CoChat
Sign Up
Cited by 296Sleep and Wakefulness ResearchNeural and Behavioral Psychology StudiesSleep and related disorders

The effects of poor quality sleep on brain function and risk taking in adolescence

Open access
Telzer, Eva H., Fuligni, Andrew J., Lieberman, Matthew D., Galván, Adriana·2013·NeuroImage
DOI 10.1016/j.neuroimage.2013.01.025PMC PMC3865864
Open this paper in CoChat — free account

Abstract

Insufficient sleep and poor quality sleep are pervasive during adolescence and relate to impairments in cognitive control and increased risk taking. However, the neurobiology underlying the association between sleep and adolescent behavior remains elusive. In the current study, we examine how poor sleep quality relates to cognitive control and reward related brain function during risk taking. Forty-six adolescents participated in a functional magnetic imaging (fMRI) scan during which they completed a cognitive control and risk taking task. Behaviorally, adolescents who reported poorer sleep also exhibited greater risk-taking. This association was paralleled by less recruitment of the dorsolateral prefrontal cortex (DLPFC) during cognitive control, greater insula activation during reward processing, and reduced functional coupling between the DLPFC and affective regions including the insula and ventral striatum during reward processing. Collectively, these results suggest that poor sleep may exaggerate the normative imbalance between affective and cognitive control systems, leading to greater risk-taking in adolescents.

AI snapshot

Written from the paper’s full text.

TL;DR

In 46 adolescents, poorer subjective sleep quality was associated with greater self-reported and behavioral risk taking, less right DLPFC recruitment during cognitive control, greater left insula activation during reward processing, and reduced DLPFC–affective functional coupling. The authors interpret this as poor sleep exaggerating the normative affective–cognitive control imbalance in adolescence.

Key findings

  • Poorer sleep quality was associated with greater risk-taking likelihood (β=.40, p<.01), greater perceived positive consequences of risk taking (β=.44, p<.005), and more adjusted pumps on the BART (β=.40, p<.01).
  • Poorer sleep quality correlated with decreased right DLPFC activation during No-go>Go trials; this reduced DLPFC response was associated with more BART pumps (β=.58, p<.001), more decision-making complacency (β=−.50, p<.001), and less decision-making vigilance (β=.43, p<.005).
  • Poorer sleep quality was associated with increased left insula activation during cash-out trials as rewards increased; insula activation related to more BART pumps (β=.41, p<.005), greater risk-taking likelihood (β=.37, p<.05), and greater positive consequences for risk taking (β=.32, p<.05).
  • Poor sleep was associated with reduced functional coupling between DLPFC and right insula (Z=3.78, p<.05) and ventral striatum (Z=4.21, p<.05) during cash-outs; reduced DLPFC activation accounted for 53.86% of the effect of poor sleep on insula activation.

Methods

  • Forty-six adolescents aged 14–16 years (Mage=15.23; 19 males, 27 females) completed fMRI during a Go–No-Go cognitive control task and the Balloon Analogue Risk Task (BART); participants were not taking medications and did not report mood or sleep disorders.
  • Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI; mean=5.3, range=2–16); risk perceptions and decision making were measured with modified CARE and Flinders Adolescent Decision Making Questionnaire.
  • Analyses used FSL whole-brain regression with sleep quality as a regressor, psychophysiological interaction (PPI) analyses for functional coupling, and mediation analyses; thresholding used Z>2.3 and p<.05 familywise error corrected.

Limitations

  • The paper states it cannot delineate the direction of effects: poor sleep may increase risk-related brain function, or adolescents already oriented toward rewards may obtain poorer sleep.
  • The paper states it cannot be certain findings are specific to adolescence or whether similar effects occur at other developmental periods; future experimental and longitudinal work is needed.
  • Evident from the text: the design is cross-sectional and correlational, sleep quality is subjective, and the sample is a modest-sized healthy non-clinical group, so causal and clinical generalizations are limited.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.1016/j.neuroimage.2013.01.025

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

0 of 51 cited sources checked · 0 supported · 0 flagged

  • Findingown data

    Poorer sleep quality is associated with lower decision-making self-esteem in adolescents.

    “Adolescents who reported poorer sleep quality reported more decision making complacency (β=.54, p<.001) and lower decision making self-esteem (β=−.30, p<.05).”
    Quote in the paperSubstantial claim
  • Findingown data

    Poorer sleep quality is associated with more decision-making complacency in adolescents.

