The DOI matches its Crossref record; 63 of the 68 references it cites were found in a registry or an index.
Renal‐clearable Molecular Semiconductor for Second Near‐Infrared Fluorescence Imaging of Kidney Dysfunction
Open accessAbstract
Real‐time imaging of kidney function is important to assess the nephrotoxicity of drugs and monitor the progression of renal diseases; however, it remains challenging because of the lack of optical agents with high renal clearance and high signal‐to‐background ratio (SBR). Herein, a second near‐infrared (NIR‐II) fluorescent molecular semiconductor (CDIR2) is synthesized for real‐time imaging of kidney dysfunction in living mice. CDIR2 not only has a high renal clearance efficiency (≈90 % injection dosage at 24 h post‐injection), but also solely undergoes glomerular filtration into urine without being reabsorbed and secreted in renal tubules. Such a unidirectional renal clearance pathway of CDIR2 permits real‐time monitoring of kidney dysfunction in living mice upon nephrotoxic exposure. Thus, this study not only introduces a molecular renal probe but also provides useful molecular guidelines to increase the renal clearance efficiency of NIR‐II fluorescent agents.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The CDIR2 probe was the first SWIR fluorogen used for a real-time evaluation of renal function in living animals.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [216]
The cited source says what the claim attributes to it.
In the citing paper
“After it is administered to mice, it passes through the glomeruli filtration system into urine without being reabsorbed or secreted in renal tubules.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [216]
The cited source says what the claim attributes to it.
In the citing paper
“This unilateral renal clearance pathway allowed one to monitor in real-time the kidney dysfunction during the progression of renal impairment.216”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [216]
The cited source says what the claim attributes to it.
In the citing paper
“In vivo study, they observed CDIR2 has greater SBR than traditional NIR molecules (ICG or CCD), and has a high renal clearance efficiency with excellent biocompatibility.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [198]
The cited source says what the claim attributes to it.
In the citing paper
“Pu and coworkers studied a new renal-clearable molecular semiconductor (CDIR2) that can real-time monitor kidney dysfunction in NIR-II components (Figure 13e), a NIR-II fluorophore with classic D-A-D structure (λem = 1050 nm) and a renal-clearance-enabling segment (HPbCD).”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [198]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Chronic kidney disease: global dimension and perspectives
Jha, V., Garcia-Garcia, G., Iseki, K., Li, Z., Naicker, S., Plattner, B., Saran, R., Wang, A. Y.-M., & Yang, C.-W. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60687-x · Cited by 4,383
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,048
Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes
Chawla, L. S., Eggers, P. W., Star, R. A., & Kimmel, P. L. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1214243 · Cited by 1,984
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Self-citationLovell, J. F., Jin, C. S., Huynh, E., Jin, H., Kim, C., Rubinstein, J. L., Chan, W. C. W., Cao, W., Wang, L. V., & Zheng, G. (2011) · Nature Materials · doi:10.1038/nmat2986 · Cited by 1,364
Fluoro- and Chromogenic Chemodosimeters for Heavy Metal Ion Detection in Solution and Biospecimens
Quang, D. T., & Kim, J. S. (2010) · Chemical Reviews · doi:10.1021/cr100154p · Cited by 1,362
Molecular imaging in drug development
Willmann, J. K., van Bruggen, N., Dinkelborg, L. M., & Gambhir, S. S. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2290 · Cited by 1,175
Li, J., & Pu, K. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00001h · Cited by 1,169
Self-citationMolecular afterglow imaging with bright, biodegradable polymer nanoparticles
Miao, Q., Xie, C., Xu, Z. J., Lyu, Y., Duan, H., Liu, X., Jokerst, J. V., & Pu, K. (2017) · Nature Biotechnology · doi:10.1038/nbt.3987 · Cited by 980
Self-citation
Flagged first, then by citations
5 of the 68 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Huang J., 2019, Nat. Mater.
