Cited by 369Circadian rhythm and melatoninSleep and related disordersAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Melatonin Secretion and the Incidence of Type 2 Diabetes

Open access

McMullan, Ciaran J., Schernhammer, Eva S., Rimm, Eric B., Hu, Frank B., Forman, John P.·2013·JAMA

DOI 10.1001/jama.2013.2710PMC PMC3804914

Open this paper in CoChat — free account

Abstract

IMPORTANCE: Loss-of-function mutations in the melatonin receptor are associated with insulin resistance and type 2 diabetes. Additionally, in a cross-sectional analysis of persons without diabetes, lower nocturnal melatonin secretion was associated with increased insulin resistance. OBJECTIVE: To study the association between melatonin secretion and the risk of developing type 2 diabetes. DESIGN, SETTING, AND PARTICIPANTS: Case-control study nested within the Nurses' Health Study cohort. Among participants without diabetes who provided urine and blood samples at baseline in 2000, we identified 370 women who developed type 2 diabetes from 2000-2012 and matched 370 controls using risk-set sampling. MAIN OUTCOME MEASURES: Associations between melatonin secretion at baseline and incidence of type 2 diabetes were evaluated with multivariable conditional logistic regression controlling for demographic characteristics, lifestyle habits, measures of sleep quality, and biomarkers of inflammation and endothelial dysfunction. RESULTS: The median urinary ratios of 6-sulfatoxymelatonin to creatinine were 28.2 ng/mg (5%-95% range, 5.5-84.2 ng/mg) among cases and 36.3 ng/mg (5%-95% range, 6.9-110.8 ng/mg) among controls. Women with lower ratios of 6-sulfatoxymelatonin to creatinine had increased risk of diabetes (multivariable odds ratio, 1.48 [95% CI, 1.11-1.98] per unit decrease in the estimated log ratio of 6-sulfatoxymelatonin to creatinine). Compared with women in the highest ratio category of 6-sulfatoxymelatonin to creatinine, those in the lowest category had a multivariable odds ratio of 2.17 (95% CI, 1.18-3.98) of developing type 2 diabetes. Women in the highest category of melatonin secretion had an estimated diabetes incidence rate of 4.27 cases/1000 person-years compared with 9.27 cases/1000 person-years in the lowest category. CONCLUSIONS AND RELEVANCE: Lower melatonin secretion was independently associated with a higher risk of developing type 2 diabetes. Further research is warranted to assess if melatonin secretion is a modifiable risk factor for diabetes within the general population.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jama.2013.2710

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,094
Diagnosis and classification of diabetes mellitus
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s081 · Cited by 5,974
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166
Television Watching and Other Sedentary Behaviors in Relation to Risk of Obesity and Type 2 Diabetes Mellitus in Women
Hu, F. B., Li, T. Y., Colditz, G. A., Willett, W. C., & Manson, J. E. (2003) · JAMA · doi:10.1001/jama.289.14.1785 · Cited by 1,892
Self-citation
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2011) · Diabetes Care · doi:10.2337/dc12-s064 · Cited by 1,539
Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire
Hu, F. B., Rimm, E., Smith-Warner, S. A., Feskanich, D., Stampfer, M. J., Ascherio, A., Sampson, L., & Willett, W. C. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.2.243 · Cited by 1,165
Physical activity and incidence of non-insulin-dependent diabetes mellitus in women
Manson, J. E., Stampfer, M. J., Colditz, G. A., Willett, W. C., Rosner, B., Hennekens, C. H., Speizer, F. E., Rimm, E. B., & Krolewski, A. S. (1991) · The Lancet · doi:10.1016/0140-6736(91)90664-b · Cited by 1,164
The basic physiology and pathophysiology of melatonin