    “Adolescents who reported poorer sleep quality reported more decision making complacency (β=.54, p<.001) and lower decision making self-esteem (β=−.30, p<.05).”
    Quote in the paperSubstantial claim
  • Findingown data

    Poorer sleep quality is associated with a greater perception of positive consequences for engaging in risk-taking behaviors in adolescents.

    “Adolescents who reported greater sleep problems reported a greater likelihood of engaging in risk taking behaviors (β=.40, p<.01) and a greater perception of positive consequences for engaging in risk taking behaviors (β= .44, p<.005).”
    Quote in the paperSubstantial claim
  • Findingown data

    Adolescents with poorer sleep show less recruitment of the dorsolateral prefrontal cortex during cognitive control.

    “This association was paralleled by less recruitment of the dorsolateral prefrontal cortex (DLPFC) during cognitive control, greater insula activation during reward processing, and reduced functional coupling between the DLPFC and affective regions including the insula and ventral striatum during reward processing.”
    Quote in the paperSubstantial claim
  • Findingown data

    Poor sleep quality is associated with greater risk-taking behavior in adolescents.

    “Behaviorally, adolescents who reported poorer sleep also exhibited greater risk-taking.”
    • Also stated in: § Behavioral results · plain
      “Adolescents who reported greater sleep problems reported a greater likelihood of engaging in risk taking behaviors (β=.40, p<.01) and a greater perception of positive consequences for engaging in risk taking behaviors (β= .44, p<.005).”
    • Also stated in: § Behavioral results · plain
      “Adolescents who reported poorer sleep quality had greater mean adjusted pumps (β=.40, p<.01).”
    Quote in the paperSubstantial claim
  • May combine two claims. 21
  • Classified as probably not a substantial claim. 17

  • May combine two claims.

    Findingown data

    No brain regions were significantly activated to cash outs>baseline or explosions>baseline on the BART.

    “No brain regions were significantly activated to cash outs>baseline or explosions>baseline.”
    Quote in the paperNot a substantial claim

  • May combine two claims.

    Findingown data

    The confidence interval of the indirect effect does not include zero, consistent with a statistically significant mediation.

    “As shown in Table 2, the confidence interval of the indirect effect does not include zero, consistent with a statistically significant mediation.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: The mediation analysis assumes no unmeasured confounding and correct temporal ordering of sleep quality, DLPFC activation, and insula activation.

  • May combine two claims.

    Premisecitation

    Sleep deprivation in adults impacts brain function related to reward processing, risk-taking, and cognition.

    “Although neuroimaging research in adults has shown that sleep deprivation impacts brain function related to reward processing, risk-taking, and cognition (Chee et al., 2011; Gujar et al., 2011; Libedinsky et al., 2011; Venkatraman et al., 2011), only a few developmental studies have examined how sleep influences reward-related brain function in adolescents (Hasler et al., 2012; Holm et al., 2009)”
    Quote in the paperNot a substantial claim0 of 3 sources checked
    • cites Chee et al., 2011 source

      Not checked in the free run.

    • cites Gujar et al., 2011 source

      Not checked in the free run.

    • cites Libedinsky et al., 2011 source

      Not checked in the free run.

  • Classified as probably not a substantial claim.

    Premisecitation

    Dual system theories of adolescent neurodevelopment posit that risk taking increases during adolescence due to a competition between the affective reward sensitivity system and the cognitive control system.

    “Dual system theories of adolescent neurodevelopment posit that risk taking increases during adolescence due to a competition between two neural systems — the affective system, which is involved in reward sensitivity, and the cognitive control system, which is involved in cognitive regulation (Somerville et al., 2010; Steinberg, 2010).”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites Somerville et al., 2010 source

      Not checked in the free run.

    • cites Steinberg, 2010 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Poor sleep quality is related to cognitive and emotional deficits, including a bias towards high risk behaviors, diminished attentional and behavioral control, and poor emotion regulation.

    “Poor sleep quality is related to a host of cognitive and emotional deficits, including a bias towards high risk behaviors, diminished attentional and behavioral control, and poor emotion regulation (Dahl, 1996; Harrison and Horne, 2000), making poor sleep a significant public health and developmental concern that may impact high risk behaviors during adolescence.”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites Dahl, 1996 source

      Not checked in the free run.

