Most cited biochemistry, genetics and molecular biology papers
- Verified
Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper – Excel-based tool using pair-wise correlations
Pfaffl, M. W., Tichopad, A., Prgomet, C., & Neuvians, T. P. (2004) · Biotechnology Letters
Molecular Biology Techniques and ApplicationsGene expression and cancer classification
Cited by 5,065
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Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Patel, A. P., Tirosh, I., Trombetta, J. J., Shalek, A. K., Gillespie, S. M., Wakimoto, H., Cahill, D. P., Nahed, B. V., Curry, W. T., Martuza, R. L., et al. (2014) · Science
Single-cell and spatial transcriptomicsGlioma Diagnosis and Treatment
Cited by 5,063
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The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
The GTEx Consortium, Ardlie, K. G., Deluca, D. S., Segrè, A. V., Sullivan, T. J., Young, T. R., Gelfand, E. T., Trowbridge, C. A., Maller, J. B., Tukiainen, T., et al. (2015) · Science
Genetic Associations and EpidemiologyGenomics and Chromatin Dynamics
Cited by 5,062
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The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research
Gut microbiota and healthMicrobial Metabolites in Food Biotechnology
Cited by 5,048
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g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)
Raudvere, U., Kolberg, L., Kuzmin, I., Arak, T., Adler, P., Peterson, H., & Vilo, J. (2019) · Nucleic Acids Research
Bioinformatics and Genomic NetworksGenomics and Phylogenetic Studies
Cited by 5,045
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Network medicine: a network-based approach to human disease
Barabási, A.-L., Gulbahce, N., & Loscalzo, J. (2011) · Nature Reviews Genetics
Bioinformatics and Genomic NetworksBiomedical Text Mining and Ontologies
Cited by 5,034
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The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology
Gut microbiota and healthInflammatory Bowel Disease
Cited by 5,029
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Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
Qi, L. S., Larson, M. H., Gilbert, L. A., Doudna, J. A., Weissman, J. S., Arkin, A. P., & Lim, W. A. (2013) · Cell
CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology
Cited by 5,016
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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology
Extracellular vesicles in diseaseMicroRNA in disease regulation
Cited by 5,001
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Gene regulation by long non-coding RNAs and its biological functions
Statello, L., Guo, C.-J., Chen, L.-L., & Huarte, M. (2021) · Nature Reviews Molecular Cell Biology
Cancer-related molecular mechanisms researchRNA Research and Splicing
Cited by 4,991
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics
Genetics and Neurodevelopmental DisordersGenomics and Rare Diseases
Cited by 4,990
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The Evolutionary Fate and Consequences of Duplicate Genes
Lynch, M., & Conery, J. S. (2000) · Science
Chromosomal and Genetic VariationsEvolution and Genetic Dynamics
Cited by 4,988
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Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models
Kollman, P. A., Massova, I., Reyes, C., Kuhn, B., Huo, S., Chong, L., Lee, M., Lee, T., Duan, Y., Wang, W., et al. (2000) · Accounts of Chemical Research
Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions
Cited by 4,978
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Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science
Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms
Cited by 4,975
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The Large-Scale Organization of Metabolic Networks
Jeong, H., Tombor, B., Albert, R., Oltvai, Z. N., & Barabási, A.-L. (2000) · Nature
Bioinformatics and Genomic NetworksComplex Network Analysis Techniques
Cited by 4,972
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Finishing the euchromatic sequence of the human genome
International Human Genome Sequencing Consortium (2004) · Nature
Genomics and Phylogenetic StudiesGenomic variations and chromosomal abnormalities
Cited by 4,971
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Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science
MicroRNA in disease regulationPlant Molecular Biology Research
Cited by 4,956
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Mauve: Multiple alignment of conserved genomic sequence with rearrangements
Darling, A. C. E., Mau, B., Blattner, F. R., & Perna, N. T. (2004) · Genome Research
Genomics and Phylogenetic StudiesGenome Rearrangement Algorithms
Cited by 4,949
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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Tirosh, I., Izar, B., Prakadan, S. M., Wadsworth, M. H., Treacy, D., Trombetta, J. J., Rotem, A., Rodman, C., Lian, C., Murphy, G., et al. (2016) · Science
Single-cell and spatial transcriptomicsCancer Immunotherapy and Biomarkers
Cited by 4,944
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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences
Bacterial Genetics and BiotechnologyGene Regulatory Network Analysis
Cited by 4,943
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Copper induces cell death by targeting lipoylated TCA cycle proteins
Tsvetkov, P., Coy, S., Petrova, B., Dreishpoon, M., Verma, A., Abdusamad, M., Rossen, J., Joesch-Cohen, L., Humeidi, R., Spangler, R. D., et al. (2022) · Science
Cell death mechanisms and regulationMitochondrial Function and Pathology
Cited by 4,932
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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology
RNA Interference and Gene DeliveryExtracellular vesicles in disease
Cited by 4,930
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Oxyl radicals, redox-sensitive signalling cascades and antioxidants
Genestra, M. (2007) · Cellular Signalling
Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress
Cited by 4,930
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DNA methylation and its basic function
Moore, L. D., Le, T., & Fan, G. (2013) · Neuropsychopharmacology
Epigenetics and DNA MethylationGenetic Syndromes and Imprinting
Cited by 4,906
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