Oxytocin enhances orienting to social information in a selective group of high-functioning male adults with autism spectrum disorder

Althaus, M.; Groen, Y.; Wijers, A.A.; Noltes, H.; Tucha, O.; Hoekstra, P.J.

doi:10.1016/j.neuropsychologia.2015.10.025

Cited by 58Neuroendocrine regulation and behaviorAutism Spectrum Disorder ResearchAction Observation and Synchronization

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Oxytocin enhances orienting to social information in a selective group of high-functioning male adults with autism spectrum disorder

Althaus, M., Groen, Y., Wijers, A.A., Noltes, H., Tucha, O., Hoekstra, P.J.·2015·Neuropsychologia

DOI 10.1016/j.neuropsychologia.2015.10.025

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Abstract

Objective The study investigated the effects of nasally administered oxytocin on neurophysiological orienting to empathy-evoking pictures in normally intelligent male adults with and without an autism spectrum disorder (ASD). It further investigated whether these effects might be moderated by the individual's approach and avoidance tendencies.Methods All subjects participated in a randomised double-blind placebo controlled crossover trial where either oxytocin (OXT) or placebo was administered preceding the viewing of affective pictures.The pictures, selected from the International Affective Picture System (IAPS), represented a systematic variation of pleasant, unpleasant and neutral scenes with and without humans. Both cardiac (ECR) and cortical (LPP) evoked orienting responses were measured and both were enhanced for the pictures with humans, in particular for the unpleasant ones.Results No significant group differences were found, nor were there any treatment effects. Moderator analysis, however, demonstrated that OXT did enhance orienting to affective pictures with humansin male adults with ASD who are easily distressed when seeing others in stressful situations and in healthy males who are highly sensitive to anticipated punishment and criticism or have a low drive for goal achievement.Conclusion Individual differences in stress-related avoidance tendencies should be taken into account when considering OXT as a treatment of social deficiencies in autism.

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Several trials have shown that a single dose of intranasal oxytocin enhanced performance on measures of social cognition or motivation, compared with placebo, in persons with autism spectrum disorder.
“Several trials have shown that a single dose of intranasal oxytocin enhanced performance on measures of social cognition10,11 or motivation,12–14 as compared with placebo, in persons with autism spectrum disorder.”
From Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder (2021) · cites this paper as [14]
Variable efficacy at the clinical trial end, combined with modest effect sizes in healthy populations, and failed replications, has tempered enthusiasm about oxytocin's potential for reducing ASD symptomatology.
“However, variable efficacy at the clinical trial end, combined with modest effect sizes in healthy populations, and failed replications, has tempered enthusiasm about the potential of this hormone for reducing ASD symptomatology.4”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [4]

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BindingDB Entry 50002504: LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism.
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The effects of oxytocin in autism
Groen, Y., Althaus, M., Oosterhoff, M., Balkom, V. I. D. C., & Hoekstra, P. J. (2019) · University of Groningen research database (University of Groningen / Centre for Information Technology)
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Do blood plasma levels of oxytocin moderate the effect of nasally administered oxytocin on social orienting in high-functioning male adults with autism spectrum disorder?
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The effects of oxytocine in autism: De werking van oxytocine bij autisme
Groen, Y., Althaus, M., Oosterhoff, M., van Balkom, I., & Hoekstra, P. J. (2017) · University of Groningen research database (University of Groningen / Centre for Information Technology)
Self-citation

Authors: Althaus, M., Groen, Y., Wijers, A. A., Noltes, H., Tucha, O., & Hoekstra, P. J.
Affiliations: University Medical Center Groningen (NL)
University of Groningen (NL)
Corresponding author: Althaus, M.
ORCID: Groen, Y.
Wijers, A.A.
Tucha, O.
Hoekstra, P.J.
Venue: Neuropsychologia
Publisher: Elsevier BV
Published: 2015-12
Volume: 79
Issue: Pt A
Pages: 53-69
ISSN: 0028-3932 (ISSN-L)
DOI: 10.1016/j.neuropsychologia.2015.10.025
OpenAlex: W2168598273
Cited by: 57
References: 72
Citations by year: 2026: 1 · 2025: 1 · 2024: 6 · 2023: 10 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 1
FWCI: 9.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropsychologia (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders: Accare Foundation
Autism Team of the North of the Netherlands
Jonx Team of Lentis, Groningen
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
Keywords: oxytocin, autism spectrum disorder, social orienting, emotional pictures, event-related potentials, late positive potential, electrocortical responses, approach-avoidance tendencies, individual differences, social stress, punishment sensitivity, goal achievement, social cognition, adult male
MeSH terms: Autism Spectrum Disorder, Adolescent, Adult, Analysis of Variance, Brain Mapping, Double-Blind Method, Electrocardiography, Electroencephalography, Evoked Potentials, Humans, Intelligence Tests, Interpersonal Relations, Male, Orientation, Oxytocin, Personality, Photic Stimulation, Psychiatric Status Rating Scales, Social Behavior, Young Adult

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Oxytocin enhances orienting to social information in a selective group of high-functioning male adults with autism spectrum disorder

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