The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: A study with relevance to inflammatory bowel disease
Open accessAbstract
AIM: To compare the anti-inflammatory properties of butyrate with two other SCFAs, namely acetate and propionate, which have less well-documented effects on inflammation. METHODS: The effect of SCFAs on cytokine release from human neutrophils was studied with ELISA. SCFA-dependent modulation of NF-kappaB reporter activity was assessed in the human colon adenocarcinoma cell line, Colo320DM. Finally, the effect of SCFAs on gene expression and cytokine release, measured with RT-PCR and ELISA, respectively, was studied in mouse colon organ cultures established from colitic mice. RESULTS: Acetate, propionate and butyrate at 30 mmol/L decreased LPS-stimulated TNFalpha release from neutrophils, without affecting IL-8 protein release. All SCFAs dose dependently inhibited NF-kappaB reporter activity in Colo320DM cells. Propionate dose-dependently suppressed IL-6 mRNA and protein release from colon organ cultures and comparative studies revealed that propionate and butyrate at 30 mmol/L caused a strong inhibition of immune-related gene expression, whereas acetate was less effective. A similar inhibition was achieved with the proteasome inhibitor MG-132, but not the p38 MAPK inhibitor SB203580. All SCFAs decreased IL-6 protein release from organ cultures. CONCLUSION: In the present study propionate and butyrate were equipotent, whereas acetate was less effective, at suppressing NF-kappaB reporter activity, immune-related gene expression and cytokine release in vitro. Our findings suggest that propionate and acetate, in addition to butyrate, could be useful in the treatment of inflammatory disorders, including IBD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409
Le Poul, E., Loison, C., Struyf, S., Springael, J.-Y., Lannoy, V., Decobecq, M.-E., Brezillon, S., Dupriez, V., Vassart, G., Van Damme, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301403200 · Cited by 1,651
Kinetic studies on the metabolism of short-chain fatty acids and glucose by isolated rat colonocytes
Clausen, M. R., & Mortensen, P. B. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90601-7 · Cited by 119
Okamoto, T., Sasaki, M., Tsujikawa, T., Fujiyama, Y., Bamba, T., & Kusunoki, M. (2000) · Journal of Gastroenterology · doi:10.1007/s005350050358 · Cited by 91
Cited by
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
Morgan, X. C., Tickle, T. L., Sokol, H., Gevers, D., Devaney, K. L., Ward, D. V., Reyes, J. A., Shah, S. A., LeLeiko, N., Snapper, S. B., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-9-r79 · Cited by 2,713
The role of short chain fatty acids in health and disease
Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800100-4.00003-9 · Cited by 2,425
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., et al. (2011) · Nature · doi:10.1038/nature09646 · Cited by 2,387
Short-chain fatty acids in control of body weight and insulin sensitivity
Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298
Machiels, K., Joossens, M., Sabino, J., De Preter, V., Arijs, I., Eeckhaut, V., Ballet, V., Claes, K., Van Immerseel, F., Verbeke, K., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-304833 · Cited by 1,904
Regulation of inflammation by short chain fatty acids
Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011) · Nutrients · doi:10.3390/nu3100858 · Cited by 1,724
Regulation of immune cell function by short‐chain fatty acids
Corrêa‐Oliveira, R., Fachi, J. L., Vieira, A., Sato, F. T., & Vinolo, M. A. R. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.17 · Cited by 1,346
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835
Al-Lahham, S. H., Peppelenbosch, M. P., Roelofsen, H., Vonk, R. J., & Venema, K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.07.007 · Cited by 614
Burger-van Paassen, N., Vincent, A., Puiman, P. J., van der Sluis, M., Bouma, J., Boehm, G., van Goudoever, J. B., van Seuningen, I., & Renes, I. B. (2009) · Biochemical Journal · doi:10.1042/bj20082222 · Cited by 611
Kaczmarczyk, M. M., Miller, M. J., & Freund, G. G. (2012) · Metabolism · doi:10.1016/j.metabol.2012.01.017 · Cited by 554
Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
Coutzac, C., Jouniaux, J.-M., Paci, A., Schmidt, J., Mallardo, D., Seck, A., Asvatourian, V., Cassard, L., Saulnier, P., Lacroix, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16079-x · Cited by 513
Iljazovic, A., Roy, U., Gálvez, E. J. C., Lesker, T. R., Zhao, B., Gronow, A., Amend, L., Will, S. E., Hofmann, J. D., Pils, M. C., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-0296-4 · Cited by 454
Butyrate and other short-chain fatty acids as modulators of immunity: What relevance for health?