Claustrat, B., Brun, J., & Chazot, G. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.08.001 · Cited by 951
Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption
Buxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003200 · Cited by 932
A prospective study of self-reported sleep duration and incident diabetes in women
Ayas, N. T., White, D. P., Al-Delaimy, W. K., Manson, J. E., Stampfer, M. J., Speizer, F. E., Patel, S., & Hu, F. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.380 · Cited by 883

Show all 54 references

Sorted by citations

Sleep duration and risk of type 2 diabetes: a meta-analysis of prospective studies
Shan, Z., Ma, H., Xie, M., Yan, P., Guo, Y., Bao, W., Rong, Y., Jackson, C. L., Hu, F. B., & Liu, L. (2015) · Diabetes Care · doi:10.2337/dc14-2073 · Cited by 902
Self-citation
Circadian clocks and insulin resistance
Stenvers, D. J., Scheer, F. A. J. L., Schrauwen, P., la Fleur, S. E., & Kalsbeek, A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0122-1 · Cited by 733
Melatonin as a Hormone: New Physiological and Clinical Insights
Cipolla‐Neto, J., & do Amaral, F. G. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00084 · Cited by 685
Systematic review of light exposure impact on human circadian rhythm
Tähkämö, L., Partonen, T., & Pesonen, A.-K. (2019) · Chronobiology International · doi:10.1080/07420528.2018.1527773 · Cited by 535
“In addition to potential increased cancer risk, lower melatonin secretion is associated with a higher risk for type 2 diabetes (McMullan et al. 2013).”
Background
The Effects of Light at Night on Circadian Clocks and Metabolism
Fonken, L. K., & Nelson, R. J. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1051 · Cited by 494
Arabidopsis Transcriptome Analysis Reveals Key Roles of Melatonin in Plant Defense Systems
Weeda, S. M., Zhang, N., Zhao, X., Ndip, G. M., Guo, Y., Buck, G. A., Fu, C., & Ren, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093462 · Cited by 381
Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses
Farez, M. F., Mascanfroni, I. D., Méndez-Huergo, S. P., Yeste, A., Murugaiyan, G., Garo, L. P., Balbuena Aguirre, M. E., Patel, B., Ysrraelit, M. C., Zhu, C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.025 · Cited by 318
Interactions between sleep, circadian function, and glucose metabolism: implications for risk and severity of diabetes
Reutrakul, S., & Van Cauter, E. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12355 · Cited by 321
Associations between chronotype, morbidity and mortality in the UK Biobank cohort
Knutson, K. L., & von Schantz, M. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1454458 · Cited by 275
Melatonin in type 2 diabetes mellitus and obesity
Karamitri, A., & Jockers, R. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0130-1 · Cited by 268
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia‐reperfusion injury by improving mitochondrial quality control: Role of SIRT6
Yu, L., Dong, X., Xue, X., Xu, S. C., Zhang, X., Xu, Y., Wang, Z., Wang, Y., Gao, H., Liang, Y., et al. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12698 · Cited by 222
Inflammaging: Implications in Sarcopenia
Antuña, E., Cachán-Vega, C., Bermejo-Millo, J. C., Potes, Y., Caballero, B., Vega‐Naredo, I., Coto‐Montes, A. M., & García-González, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315039 · Cited by 234
Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation
Lou, S., Lee, H. M., Qin, H., Li, J., Gao, Z., Liu, X., Chan, L. L., Lam, V. K. L., So, W., Wang, Y., et al. (2014) · Genome biology · doi:10.1186/s13059-014-0408-0 · Cited by 203
The Epidemiology of Sleep and Diabetes
Ogilvie, R. P., & Patel, S. R. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1055-8 · Cited by 211
Cross-sectional and Prospective Associations of Actigraphy-Assessed Sleep Regularity With Metabolic Abnormalities: The Multi-Ethnic Study of Atherosclerosis
