Improved glucose homeostasis in obese mice treated with resveratrol is associated with alterations in the gut microbiome
Abstract
Oral administration of resveratrol is able to improve glucose homeostasis in obese individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes in the gut microbiome were characterized by a decreased relative abundance of Turicibacteraceae, Moryella, Lachnospiraceae, and Akkermansia and an increased relative abundance of Bacteroides and Parabacteroides Moreover, fecal transplantation from healthy resveratrol-fed donor mice is sufficient to improve glucose homeostasis in obese mice, suggesting that the resveratrol-mediated changes in the gut microbiome may play an important role in the mechanism of action of resveratrol.
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Resveratrol may remodel the gut microbiome to yield cardiovascular benefits, antiobesity effects, and improvements in glucose homeostasis.
“Recent evidence suggests that resveratrol, for example, may act to remodel the gut microbiome to yield cardiovascular benefits, antiobesity effects, and improvements in glucose homeostasis (Chen et al., 2016;Bird et al., 2017;Sung et al., 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Sung et al., 2017
Some flavonoids, such as quercetin, resveratrol, and catechin, can regulate the gut microbiota in animal models.
“The ability of some flavonoids, such as quercetin, resveratrol, and catechin, to regulate the gut microbiota has been documented in animal models (25–27).”
From Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice (2021) · cites this paper as [25]
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“Some studies have assessed the possibility to transfer metabolic improvement achieved after a prebiotic or polyphenol treatments trough FMT. Sung et al. (2017) found an improvement in glucose homeostasis and reduced fat mass in HFHS fed mice linked to changes in IM composition after 8 weeks of resveratrol supplementat…”
BackgroundInfluentialAlteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis
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BackgroundFecal Microbial Transplantation and Its Potential Application in Cardiometabolic Syndrome
Leshem, A., Horesh, N., & Elinav, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01341 · Cited by 95 · see citing works
“FMT from Resveratroltreated donor mice improved insulin resistance in recipient mice (112).”
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Dietary polyphenols in lipid metabolism: A role of gut microbiome
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The Role of the Gut Microbiome in Energy Balance With a Focus on the Gut-Adipose Tissue Axis
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Implications of Resveratrol in Obesity and Insulin Resistance: A State-of-the-Art Review
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“Indeed, by increasing the population of Bacteroidetes within the gut of mice, resveratrol supplementation reduces the hepatic production of trimethylamine-N-oxide (TMAO), of relevance for a potential mechanism of action of resveratrol given the association of TMAO production with T2D, obesity and cardiovascular diseas…”
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“Another potential mechanism may be by inducing resveratrol-mediated changes in the gut microbiome, as recent studies in obese mice suggested, showing that faecal transplantation from healthy resveratrol-fed donor improved glucose homeostasis [63].”
BackgroundModulation of fat metabolism and gut microbiota by resveratrol on high-fat diet-induced obese mice
Campbell, C. L., Yu, R., Li, F., Zhou, Q., Chen, D., Qi, C., Yin, Y., & Sun, J. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s192228 · Cited by 79 · see citing works
“The study also found improved glucose homeostasis in mice after fecal transferring from healthy RSV-administrated donor mice.”
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“…weight homeostasis like fasting-induced adipose factor (Fiaf) or mTOR (Kim et al., 2010; Qiao et al., 2014; Jung et al., 2016), or by reversing the gut microbial dysbiosis caused by a high-fat diet by modifying the relative Bacteroidetes: Firmicutes ratio (Qiao et al., 2014; Sung et al., 2017).”
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“Specifically, B. adolescentis significantly increased the abundance of Bifidobacterium [39] (26M1, 30M5 and 2016), Coprococcus [40] (8M4 and 34M4), Dorea [41] (41M3), Ruminococcus [42,43] (26M1), and Allobaculum (3M10).”
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“Compared with the NC group, the HFD group presented a significantly higher relative abundance of Blautia, Sutterella, and Akker- mansia (P < 0:05), and a lower relative abundance of Blautia and Sutterella CGA treatment.”
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“, 2017 [47] C57BL/6N mice, M, 8 w 10/grp NDND + RHFHSHFHs + R p 8 w 45% Resveratrol (R)-0.”
BackgroundInfluentialDeciphering the Anti-obesity Benefits of Resveratrol: The “Gut Microbiota-Adipose Tissue” Axis
Zhou, L., Xiao, X., Zhang, Q., Zheng, J., & Deng, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00413 · Cited by 66 · see citing works
Effects of bioactive components of Pu-erh tea on gut microbiomes and health: A review
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Gut microbiota and its metabolites: Bridge of dietary nutrients and obesity-related diseases
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“Various studies revealed that RES improved insulin action in hyperlipidemic mice [100], obese Zucker rats [101] and T2D animals [10].”
