The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis
Open accessAbstract
Adult hippocampal neurogenesis occurs in an exceptional permissive microenvironment. Neuroimmunological mechanisms might be prominently involved in the endogenous homeostatic principles that control baseline levels of adult neurogenesis. We show in this study that this homeostasis is partially dependent on CD4-positive T lymphocytes. Systemic depletion of CD4-positive T lymphocytes led to significantly reduced hippocampal neurogenesis, impaired reversal learning in the Morris water maze, and decreased brain-derived neurotrophic factor expression in the brain. No such effect of CD8 or B cells was observed. Repopulation of RAG2−/− mice with CD4, but not with CD8 cells again increased precursor cell proliferation. The T cells in our experiments were non-CNS specific and rarely detectable in the healthy brain. Thus, we can exclude cell-cell contacts between immune and brain cells or lymphocyte infiltration into the CNS as a prerequisite for an effect of CD4-T cells on neurogenesis. We propose that systemic CD4-T cell activity is required for maintaining cellular plasticity in the adult hippocampus and represents an evolutionary relevant communication route for the brain to respond to environmental changes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“CD4+ T cells are necessary for hippocampal neurogenesis in adult rodents”
From Inflammatory T helper 17 cells promote depression-like behavior in mice (2013) · cites this paper as [28]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Self-citationTracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Self-citationInflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426
Learning enhances adult neurogenesis in the hippocampal formation
Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J. (1999) · Nature Neuroscience · doi:10.1038/6365 · Cited by 2,157
Inflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559
Research works printed but not linked: 2
- 1993, Lymphocyte traffic to the brain. W. M. Pardridge, ed., 67
- 2000, Type I interferons and chronic inflammatory demyelinating polyneuropathy: treatment or cause?., 307
Cited by
Sorted by citations
Immune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483
Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000
Regulation of learning and memory by meningeal immunity: a key role for IL-4
Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800
Revisiting the Mechanisms of CNS Immune Privilege
Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682
Plasmacytoid Dendritic Cells: Recent Progress and Open Questions
Reizis, B., Bunin, A., Ghosh, H. S., Lewis, K. L. T., & Sisirak, V. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101345 · Cited by 680
Aging-induced type I interferon response at the choroid plexus negatively affects brain function
Baruch, K., Deczkowska, A., David, E., Castellano, J. M., Miller, O., Kertser, A., Berkutzki, T., Barnett-Itzhaki, Z., Bezalel, D., Wyss-Coray, T., et al. (2014) · Science · doi:10.1126/science.1252945 · Cited by 615
IL-4 in the brain: a cytokine to remember
Gadani, S. P., Cronk, J. C., Norris, G. T., & Kipnis, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202246 · Cited by 549
Möhle, L., Mattei, D., Heimesaat, M. M., Bereswill, S., Fischer, A., Alutis, M., French, T., Hambardzumyan, D., Matzinger, P., Dunay, I. R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.074 · Cited by 470
Self-citationTransforming the understanding of brain immunity
Castellani, G., Croese, T., Peralta Ramos, J. M., & Schwartz, M. (2023) · Science · doi:10.1126/science.abo7649 · Cited by 386
Sankowski, R., Mader, S., & Valdés-Ferrer, S. I. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00028 · Cited by 351
Alves de Lima, K., Rustenhoven, J., & Kipnis, J. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102319-103410 · Cited by 348
Depression and immunity: A role for T cells?
