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Genetic Risk and Outcome of Psychosis (GROUP), a multi site longitudinal cohort study focused on gene–environment interaction: objectives, sample characteristics, recruitment and assessment methods
Open accessAbstract
Objective: A longitudinal focus on gene–environment vulnerability and resilience in both patients, their unaffected family members and non‐related controls offers the opportunity to elucidate etiological and pathogenetic factors influencing the onset and course of psychotic disorders. The current paper delineates the objectives, sample characteristics, recruitment and assessment procedures of the Genetic Risk and Outcome of Psychoses (GROUP) study. Methods: A naturalistic longitudinal cohort study with assessments at baseline, after three and six years of follow‐up. The study is conducted by a consortium of four university psychiatric centres, with their affiliated mental health care institutions in the Netherlands covering more than 7.5 million inhabitants. Extensive assessment of genetic factors, environmental factors, (endo)phenotypes, and outcome. Results: At baseline, 1120 patients, 1057 siblings, 919 parents and 590 healthy controls were included. Conclusion: The GROUP study will contribute to insight in risk and protective factors in the aetiology of non‐affective psychotic disorders, and in the variation in their course and outcome. Copyright © 2012 John Wiley & Sons, Ltd.
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Uher, R. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00048 · Cited by 251
Quee, P. J., van der Meer, L., Krabbendam, L., de Haan, L., Cahn, W., Wiersma, D., van Beveren, N., Pijnenborg, G. H. M., Mulder, C. L., Bruggeman, R., et al. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12138 · Cited by 29
Self-citationSubjective quality of life in psychosis: evidence for an association with real world functioning?
Leendertse, P., Myin-Germeys, I., Lataster, T., Simons, C. J. P., Oorschot, M., Lardinois, M., Schneider, M., van Os, J., & Reininghaus, U. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2017.11.074 · Cited by 24
Self-citationBoumans, J., Baart, I., Widdershoven, G., & Kroon, H. (2017) · Psychosis · doi:10.1080/17522439.2016.1178798 · Cited by 13
Metadata
- Authors
- Korver, N., Quee, P. J., Boos, H. B. M., Simons, C. J. P., de Haan, L., & GROUP investigators
- Venue
- International Journal of Methods in Psychiatric Research
- Publisher
- Wiley
- Published
- 2012-03-15
- Volume
- 21
- Issue
- 3
- Pages
- 205-221
- ISSN
- 1049-8931 (ISSN-L)
- 1557-0657
- OpenAlex
- W1946774659
- Cited by
- 270
- References
- 104
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.