    • cites Harrison and Horne, 2000 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Variability in weekend-weeknight sleep time and insufficient sleep (<8 h on school nights) are associated with tobacco, alcohol, and drug use, unsafe sex, poorer safety behaviors, and aggressive behaviors in adolescents.

    “In terms of risky behavior, variability in weekend–weeknight sleep time and insufficient sleep (i.e., <8 h on school nights) are associated with tobacco, alcohol, and drug use, unsafe sex, poorer safety behaviors, and aggressive behaviors (McKnight-Eily et al., 2011; O'Brien and Mindell, 2005).”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites McKnight-Eily et al., 2011 source

      Not checked in the free run.

    • cites O'Brien and Mindell, 2005 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Functional connectivity analyses in adults reveal that poor sleep impairs brain function in affective and cognitive control regions and disrupts cross-talk between these neural networks.

    “Indeed, functional connectivity analyses in adults reveal that poor sleep not only impairs brain function in affective and cognitive control regions but also disrupts cross-talk between these neural networks (Gujar et al., 2011; Venkatraman et al., 2011; Yoo et al., 2007).”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Gujar et al., 2011 source

      Not checked in the free run.

    • cites Venkatraman et al., 2011 source

      Not checked in the free run.

    • cites Yoo et al., 2007 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Sleep-deprived adolescents and adolescents who report high levels of sleepiness show detriments in higher-level executive functioning, decreased cognitive modulation of drives, impulses, and emotions, and less effortful control of attention.

    “For example, sleep-deprived adolescents and adolescents who report high levels of sleepiness show detriments in higher-level executive functioning, decreased cognitive modulation of drives, impulses, and emotions, and less effortful control of attention (Anderson et al., 2008; Beebe et al., 2008; Dahl, 1996).”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Anderson et al., 2008 source

      Not checked in the free run.

    • cites Beebe et al., 2008 source

      Not checked in the free run.

    • cites Dahl, 1996 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Reward sensitivity shows curvilinear developmental patterns peaking in mid adolescence, while impulse control gradually increases throughout adolescence into adulthood.

    “Whereas reward sensitivity shows curvilinear developmental patterns, peaking in mid adolescence, impulse control gradually increases throughout adolescence, showing linear improvements into adulthood (Bunge et al., 2002; Galván et al., 2006; Geier et al., 2010).”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Bunge et al., 2002 source

      Not checked in the free run.

    • cites Galván et al., 2006 source

      Not checked in the free run.

    • cites Geier et al., 2010 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Only a few developmental studies have examined how sleep influences reward-related brain function in adolescents, and none have examined how sleep impacts risk taking behavior, cognitive control, and related neural circuitry.

    “Although neuroimaging research in adults has shown that sleep deprivation impacts brain function related to reward processing, risk-taking, and cognition (Chee et al., 2011; Gujar et al., 2011; Libedinsky et al., 2011; Venkatraman et al., 2011), only a few developmental studies have examined how sleep influences reward-related brain function in adolescents (Hasler et al., 2012; Holm et al., 2009)”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites Hasler et al., 2012 source

      Not checked in the free run.

    • cites Holm et al., 2009 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductown data

    No participants exceeded 2 mm in movement.

    “No participants exceeded >2 mm in movement.”
    Quote in the paperNot a substantial claim

  • Classified as probably not a substantial claim. May combine two claims.

    Study design and conductnone given

    Participants were not currently taking any medications and did not report being diagnosed with any mood or sleep disorder.

    “Participants were not currently taking any medications and did not report being diagnosed with any mood or sleep disorder.”
    Quote in the paperSubstantial claim

  • Classified as probably not a substantial claim.

    Study design and conductcitation

    Statistical maps were thresholded using a corrected cluster-forming threshold of Z>2.3 and an extent threshold of p<.05 familywise error corrected using Gaussian random fields.

    “Thresholded Z statistic images were prepared to show clusters determined by a corrected, cluster-forming threshold of Z>2.3 and an extent threshold of p<.05 familywise error corrected using the theory of Gaussian random fields (Poline et al., 1997).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Poline et al., 1997 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductcitation

    Outliers were de-weighted in the multi-subject statistics using mixture modeling.

    “Outliers were de-weighted in the multi-subject statistics using mixture modeling (Woolrich, 2008).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Woolrich, 2008 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Prior research has found an association between sleep deprivation and risk taking on the BART in adults.

    “Prior research has used the BART in adults to examine risk taking and sleep and has found an association between sleep deprivation and risk taking on the task (Killgore et al., 2011).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Killgore et al., 2011 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Adults recruit the lateral PFC to a greater extent than adolescents during risk taking.