- 10.1021/nl072014 · DOI
Cited by
Sorted by citations
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037
Emerging combination strategies with phototherapy in cancer nanomedicine
Xie, Z., Fan, T., An, J., Choi, W., Duo, Y., Ge, Y., Zhang, B., Nie, G., Xie, N., Zheng, T., et al. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00215a · Cited by 718
Xu, M., Qi, Y., Liu, G. H., Song, Y., Jiang, X., & Du, B. (2023) · ACS Nano · doi:10.1021/acsnano.3c05853 · Cited by 654
J -Aggregates of Cyanine Dye for NIR-II in Vivo Dynamic Vascular Imaging beyond 1500 nm
Sun, C., Li, B., Zhao, M., Wang, S., Lei, Z., Lu, L., Zhang, H., Feng, L., Dou, C., Yin, D., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10043 · Cited by 582
In vivo NIR-II fluorescence imaging for biology and medicine
Wang, F., Zhong, Y., Bruns, O., Liang, Y., & Dai, H. (2024) · Nature Photonics · doi:10.1038/s41566-024-01391-5 · Cited by 564
“A caveat is that attaching highly hydrophilic side groups such as β-cyclodextrin (β-CD) 56 and poly(oligo(ethylene glycol) dimethacrylate) polymer brushes 48 to NIR-II fluorophores can facilitate renal excretion, but this typically lowers the fluorescence QY due to non-radiative relaxation of…”
Fluorescent Probes for Disease Diagnosis
Wang, X., Ding, Q., Groleau, R. R., Wu, L., Mao, Y., Che, F., Kotova, O. V., Scanlan, E. M., Lewis, S. E., Li, P., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00776 · Cited by 570
Huang, J., & Pu, K. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202001783 · Cited by 551
Self-citationMolecular imaging and disease theranostics with renal-clearable optical agents
Cheng, P., & Pu, K. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00328-6 · Cited by 418
“Panel b reprinted with permission from ref.(77), Wiley.”
BackgroundSelf-citationSmall-molecule fluorescence-based probes for interrogating major organ diseases
Han, H., Tian, H., Zang, Y., Sedgwick, A. C., Li, J. X., Sessler, J. L., He, X., & James, T. D. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01183e · Cited by 367
Self-citationHe, S., Li, J., Lyu, Y., Huang, J., & Pu, K. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c00659 · Cited by 284
Self-citationLiu, S., Ou, H., Li, Y., Zhang, H., Liu, J., Lu, X., Kwok, R. T. K., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07193 · Cited by 277
NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing
Lu, L., Li, B., Ding, S., Fan, Y., Wang, S., Sun, C., Zhao, M., Zhao, C.-X., & Zhang, F. (2020) · Nature Communications · doi:10.1038/s41467-020-18051-1 · Cited by 274
Multiplexed NIR‐II Probes for Lymph Node‐Invaded Cancer Detection and Imaging‐Guided Surgery
Tian, R., Ma, H., Zhu, S., Lau, J., Ma, R., Liu, Y., Lin, L., Chandra, S., Wang, S., Zhu, X., et al. (2020) · Advanced Materials · doi:10.1002/adma.201907365 · Cited by 269
A New Class of NIR‐II Gold Nanocluster‐Based Protein Biolabels for In Vivo Tumor‐Targeted Imaging
Song, X., Zhu, W., Ge, X., Li, R., Li, S., Chen, X., Song, J., Xie, J., Chen, X., & Yang, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202010870 · Cited by 266
An NIR‐II‐Emissive Photosensitizer for Hypoxia‐Tolerant Photodynamic Theranostics
Li, L., Shao, C., Liu, T., Chao, Z., Chen, H., Xiao, F., He, H., Wei, Z., Zhu, Y., Wang, H., et al. (2020) · Advanced Materials · doi:10.1002/adma.202003471 · Cited by 254