Huang, T., & Redline, S. S. (2019) · Diabetes Care · doi:10.2337/dc19-0596 · Cited by 190
Melatonin effects on glucose metabolism: time to unlock the controversy
Garaulet, M., Qian, J., Florez, J. C., Arendt, J., Saxena, R., & Scheer, F. A. J. L. (2020) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2019.11.011 · Cited by 193
Delay in leaf senescence of Malus hupehensis by long‐term melatonin application is associated with its regulation of metabolic status and protein degradation
Wang, P., Sun, X., Chang, C., Feng, F., Liang, D., Cheng, L., & Ma, F. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12091 · Cited by 184
Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening
Rubio-Sastre, P., Scheer, F. A. J. L., Gómez-Abellán, P., Madrid, J. A., & Garaulet, M. (2014) · SLEEP · doi:10.5665/sleep.4088 · Cited by 180
Impact of sleep and circadian disruption on energy balance and diabetes: a summary of workshop discussions
Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.5226 · Cited by 173
Endocrine Effects of Circadian Disruption
Bedrosian, T. A., Fonken, L. K., & Nelson, R. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105102 · Cited by 170
Shift Work, Chronotype, and Melatonin Rhythm in Nurses
Razavi, P., Devore, E. E., Bajaj, A., Lockley, S. W., Figueiro, M. G., Ricchiuti, V., Gauderman, W. J., Hankinson, S. E., Willett, W. C., & Schernhammer, E. S. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-18-1018 · Cited by 178
Consequences of Circadian Disruption on Cardiometabolic Health
Reutrakul, S., & Knutson, K. L. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.07.005 · Cited by 169
Diet, Lifestyle, and Genetic Risk Factors for Type 2 Diabetes: A Review from the Nurses’ Health Study, Nurses’ Health Study 2, and Health Professionals’ Follow-Up Study
Ardisson Korat, A. V., Willett, W. C., & Hu, F. B. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0103-5 · Cited by 162
Circadian disruption and human health: A bidirectional relationship
Abbott, S. M., Malkani, R. G., & Zee, P. C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14298 · Cited by 161
Association between short and long sleep durations and cardiovascular outcomes: a systematic review and meta-analysis
Krittanawong, C., Tunhasiriwet, A., Wang, Z., Zhang, H., Farrell, A. M., Chirapongsathorn, S., Sun, T., Kitai, T., & Argulian, E. (2017) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872617741733 · Cited by 162
Physiological responses to food intake throughout the day
Johnston, J. D. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000055 · Cited by 158
Evening light exposure to computer screens disrupts human sleep, biological rhythms, and attention abilities
Green, A., Cohen-Zion, M., Haim, A., & Dagan, Y. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1324878 · Cited by 158
Light exposure during sleep impairs cardiometabolic function
Mason, I. C., Grimaldi, D., Reid, K. J., Warlick, C., Malkani, R. G., Abbott, S. M., & Zee, P. C. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113290119 · Cited by 160
Sleep habits and diabetes
Larcher, S., Benhamou, P., Pépin, J., & Borel, A. (2015) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.12.004 · Cited by 139
Timing and Intensity of Light Correlate with Body Weight in Adults
Reid, K. J., Santostasi, G., Baron, K. G., Wilson, J. A., Kang, J., & Zee, P. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092251 · Cited by 124
Administration of Exogenous Melatonin Improves the Diurnal Rhythms of the Gut Microbiota in Mice Fed a High-Fat Diet
Yin, J., Li, Y., Han, H. L., Ma, J., Liu, G., Wu, X., Huang, X., Fang, R., Baba, K., Bin, P., et al. (2020) · mSystems · doi:10.1128/msystems.00002-20 · Cited by 122