    “Prior work has found that adults recruit the lateral PFC to a greater extent than adolescents during risk taking (Chein et al., 2011; Eshel et al., 2007), and children show decreased activation in the lateral PFC compared to adults when matched on performance during a cognitive control task (Bunge et al., 2002).”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites Chein et al., 2011 source

      Not checked in the free run.

    • cites Eshel et al., 2007 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Poor sleep relates to impairments in cognitive regulation and increases in health compromising behaviors such as substance use.

    “Insufficient sleep and poor quality sleep are pervasive during adolescence (Carskadon, 2011; Dahl and Lewin, 2002) and relate to impairments in cognitive regulation and increases in health compromising behaviors such as substance use (Hasler et al., 2012; Kenney et al., 2012; McKnight-Eily et al., 2011; O'Brien and Mindell, 2005).”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Hasler et al., 2012 source

      Not checked in the free run.

    • cites Kenney et al., 2012 source

      Not checked in the free run.

    • cites McKnight-Eily et al., 2011 source

      Not checked in the free run.

  • May combine two claims.

    Interpretationown data

    Adolescents who obtain poorer quality sleep are more oriented towards rewards, which may account for their riskier behavior.

    “These behavioral findings suggest that adolescents who obtain poorer quality sleep are more oriented towards rewards, which may account for their riskier behavior.”
    Quote in the paperSubstantial claim

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Interpretationreasoning

    The lack of differences in false alarm rates may be due to adolescents with poorer sleep taking more time on go trials and thus having to inhibit less on no-go trials.

    “Although we did not find differences in false alarm rates as a function of sleep, this may be due to adolescents with poorer sleep taking more time on go trials and thus having to inhibit less on the no-go trials.”
    Quote in the paperNot a substantial claim

  • May combine two claims.

    Interpretationown data

    Adolescents with poorer sleep quality may have both a greater orientation towards risk and compromised decision making abilities.

    “Thus, adolescents with poorer sleep quality may have both a greater orientation towards risk and compromised decision making abilities.”
    Quote in the paperSubstantial claim

  • Classified as probably not a substantial claim.

    Premisecitation

    Sleep deprived adults show hyperactivation in the insula when processing positive stimuli.

    “During risk taking, adolescents who reported poorer sleep quality showed greater activation in the insula during cash out trials as the reward increased, findings that are consistent with research on sleep deprived adults who show hyperactivation in the insula when processing positive stimuli (Gujar et al., 2011).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Gujar et al., 2011 source

      Not checked in the free run.

  • Classified as probably not a substantial claim.

    Premisecitation

    Children show decreased activation in the lateral PFC compared to adults when matched on performance during a cognitive control task.

    “Prior work has found that adults recruit the lateral PFC to a greater extent than adolescents during risk taking (Chein et al., 2011; Eshel et al., 2007), and children show decreased activation in the lateral PFC compared to adults when matched on performance during a cognitive control task (Bunge et al., 2002).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Bunge et al., 2002 source

      Not checked in the free run.

  • May combine two claims.

    Interpretationreasoning

    Adolescents with poorer sleep may be more apathetic, less confident, and take less care during decision making, demonstrating lower motivation to engage in the cognitive control task.

    “These associations suggest that adolescents with poorer sleep may be more apathetic, less confident, and take less care during decision making thus demonstrating lower motivation to engage in the cognitive control task.”
    Quote in the paperSubstantial claim

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    The insula has shown heightened activation among adults during the BART.

    “Indeed, the insula is a brain region involved in tracking risk in the environment (Singer et al., 2009) and has shown heightened activation among adults during the BART (Schonberg et al., 2012).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Schonberg et al., 2012 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    The lateral PFC is involved in cognitive control, goal directed behavior, and impulse control, and is one of the last brain regions to develop both structurally and functionally.

    “The lateral PFC is involved in cognitive control, goal directed behavior, and impulse control, and is one of the last brain regions to develop both structurally and functionally (Gogtay et al., 2004).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Gogtay et al., 2004 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Cognitive control capacities may be highly flexible and depend on the social and motivational context rather than being immature during adolescence.

    “In addition, researchers have recently suggested that rather than being immature during adolescence, cognitive control capacities may be highly flexible and depend on the social and motivational context (Crone and Dahl, 2012).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Crone and Dahl, 2012 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    The insula plays a role in reactivity to and encoding of positive stimuli, supporting motivated behaviors.