Self-citationZhang, Z., Fang, X., Liu, Z., Liu, H., Chen, D., He, S., Zheng, J., Yang, B., Qin, W., Zhang, X., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201914397 · Cited by 242
Self-citationZhao, M., Li, B., Wu, Y., He, H., Zhu, X., Zhang, H., Dou, C., Feng, L., Fan, Y., & Zhang, F. (2020) · Advanced Materials · doi:10.1002/adma.202001172 · Cited by 238
NIR-quantum dots in biomedical imaging and their future
Gil, H. M., Price, T. W., Chelani, K., Bouillard, J. G., Calaminus, S. D. J., & Stasiuk, G. J. (2021) · iScience · doi:10.1016/j.isci.2021.102189 · Cited by 239
Rosenkrans, Z. T., Sun, T., Jiang, D., Chen, W., Barnhart, T. E., Zhang, Z., Ferreira, C. A., Wang, X., Engle, J. W., Huang, P., et al. (2020) · Advanced Science · doi:10.1002/advs.202000420 · Cited by 219
Xanthene-Based NIR-II Dyes for In Vivo Dynamic Imaging of Blood Circulation
Liu, D., He, Z., Zhao, Y., Yang, Y., Shi, W., Li, X., & Ma, H. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c07711 · Cited by 217
Zhang, Q., Yu, P., Fan, Y., Sun, C., He, H., Liu, X., Lu, L., Zhao, M., Zhang, H., & Zhang, F. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202012427 · Cited by 216
Rational Design of High Brightness NIR-II Organic Dyes with S-D-A-D-S Structure
Yang, Q., Ma, H., Liang, Y., & Dai, H. (2021) · Accounts of Materials Research · doi:10.1021/accountsmr.0c00114 · Cited by 189
Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm
Li, Y., Liu, Y., Li, Q., Zeng, X., Tian, T., Zhou, W., Cui, Y., Wang, X., Cheng, X., Ding, Q., et al. (2020) · Chemical Science · doi:10.1039/c9sc06567a · Cited by 177
Yan, D., Xie, W., Zhang, J., Wang, L., Wang, D., & Tang, B. Z. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202111767 · Cited by 179
Recent advances in the development of NIR-II organic emitters for biomedicine
Li, J., Liu, Y., Xu, Y., Li, L., Sun, Y., & Huang, W. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213318 · Cited by 174
Self-citationWeng, J., Wang, Y., Zhang, Y., & Ye, D. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c08898 · Cited by 173
Jia, J., Liu, G., Xu, W., Tian, X., Li, S., Han, F. X., Feng, Y., Dong, X., & Chen, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202000474 · Cited by 170
Li, J., Xie, L., Li, B., Yin, C., Wang, G., Sang, W., Li, W., Tian, H., Zhang, Z., Zhang, X., et al. (2021) · Advanced Materials · doi:10.1002/adma.202008481 · Cited by 169
Self-citationLiu, Z., Wang, Q., Qiu, W., Lyu, Y., Zhu, Z., Zhao, X., & Zhu, W. (2022) · Chemical Science · doi:10.1039/d2sc00067a · Cited by 162
Near-infrared fluorescence imaging in immunotherapy
Ji, Y., Jones, C., Baek, Y., Park, G. K., Kashiwagi, S., & Choi, H. S. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.012 · Cited by 161
“2), and high resolution and contrast in images compared to visible or NIR-I light [16-18].”
BackgroundOrganic Semiconducting Macromolecular Dyes for NIR‐II Photoacoustic Imaging and Photothermal Therapy
Yin, C., Li, X., Wang, Y., Liang, Y., Zhou, S. D., Zhao, P., Lee, C., Fan, Q., & Huang, W. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202104650 · Cited by 158
Self-citationRecent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156
“Furthermore, CDIR2 has potential to use in noninvasive monitoring of kidney dysfunction and nephrotoxicity and high-throughput drug screening with the animals alive [198].”
