NF‐κB signaling in inflammation and cancer

Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models

Gerondakis, S., Grumont, R., Gugasyan, R., Wong, L., Isomura, I., Ho, W., & Banerjee, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209944 · Cited by 304

Noncanonical NF-κB Signaling in Health and Disease

Cildir, G., Low, K. C., & Tergaonkar, V. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.03.002 · Cited by 301

Signaling to NF- B: Regulation by Ubiquitination

Wertz, I. E., & Dixit, V. M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003350 · Cited by 300

NF-kappaB Is Involved in the Regulation of EMT Genes in Breast Cancer Cells

Pires, B. R. B., Mencalha, A. L., Ferreira, G. M., de Souza, W. F., Morgado-Díaz, J. A., Maia, A. M., Corrêa, S., & Abdelhay, E. S. F. W. (2017) · PLOS ONE · doi:10.1371/journal.pone.0169622 · Cited by 296

Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

Wang, D., Fu, L., Sun, H., Guo, L., & DuBois, R. N. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.064 · Cited by 292

NF- B controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program

Kempe, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki836 · Cited by 284

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

Shembade, N., Harhaj, N. S., Parvatiyar, K., Copeland, N. G., Jenkins, N. A., Matesic, L. E., & Harhaj, E. W. (2008) · Nature Immunology · doi:10.1038/ni1563 · Cited by 278

Role of hypoxia-inducible factors in breast cancer metastasis

Gilkes, D. M., & Semenza, G. L. (2013) · Future Oncology · doi:10.2217/fon.13.92 · Cited by 274

PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity

Liu, B., Mink, S., Wong, K. A., Stein, N., Getman, C., Dempsey, P. W., Wu, H., & Shuai, K. (2004) · Nature Immunology · doi:10.1038/ni1104 · Cited by 271

Beyond IκBs: alternative regulation of NF‐KB activity

Neumann, M., & Naumann, M. (2007) · The FASEB Journal · doi:10.1096/fj.06-7615rev · Cited by 267

TRAF6 Is a Critical Factor for Dendritic Cell Maturation and Development

Kobayashi, T., Walsh, P. T., Walsh, M. C., Speirs, K. M., Chiffoleau, E., King, C. G., Hancock, W. W., Caamano, J. H., Hunter, C. A., Scott, P., et al. (2003) · Immunity · doi:10.1016/s1074-7613(03)00230-9 · Cited by 267

Tumor Microenvironment, Metabolism, and Immunotherapy

DeBerardinis, R. J. (2020) · New England Journal of Medicine · doi:10.1056/nejmcibr1914890 · Cited by 266

The NF-κB Pathway and Cancer Stem Cells

Rinkenbaugh, A., & Baldwin, A. (2016) · Cells · doi:10.3390/cells5020016 · Cited by 260

The Anti-Inflammatory Properties of Phytochemicals and Their Effects on Epigenetic Mechanisms Involved in TLR4/NF-κB-Mediated Inflammation

Saleh, H. A., Yousef, M. H., & Abdelnaser, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.606069 · Cited by 255

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

Isomura, I., Palmer, S., Grumont, R. J., Bunting, K., Hoyne, G., Wilkinson, N., Banerjee, A., Proietto, A., Gugasyan, R., Wu, L., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20091411 · Cited by 253

Human memory B cells

Seifert, M., & Küppers, R. (2016) · Leukemia · doi:10.1038/leu.2016.226 · Cited by 249

Molecular biology of Hodgkin lymphoma

Weniger, M. A., & Küppers, R. (2021) · Leukemia · doi:10.1038/s41375-021-01204-6 · Cited by 248

Up-regulation of IL-6 and TNF-α induced by SARS-coronavirus spike protein in murine macrophages via NF-κB pathway

Wang, W., Ye, L., Ye, L., Li, B., Gao, B., Zeng, Y., Kong, L., Fang, X., Zheng, H., Wu, Z., et al. (2007) · Virus Research · doi:10.1016/j.virusres.2007.02.007 · Cited by 247

A20: from ubiquitin editing to tumour suppression

Hymowitz, S. G., & Wertz, I. E. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2775 · Cited by 247

Impaired regulation of NF-κB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

Zhang, J., Stirling, B., Temmerman, S. T., Ma, C. A., Fuss, I. J., Derry, J. M. J., & Jain, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28746 · Cited by 245

Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis

Zheng, Z., Bian, Y., Zhang, Y., Ren, G., & Li, G. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1743911 · Cited by 245

Ibrutinib inhibits BCR and NF-κB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL

Herman, S. E. M., Mustafa, R. Z., Gyamfi, J. A., Pittaluga, S., Chang, S., Chang, B., Farooqui, M., & Wiestner, A. (2014) · Blood · doi:10.1182/blood-2014-02-548610 · Cited by 244

NFKBIA Deletion in Glioblastomas

Bredel, M., Scholtens, D. M., Yadav, A. K., Alvarez, A. A., Renfrow, J. J., Chandler, J. P., Yu, I. L. Y., Carro, M. S., Dai, F., Tagge, M. J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1006312 · Cited by 243

OX40 signaling favors the induction of TH9 cells and airway inflammation

Xiao, X., Balasubramanian, S., Liu, W., Chu, X., Wang, H., Taparowsky, E. J., Fu, Y.-X., Choi, Y., Walsh, M. C., & Li, X. C. (2012) · Nature Immunology · doi:10.1038/ni.2390 · Cited by 237

A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas

Hong, D. S., Kurzrock, R., Supko, J. G., He, X., Naing, A., Wheler, J., Lawrence, D., Eder, J. P., Meyer, C. J., Ferguson, D. A., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2703 · Cited by 236

NF-κB control of T cell development

Gerondakis, S., Fulford, T. S., Messina, N. L., & Grumont, R. J. (2014) · Nature Immunology · doi:10.1038/ni.2785 · Cited by 233

The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer

Ward, J. P., Gubin, M. M., & Schreiber, R. D. (2016) · Advances in Immunology · doi:10.1016/bs.ai.2016.01.001 · Cited by 228

An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function

Oh, H., Grinberg-Bleyer, Y., Liao, W., Maloney, D., Wang, P., Wu, Z., Wang, J., Bhatt, D. M., Heise, N., Schmid, R. M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.010 · Cited by 226

IκBε provides negative feedback to control NF-κB oscillations, signaling dynamics, and inflammatory gene expression

Kearns, J. D., Basak, S., Werner, S. L., Huang, C. S., & Hoffmann, A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510155 · Cited by 224

Targeting Cancer Stem Cells: A Strategy for Effective Eradication of Cancer

Shibata, M., & Hoque, M. O. (2019) · Cancers · doi:10.3390/cancers11050732 · Cited by 223

OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3

Hu, H., Brittain, G. C., Chang, J.-H., Puebla-Osorio, N., Jin, J., Zal, A., Xiao, Y., Cheng, X., Chang, M., Fu, Y.-X., et al. (2013) · Nature · doi:10.1038/nature11831 · Cited by 220

Noncanonical NF-κB Activation Mediates STAT3-Stimulated IDO Upregulation in Myeloid-Derived Suppressor Cells in Breast Cancer

Yu, J., Wang, Y., Yan, F., Zhang, P., Li, H., Zhao, H., Yan, C., Yan, F., & Ren, X. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400833 · Cited by 219

Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines

Weih, D. S., Yilmaz, Z. B., & Weih, F. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1909 · Cited by 219

The germinal center reaction

Gatto, D., & Brink, R. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.007 · Cited by 219

Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers

Ji, Z., He, L., Regev, A., & Struhl, K. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821068116 · Cited by 219

B7-H3 promotes colorectal cancer angiogenesis through activating the NF-κB pathway to induce VEGFA expression

Wang, R., Ma, Y., Zhan, S., Zhang, G., Cao, L., Zhang, X., Shi, T., & Chen, W. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2252-3 · Cited by 216

NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases

Fiordelisi, A., Iaccarino, G., Morisco, C., Coscioni, E., & Sorriento, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071599 · Cited by 215

Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes

Bessho, R., Matsubara, K., Kubota, M., Kuwakado, K., Hirota, H., Wakazono, Y., Lin, Y. W., Okuda, A., Kawai, M., Nishikomori, R., et al. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90586-x · Cited by 211

Targeting monocytes/macrophages in the treatment of rheumatoid arthritis

Davignon, J.-L., Hayder, M., Baron, M., Boyer, J.-F., Constantin, A., Apparailly, F., Poupot, R., & Cantagrel, A. (2013) · Rheumatology · doi:10.1093/rheumatology/kes304 · Cited by 209

Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts

Ammirante, M., Shalapour, S., Kang, Y., Jamieson, C. A. M., & Karin, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416498111 · Cited by 206

Inflammation and p53: A Tale of Two Stresses

Gudkov, A. V., Gurova, K. V., & Komarova, E. A. (2011) · Genes & Cancer · doi:10.1177/1947601911409747 · Cited by 205

Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

Su, C.-M., Wang, L., & Yoo, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-92941-2 · Cited by 203

Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing

Pflueger, D., Terry, S., Sboner, A., Habegger, L., Esgueva, R., Lin, P.-C., Svensson, M. A., Kitabayashi, N., Moss, B. J., MacDonald, T. Y., et al. (2011) · Genome Research · doi:10.1101/gr.110684.110 · Cited by 201

NF-κB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients

Kircheis, R., Haasbach, E., Lueftenegger, D., Heyken, W. T., Ocker, M., & Planz, O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.598444 · Cited by 201

Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

Hilliard, B. A., Mason, N., Xu, L., Sun, J., Lamhamedi-Cherradi, S.-E., Liou, H.-C., Hunter, C., & Chen, Y. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15254 · Cited by 200

Mesenchymal Cells in Colon Cancer

Koliaraki, V., Pallangyo, C. K., Greten, F. R., & Kollias, G. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.11.049 · Cited by 199

Germinal centers: programmed for affinity maturation and antibody diversification

Bannard, O., & Cyster, J. G. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.12.004 · Cited by 198

CARD–BCL-10–MALT1 signalling in protective and pathological immunity

Ruland, J., & Hartjes, L. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0087-2 · Cited by 196

Innate and adaptive immunity in atherosclerosis

Packard, R. R. S., Lichtman, A. H., & Libby, P. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0153-8 · Cited by 190

Icariin‐induced inhibition of SIRT6/NF‐κB triggers redox mediated apoptosis and enhances anti‐tumor immunity in triple‐negative breast cancer

Song, L., Chen, X., Mi, L., Liu, C., Zhu, S., Yang, T., Luo, X., Zhang, Q., Lu, H., & Liang, X. (2020) · Cancer Science · doi:10.1111/cas.14648 · Cited by 190

NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype

Yamamoto, M., Taguchi, Y., Ito-Kureha, T., Semba, K., Yamaguchi, N., & Inoue, J.-I. (2013) · Nature Communications · doi:10.1038/ncomms3299 · Cited by 189

IκBβ acts to inhibit and activate gene expression during the inflammatory response

Rao, P., Hayden, M. S., Long, M., Scott, M. L., West, A. P., Zhang, D., Oeckinghaus, A., Lynch, C., Hoffmann, A., Baltimore, D., et al. (2010) · Nature · doi:10.1038/nature09283 · Cited by 186

Plasma cell and memory B cell differentiation from the germinal center

Suan, D., Sundling, C., & Brink, R. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.03.006 · Cited by 185

The cross-talk between NF-κB and HIF-1: further evidence for a significant liaison

Görlach, A., & Bonello, S. (2008) · Biochemical Journal · doi:10.1042/bj20080920 · Cited by 182

Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma

Zheng, H., Dai, W., Cheung, A. K. L., Ko, J. M. Y., Kan, R., Wong, B. W. Y., Leong, M. M. L., Deng, M., Kwok, T. C. T., Chan, J. Y.-W., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607606113 · Cited by 182

Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

Hilliard, B. A., Mason, N., Xu, L., Sun, J., Lamhamedi-Cherradi, S.-E., Liou, H.-C., Hunter, C., & Chen, Y. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215254 · Cited by 181

Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways

Shih, V. F.-S., Davis-Turak, J., Macal, M., Huang, J. Q., Ponomarenko, J., Kearns, J. D., Yu, T., Fagerlund, R., Asagiri, M., Zuniga, E. I., et al. (2012) · Nature Immunology · doi:10.1038/ni.2446 · Cited by 177

Tumor Necrosis Factor α Blockade: An Opportunity to Tackle Breast Cancer

Mercogliano, M. F., Bruni, S., Elizalde, P. V., & Schillaci, R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00584 · Cited by 177

Suppression of Ras-Induced Apoptosis by the Rac GTPase

Joneson, T., & Bar-Sagi, D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.5892 · Cited by 174

Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF- B decoy oligonucleotides

Fichtner-Feigl, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24792 · Cited by 172

Inflammation-Induced Cell Proliferation Potentiates DNA Damage-Induced Mutations In Vivo

Kiraly, O., Gong, G., Olipitz, W., Muthupalani, S., & Engelward, B. P. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1004901 · Cited by 169

The Role of Interleukin 17 in Tumour Proliferation, Angiogenesis, and Metastasis

Yang, B., Kang, H., Fung, A., Zhao, H., Wang, T., & Ma, D. (2014) · Mediators of Inflammation · doi:10.1155/2014/623759 · Cited by 169

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma

Busino, L., Millman, S. E., Scotto, L., Kyratsous, C. A., Basrur, V., O’Connor, O., Hoffmann, A., Elenitoba-Johnson, K. S., & Pagano, M. (2012) · Nature Cell Biology · doi:10.1038/ncb2463 · Cited by 167

Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo.

Aronica, M. A., Mora, A. L., Mitchell, D. B., Finn, P. W., Johnson, J. E., Sheller, J. R., & Boothby, M. R. (1999) · PubMed · Cited by 165

Fine-tuning of dendritic cell biology by the TNF superfamily

deLuca, L. S., & Gommerman, J. L. (2012) · Nature reviews. Immunology · doi:10.1038/nri3193 · Cited by 164

Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance

Baratin, M., Foray, C., Demaria, O., Habbeddine, M., Pollet, E., Maurizio, J., Verthuy, C., Davanture, S., Azukizawa, H., Flores-Langarica, A., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.003 · Cited by 163

Role of nuclear factor‐κB in the immune system and bone

Jimi, E., & Ghosh, S. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00329.x · Cited by 163

Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells

Burnett, J., Lim, G., Li, Y., Shah, R. B., Lim, R., Paholak, H. J., McDermott, S., Sun, L., Tsume, Y., Bai, S., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.02.023 · Cited by 163

Pathogenic B‐cell receptor signaling in lymphoid malignancies: New insights to improve treatment

Young, R. M., Phelan, J. D., Wilson, W. H., & Staudt, L. M. (2019) · Immunological Reviews · doi:10.1111/imr.12792 · Cited by 163

Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia ( aly ) Mice, a Natural Strain with Mutant NF-κB-Inducing Kinase

Yamada, T., Mitani, T., Yorita, K., Uchida, D., Matsushima, A., Iwamasa, K., Fujita, S., & Matsumoto, M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.804 · Cited by 162

IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases

Song, X., & Qian, Y. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.07.021 · Cited by 162

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

Ljungström, V., Cortese, D., Young, E., Pandzic, T., Mansouri, L., Plevová, K., Ntoufa, S., Baliakas, P., Clifford, R. M., Sutton, L., et al. (2015) · Blood · doi:10.1182/blood-2015-10-674572 · Cited by 162

Differential Requirement for Rel/Nuclear Factor κB Family Members in Natural Killer T Cell Development

Sivakumar, V., Hammond, K. J. L., Howells, N., Pfeffer, K., & Weih, F. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022234 · Cited by 160

Preferential Role for NF-κB/Rel Signaling in the Type 1 But Not Type 2 T Cell-Dependent Immune Response In Vivo

Aronica, M. A., Mora, A. L., Mitchell, D. B., Finn, P. W., Johnson, J. E., Sheller, J. R., & Boothby, M. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.9.5116 · Cited by 160

The c-Rel Transcription Factor in Development and Disease

Gilmore, T. D., & Gerondakis, S. (2011) · Genes & Cancer · doi:10.1177/1947601911421925 · Cited by 157

Proinflammatory Stimuli Induce IKKα-Mediated Phosphorylation of PIAS1 to Restrict Inflammation and Immunity

Liu, B., Yang, Y., Chernishof, V., Loo, R. R. O., Jang, H., Tahk, S., Yang, R., Mink, S. R., Shultz, D. B., Bellone, C. J., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.056 · Cited by 156

Type 2 innate immune responses and the natural helper cell

Koyasu, S., & Moro, K. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03413.x · Cited by 155

