New therapeutic options for autism spectrum disorder: experimental evidences
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Autism spectrum disorder (ASD) is characterized by impairment in two behavioral domains: social interaction/communication together with the presence of stereotyped behaviors and restricted interests. The heterogeneity in the phenotype among patients and the complex etiology of the disorder have long impeded the advancement of the development of successful pharmacotherapies. However, in the recent years, the integration of findings of multiple levels of research, from human genetics to mouse models, have made considerable progress towards the understanding of ASD pathophysiology, allowing the development of more effective targeted drug therapies. The present review discusses the current state of pharmacological research in ASD based on the emerging common pathophysiology signature.
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There is a complete lack of pharmacological therapies motivated by concrete pathophysiological theories that influence either neurodevelopment in children or tackle the mechanisms behind autistic symptoms in adolescents and adults.
“(viii) There is a complete lack of pharmacological therapies that are motivated by concrete pathophysiological theories and influence either the neurodevelopment in children or tackle the mechanisms behind autistic symptoms in adolescents and adults (53, 54).”
From Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice? (2016) · cites this paper as [54]
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- Authors
- Peñagarikano, O.
- Affiliations
- University of the Basque Country (ES)
- Corresponding author
- Peñagarikano, Olga
- ORCID
- Peñagarikano, Olga
- Venue
- Experimental Neurobiology
- Published
- 2015-12-30
- Volume
- 24
- Issue
- 4
- Pages
- 301-311
- ISSN
- 1226-2560 (ISSN-L)
- 2093-8144
- PMC
- PMC4688330
- OpenAlex
- W2207410147
- Cited by
- 24
- References
- 94
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 5
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Experimental Neurobiology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- autism spectrum disorder, pharmacotherapy, ASD pathophysiology, targeted therapy, mouse model, genetic etiology, social interaction deficits, stereotypy, restricted interests
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