Reduced silent information regulator 1 signaling exacerbates myocardial ischemia–reperfusion injury in type 2 diabetic rats and the protective effect of melatonin
Yu, L., Liang, H., Dong, X., Zhao, G., Jin, Z., Zhai, M., Yang, Y., Chen, W., Liu, J., Yi, W., et al. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12269 · Cited by 119
Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism
Owino, S., Buonfiglio, D. D. C., Tchio, C. I. M., & Tosini, G. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00488 · Cited by 124
Short-term sleep deprivation with nocturnal light exposure alters time-dependent glucagon-like peptide-1 and insulin secretion in male volunteers
Gil‐Lozano, M., Hunter, P. M., Behan, L., Gladanac, B., Casper, R. F., & Brubaker, P. L. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00298.2015 · Cited by 114
Association Between Sleep Timing, Obesity, Diabetes: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Cohort Study
Knutson, K. L., Wu, D., Patel, S. R., Loredo, J. S., Redline, S. S., Cai, J., Gallo, L. C., Mossavar‐Rahmani, Y., Ramos, A. R., Teng, Y., et al. (2017) · SLEEP · doi:10.1093/sleep/zsx014 · Cited by 113
G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus
Riddy, D. M., Delerive, P., Summers, R. J., Sexton, P. M., & Langmead, C. J. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014373 · Cited by 108
Connecting insufficient sleep and insomnia with metabolic dysfunction
Duan, D., Kim, L. J., Jun, J. C., & Polotsky, V. Y. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14926 · Cited by 110
Contribution of the Nurses’ Health Studies to Uncovering Risk Factors for Type 2 Diabetes: Diet, Lifestyle, Biomarkers, and Genetics
Ley, S. H., Korat, A. V. A., Sun, Q., Tobias, D. K., Zhang, C., Qi, L., Willett, W. C., Manson, J. E., & Hu, F. B. (2016) · American Journal of Public Health · doi:10.2105/ajph.2016.303314 · Cited by 116
Effect of Light and Melatonin and Other Melatonin Receptor Agonists on Human Circadian Physiology
Emens, J. S., & Burgess, H. J. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.08.001 · Cited by 102
Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity
Song, S. O., He, K., Narla, R. R., Kang, H. G., Ryu, H. U., & Boyko, E. J. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2018.0256 · Cited by 106
Light at night in older age is associated with obesity, diabetes, and hypertension
Kim, M., Vu, T. T., Maas, M. B., Braun, R., Wolf, M. S., Roenneberg, T., Daviglus, M. L., Reid, K. J., & Zee, P. C. (2022) · SLEEP · doi:10.1093/sleep/zsac130 · Cited by 100
Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease
Nikolaev, G., Robeva, R. N., & Konakchieva, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010471 · Cited by 101
Sleep Apnea, Obesity, and Disturbed Glucose Homeostasis: Epidemiologic Evidence, Biologic Insights, and Therapeutic Strategies
Pugliese, G., Barrea, L., Laudisio, D., Salzano, C., Aprano, S., Colao, A., Savastano, S., & Muscogiuri, G. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00369-y · Cited by 94
Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology
Lane, J. M., Chang, A., Bjonnes, A., Aeschbach, D., Anderson, C., Cade, B. E., Cain, S. W., Czeisler, C. A., Gharib, S. A., Gooley, J. J., et al. (2016) · Diabetes · doi:10.2337/db15-0999 · Cited by 97
Circadian desynchrony and glucose metabolism
Speksnijder, E. M., Bisschop, P. H. L. T., Siegelaar, S. E., Stenvers, D. J., & Kalsbeek, A. (2024) · Journal of Pineal Research · doi:10.1111/jpi.12956 · Cited by 100
Night‐shift work is associated with poorer glycaemic control in patients with type 2 diabetes
Manodpitipong, A., Saetung, S., Nimitphong, H., Siwasaranond, N., Wongphan, T., Sornsiriwong, C., Luckanajantachote, P., Mangjit, P., Keesukphan, P., Crowley, S. J., et al. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12554 · Cited by 92
Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?