Exosomal miR-1910-3p promotes proliferation, metastasis, and autophagy of breast cancer cells by targeting MTMR3 and activating the NF-κB signaling pathway

Wang, B., Mao, J., Wang, B.-Y., Wang, L., Wen, H., Xu, L., Fu, J., & Yang, H. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.05.038 · Cited by 155

RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation

Wu, Y., Ma, L., Cai, S., Zhuang, Z., Zhao, Z., Jin, S., Xie, W., Zhou, L., Zhang, L., Zhao, J., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00575-7 · Cited by 154

Negative Regulation of NF-κB Signaling by PIAS1

Liu, B., Yang, R., Wong, K. A., Getman, C., Stein, N., Teitell, M. A., Cheng, G., Wu, H., & Shuai, K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.1113-1123.2005 · Cited by 153

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

Yao, Z., Xing, L., & Boyce, B. F. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38716 · Cited by 152

NF-κB Activation Mediates Doxorubicin-induced Cell Death in N-type Neuroblastoma Cells

Bian, X., McAllister‐Lucas, L. M., Shao, F., Schumacher, K. R., Feng, Z., Porter, A. G., Castle, V. P., & Opipari, A. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108674200 · Cited by 151

Infliximab in inflammatory bowel disease

Papamichael, K., Lin, S., Moore, M., Papaioannou, G., Sattler, L., & Cheifetz, A. S. (2019) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622319838443 · Cited by 150

The Role of NF-κB in Physiological Bone Development and Inflammatory Bone Diseases: Is NF-κB Inhibition “Killing Two Birds with One Stone”?

Jimi, E., Takakura, N., Hiura, F., Nakamura, I., & Hirata‐Tsuchiya, S. (2019) · Cells · doi:10.3390/cells8121636 · Cited by 150

Pathogenetic importance and therapeutic implications of NF‐κB in lymphoid malignancies

Lim, K., Yang, Y., & Staudt, L. M. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01105.x · Cited by 147

Epigenetic Regulation of SOX9 by the NF-κB Signaling Pathway in Pancreatic Cancer Stem Cells

Sun, L., Mathews, L., Cabarcas‐Petroski, S., Zhang, X., Yang, A., Zhang, Y., Young, M. R., Klarmann, K. D., Keller, J. R., & Farrar, W. L. (2013) · Stem Cells · doi:10.1002/stem.1394 · Cited by 143

A20 controls intestinal homeostasis through cell-specific activities

Vereecke, L., Vieira‐Silva, S., Billiet, T., van Es, J. H., Guire, C. M., Slowicka, K., Sze, M., van den Born, M., Hertogh, G. D., Clevers, H. C., et al. (2014) · Nature Communications · doi:10.1038/ncomms6103 · Cited by 142

Selinexor plus low-dose bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma

Bahlis, N. J., Sutherland, H. J., White, D. J., Sébag, M., Lentzsch, S., Kotb, R. R., Venner, C. P., Gasparetto, C., Col, A. D., Neri, P. E., et al. (2018) · Blood · doi:10.1182/blood-2018-06-858852 · Cited by 141

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes

Kaustio, M., Haapaniemi, E. M., Göös, H., Hautala, T., Park, G., Syrjänen, J., Einarsdóttir, E., Sahu, B., Kilpinen, S., Rounioja, S., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.10.054 · Cited by 140

The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling

Jin, J., Xiao, Y., Chang, J.-H., Yu, J., Hu, H., Starr, R., Brittain, G. C., Chang, M., Cheng, X., & Sun, S.-C. (2012) · Nature Immunology · doi:10.1038/ni.2423 · Cited by 136

Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde?

Noort, A. R., Tak, P. P., & Tas, S. W. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0527-3 · Cited by 136

Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells

Chang, J., Xiao, Y., Hu, H., Jin, J., Yu, J., Zhou, X., Wu, X., Johnson, H. M., Akira, S., Pasparakis, M., et al. (2012) · Nature Immunology · doi:10.1038/ni.2267 · Cited by 136

Nuclear Factor-κB Activation as a Pathological Mechanism of Lipid Metabolism and Atherosclerosis

Yu, X., Zheng, X., & Tang, C. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.03.004 · Cited by 134

Genome reading by the NF-κB transcription factors

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