Miller, A. H. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.009 · Cited by 345
Advances in Meningeal Immunity
Rua, R., & McGavern, D. B. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.003 · Cited by 326
Depression's Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome
Cruz-Pereira, J. S., Rea, K., Nolan, Y. M., O'Leary, O. F., Dinan, T. G., & Cryan, J. F. (2020) · Annual Review of Psychology · doi:10.1146/annurev-psych-122216-011613 · Cited by 320
Neuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319
Commentary: IL-4 and IL-13 receptors and signaling
McCormick, S. M., & Heller, N. M. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.023 · Cited by 329
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
Wu, A., & Zhang, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02964-x · Cited by 354
Lung Dendritic Cells in Respiratory Viral Infection and Asthma: From Protection to Immunopathology
Lambrecht, B. N., & Hammad, H. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075021 · Cited by 302
Baruch, K., Ron‐Harel, N., Gal, H., Deczkowska, A., Shifrut, E., Ndifon, W. O., Mirlas-Neisberg, N., Cardon, M., Vaknin, I., Cahalon, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211270110 · Cited by 303
London, A., Cohen, M., & Schwartz, M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00034 · Cited by 282
Benedetto, S. D., Müller, L., Wenger, E., Düzel, S., & Pawelec, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.044 · Cited by 295
How Do Immune Cells Support and Shape the Brain in Health, Disease, and Aging?
Schwartz, M., Kipnis, J., Rivest, S., & Prat, A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3241-13.2013 · Cited by 269
Inflammatory T helper 17 cells promote depression-like behavior in mice
Beurel, E., Harrington, L. E., & Jope, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.021 · Cited by 254
Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders
Zengeler, K. E., & Lukens, J. R. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-020-00487-7 · Cited by 264
Sierra, A., Beccari, S., Díaz‐Aparicio, I., Encinas, J. M., Comeau, S., & Tremblay, M. (2014) · Neural Plasticity · doi:10.1155/2014/610343 · Cited by 268
Pro-cognitive properties of T cells
Kipnis, J., Gadani, S., & Derecki, N. C. (2012) · Nature Reviews Immunology · doi:10.1038/nri3280 · Cited by 246
Aging and Rejuvenation of Neural Stem Cells and Their Niches
Navarro Negredo, P., Yeo, R. W., & Brunet, A. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.07.002 · Cited by 246
Systemic inflammatory cells fight off neurodegenerative disease
Schwartz, M., & Shechter, R. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.71 · Cited by 240
Martino, G., Pluchino, S., Bonfanti, L., & Schwartz, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00032.2010 · Cited by 246
Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases
Tian, L., Ma, L., Kaarela, T., & Li, Z. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-155 · Cited by 224
Peripheral immune system in aging and Alzheimer’s disease
Cao, W., & Zheng, H. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0284-2 · Cited by 214
Interactions of innate and adaptive immunity in brain development and function
Filiano, A. J., Gadani, S. P., & Kipnis, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.050 · Cited by 229
Merlini, M., Kirabali, T., Kulic, L., Nitsch, R. M., & Ferretti, M. T. (2018) · Neurodegenerative Diseases · doi:10.1159/000486200 · Cited by 219
Wolf, S. A., Bick-Sander, A., Fabel, K., Leal-Galicia, P., Tauber, S., Ramirez-Rodriguez, G., Müller, A., Melnik, A., Waltinger, T. P., Ullrich, O., et al. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-12 · Cited by 208
Self-citationAnandasabapathy, N., Victora, G. D., Meredith, M. M., Feder, R. E., Dong, B., Kluger, C., Yao, K.-H., Dustin, M. L., Nussenzweig, M. C., Steinman, R. M., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102657 · Cited by 206
The effects of microglia‐ and astrocyte‐derived factors on neurogenesis in health and disease
Araki, T., Ikegaya, Y., & Koyama, R. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14969 · Cited by 220
How and why do T cells and their derived cytokines affect the injured and healthy brain?
Filiano, A. J., Gadani, S. P., & Kipnis, J. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.39 · Cited by 199
Importance of T Lymphocytes in Brain Injury, Immunodeficiency, and Recovery after Cerebral Ischemia
Brait, V. H., Arumugam, T. V., Drummond, G. R., & Sobey, C. G. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.6 · Cited by 198
CNS-specific T cells shape brain function via the choroid plexus
Baruch, K., & Schwartz, M. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.04.002 · Cited by 200
Neuroimmunological effects of physical exercise in depression
Eyre, H. A., & Baune, B. T. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.015 · Cited by 201
Phagocytic activity of neuronal progenitors regulates adult neurogenesis
Lu, Z., Elliott, M. R., Chen, Y., Walsh, J. T., Klibanov, A. L., Ravichandran, K. S., & Kipnis, J. (2011) · Nature Cell Biology · doi:10.1038/ncb2299 · Cited by 183
Role of the Immune System in the Development of the Central Nervous System
Morimoto, K., & Nakajima, K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00916 · Cited by 190
Biomarkers of PTSD: Neuropeptides and immune signaling
Baker, D. G., Nievergelt, C. M., & O’Connor, D. T. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.027 · Cited by 177
Learning and memory … and the immune system
Marin, I., & Kipnis, J. (2013) · Learning & Memory · doi:10.1101/lm.028357.112 · Cited by 166
Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?