Jiki, Z., Lecour, S., & Nduhirabandi, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00528 · Cited by 88
Physiology of the Pineal Gland and Melatonin
Aulinas, A. (2019) · Europe PMC (PubMed Central) · Cited by 90
Independent and joint associations of dietary antioxidant intake with risk of post-stroke depression and all-cause mortality
Xu, Q., Qian, X., Sun, F., Liu, H., Dou, Z., & Zhang, J. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.11.013 · Cited by 91
The Interlinked Rising Epidemic of Insufficient Sleep and Diabetes Mellitus
Chattu, V. K., Chattu, S. K., Burman, D., Spence, D. W., & Pandi-Perumal, S. R. (2019) · Healthcare · doi:10.3390/healthcare7010037 · Cited by 87
A Review of Data of Findings on Night Shift Work and the Development of DM and CVD Events: a Synthesis of the Proposed Molecular Mechanisms
Strohmaier, S., Devore, E. E., Zhang, Y., & Schernhammer, E. S. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1102-5 · Cited by 89
Activation of melatonin signaling promotes β-cell survival and function
Costes, S., Boss, M., Thomas, A. P., & Matveyenko, A. V. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1293 · Cited by 84
Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity
Owino, S., Sánchez-Bretaño, A., Tchio, C., Cecon, E., Karamitri, A., Dam, J., Jockers, R., Piccione, G., Noh, H., Kim, T., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12462 · Cited by 86
Melatonin synthesis impairment as a new deleterious outcome of diabetes‐derived hyperglycemia
do Amaral, F. G., Turati, A. D. O., Barone, M. T. U., Scialfa, J. H., Buonfiglio, D. D. C., Peres, R., Garcia, R. A. P., Afeche, S. C., Lima, L. D. S., Scavone, C., et al. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12144 · Cited by 86
Melatonin redirects carbohydrates metabolism during sugar starvation in plant cells
Kobylińska, A., Borek, S., & Posmyk, M. M. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12466 · Cited by 82
Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha‐2‐ HS ‐glycoprotein
Heo, J., Yoon, D. W., Yu, J. H., Kim, N. H., Yoo, H. J., Seo, J. A., Kim, S. G., Choi, K. M., Baik, S. H., Choi, D. S., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12493 · Cited by 80
Chronomedicine and type 2 diabetes: shining some light on melatonin
Forrestel, A. C., Miedlich, S. U., Yurcheshen, M. E., Wittlin, S. D., & Sellix, M. T. (2016) · Diabetologia · doi:10.1007/s00125-016-4175-1 · Cited by 82
Change in Sleep Duration and Type 2 Diabetes: The Whitehall II Study
Ferrie, J. E., Mika Kivimaki, B., Akbaraly, T. N., Tabák, Á. G., Abell, J. G., Smith, G. D., Virtanen, M., Meena Kumari, B., & Shipley, M. J. (2015) · Diabetes Care · doi:10.2337/dc15-0186 · Cited by 78
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial
Garaulet, M., Lopez-Minguez, J., Dashti, H. S., Vetter, C., Hernández-Martínez, A. M., Pérez-Ayala, M., Baraza, J. C., Wang, W., Florez, J. C., Scheer, F. A. J. L., et al. (2022) · Diabetes Care · doi:10.2337/dc21-1314 · Cited by 77
Later chronotype is associated with higher hemoglobin A1c in prediabetes patients
Anothaisintawee, T., Lertrattananon, D., Thamakaison, S., Knutson, K. L., Thakkinstian, A., & Reutrakul, S. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1279624 · Cited by 75
Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial
Goyal, A., Terry, P., Superak, H. M., Nell‐Dybdahl, C., Chowdhury, R., Phillips, L. S., & Kutner, M. H. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-124 · Cited by 74
Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3‐L1 preadipocytes
Kato, H., Tanaka, G., Masuda, S., Ogasawara, J., Sakurai, T., Kizaki, T., Ohno, H., & Izawa, T. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12259 · Cited by 72
Melatonin and metabolic regulation: a review
Navarro‐Alarcón, M., Ruiz‐Ojeda, F. J., Blanca-Herrera, R. M., A‐Serrano, M. M., Acuña-Castroviejo, D., Fernández‐Vázquez, G., & Agil, A. (2014) · Food & Function · doi:10.1039/c4fo00317a · Cited by 77