BackgroundLiu, X., Yu, B., Shen, Y., & Cong, H. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214609 · Cited by 151
Xu, Y., Zhang, Y., Li, J., An, J., Li, C., Bai, S., Sharma, A. K., Deng, G., Kim, J. S., & Sun, Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120315 · Cited by 150
Self-citationBioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition
Ma, H., Zhang, X., Liu, L., Huang, Y., Sun, S., Chen, K., Qi, X., Liu, P., Yan, Y., Wang, Y., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh7828 · Cited by 151
Self-citationSmall Molecular NIR-II Fluorophores for Cancer Phototheranostics
Dai, H., Shen, Q., Shao, J., Wang, W., Gao, F., & Dong, X. (2021) · The Innovation · doi:10.1016/j.xinn.2021.100082 · Cited by 150
“Traditional diagnostic modalities, such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), face the problems of insufficient sensitivity, low resolution, poor signal-to-background ratio (SBR) and high cost.(14,15) As an emerging imaging modality, fluorescence imaging…”
BackgroundLi, Q., Li, S., He, S., Chen, W., Cheng, P., Zhang, Y., Miao, Q., & Pu, K. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202000035 · Cited by 146
Self-citationNear-infrared fluorescent molecular probes for imaging and diagnosis of nephro-urological diseases
Huang, J., & Pu, K. (2020) · Chemical Science · doi:10.1039/d0sc02925d · Cited by 144
Self-citationZhou, H., Ge, J., Miao, Q., Zhu, R., Wen, L., Zeng, J., & Gao, M. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00699 · Cited by 141
He, L., He, L., Xu, S., Ren, T., Zhang, X., Qin, Z., Zhang, X., & Yuan, L. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202211409 · Cited by 136
Self-citationMeng, X., Pang, X., Zhang, K., Gong, C., Yang, J., Dong, H., & Zhang, X. (2022) · Small · doi:10.1002/smll.202202035 · Cited by 135
Self-citationRecent advances in near-infrared II imaging technology for biological detection
Zhang, N., Lu, C., Chen, M.-J., Xu, X., Shu, G., Du, Y., & Ji, J. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00870-z · Cited by 136
Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging
Chen, H., Liu, L., Qian, K., Liu, H., Wang, Z., Gao, F., Qu, C., Dai, W., Lin, D., Chen, K., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo3289 · Cited by 133
“It has the properties of low cost, easy to perform, minor light damage to the biological specimen, and high detection sensitivity (3).”
BackgroundLiu, P., Mu, X., Zhang, X., & Ming, D. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00610 · Cited by 126
Self-citationA Renal‐Clearable Macromolecular Reporter for Near‐Infrared Fluorescence Imaging of Bladder Cancer
Huang, J., Jiang, Y., Li, J., He, S., Huang, J., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201911859 · Cited by 126
Self-citationEmerging ultrasmall luminescent nanoprobes for in vivo bioimaging
Li, S., Wei, J., Yao, Q., Song, X., Xie, J., & Yang, H. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00497f · Cited by 128
Chen, S., Pan, Y., Chen, K., Chen, P., Shen, Q., Sun, P., Hu, W., & Fan, Q. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202215372 · Cited by 122
Self-citationLi, X., Fang, F., Sun, B., Yin, C., Tan, J., Wan, Y., Zhang, J., Sun, P., Fan, Q., Wang, P., et al. (2020) · Nanoscale Horizons · doi:10.1039/d0nh00672f · Cited by 123
Self-citationAn Activatable NIR‐II Fluorescent Reporter for In Vivo Imaging of Amyloid‐β Plaques
