Cited by 34Pleistocene-Era Hominins and ArchaeologyForensic and Genetic ResearchEvolution and Genetic Dynamics

Evolutionary and medical consequences of archaic introgression into modern human genomes

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Dolgova, Olga, Lao, Oscar·2018·Genes

Published version of a preprint

Abstract

The demographic history of anatomically modern humans (AMH) involves multiple migration events, population extinctions and genetic adaptations. As genome-wide data from complete genome sequencing becomes increasingly abundant and available even from extinct hominins, new insights of the evolutionary history of our species are discovered. It is currently known that AMH interbred with archaic hominins once they left the African continent. Current non-African human genomes carry fragments of archaic origin. This review focuses on the fitness consequences of archaic interbreeding in current human populations. We discuss new insights and challenges that researchers face when interpreting the potential impact of introgression on fitness and testing hypotheses about the role of selection within the context of health and disease.

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Authors
Dolgova, O., & Lao, O.
Affiliations
  • Centro Nacional de Análisis Genómico (ES)
  • Population Genomics Group, Centre Nacional d’Anàlisi Genòmica, Centre de Regulació Genòmica (CRG-CNAG), Parc Científic de Barcelona, Baldiri Reixac 4, 08028 Barcelona, Catalonia, Spain
Corresponding author
Dolgova, Olga
Venue
Genes
Publisher
MDPI AG
Published
2018-07-18
Volume
9
Issue
7
Pages
358
ISSN
2073-4425 (ISSN-L)
OpenAlex
W2809495114
Cited by
34
References
116
Citations by year
2025: 1 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 8 · 2020: 3 · 2019: 6 · 2018: 2
FWCI
3.64
Type
journal article
Language
en
Open access
Locations
  • Genes (publishedVersion, cc-by)
  • Preprints.org (acceptedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by)
Funders
  • Ministerio de Economía y Competitividad (BFU2015-68759-P)
  • Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 937)
  • MINECO (RYC-2013-14797)
Topics
  • Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
archaic introgression, modern human genomes, archaic humans, Neanderthal admixture, Denisovan admixture, interbreeding, fitness effects, natural selection, disease susceptibility, human evolutionary history, non-African populations

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