Aiding sleep in type 2 diabetes: therapeutic considerations
Tan, X., van Egmond, L., Chapman, C. D., Cedernaes, J., & Benedict, C. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30233-4 · Cited by 72
Impact of sleep behavior on glycemic control in type 1 diabetes: the role of social jetlag
Larcher, S., Gauchez, A., Lablanche, S., Pépin, J., Benhamou, P., & Borel, A. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0188 · Cited by 72
Enhancement of high glucose‐induced PINK1 expression by melatonin stimulates neuronal cell survival: Involvement of MT 2 /Akt/NF‐κB pathway
Onphachanh, X., Lee, H. J., Lim, J. R., Jung, Y. H., Kim, J. S., Chae, C. W., Lee, S., Gabr, A. A., & Han, H. J. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12427 · Cited by 71
The Effects of Melatonin Supplementation on Parameters of Mental Health, Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress in Diabetic Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
Ostadmohammadi, V., Soleimani, A., Bahmani, F., Aghadavod, E., Ramezani, R., Reiter, R. J., Mansournia, M. A., Banikazemi, Z., Soleimani, M., Zaroudi, M., et al. (2019) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2019.08.003 · Cited by 70
Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome
Li, S., Zhai, J., Chu, W., Geng, X., Chen, Z., & Du, Y. (2020) · Translational research · doi:10.1016/j.trsl.2020.02.003 · Cited by 69
Melatonin, mitochondria, and the metabolic syndrome
Cardinali, D. P., & Vigo, D. E. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2611-0 · Cited by 70
New insights into the function of melatonin and its role in metabolic disturbances
do Amaral, F. G., Andrade-Silva, J., Kuwabara, W. M. T., & Cipolla‐Neto, J. (2019) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2019.1631158 · Cited by 66
Human Gastroenteropancreatic Expression of Melatonin and Its Receptors MT1 and MT2
Söderquist, F., Hellström, P. M., & Cunningham, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120195 · Cited by 65
Melatonin Increases Brown Adipose Tissue Volume and Activity in Patients With Melatonin Deficiency: A Proof-of-Concept Study
Halpern, B., Mancini, M. C., Bueno, C., de Barcelos, I. P., de Melo, M. E., Lima, M. S., Carneiro, C. D. G., Sapienza, M. T., Buchpiguel, C. A., do Amaral, F. G., et al. (2019) · Diabetes · doi:10.2337/db18-0956 · Cited by 69
Novel therapeutics for type 2 diabetes: insulin resistance
Altaf, Q. A., Barnett, A. H., & Tahrani, A. A. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12400 · Cited by 66
Night workers with circadian misalignment are susceptible to alcohol-induced intestinal hyperpermeability with social drinking
Swanson, G. R., Gorenz, A., Shaikh, M. W., Desai, V., Kaminsky, T. J., van den Berg, J., Murphy, T. E., Raeisi, S., Fogg, L., Vitaterna, M. H., et al. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00087.2016 · Cited by 63
Type 2 diabetes–associated variants of the MT 2 melatonin receptor affect distinct modes of signaling
Karamitri, A., Plouffe, B., Bonnefond, A., Chen, M., Gallion, J., Guillaume, J.-L., Hegron, A., Boissel, M., Canouil, M., Langenberg, C., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aan6622 · Cited by 62
Diabetes Pathology and Risk of Primary Open-Angle Glaucoma: Evaluating Causal Mechanisms by Using Genetic Information
Shen, L., Walter, S., Melles, R. B., Glymour, M. M., & Jorgenson, E. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwv204 · Cited by 62
Minireview: Toward the Establishment of a Link between Melatonin and Glucose Homeostasis: Association of Melatonin MT2Receptor Variants with Type 2 Diabetes
Karamitri, A., Renault, N., Clément, N., Guillaume, J., & Jockers, R. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1101 · Cited by 63
Melatonin in Heart Failure: A Promising Therapeutic Strategy?