Miao, J., Miao, M., Jiang, Y., Zhao, M., Li, Q., Zhang, Y., An, Y., Pu, K., & Miao, Q. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202216351 · Cited by 119
Self-citationStellate Plasmonic Exosomes for Penetrative Targeting Tumor NIR-II Thermo-Radiotherapy
Zhu, D., Lyu, M., Huang, Q., Suo, M., Liu, Y., Jiang, W., Duo, Y., & Fan, K. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c09969 · Cited by 117
Dai, Y., Zhao, H., He, K., Du, W., Kong, Y., Wang, Z., Li, M., Shen, Q., Sun, P., & Fan, Q. (2021) · Small · doi:10.1002/smll.202102527 · Cited by 116
Self-citationLiu, Z., Xie, L., Qiu, K., Liao, X., Rees, T. W., Zhao, Z., Ji, L., & Chao, H. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c07886 · Cited by 112
A short review on NIR-II organic small molecule dyes
Li, L., Dong, X., Li, J., & Wei, J. (2020) · Dyes and Pigments · doi:10.1016/j.dyepig.2020.108756 · Cited by 115
Self-citationZhang, Y., Yang, H., An, X., Wang, Z., Yang, X., Yu, M., Zhang, R., Sun, Z., & Wang, Q. (2020) · Small · doi:10.1002/smll.202001003 · Cited by 115
Yao, C., Chen, Y., Zhao, M., Wang, S., Wu, B., Yang, Y., Yin, D., Yu, P., Zhang, H., & Zhang, F. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202114273 · Cited by 117
Propylenedioxy Thiophene Donor to Achieve NIR-II Molecular Fluorophores with Enhanced Brightness
Ma, H., Liu, C., Hu, Z., Yu, P., Zhu, X., Ma, R., Sun, Z., Zhang, C.-H., Sun, H., Zhu, S., et al. (2020) · Chemistry of Materials · doi:10.1021/acs.chemmater.9b05159 · Cited by 110
Li, X., Yin, C., Liew, S. S., Lee, C., & Pu, K. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202106154 · Cited by 107
Self-citationDeng, Z., Bi, S., Jiang, M., & Zeng, S. (2021) · ACS Nano · doi:10.1021/acsnano.0c09799 · Cited by 106
Nanomedicines for Renal Management: From Imaging to Treatment
Jiang, D., Rosenkrans, Z. T., Ni, D., Lin, J., Huang, P., & Cai, W. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.0c00323 · Cited by 108
Yan, D., Li, T., Yang, Y., Niu, N., Wang, D., Ge, J., Wang, L., Zhang, R., Wang, D., & Tang, B. Z. (2022) · Advanced Materials · doi:10.1002/adma.202206643 · Cited by 103
Yuan, Y., Feng, Z., Li, S., Huang, Z., Wan, Y., Cao, C., Lin, S., Wu, L., Zhou, J., Liao, L., et al. (2022) · Advanced Materials · doi:10.1002/adma.202201263 · Cited by 99
Phototheranostics for multifunctional treatment of cancer with fluorescence imaging
Yin, X., Cheng, Y., Feng, Y., Stiles, W. R., Park, S. H., Kang, H., & Choi, H. S. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114483 · Cited by 98
Activatable Rare Earth Near-Infrared-II Fluorescence Ratiometric Nanoprobes
Sun, Z., Huang, H., Zhang, R., Yang, X., Yang, H., Li, C., Zhang, Y., & Wang, Q. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01962 · Cited by 97
Huang, J., & Pu, K. (2020) · Angewandte Chemie · doi:10.1002/ange.202001783 · Cited by 99
Self-citationSingle Wavelength Laser Excitation Ratiometric NIR-II Fluorescent Probe for Molecule Imaging in Vivo
Ge, X., Lou, Y., Su, L., Chen, B., Guo, Z., Gao, S. Q., Zhang, W., Chen, T., Song, J., & Yang, H. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c00556 · Cited by 94
Zhang, D., Tu, T., Younis, M. R., Zhu, K. S., Liu, H., Lei, S., Qu, J., Lin, J., & Huang, P. (2021) · Theranostics · doi:10.7150/thno.66518 · Cited by 91
“5 nm), allowing an effective renal enrichment [57-60].”
BackgroundUltra-photostable small-molecule dyes facilitate near-infrared biophotonics
Yan, K., Hu, Z., Yu, P., He, Z., Chen, Y., Chen, J., Sun, H., Wang, S., & Zhang, F. (2024) · Nature Communications · doi:10.1038/s41467-024-46853-0 · Cited by 101
Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs
Xu, L., Zhang, Q., Wang, X., & Lin, W. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216122 · Cited by 86
Xu, W., Zhang, Z., Kang, M., Guo, H., Li, Y., Wen, H., Lee, M. M. S., Wang, Z., Kwok, R. T. K., Lam, J. W. Y., et al. (2020) · ACS Materials Letters · doi:10.1021/acsmaterialslett.0c00263 · Cited by 81
Near‐Infrared‐II Nanomaterials for Fluorescence Imaging and Photodynamic Therapy
Lin, H., Lin, Z., Konghua, Z., Wang, C., Lin, L., Chen, J., & Song, J. (2021) · Advanced Optical Materials · doi:10.1002/adom.202002177 · Cited by 81
Yang, J., He, S., Hu, Z., Zhang, Z., Cao, C., Cheng, Z., Fang, C., & Tian, J. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101120 · Cited by 79
Wang, K., Zhang, Y., Mao, W., Feng, W., Lu, S., Wan, J., Song, X., Chen, Y., & Peng, B. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202109221 · Cited by 77
Hu, X., Fang, Z.-T., Zhu, C., Yang, Y., Yáng, Z., & Huang, W. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202401325 · Cited by 79
Dual-Modality Detection of Early-Stage Drug-Induced Acute Kidney Injury by an Activatable Probe
Liu, L., Jiang, L., Yuan, W., Liu, Z., Liu, D., Wei, P., Zhang, X., & Yi, T. (2020) · ACS Sensors · doi:10.1021/acssensors.0c00640 · Cited by 75
Self-citationLiu, Q., Yang, Z., Su, Y., Zhao, L., & Peng, J. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c00548 · Cited by 73
Huang, J., Xian, S., Liu, Y., Chen, X., Pu, K., & Wang, H. (2022) · Advanced Materials · doi:10.1002/adma.202201357 · Cited by 72
Self-citationGe, X., Su, L., Chen, Z., Zhu, K., Zhang, X., Wu, Y., & Song, J. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202305744 · Cited by 72
Self-citationHighly Stable and Bright NIR-II AIE Dots for Intraoperative Identification of Ureter
Du, J., Liu, S., Zhang, P., Liu, H., Li, Y., He, W., Li, C., Chau, J. H. C., Kwok, R. T. K., Lam, J. W. Y., et al. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b22957 · Cited by 70
Multiplex Optical Urinalysis for Early Detection of Drug-Induced Kidney Injury
Cheng, P., Miao, Q., Huang, J., Li, J., & Pu, K. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c00989 · Cited by 69
Self-citationCoordination polymers nanoparticles for bioimaging
Suárez–García, S., Solórzano, R., Novio, F., Alibés, R., Busquè, F., & Ruiz‐Molina, D. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213716 · Cited by 70
Huang, L., Zhu, S., Cui, R., & Zhang, M. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04156 · Cited by 69
Molecular imaging: design mechanism and bioapplications
Chen, L., Lyu, Y., Zhang, X., Zheng, L., Li, Q., Ding, D., Chen, F., Li, W., Li, W., Zhang, Y., et al. (2023) · Science China Chemistry · doi:10.1007/s11426-022-1461-3 · Cited by 69
Self-citationTHQ–Xanthene: An Emerging Strategy to Create Next‐Generation NIR‐I/II Fluorophores
Mao, Z., Rha, H., Kim, J., You, X., Zhang, F., Tao, W., & Kim, J. S. (2023) · Advanced Science · doi:10.1002/advs.202301177 · Cited by 67
Luo, X., Hu, D., Gao, D., Wang, Y., Chen, X., Liu, X., Zheng, H., Sun, M., & Sheng, Z. (2021) · ACS Nano · doi:10.1021/acsnano.1c01608 · Cited by 68
Recent advances in optical imaging of biomarkers in vivo
Meng, X., Yang, F., Dong, H., Dou, L., & Zhang, X. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101156 · Cited by 66
Self-citationZeng, C., Tan, Y., Sun, L., Long, Y., Zeng, F., & Wu, S. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c00956 · Cited by 66