    “The insula also plays a role in reactivity to and encoding of positive stimuli, supporting motivated behaviors (Camara et al., 2008; Gujar et al., 2011).”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites Camara et al., 2008 source

      Not checked in the free run.

    • cites Gujar et al., 2011 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductreasoning

    The findings cannot be certain to be specific to adolescence, or whether similar effects would be found at other developmental periods.

    “We cannot be certain that our findings are specific to adolescence, or whether similar effects would be found at other developmental periods.”
    Quote in the paperNot a substantial claim

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Sleep and reward-related brain function differ in early versus late pubertal adolescents.

    “There is some initial evidence that sleep and reward-related brain function differ in early versus late pubertal adolescents (Hasler et al., 2012).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Hasler et al., 2012 source

      Not checked in the free run.

  • May combine two claims.

    Interpretationown data

    Sleep is associated with greater arousal to rewards and a potential lack of motivation to engage in cognitive control.

    “Our findings suggest that sleep is associated with greater arousal to rewards and a potential lack of motivation to engage in cognitive control.”
    Quote in the paperSubstantial claim

  • Classified as probably not a substantial claim. May combine two claims.

    Premisecitation

    The insula integrates emotional information to and from limbic and cortical areas and is involved in the representation of interoceptive responses to emotionally salient and rewarding stimuli, such as drug craving, urgency, and impulsivity.

    “Moreover, the insula integrates emotional information to and from limbic and cortical areas and is involved in the representation of interoceptive responses to emotionally salient and rewarding stimuli, such as drug craving, urgency, and impulsivity (Bonson et al., 2002; Naqvi and Bechara, 2009; Villafuerte et al., 2011).”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Bonson et al., 2002 source

      Not checked in the free run.

    • cites Naqvi and Bechara, 2009 source

      Not checked in the free run.

    • cites Villafuerte et al., 2011

      Not checked in the free run.

  • May combine two claims.

    Interpretationown data

    Even relatively small, normative levels of poor sleep can disrupt brain function and make adolescents even more vulnerable to suboptimal decision making.

    “Our findings underscore how important sleep is during adolescence, and that even relatively small, normative levels of poor sleep can disrupt brain function and make adolescents even more vulnerable to suboptimal decision making.”
    Quote in the paperSubstantial claim

  • Classified as probably not a substantial claim. May combine two claims.

    Interpretationreasoning

    The interaction between poor sleep, heightened arousal, and dampened cognitive control may create a negative spiral of events whereby sleep increases arousal and decreases regulation which then pushes adolescents towards more arousing stimuli and thereby are less likely to obtain sleep at night.

    “The interaction between poor sleep, heightened arousal, and dampened cognitive control may create a negative spiral of events whereby sleep increases arousal and decreases regulation which then pushes adolescents towards more arousing stimuli and thereby are less likely to obtain sleep at night.”
    Quote in the paperSubstantial claim
33 of 33

  • The paper relies on this without support.

    The neurobiology underlying the association between sleep and adolescent behavior remains elusive.

    “However, the neurobiology underlying the association between sleep and adolescent behavior remains elusive.”

  • The paper relies on this without support.

    The Go–No-Go task targets primarily cognitive control-related brain function.

    “We focused the PPI analyses on the BART task, given that both affective and cognitive control regions are involved during the task (Schonberg et al., 2012), whereas the GNG task targets primarily cognitive control-related brain function.”

  • The paper relies on this without support.

    The sample of 46 adolescents is representative of the broader adolescent population.

    “Participants included forty-six adolescents from a larger sample of adolescents who participated in an fMRI scan during which they completed a risk taking task and a cognitive control task.”

  • The paper relies on this without support.

    The BART task models unpredictable rewards and punishments that characterize real-world risky behaviors.

    “This pattern models the unpredictable rewards and punishments that characterize real-world risky behaviors.”

  • The paper relies on this without support.

    The mediation analysis assumes no unmeasured confounding and correct temporal ordering of sleep quality, DLPFC activation, and insula activation.

    “Mediation analyses were conducted in SPSS by regressing sleep quality on percent BOLD signal change in the insula to cash outs, and entering percent BOLD signal change in the DLPFC during No-go>Go trials as the mediator.”
5 of 5

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Sleep deprivation disrupts reward neural circuitry, usually enhancing brain reactivity to positive experiences.

    “Sleep deprivation also disrupts reward neural circuitry, usually enhancing brain reactivity to positive experiences.”

    From Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents (2018) · cites this paper as [89]

  • Typically-developing adolescents with shorter sleep duration and lower sleep quality exhibit lower caudate response to reward anticipation, greater insula response to risk-taking, and lower functional connectivity between DLPFC and both insula and ventral striatum during risk taking.

    “Typically-developing adolescents with shorter sleep duration and lower sleep quality exhibit lower caudate response to reward anticipation (85), greater insula response to risk-taking, and lower functional connectivity between DLPFC and both insula and VS during risk taking (89)”

    From Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents (2018) · cites this paper as [89]

  • As youth transition to adolescence, their sleep patterns undergo important changes that may exacerbate the cognitive-affective imbalance and contribute to risky behavior.

    “As youth transition to adolescence, their sleep patterns also undergo important changes that may exacerbate this cognitiveaffective imbalance and contribute to risky behavior (Telzer et al. 2013).”

    From Sleep Problems Across Development: A Pathway to Adolescent Risk Taking Through Working Memory (2015) · cites this paper as Telzer et al. 2013

  • Lower sleep quality was associated with reduced dorsolateral PFC activation on a Go/No Go task in healthy adolescents 14-16, suggesting impaired cognitive control.

    “A study of healthy adolescents (14–16 years old) found that lower sleep quality was associated with reduced dorsolateral PFC activation on a Go/No Go task, suggesting impaired cognitive control.”

    From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Telzer, Fuligni, Lieberman, & Galván, 2013

Statistics recomputed

Every reported test result, recomputed from its test statistic and degrees of freedom. A result shows as not adding up only once an independent check has confirmed it.

  • Consistentt(45) = 7.67reported p < .001 · recomputed p < .001

    “t(45)=7.67, p < .001”

  • Consistentt(45) = 3.96reported p < .001 · recomputed p < .001

    “t(45)=3.96, p < .001”

  • Consistentz = 3.78reported p < .05 · recomputed p < .001

    “Z=3.78, p < .05”

  • Consistentz = 4.21reported p < .05 · recomputed p < .001

    “Z=4.21, p < .05”

  • Consistentz = 2.89reported p < .05 · recomputed p = .004

    “Z=2.89, p < .05”

5 of 5

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • Explosion point assigned two different distributions

    Major

    The number of pumps before explosion and the explosion point describe the same threshold, but one is said to follow a Poisson distribution and the other a uniform distribution.

  • PPI physiological regressor does not match the stated seed

    Minor

    The PPI description defines the seed as a DLPFC region and identifies its time course as a design-matrix regressor, but then says the physiological regressor is the time series of the ventral striatum or insula.

2 of 2

Cites

Flagged first, then by citations

1 of the 57 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Telzer, E. H., Fuligni, A. J., Lieberman, M. D., & Galván, A.
Affiliations
  • University of Illinois Urbana-Champaign (US)
  • University of California, Los Angeles (US)
Corresponding author
Telzer, Eva H.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2013-05
Volume
71
Pages
275-283
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2013.01.025
PMC
PMC3865864
OpenAlex
W2139046563
Semantic Scholar
f84711d4dd99d3b7453519b8b150cf070d11b4d0
Cited by
296
References
57
Citations by year
2026: 17 · 2025: 30 · 2024: 26 · 2023: 19 · 2022: 33 · 2021: 21 · 2020: 23 · 2019: 31 · 2018: 20 · 2017: 13 · 2016: 22 · 2015: 21 · 2014: 13 · 2013: 6 · 2012: 1
FWCI
11.29
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NICHD (R01HD057164-S, R01HD057164)
  • UCLA Center for Culture, Brain and Development Research Grant
  • NSF Doctoral Dissertation Improvement Grant
  • SRCD Dissertation Fund Award
  • APF and COGDOP Graduate Research Grant
  • University of California Institute for Mexico and the United States Dissertation Research Grant
  • National Research Service Award Graduate Fellowship
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
sleep quality, insufficient sleep, adolescence, risk-taking, cognitive control, reward processing, dorsolateral prefrontal cortex, insula, ventral striatum, functional connectivity
MeSH terms
Adolescent, Brain, Brain Mapping, Decision Making, Female, Humans, Magnetic Resonance Imaging, Male, Reward, Risk-Taking, Sleep

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-10.

Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-10.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review