Mayne, K., White, J. A., McMurran, C. E., Rivera, F. J., & de la Fuente, A. G. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.572090 · Cited by 167
When encephalitogenic T cells collaborate with microglia in multiple sclerosis
Dong, Y., & Yong, V. W. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0253-6 · Cited by 169
Understanding the Role of T Cells in CNS Homeostasis
Ellwardt, E., Walsh, J. T., Kipnis, J., & Zipp, F. (2016) · Trends in Immunology · doi:10.1016/j.it.2015.12.008 · Cited by 156
Role of neuro-immunological factors in the pathophysiology of mood disorders
Bhattacharya, A., Derecki, N. C., Lovenberg, T. W., & Drevets, W. C. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4214-0 · Cited by 149
Radjavi, A., Smirnov, I., & Kipnis, J. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.08.013 · Cited by 141
Patanella, A. K., Zinno, M., Quaranta, D., Nociti, V., Frisullo, G., Gainotti, G., Tonali, P., Batocchi, A. P., & Marra, C. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22276 · Cited by 131
Schwartz, M., & Shechter, R. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.31 · Cited by 129
Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology
Deczkowska, A., Baruch, K., & Schwartz, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.01.006 · Cited by 131
Absence of IFNγ promotes hippocampal plasticity and enhances cognitive performance
Monteiro, S., Ferreira, F. M., Pinto, V., Roque, S., Morais, M., Calçada, D. D. S., Mota, C., Correia‐Neves, M., & Cerqueira, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.194 · Cited by 133
Coles, J. A., Myburgh, E., Brewer, J. M., & McMenamin, P. G. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.002 · Cited by 123
Correlates of cognitive dysfunction in multiple sclerosis
Heesen, C., Schulz, K., Fiehler, J., Mark, U., Otte, C., Jung, R., Poettgen, J., Krieger, T., & Gold, S. M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.05.006 · Cited by 116
Šekeljić, V., Bataveljić, D., Stamenković, S., Ułamek, M., Jabłoński, M., Radenović, L., Pluta, R. M., & Anđjus, P. R. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0336-7 · Cited by 111
Wang, J., Xie, L., Yang, C., Ren, C., Zhou, K., Wang, B. Z., Zhang, Z., Wang, Y., Jin, K., & Yang, G. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00361 · Cited by 108
Hippocampal adult neurogenesis: Does the immune system matter?
de Miranda, A. S., Zhang, C., Katsumoto, A., & Teixeira, A. L. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.10.052 · Cited by 103
Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology?
