Fragile X mental retardation protein control of neuronal mRNA metabolism: Insights into mRNA stability
Abstract
The fragile X mental retardation protein (FMRP) is an RNA binding protein that has an essential role in neurons. From the soma to the synapse, FMRP is associated with a specific subset of messenger RNAs and controls their posttranscriptional fates, i.e., dendritic localization and local translation. Because FMRP target mRNAs encode important neuronal proteins, the deregulation of their expression in the absence of FMRP leads to a strong impairment of synaptic function. Here, we review emerging evidence indicating a critical role for FMRP in the control of mRNA stability. To date, two mRNAs have been identified as being regulated in this manner: PSD-95 mRNA, encoding a scaffolding protein, and Nxf1 mRNA, encoding a general export factor. Moreover, expression studies suggest that the turnover of other neuronal mRNAs, including those encoding for the GABA(A) receptors subunits, could be affected by the loss of FMRP. According to the specific target and/or cellular context, FMRP could influence mRNA stability in the brain.
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FMRP is an RNA-binding protein that regulates target RNAs post-transcriptionally and binds about 4% of brain mRNA.
“FMRP, translated from the Fragile X mental retardation-1 (FMR1) gene, is an RNA-binding protein involved in post-transcriptional regulation of target RNAs [157] and binds approximately 4% of the mRNA expressed in the brain [158].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [157]
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Self-citation
- Authors
- De Rubeis, S., & Bagni, C.
- Affiliations
- University of Rome Tor Vergata (IT)
- Corresponding author
- Bagni, Claudia
- ORCID
- Bagni, Claudia
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 43
- Issue
- 1
- Pages
- 43-50
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2023894260
- Cited by
- 126
- References
- 108
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 10 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 1 · 2014: 6 · 2013: 16 · 2012: 18
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Lirias (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- FMRP, mRNA stability, post-transcriptional regulation, RNA-binding proteins, PSD-95, NXF1, GABAA receptor subunits, dendritic mRNA localization, local translation, synaptic function, fragile X syndrome
- MeSH terms
- Heterogeneous Nuclear Ribonucleoprotein D0, Animals, Nerve Tissue Proteins, Neurons, RNA, Messenger, RNA-Binding Proteins, RNA Stability, Nucleocytoplasmic Transport Proteins, Heterogeneous-Nuclear Ribonucleoprotein D, Fragile X Messenger Ribonucleoprotein 1, ELAV Proteins
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