Nduhirabandi, F., & Maarman, G. J. (2018) · Molecules · doi:10.3390/molecules23071819 · Cited by 61
Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19
Tan, D. X., & Hardeland, R. (2020) · Molecules · doi:10.3390/molecules25194410 · Cited by 60
Circadian Disruption and Diet-Induced Obesity Synergize to Promote Development of β-Cell Failure and Diabetes in Male Rats
Qian, J., Yeh, B., Rakshit, K., Colwell, C. S., & Matveyenko, A. V. (2015) · Endocrinology · doi:10.1210/en.2015-1516 · Cited by 61
Circadian rhythms, insulin action, and glucose homeostasis
Tan, E., & SCOTT, E. M. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000061 · Cited by 58
Circadian transcription from beta cell function to diabetes pathophysiology
Perelis, M., Ramsey, K. M., Marcheva, B., & Bass, J. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416656949 · Cited by 57
Diabetes mellitus and melatonin: Where are we?
Patel, R., PARMAR, N. R., Palit, S. P., RATHWA, N. N., Ramachandran, A. V., & Begum, R. (2022) · Biochimie · doi:10.1016/j.biochi.2022.01.001 · Cited by 58
Salivary melatonin levels and sleep-wake rhythms in pregnant women with hypertensive and glucose metabolic disorders: A prospective analysis
Shimada, M., Seki, H., Samejima, M., Hayase, M., & Shirai, F. (2016) · BioScience Trends · doi:10.5582/bst.2015.01123 · Cited by 55
Disrupted diurnal oscillation of gut-derived Short chain fatty acids in shift workers drinking alcohol: Possible mechanism for loss of resiliency of intestinal barrier in disrupted circadian host
Swanson, G. R., Siskin, J., Gorenz, A., Shaikh, M. W., Raeisi, S., Fogg, L., Forsyth, C. B., & Keshavarzian, A. (2020) · Translational research · doi:10.1016/j.trsl.2020.04.004 · Cited by 57
Type 2 diabetes and cardiovascular disease: what next?
Joseph, J. J., & Golden, S. H. (2014) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000044 · Cited by 57
Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials
Delpino, F. M., Figueiredo, L. M., & Nunes, B. P. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.06.007 · Cited by 56
Obstructive sleep apnoea and diabetes
Tahrani, A. A., Ali, A., & Stevens, M. J. (2013) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e3283659da5 · Cited by 56
Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes
Kimple, M. E., Neuman, J. C., Linnemann, A. K., & Casey, P. J. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.40 · Cited by 54
Administration of Melatonin and Metformin Prevents Deleterious Effects of Circadian Disruption and Obesity in Male Rats
Thomas, A. P., Hoang, J. D., Vongbunyong, K. E., Nguyen, A., Rakshit, K., & Matveyenko, A. V. (2016) · Endocrinology · doi:10.1210/en.2016-1309 · Cited by 54
Disrupted circadian rhythms of body temperature, heart rate and fasting blood glucose in prediabetes and type 2 diabetes mellitus
Gubin, D. G., Nelaeva, A. A., Uzhakova, A. E., Валерьевна, Х. Ю., Cornélissen, G., & Weinert, D. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1347670 · Cited by 54
Incident Type 2 Diabetes Among Individuals With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
Jepson, C., Hsu, J. Y., Fischer, M. J., Kusek, J. W., Lash, J. P., Ricardo, A. C., Schelling, J. R., Feldman, H. I., Appel, L. J., Feldman, H. I., et al. (2018) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2018.06.017 · Cited by 53
