Cited by 127DNA Repair MechanismsFungal and yeast genetics researchCancer-related Molecular Pathways

The DOI matches its Crossref record; 399 of the 399 references it cites were found in a registry or an index.

Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

Open access

Finn, Karen, Lowndes, Noel Francis, Grenon, Muriel·2012·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-011-0875-3PMC PMC11115150

Open this paper in CoChat — free account

Abstract

Double-strand breaks (DSBs) are the most detrimental form of DNA damage. Failure to repair these cytotoxic lesions can result in genome rearrangements conducive to the development of many diseases, including cancer. The DNA damage response (DDR) ensures the rapid detection and repair of DSBs in order to maintain genome integrity. Central to the DDR are the DNA damage checkpoints. When activated by DNA damage, these sophisticated surveillance mechanisms induce transient cell cycle arrests, allowing sufficient time for DNA repair. Since the term "checkpoint" was coined over 20 years ago, our understanding of the molecular mechanisms governing the DNA damage checkpoint has advanced significantly. These pathways are highly conserved from yeast to humans. Thus, significant findings in yeast may be extrapolated to vertebrates, greatly facilitating the molecular dissection of these complex regulatory networks. This review focuses on the cellular response to DSBs in Saccharomyces cerevisiae, providing a comprehensive overview of how these signalling pathways function to orchestrate the cellular response to DNA damage and preserve genome stability in eukaryotic cells.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00018-011-0875-3

Cites

399 of 399 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Items 201–399 of 399

The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1‐dependent hyperphosphorylation and interacts with Rad53 after DNA damage
Vialard, J., Gilbert, C. S., Green, C. M., & Lowndes, N. F. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5679 · Cited by 284
Self-citation
p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.
Parker, L. L., Atherton-Fessler, S., & Piwnica-Worms, H. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2917 · Cited by 282
Exo1 Processes Stalled Replication Forks and Counteracts Fork Reversal in Checkpoint-Defective Cells
Cotta‐Ramusino, C., Fachinetti, D., Lucca, C., Doksani, Y., Lopes, M., Sogo, J. M., & Foiani, M. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.11.032 · Cited by 281
Common mechanisms of PIKK regulation
Lovejoy, C. A., & Cortez, D. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.04.006 · Cited by 277
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
Bekker‐Jensen, S., Danielsen, J. M. R., Fugger, K., Gromova, I., