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Self‐Assembled Single‐Site Nanozyme for Tumor‐Specific Amplified Cascade Enzymatic Therapy
Open accessAbstract
Nanomaterials with enzyme‐mimicking activity (nanozymes) show potential for therapeutic interventions. However, it remains a formidable challenge to selectively kill tumor cells through enzymatic reactions, while leaving normal cells unharmed. Herein, we present a new strategy based on a single‐site cascade enzymatic reaction for tumor‐specific therapy that avoids off‐target toxicity to normal tissues. A copper hexacyanoferrate (Cu‐HCF) nanozyme with active single‐site copper exhibited cascade enzymatic activity within the tumor microenvironment: Tumor‐specific glutathione oxidase activity by the Cu‐HCF single‐site nanozymes (SSNEs) led to the depletion of intracellular glutathione and the conversion of single‐site Cu II species into Cu I for subsequent amplified peroxidase activity through a Fenton‐type Harber–Weiss reaction. In this way, abundant highly toxic hydroxyl radicals were generated for tumor cell apoptosis. The results show that SSNEs could amplify the tumor‐killing efficacy of reactive oxygen species and suppress tumor growth in vivo.
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Cited by
Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121110 · Cited by 1,168
Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy
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Self-citationStrategies for enhancing cancer chemodynamic therapy performance
Jana, D., & Zhao, Y. (2022) · Exploration · doi:10.1002/exp.20210238 · Cited by 284
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Glutathione-responsive and -exhausting metal nanomedicines for robust synergistic cancer therapy
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Metadata
- Authors
- Wang, D., Wu, H., Wang, C., Gu, L., Chen, H., Jana, D., Feng, L., Liu, J., Wang, X., Xu, P., Guo, Z., Chen, Q., & Zhao, Y.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-12-10
- Volume
- 60
- Issue
- 6
- Pages
- 3001-3007
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3093986491
- Cited by
- 275
- References
- 4
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- green
- Funders
- National Key Research and Development Program of China (2016YFA0101202)
- National Natural Science Foundation of China (21571168)
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- Wang, D., Wu, H., Wang, C., Gu, L., Chen, H., Jana, D., Feng, L., Liu, J., Wang, X., Xu, P., Guo, Z., Chen, Q., & Zhao, Y. (2021). Self‐Assembled Single‐Site Nanozyme for Tumor‐Specific Amplified Cascade Enzymatic Therapy. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202008868
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