The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Doosti-Irani, A., Ostadmohammadi, V., Mirhosseini, N., Mansournia, M., Reiter, R., Kashanian, M., Rahimi, M., Razavi, M., & Asemi, Z. (2018) · Hormone and Metabolic Research · doi:10.1055/a-0752-8462 · Cited by 52
Decreased melatonin secretion is associated with increased intestinal permeability and marker of endotoxemia in alcoholics
Swanson, G. R., Gorenz, A., Shaikh, M. W., Desai, V., Forsyth, C. B., Fogg, L., Burgess, H. J., & Keshavarzian, A. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00002.2015 · Cited by 52
Melatonin Affects Mitochondrial Fission/Fusion Dynamics in the Diabetic Retina
Chang, J. Y.-A., Yu, F., Shi, L., Ko, M. L., & Ko, G. Y. ‐. (2019) · Journal of Diabetes Research · doi:10.1155/2019/8463125 · Cited by 55
Sleep Duration Patterns in Early to Middle Adulthood and Subsequent Risk of Type 2 Diabetes in Women
Baden, M. Y., Hu, F. B., Vetter, C., Schernhammer, E. S., Redline, S. S., & Huang, T. (2020) · Diabetes Care · doi:10.2337/dc19-2371 · Cited by 56
Pleiotropic Effects of Melatonin
Mahmood, D. (2019) · Drug Research · doi:10.1055/a-0656-6643 · Cited by 52
Melatonin and Male Reproductive Health: Relevance of Darkness and Antioxidant Properties
Rocha, C. S. F., Rato, L., Martins, A. D., Alves, M. G., & Oliveira, P. F. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150505155530 · Cited by 49
Cross-sectional and Prospective Associations between Sleep Regularity and Metabolic Health in the Hispanic Community Health Study/Study of Latinos.
Fritz, J., Phillips, A., Hunt, L., Imam, A., Reid, K., Perreira, K., Mossavar-Rahmani, Y., Daviglus, M., Sotres-Alvarez, D., Zee, P., et al. (2020) · Sleep · doi:10.1093/sleep/zsaa218 · Cited by 36
Transcutaneous Vagus Nerve Stimulation Induces Tidal Melatonin Secretion and Has an Antidiabetic Effect in Zucker Fatty Rats
Wang, S., Zhai, X., Li, S., McCabe, M. F., Wang, X., & Rong, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124195 · Cited by 47

Authors: McMullan, C. J., Schernhammer, E. S., Rimm, E. B., Hu, F. B., & Forman, J. P.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
Corresponding author: McMullan, Ciaran J.
ORCID: McMullan, Ciaran J.
Schernhammer, Eva S.
Rimm, Eric B.
Hu, Frank B.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2013-04-03
Volume: 309
Issue: 13
Pages: 1388
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2013.2710
PMC: PMC3804914
OpenAlex: W2086677877
Cited by: 369
References: 54
Citations by year: 2026: 15 · 2025: 21 · 2024: 18 · 2023: 30 · 2022: 29 · 2021: 26 · 2020: 36 · 2019: 25 · 2018: 43 · 2017: 24 · 2016: 28 · 2015: 39 · 2014: 28 · 2013: 6
FWCI: 18.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: National Heart, Lung, and Blood Institute (R01HL103607, HL103607)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058845, DK58845)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: melatonin secretion, type 2 diabetes, 6-sulfatoxymelatonin, urinary melatonin metabolites, insulin resistance, diabetes risk, women, sleep quality, inflammation, endothelial dysfunction
MeSH terms: Aged, Creatinine, Diabetes Mellitus, Type 2, Female, Humans, Melatonin, Middle Aged, Regression Analysis, Risk Factors, United States, Cohort Studies, Incidence, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Melatonin Secretion and the Incidence of Type 2 Diabetes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks