Effect of computerized physician order entry and a team intervention on prevention of serious medication errors
Abstract
CONTEXT: Adverse drug events (ADEs) are a significant and costly cause of injury during hospitalization. OBJECTIVES: To evaluate the efficacy of 2 interventions for preventing nonintercepted serious medication errors, defined as those that either resulted in or had potential to result in an ADE and were not intercepted before reaching the patient. DESIGN: Before-after comparison between phase 1 (baseline) and phase 2 (after intervention was implemented) and, within phase 2, a randomized comparison between physician computer order entry (POE) and the combination of POE plus a team intervention. SETTING: Large tertiary care hospital. PARTICIPANTS: For the comparison of phase 1 and 2, all patients admitted to a stratified random sample of 6 medical and surgical units in a tertiary care hospital over a 6-month period, and for the randomized comparison during phase 2, all patients admitted to the same units and 2 randomly selected additional units over a subsequent 9-month period. INTERVENTIONS: A physician computer order entry system (POE) for all units and a team-based intervention that included changing the role of pharmacists, implemented for half the units. MAIN OUTCOME MEASURE: Nonintercepted serious medication errors. RESULTS: Comparing identical units between phases 1 and 2, nonintercepted serious medication errors decreased 55%, from 10.7 events per 1000 patient-days to 4.86 events per 1000 (P=.01). The decline occurred for all stages of the medication-use process. Preventable ADEs declined 17% from 4.69 to 3.88 (P=.37), while nonintercepted potential ADEs declined 84% from 5.99 to 0.98 per 1000 patient-days (P=.002). When POE-only was compared with the POE plus team intervention combined, the team intervention conferred no additional benefit over POE. CONCLUSIONS: Physician computer order entry decreased the rate of nonintercepted serious medication errors by more than half, although this decrease was larger for potential ADEs than for errors that actually resulted in an ADE.
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Clinical decision support systems (CDSS) can reduce medication errors and adverse drug events.
“Clinical decision support systems (CDSS), which provide alerts at the point of ordering, can reduce medication errors and adverse drug events [1, 2].”
From Effects of workload, work complexity, and repeated alerts on alert fatigue in a clinical decision support system (2017) · cites this paper as [1]
A study by Bates et al. found a significant reduction in medication errors with physician-computerized order entry.
“A study by Bates et al. found a significant reduction in medication errors with physician-computerized order entry (9).”
From Application of zero trust model in preventing medical errors (2024) · cites this paper as [9]
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“A study by Bates et al. found a signi fi cant reduction in medication errors with physician-computerized order entry (9).”
Background
- Authors
- Bates, D. W.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Bates, David W.
- ORCID
- Bates, David W.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1998-10-21
- Volume
- 280
- Issue
- 15
- Pages
- 1311
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2095818009
- Cited by
- 2,107
- References
- 28
- Citations by year
- 2026: 39 · 2025: 24 · 2024: 31 · 2023: 22 · 2022: 28 · 2021: 50 · 2020: 51 · 2019: 64 · 2018: 38 · 2017: 71 · 2016: 50 · 2015: 73 · 2014: 75 · 2013: 98 · 2012: 100
- FWCI
- 101.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion)
- Topics
- Health Sciences › Health Professions › Emergency Medical Services › Patient Safety and Medication Errors
- Health Sciences › Health Professions › Health Information Management › Electronic Health Records Systems
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- computerized physician order entry, medication errors, adverse drug reactions, team-based intervention, pharmacist role, drug safety, inpatient care, medication process, error prevention
- MeSH terms
- Drug Therapy, Computer-Assisted, Humans, Medication Errors, Pharmacies, Physician's Role, Drug Prescriptions, Random Allocation, Clinical Pharmacy Information Systems, Decision Support Systems, Clinical, Drug-Related Side Effects and Adverse Reactions
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