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MicroRNAs as biomarkers for CNS disease

Rao, Pooja, Benito, Eva, Fischer, André·2013·Frontiers in Molecular Neuroscience
DOI 10.3389/fnmol.2013.00039PMC PMC3840814
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Figure 1 A model for miRNA-based biomarker development: Disease-causing factors impact the brain both directly and indirectly (via immune and other cells), eliciting changes in gene and microRNA expression patterns. Many of these stimuli concurrently exert their influence on non-neuronal cells, where they also elicit a response. In CNS diseases, in the absence of direct access to diseased tissue, microRNA expression patterns from peripheral cells such as blood cells could be used a proxy for genome-environment interaction in the CNS. Moreover, microRNAs circulate stably in cerebrospinal fluid and plasma in extracellular vesicles and in lipoprotein complexes, and can be isolated from these body fluids and profiled. Information derived from peripheral sources could thus be used to construct a picture of neuronal function both in the healthy and the diseased state.
Figure 1 A model for miRNA-based biomarker development: Disease-causing factors impact the brain both directly and indirectly (via immune and other cells), eliciting changes in gene and microRNA expression patterns. Many of these stimuli concurrently exert their influence on non-neuronal cells, where they also elicit a response. In CNS diseases, in the absence of direct access to diseased tissue, microRNA expression patterns from peripheral cells such as blood cells could be used a proxy for genome-environment interaction in the CNS. Moreover, microRNAs circulate stably in cerebrospinal fluid and plasma in extracellular vesicles and in lipoprotein complexes, and can be isolated from these body fluids and profiled. Information derived from peripheral sources could thus be used to construct a picture of neuronal function both in the healthy and the diseased state.CC BY · PubMed Central

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Metadata

Authors
Rao, P., Benito, E., & Fischer, A.
Venue
Frontiers in Molecular Neuroscience
Publisher
Frontiers Media SA
Published
2013
Volume
6
ISSN
1662-5099
DOI
10.3389/fnmol.2013.00039
PMC
PMC3840814
Cited by
171
References
11

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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