BackgroundResveratrol-Induced White Adipose Tissue Browning in Obese Mice by Remodeling Fecal Microbiota
Liao, W., Yin, X., Li, Q., Zhang, H., Liu, Z., Zheng, X., Zheng, L., & Feng, X. (2018) · Molecules · doi:10.3390/molecules23123356 · Cited by 62 · see citing works
“In previous studies, RES was observed to potentially alter the composition of the gut microbiota, to ameliorate the increases in weight of the body and the adipose tissues, and to improve glucose homeostasis in HFD-fed mice [18,19].”
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“- Enhanced growth of beneficial bacteria - Reduced pathogenic bacteria -Increased production of beneficial metabolites - Attenuated colonic inflammation [24,37]”
BackgroundAntiaging effects of dietary supplements and natural products
Gao, L., Liu, X., Luo, X., Lou, X., Li, P., Li, X., & Liu, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1192714 · Cited by 60 · see citing works
“The oral administration of resveratrol can improve glucose homeostasis in high-fat-dietinduced obese mice (Sung et al., 2017).”
BackgroundÁlvarez‐Cilleros, D., Ramos, S., López‐Oliva, M. E., Escrivá, F., Álvarez, C., Fernández‐Millán, E., & Martín, M. Á. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109058 · Cited by 59 · see citing works
Host–Microbe Interplay in the Cardiometabolic Benefits of Dietary Polyphenols
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“Thus, it is highly possible that one or more metabolites of resveratrol (derived from either liver or intestinal cells [53] or microbes) or some other microbederived metabolites/products are also administered to the mice during a FMT protocol [14,15] and that these compounds produce the improvement in glucose homeosta…”
BackgroundInfluentialDu, F., Huang, R., Lin, D., Wang, Y., Yang, X., Huang, X., Zheng, B., Chen, Z., Huang, Y., Wang, X., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.611323 · Cited by 58 · see citing works
“…fed a high-fat and high-sugar diet; when the gut microbiota was transferred from RSV-treated mice to non-treated mice, the normalization of insulin resistance was observed in recipient mice, indicating that gut microbiota mediates the effects of RSV (Abbasi Oshaghi et al., 2017; Sung et al., 2017).”
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“Akkermansia and increased relative abundance of Bacteroides, Ruminococcus and Parabacteroides in the gut microbiome can improve glucose homeostasis in obese mice and provide a catabolic pathway through a novel mannosylglucose phosphorylase, suggesting that Akkermansia, Bacteroides, Ruminococcus and Parabacteroides may…”
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Cancer Metabolism as a Therapeutic Target and Review of Interventions
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“Different BAs may serve as either FXR agonist or antagonist of FXR. REV-I can target gut microbiome, improving gut microbiome diversity 4,10,11 .”
InfluentialLuo, S., Li, H., Zhang, H., Li, Z., Liu, C., & Chen, T. (2022) · Food & Function · doi:10.1039/d2fo00569g · Cited by 52 · see citing works
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“Among these monomers, astragaloside IV [117], quercetin [118], and resveratrol [119] affect gut microbiota, and notoginsenoside [120], Lycium barbarum polysaccharide [121], and allicin [122] affect the function of alleviating intestinal mucosal immunity; the anti-inflammatory monomers are tetrandrine [123], Lycium bar…”
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Monocyte mobilisation, microbiota & mental illness
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Natural products and skeletal muscle health
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- Authors
- Sung, M. M., Kim, T. T., Denou, E., Soltys, C.-L. M., Hamza, S. M., Byrne, N. J., Masson, G., Park, H., Wishart, D. S., Madsen, K. L., Schertzer, J. D., & Dyck, J. R. B.
- Affiliations
- University of Alberta (CA)
- McMaster University (CA)
- Corresponding author
- Dyck, Jason R.B.
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2016-11-30
- Volume
- 66
- Issue
- 2
- Pages
- 418-425
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2559088801
- Cited by
- 204
- References
- 40
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 17 · 2023: 30 · 2022: 24 · 2021: 27 · 2020: 28 · 2019: 28 · 2018: 21 · 2017: 11
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institute of Circulatory and Respiratory Health
- Genome Canada
- Canadian Diabetes Association
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- resveratrol, glucose homeostasis, obesity, gut microbiota, fecal microbiota transplantation, Akkermansia, Bacteroides, Parabacteroides, Lachnospiraceae
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Resveratrol, Animals, Bacteroides, Blood Glucose, Chromatography, Liquid, Glucose, Glucose Tolerance Test, Homeostasis, Male, Mice, Obese, Obesity, Stilbenes, Mice, Tandem Mass Spectrometry
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