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Cited by 987

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

A Family Study of Schizoaffective, Bipolar I, Bipolar II, Unipolar, and Normal Control Probands

Gershon, Elliot S.·1982·Archives of General Psychiatry
DOI 10.1001/archpsyc.1982.04290100031006
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Abstract

In a family study of 1,254 adult relatives of patients and controls, lifetime prevalences of major affective disorder (including schizoaffective) were 37%, 24%, 25%, 20% and 7% in relatives of probands with schizoaffective, bipolar I, bipolar II, and unipolar disease, and normal controls. These data were compatible with the different affective disorders representing thresholds on a continuum of underlying multifactorial vulnerability. In this model, schizoaffective illness represents greatest vulnerability, followed by bipolar I and bipolar II, then unipolar illnesses. Alcoholism, drug abuse, and sociopathy were not more frequent in relatives of patients v relatives of controls. Sex-related transmission of morbid risk was not present. Morbid risk was 74% to offspring of two III parents, and 27% to offspring of one III parent. Nationality and age at time of interview seem to be nongenetic factors that affect frequency of diagnosis.

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Metadata

Authors
Gershon, E. S.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1982-10-01
Volume
39
Issue
10
Pages
1157
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1982.04290100031006
OpenAlex
W2003491970
Cited by
987
References
1
FWCI
19.76
Type
journal article
Language
en
Open access
closed

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