Larochelle, C., Uphaus, T., Prat, A., & Zipp, F. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.02.001 · Cited by 98
Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice
Derecki, N. C., Quinnies, K. M., & Kipnis, J. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.009 · Cited by 102
Activation of group 2 innate lymphoid cells alleviates aging-associated cognitive decline
Fung, I. T. H., Sankar, P., Zhang, Y., Robison, L. S., Zhao, X., D’Souza, S. S., Salinero, A. E., Wang, Y., Qian, J., Kuentzel, M. L., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190915 · Cited by 97
Role of Inflammation in Depression and Treatment Implications
Felger, J. C. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_166 · Cited by 94
miR-155 is involved in Alzheimer’s disease by regulating T lymphocyte function
Song, J., & Lee, J. E. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00061 · Cited by 91
The Microbiota–Gut–Brain Axis and Neurological Disorders: A Comprehensive Review
Nakhal, M. M., Yassin, L. K., Alyaqoubi, R., Saeed, S., Alderei, A., Alhammadi, A., Alshehhi, M., Almehairbi, A., Houqani, S. A., BaniYas, S., et al. (2024) · Life · doi:10.3390/life14101234 · Cited by 136
Späni, C., Suter, T., Derungs, R., Ferretti, M. T., Welt, T., Wirth, F., Gericke, C., Nitsch, R. M., & Kulic, L. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0251-x · Cited by 88
‘As above, so below’ examining the interplay between emotion and the immune system
Brod, S., Rattazzi, L., Piras, G., & D’Acquisto, F. (2014) · Immunology · doi:10.1111/imm.12341 · Cited by 91
Shao, A., Zhu, Z., Li, L., Zhang, S., & Zhang, J. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.012 · Cited by 86
The Cross-Talk Between the Dopaminergic and the Immune System Involved in Schizophrenia
Vidal, P. M., & Pacheco, R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00394 · Cited by 92
Protective Autoimmunity: A Unifying Model for the Immune Network Involved in CNS Repair
Schwartz, M., & Raposo, C. (2014) · The Neuroscientist · doi:10.1177/1073858413516799 · Cited by 86
Cognitive and Behavioral Consequences of Impaired Immunoregulation in Aging
Corona, A. W., Fenn, A. M., & Godbout, J. P. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9313-4 · Cited by 87
Fisher, Y., Nemirovsky, A., Baron, R., & Monsonego, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010830 · Cited by 83
Schwartz, M., & Baruch, K. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.08.002 · Cited by 85
The role of neutrophils in the dysfunction of central nervous system barriers
Santos-Lima, B., Pietronigro, E. C., Terrabuio, E., Zenaro, E., & Constantin, G. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.965169 · Cited by 82
Patas, K., Penninx, B. W. J. H., Bus, B. A. A., Vogelzangs, N., Molendijk, M. L., Elzinga, B. M., Bosker, F. J., & Oude Voshaar, R. C. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.10.007 · Cited by 80
Poletti, S., de Wit, H., Mazza, E. B., Wijkhuijs, A. J. M., Locatelli, C., Aggio, V., Colombo, C., Benedetti, F., & Drexhage, H. A. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.12.020 · Cited by 79
Redox Signaling, Neuroinflammation, and Neurodegeneration
Aguilera, G., Colín-González, A. L., Rangel‐López, E., Chavarría, A., & Santamaría, A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7099 · Cited by 81
Protective and Regenerative Roles of T Cells in Central Nervous System Disorders
Evans, F., Dittmer, M., de la Fuente, A. G., & Fitzgerald, D. C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02171 · Cited by 80
Adult Neurogenesis and the Promise of Adult Neural Stem Cells
Ghosh, H. S. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519856876 · Cited by 81
Sarno, E., Moeser, A. J., & Robison, A. J. (2021) · Advances in pharmacology · doi:10.1016/bs.apha.2021.03.004 · Cited by 84
Morris, G., Reiche, E. M. V., Murru, A., Carvalho, A. F., Maes, M. H. J., Berk, M., & Puri, B. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0843-5 · Cited by 75
Bhattacharya, A., & Drevets, W. C. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_43 · Cited by 76
Brain interference: Revisiting the role of IFNγ in the central nervous system
Monteiro, S., Roque, S., Marques, F., Correia‐Neves, M., & Cerqueira, J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.003 · Cited by 75
Exploring new perspectives in immunology
Medzhitov, R. M., & Iwasaki, A. (2024) · Cell · doi:10.1016/j.cell.2024.03.038 · Cited by 85
