Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed dictyopteris delicatula

Magalhaes, Kaline Dantas; Costa, Leandro Silva; Fidelis, Gabriel Pereira; Oliveira, Ruth Medeiros; Nobre, Leonardo Thiago Duarte Barreto; Dantas-Santos, Nednaldo; Camara, Rafael Barros Gomes; Albuquerque, Ivan Rui Lopes; Cordeiro, Sara Lima; Sabry, Diego Araujo; Costa, Mariana Santana Santos Pereira; Alves, Luciana Guimaraes; Rocha, Hugo Alexandre Oliveira

doi:10.3390/ijms12053352

Cited by 97Seaweed-derived Bioactive CompoundsPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell Walls

Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed dictyopteris delicatula

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Magalhaes, Kaline Dantas, Costa, Leandro Silva, Fidelis, Gabriel Pereira, Oliveira, Ruth Medeiros, Nobre, Leonardo Thiago Duarte Barreto, Dantas-Santos, Nednaldo, Camara, Rafael Barros Gomes, Albuquerque, Ivan Rui Lopes +5 more·2011·International Journal of Molecular Sciences

DOI 10.3390/ijms12053352PMC PMC3116195

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Abstract

In the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100. Chemical analyses demonstrated that all polysaccharides contain heterofucans composed mainly of fucose, xylose, glucose, galactose, uronic acid, and sulfate. The fucans F0.5v and F0.7v at 1.0 mg/mL showed high ferric chelating activity (∼45%), whereas fucans F1.3v (0.5 mg/mL) showed considerable reducing power, about 53.2% of the activity of vitamin C. The fucan F1.5v presented the most prominent anticoagulant activity. The best antiproliferative activity was found with fucans F1.3v and F0.7v. However, F1.3v activity was much higher than F0.7v inhibiting almost 100% of HeLa cell proliferation. These fucans have been selected for further studies on structural characterization as well as in vivo experiments, which are already in progress.

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Phlorotannins and sulfated polysaccharides such as fucoidans in brown algae, carrageenans in red algae, and ulvans in green algae have been recognized as potential anticoagulant agents.
“Phlorotannins and sulfated polysaccharides such as fucoidans in brown algae, carrageenans in red algae, and ulvans in green algae have been recognized as potential anticoagulant agents [61,62,63,64].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [63]

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Authors: Magalhaes, K. D., Costa, L. S., Fidelis, G. P., Oliveira, R. M., Nobre, L. T. D. B., Dantas-Santos, N., Camara, R. B. G., Albuquerque, I. R. L., Cordeiro, S. L., Sabry, D. A., Costa, M. S. S. P., Alves, L. G., & Rocha, H. A. O.
Affiliations: Laboratory of Biotechnology of Natural Polymers (BIOPOL), Department of Biochemistry, Federal University of Rio Grande do Norte (UFRN), 59020-100 Natal-RN, Brazil
Instituto Federal do Rio Grande do Norte (BR)
Universidade Federal do Rio Grande do Norte (BR)
Corresponding author: Rocha, Hugo Alexandre Oliveira
ORCID: Costa, Leandro Silva
Fidelis, Gabriel Pereira
Nobre, Leonardo Thiago Duarte Barreto
Cordeiro, Sara Lima
Costa, Mariana Santana Santos Pereira
Rocha, Hugo Alexandre Oliveira
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2011-05-23
Volume: 12
Issue: 5
Pages: 3352-3365
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms12053352
PMC: PMC3116195
OpenAlex: W2021023697
Cited by: 97
References: 37
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 10 · 2021: 7 · 2020: 12 · 2019: 10 · 2018: 9 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 4
FWCI: 10.67
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords: fucan, anticoagulant activity, antioxidant activity, reducing power, antiproliferative activity, HeLa cells, uronic acid, sulfated polysaccharides
MeSH terms: Anticoagulants, Antineoplastic Agents, Phytogenic, Antioxidants, Furans, HeLa Cells, Humans, Plant Extracts, Seaweed

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Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed dictyopteris delicatula

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