Cited by 116Eating Disorders and BehaviorsRegulation of Appetite and ObesityNutrition, Health and Food Behavior

Differences between liking and wanting signals in the human brain and relations with cognitive dietary restraint and body mass index

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Born, Jurriaan M, Lemmens, Sofie GT, Martens, Mieke JI, Formisano, Elia, Goebel, Rainer, Westerterp-Plantenga, Margriet S·2011·The American Journal of Clinical Nutrition

Abstract

Background Eating behavior is determined, to a significant extent, by the rewarding value of food (ie, liking and wanting).Objective We determined brain regions involved in liking and wanting and related brain signaling to body mass index (BMI; in kg/m(2)) and dietary restraint.Design Fifteen normal-weight female subjects [mean ± SEM age: 21.5 ± 0.4 y; BMI: 22.2 ± 0.2] completed a food-choice paradigm by using visually displayed food items during functional magnetic resonance imaging scans. Two scans were made as follows: one scan was made in a fasted condition, and one scan was made in a satiated condition. The paradigm discriminated between liking and wanting, and subjects were offered items rated highly for wanting immediately after each scan. Imaging contrasts for high and low liking and wanting were made, and data for regions of interest were extracted. Activation related to liking and wanting, respectively, was determined. Outcomes were correlated to cognitive dietary restraint and BMI.Results Dietary restraint predicted liking task-related signaling (TRS) in the amygdala, striatum, thalamus, and cingulate cortex (r = -0.5 ± 0.03, P < 0.00001). In the nucleus accumbens, the premeal liking and wanting TRS and premeal to postmeal liking TRS changes correlated positively with dietary restraint [bilateral average r = 0.6 ± 0.02, P < 0.04 (Bonferroni corrected)]. BMI and hunger predicted wanting TRS in the hypothalamus and striatum (P < 0.05). Postmeal liking TRS in the striatum, anterior insula, and cingulate cortex and wanting TRS in the striatum predicted the energy intake (liking: r = -0.3 ± 0.05, P < 0.0001; wanting: r = -0.3 ± 0.03, P < 0.00001).Conclusions Successful dietary restraint was supported by liking TRS from premeal to postmeal in the nucleus accumbens. Reward-related signaling was inversely related to BMI and energy intake, indicating reward deficiency.

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Crossref · 10.3945/ajcn.111.012161

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Authors
Born, J. M., Lemmens, S. G., Martens, M. J., Formisano, E., Goebel, R., & Westerterp-Plantenga, M. S.
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2011-08
Volume
94
Issue
2
Pages
392-403
ISSN
0002-9165 (ISSN-L)
OpenAlex
W2100777944
Cited by
116
References
43
Citations by year
2026: 3 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 42 · 2018: 8 · 2017: 3 · 2016: 8 · 2015: 2 · 2014: 7 · 2013: 7 · 2012: 12
FWCI
11.04
Type
journal article
Language
en
Open access
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, other-oa)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
Keywords
food liking, desire to eat, body mass index, food reward, nucleus accumbens, striatum, amygdala, hypothalamus, hunger, energy intake, satiety, dietary habits, brain activation
MeSH terms
Adult, Brain, Energy Intake, Energy Metabolism, Female, Food Deprivation, Humans, Hunger, Magnetic Resonance Imaging, Reward, Satiety Response, Body Mass Index, Young Adult

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