Kuijer, E. J., & Steenbergen, L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105296 · Cited by 76
Lysophosphatidic Acid Receptor Is a Functional Marker of Adult Hippocampal Precursor Cells
Walker, T. L., Overall, R. W., Vogler, S., Sykes, A. M., Ruhwald, S., Lasse, D., Ichwan, M., Fabel, K., & Kempermann, G. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.03.002 · Cited by 72
Self-citationMicrobiota-Gut-Brain Axis Regulation of Adult Hippocampal Neurogenesis
Guzzetta, K. E., Cryan, J. F., & O’Leary, O. F. (2022) · Brain Plasticity · doi:10.3233/bpl-220141 · Cited by 74
CD 4 T cells in immunity and immunotherapy of A lzheimer's disease
Monsonego, A., Nemirovsky, A., & Harpaz, I. (2013) · Immunology · doi:10.1111/imm.12103 · Cited by 72
Leschik, J., Lutz, B., & Gentile, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147339 · Cited by 77
Neuroimmune responses in the developing brain following traumatic brain injury
Nasr, I. W., Chun, Y., & Kannan, S. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112957 · Cited by 74
The systemic environment: at the interface of aging and adult neurogenesis
Smith, L. K., White, C., & Villeda, S. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2715-8 · Cited by 70
Current perspectives on the link between neuroinflammation and neurogenesis
Wang, B. Z., & Jin, K. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9523-6 · Cited by 68
T cells establish and maintain CNS viral infection in HIV-infected humanized mice
Honeycutt, J. B., Liao, B., Nixon, C. C., Cleary, R. A., Thayer, W. O., Birath, S., Swanson, M. D., Sheridan, P. A., Zakharova, O. I., Prince, F., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98968 · Cited by 63
O’Connor, T. G., Moynihan, J. A., & Caserta, M. T. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12187 · Cited by 68
Mackay, M. C. (2015) · Immunologic Research · doi:10.1007/s12026-015-8716-3 · Cited by 73
Neuron-Microglia Dialogue and Hippocampal Neurogenesis in the Aged Brain.
Gemma, C., Bachstetter, A. D., & Bickford, P. C. (2010) · Europe PMC (PubMed Central) · Cited by 62
Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury
Dong, T., Liang, Z., Bhayana, B., & Wu, M. X. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0663-y · Cited by 64
Becking, K., Haarman, B. C. M., Grosse, L., Nolen, W. A., Claes, S. J., Arolt, V., Schoevers, R. A., & Drexhage, H. A. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.03.004 · Cited by 62
Debnath, M. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9626-9 · Cited by 60
Kunz, N., & Kemper, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.629986 · Cited by 63
Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI
Wolf, A. I., Mozdzanowska, K., Quinn, W. J., Metzgar, M. H., Williams, K. L., Caton, A. J., Meffre, E., Bram, R. J., Erickson, L. D., Allman, D., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57362 · Cited by 61
Metadata
- Authors
- Wolf, S. A., Steiner, B., Akpinarli, A., Kammertoens, T., Nassenstein, C., Braun, A., Blankenstein, T., & Kempermann, G.
- Affiliations
- University of Zurich (CH)
- Max Delbrück Center (DE)
- National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Cellular and Molecular Immunology , Bethesda, MD
- Fraunhofer Institute for Toxicology and Experimental Medicine (DE)
- Corresponding author
- Steiner, Barbara
- Kempermann, Gerd
- ORCID
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-01
- Volume
- 182
- Issue
- 7
- Pages
- 3979-3984
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2109261715
- Cited by
- 329
- References
- 47
- Citations by year
- 2026: 8 · 2025: 26 · 2024: 15 · 2023: 25 · 2022: 15 · 2021: 25 · 2020: 11 · 2019: 20 · 2018: 18 · 2017: 17 · 2016: 28 · 2015: 21 · 2014: 23 · 2013: 16 · 2012: 20
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- adult hippocampal neurogenesis, CD4-positive T lymphocytes, neuroimmunology, reversal learning, brain-derived neurotrophic factor, CD8+ T cells, B cells, Rag2 knockout mice, neural progenitor proliferation, hippocampal plasticity
- MeSH terms
- Animals, B-Lymphocytes, DNA-Binding Proteins, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Fluorescent Antibody Technique, Hippocampus, Immunohistochemistry, Mice, Inbred C57BL, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Mice, Knockout, Maze Learning, Cell Proliferation, Mice, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
