Differences between liking and wanting signals in the human brain and relations with cognitive dietary restraint and body mass index
Open accessAbstract
Background Eating behavior is determined, to a significant extent, by the rewarding value of food (ie, liking and wanting).Objective We determined brain regions involved in liking and wanting and related brain signaling to body mass index (BMI; in kg/m(2)) and dietary restraint.Design Fifteen normal-weight female subjects [mean ± SEM age: 21.5 ± 0.4 y; BMI: 22.2 ± 0.2] completed a food-choice paradigm by using visually displayed food items during functional magnetic resonance imaging scans. Two scans were made as follows: one scan was made in a fasted condition, and one scan was made in a satiated condition. The paradigm discriminated between liking and wanting, and subjects were offered items rated highly for wanting immediately after each scan. Imaging contrasts for high and low liking and wanting were made, and data for regions of interest were extracted. Activation related to liking and wanting, respectively, was determined. Outcomes were correlated to cognitive dietary restraint and BMI.Results Dietary restraint predicted liking task-related signaling (TRS) in the amygdala, striatum, thalamus, and cingulate cortex (r = -0.5 ± 0.03, P < 0.00001). In the nucleus accumbens, the premeal liking and wanting TRS and premeal to postmeal liking TRS changes correlated positively with dietary restraint [bilateral average r = 0.6 ± 0.02, P < 0.04 (Bonferroni corrected)]. BMI and hunger predicted wanting TRS in the hypothalamus and striatum (P < 0.05). Postmeal liking TRS in the striatum, anterior insula, and cingulate cortex and wanting TRS in the striatum predicted the energy intake (liking: r = -0.3 ± 0.05, P < 0.0001; wanting: r = -0.3 ± 0.03, P < 0.00001).Conclusions Successful dietary restraint was supported by liking TRS from premeal to postmeal in the nucleus accumbens. Reward-related signaling was inversely related to BMI and energy intake, indicating reward deficiency.
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Frontostriatal brain regions are critically implicated in reward, in particular the orbitofrontal cortex (OFC) and ventral striatum including nucleus accumbens (NAcc).
“Frontostriatal brain regions are also critically implicated in reward, in particular the orbitofrontal cortex (OFC) (Rolls, 2004) and ventral striatum including nucleus accumbens (NAcc) (Born et al., 2011).”
From Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers (2014) · cites this paper as Born et al., 2011
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The Theory of Hedonic Motivation
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.017 · Cited by 3 · see citing works
Martens, M. J. I., Born, J. R., Lemmens, S. G. T., Adam, T. C., & Westerterp‐Plantenga, M. S. (2012) · Food Quality and Preference · doi:10.1016/j.foodqual.2012.05.005 · Cited by 4 · see citing works
LikeWant: A new methodology to measure implicit wanting for flavors and fragrances
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The Evolutionary Function of Psychological Hedonism
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.020 · Cited by 1 · see citing works
An Investigation of Brain-Gut-Microbiome Interactions in Food Addiction and Obesity
Sood, R., Ravichandran, S., & Gupta, A. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780190671051.003.0019 · Cited by 1 · see citing works
Darwinian Hedonism and Hedonic Dread of Physical Activity
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.025 · Cited by 1 · see citing works
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Attachment insecurity and emotional eating
Alexander, K. (2013) · doi:10.7282/t34j0c3r
reward brain regions Aerobic exercise reduces neuronal responses in food
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Prevention of diabetes through lifestyle intervention
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Food Characteristics Implicated in Biobehavioral Indicators of Addiction in Vulnerable Individuals
Schulte, E. M. (2019) · Deep Blue (University of Michigan)
Darwinian Hedonism and Unhealthy Behavior
Williams, D. M. (2019)
What Are the Causes of Unhealthy Behavior?
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.007
Hedonic Motivation versus Reflective Motivation
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.015
Pleasure, Displeasure, and Affective Valence
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.010
Psychological Hedonism and Its Problems
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.008
Exploring the boundaries of Bariatric Surgery
Paulus, G. F. (2021) · doi:10.26481/dis.20210416gp
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.027
Reward, Incentive Salience, and Hedonic Motivation
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.013
Reformulating Psychological Hedonism
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.009
Understanding the Causes of Behavior
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.004
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.012
The Phylogenetic Development of Psychological Hedonism
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.021
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.018
From Hedonic Motivation to Unhealthy Behavior
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.016
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.022
Darwinian Hedonism and Political Will
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.029
Darwinian Hedonism and Hedonic Desire for Calorie-Dense Foods
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.024
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.001
Conclusions and Future Directions
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.030
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.002
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.033
The Epidemic of Unhealthy Behavior
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.003
Darwinian Hedonism and Hedonic Desire for Smoking, Drinking, and Drug Use
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.026
Anticipating Criticisms of Darwinian Hedonism
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.032
- Authors
- Born, J. M., Lemmens, S. G., Martens, M. J., Formisano, E., Goebel, R., & Westerterp-Plantenga, M. S.
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 94
- Issue
- 2
- Pages
- 392-403
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2100777944
- Cited by
- 116
- References
- 43
- Citations by year
- 2026: 3 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 42 · 2018: 8 · 2017: 3 · 2016: 8 · 2015: 2 · 2014: 7 · 2013: 7 · 2012: 12
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- food liking, desire to eat, body mass index, food reward, nucleus accumbens, striatum, amygdala, hypothalamus, hunger, energy intake, satiety, dietary habits, brain activation
- MeSH terms
- Adult, Brain, Energy Intake, Energy Metabolism, Female, Food Deprivation, Humans, Hunger, Magnetic Resonance Imaging, Reward, Satiety Response, Body Mass Index, Young Adult
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