Development of Second Near-Infrared Photoacoustic Imaging Agents
Zhang, J., Ning, L., Zeng, Z., & Pu, K. (2021) · Trends in Chemistry · doi:10.1016/j.trechm.2021.01.002 · Cited by 65
Self-citationEnhanced Ultrasound Contrast of Renal‐Clearable Luminescent Gold Nanoparticles
Tan, Y., Chen, M., Chen, H., Wu, J., & Liu, J. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202017273 · Cited by 64
Zhang, M., Wang, Z., Wang, C., Wu, Y., Li, Z., & Liu, Z. (2021) · ACS Nano · doi:10.1021/acsnano.1c03117 · Cited by 64
Prussian blue-based theranostics for ameliorating acute kidney injury
Zhang, D., Liu, H., Zhu, K. S., He, T., Younis, M. R., Yang, C., Lei, S., Wu, J., Lin, J., Qu, J., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01006-z · Cited by 62
Wang, F., Jiang, X., Xiang, H., Wang, N., Zhang, Y., Yao, X., Wang, P., Pan, H., Yu, L.-F., Cheng, Y., et al. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112756 · Cited by 61
Huang, Y., Chen, K., Liu, L., Ma, H., Zhang, X., Tan, K., Li, Y., Liu, Y., Liu, C., Wang, H., et al. (2023) · Small · doi:10.1002/smll.202300145 · Cited by 61
Self-citationLiu, Y., Diao, S., Ruan, B., Zhou, Y., Yu, M., Dong, G., Xu, W., Ning, L., Zhou, W. J., Jiang, Y., et al. (2024) · ACS Nano · doi:10.1021/acsnano.3c13105 · Cited by 62
Self-citationTang, Z., Song, B., Zhang, W., Guo, L., & Yuan, J. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03602 · Cited by 61
Jiang, W., Wang, W., Liu, J., Li, Y., & Li, C. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.128054 · Cited by 61
Shen, Q., Wang, S., Yang, N., Zhang, C., Wu, Q., & Yu, C. (2020) · Journal of Luminescence · doi:10.1016/j.jlumin.2020.117338 · Cited by 63
Li, S., Chen, H., Liu, H., Liu, L., Yuan, Y., Mao, C., Zhang, W., Zhang, X., Guo, W., Lee, C.-S., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c05885 · Cited by 60
Self-citationLi, Q., Li, S., He, S., Chen, W., Cheng, P., Zhang, Y., Miao, Q., & Pu, K. (2020) · Angewandte Chemie · doi:10.1002/ange.202000035 · Cited by 56
Self-citationYue, Y., Zhao, T., Zhou, X., Chi, W., Chai, X., Ai, J., Zhang, J., Huo, F., Strongin, R. M., & Yin, C. (2022) · Advanced Science · doi:10.1002/advs.202205080 · Cited by 58
Self-Referenced Synthetic Urinary Biomarker for Quantitative Monitoring of Cancer Development
Wang, F., Sun, N., Li, Q., Yang, J. A., Yang, X., & Liu, D. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c09538 · Cited by 56
Metadata
- Authors
- Huang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K.
- Affiliations
- Nanyang Technological University (SG)
- Nanjing University of Posts and Telecommunications (CN)
- Tianjin University (CN)
- School of Chemical and Biomedical Engineering Nanyang Technological University 70 Nanyang Drive Singapore 637457 Singapore
- Corresponding author
- Fan, Quli
- Pu, Kanyi
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-09-05
- Volume
- 58
- Issue
- 42
- Pages
- 15120-15127
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2971196856
- Cited by
- 258
- References
- 68
- Citations by year
- 2026: 8 · 2025: 23 · 2024: 36 · 2023: 30 · 2022: 38 · 2021: 55 · 2020: 59 · 2019: 9
- FWCI
- 16.03
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion)
- Funders
- Nanyang Technological University (Tier 1)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Keywords
- NIR-II fluorescence imaging, renal clearance, renal dysfunction, nephrotoxicity, glomerular filtration, drug-induced nephrotoxicity, signal-to-background ratio
- MeSH terms
- Animals, Cell Line, Female, Fluorescent Dyes, Kidney, Kidney Diseases, Kidney Function Tests, Metabolic Clearance Rate, Mice, Nude, Semiconductors, Spectroscopy, Near-Infrared, Mice, Optical Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
