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Cited by 164Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchPain Management and Treatment

Pain and post traumatic stress disorder - review of clinical and experimental evidence

Moeller-Bertram, Tobias, Keltner, John, Strigo, Irina A.·2012·Neuropharmacology
DOI 10.1016/j.neuropharm.2011.04.028
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Abstract

Pain and Post Traumatic Stress Disorder (PTSD) are highly comorbid conditions. Patients with chronic pain have higher rates of PTSD. Likewise, patients with PTSD are often diagnosed with numerous chronic pain conditions. Despite the high pain-PTSD comorbidity, the neurobehavioral mechanisms underlying this phenomenon are incompletely understood and only recently researchers have started investigating it using experimental models. In this article, we systematically review the substantial clinical evidence on the co-occurrence of pain and PTSD, and the limited experimental evidence of pain processing in this disorder. We provide a detailed overview of the psychophysical and brain imaging experiments that compared somatosensory and pain processing in PTSD and non-PTSD populations. Based on the presented evidence, an extensive body of literature substantiates the clinical coexistence of pain and PTSD in patients but the limited experimental data show inconsistent results highlighting the need for well-controlled future studies. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.

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Crossref · 10.1016/j.neuropharm.2011.04.028

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189 of 189 references verified0 citation errors · 0 not checkable

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  • Individual differences in how people apply pain-coping strategies have an important influence on pain-related outcomes.

    “individual differences in the application of paincoping strategies have an important influence on pain-related outcomes.”

    From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [266]

  • Differences in pain coping are associated with differences in pain intensity, adjustment to chronic pain, and psychological and physical functioning.

    “Differences in pain coping are associated with differences in pain intensity, adjustment to chronic pain, and psychological and physical functioning 85, 263–266.”

    From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [266]

  • High levels of interoception and/or insula activation are associated with a wide range of undesirable effects, including increased arousal and emotional intensity, depression, sadness, anxiety, panic, traumatic flashbacks, and clinical pain syndromes.

    “High levels of interoception and/or insula activation are associated with a wide range of undesirable effects, including increased arousal and emotional intensity, depression, sadness, anxiety, panic, traumatic flashbacks and clinical pain syndromes [23–27]”

    From Can mindfulness be too much of a good thing? The value of a middle way (2019) · cites this paper as [24]

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Related

Authors
Moeller-Bertram, T., Keltner, J., & Strigo, I. A.
Affiliations
University of California San Diego (US)
ORCID
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2012-02
Volume
62
Issue
2
Pages
586-597
ISSN
0028-3908 (ISSN-L)
DOI
10.1016/j.neuropharm.2011.04.028
OpenAlex
W2021224881
Cited by
163
References
191
Citations by year
2026: 2 · 2025: 10 · 2024: 7 · 2023: 10 · 2022: 16 · 2021: 6 · 2020: 12 · 2019: 10 · 2018: 9 · 2017: 13 · 2016: 22 · 2015: 13 · 2014: 18 · 2013: 10 · 2012: 5
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
post-traumatic stress disorder, chronic pain, pain processing, somatosensory processing, neuroimaging, psychophysical experiments, neurobehavioral mechanisms
MeSH terms
Brain, Humans, Pain, Stress Disorders, Post-Traumatic, Pain Threshold, Neuroimaging

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