Meijer, K., de Vos, P., & Priebe, M. G. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32833eebe5 · Cited by 443
Macfarlane, G. T., & Macfarlane, S. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31822fecfe · Cited by 406
Effects of Probiotics on Gut Microbiota: An Overview
Chandrasekaran, P., Weiskirchen, S., & Weiskirchen, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116022 · Cited by 382
Rebuilding the Gut Microbiota Ecosystem
Gagliardi, A., Totino, V., Cacciotti, F., Iebba, V., Neroni, B., Bonfiglio, G., Trancassini, M., Passariello, C., Pantanella, F., & Schippa, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15081679 · Cited by 340
Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice
Matt, S. M., Allen, J. M., Lawson, M. A., Mailing, L. J., Woods, J. A., & Johnson, R. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01832 · Cited by 330
Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice
Zhu, Y., He, C., Li, X., Cai, Y., Hu, J., Liao, Y., Zhao, J., Xia, L., He, W., Liu, L., et al. (2019) · Journal of Gastroenterology · doi:10.1007/s00535-018-1529-0 · Cited by 250
van der Beek, C. M., Canfora, E. E., Lenaerts, K., Troost, F. J., Olde Damink, S. W. M., Holst, J. J., Masclee, A. A. M., Dejong, C. H. C., & Blaak, E. E. (2016) · Clinical Science · doi:10.1042/cs20160263 · Cited by 230
Masui, R., Sasaki, M., Funaki, Y., Ogasawara, N., Mizuno, M., Iida, A., Izawa, S., Kondo, Y., Ito, Y., Tamura, Y., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000435444.14860.ea · Cited by 217
Liu, J., Li, H., Gong, T., Chen, W., Mao, S., Kong, Y., Yu, J., & Sun, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c02807 · Cited by 199
Dietary fiber and its associations with depression and inflammation
Swann, O. G., Kilpatrick, M., Breslin, M., & Oddy, W. H. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuz072 · Cited by 185
The microbiota, immunoregulation, and mental health: implications for public health
Lowry, C. A., Smith, D. G., Siebler, P. H., Schmidt, D., Stamper, C. E., Hassell, J. E., Yamashita, P. S., Fox, J. H., Reber, S. O., Brenner, L. A., et al. (2016) · Current Environmental Health Reports · doi:10.1007/s40572-016-0100-5 · Cited by 172
Gut microbiota–derived short-chain fatty acids and kidney diseases
Li, L., Ma, L., & Fu, P. (2017) · Drug Design, Development and Therapy · doi:10.2147/dddt.s150825 · Cited by 164
Towards modulating the gut microbiota to enhance the efficacy of immune-checkpoint inhibitors
Simpson, R. C., Shanahan, E. R., Scolyer, R. A., & Long, G. V. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00803-9 · Cited by 153
Ahmadi, S., Nagpal, R., Wang, S., Gagliano, J., Kitzman, D. W., Soleimanian-Zad, S., Sheikh-Zeinoddin, M., Read, R., & Yadav, H. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.01.011 · Cited by 124
Synbiotics for Improved Human Health: Recent Developments, Challenges, and Opportunities
Krumbeck, J. A., Walter, J., & Hutkins, R. W. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012757 · Cited by 84
Roelofsen, H., Priebe, M., & Vonk, R. (2010) · Beneficial Microbes · doi:10.3920/bm2010.0028 · Cited by 80
Gut-microbiota derived bioactive metabolites and their functions in host physiology
Debnath, N., Kumar, R., Kumar, A., Mehta, P. K., & Yadav, A. K. (2021) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2021.1989847 · Cited by 77
Gut–Brain Axis in Regulation of Blood Pressure
Yang, T., & Zubcevic, J. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00845 · Cited by 74
In Vitro Study of the Effect of Quinoa and Quinoa Polysaccharides on Human Gut Microbiota
Zeyneb, H., Pei, H., Cao, X., Wang, Y., Win, Y., & Gong, L. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2540 · Cited by 62
The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders
Młynarska, E., Barszcz, E., Budny, E., Gajewska, A., Kopeć, K., Wasiak, J., Rysz, J., & Franczyk, B. (2025) · Nutrients · doi:10.3390/nu17071135 · Cited by 44
Wangchuk, P., Shepherd, C., Constantinoiu, C., Ryan, R. Y. M., Kouremenos, K. A., Becker, L., Jones, L., Buitrago, G., Giacomin, P., Wilson, D., et al. (2019) · Infection and Immunity · doi:10.1128/iai.00851-18 · Cited by 42
Kefir reduces the incidence of pre-neoplastic lesions in an animal model for colorectal cancer
dos Reis, S. A., da Conceição, L. L., e Dias, M. M., Siqueira, N. P., Rosa, D. D., de Oliveira, L. L., da Matta, S. L. P., & Peluzio, M. D. C. G. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2018.11.050 · Cited by 35
Metadata
- Authors
- Tedelind, S., Westberg, F., Kjerrulf, M., & Vidal, A.
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2007
- Volume
- 13
- Issue
- 20
- Pages
- 2826
- ISSN
- 1007-9327 (ISSN-L)
- OpenAlex
- W2127906539
- Cited by
- 853
- References
- 4
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
