
Bortoluci, Karina Ramalho
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2015-05-19
Volume: 6
Pages: 225-225
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2015.00225
PMC: PMC4437037
OpenAlex: W1553047467
Cited by: 315
References: 97
Citations by year: 2026: 18 · 2025: 24 · 2024: 31 · 2023: 38 · 2022: 25 · 2021: 48 · 2020: 36 · 2019: 27 · 2018: 23 · 2017: 24 · 2016: 17 · 2015: 4
FWCI: 2.13
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo (13/16010-5, 13/07140-2)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico (2013/07140-2)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: peritoneal macrophages, macrophage heterogeneity, macrophage development, macrophage origin, inflammatory monocytes, MHC class II expression, F4/80, transcriptional regulation, IgA production, gut-associated lymphoid tissue, retinoic acid, infection, inflammation, tissue homeostasis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Revisiting Mouse Peritoneal Macrophages: Heterogeneity, Development, and Function

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks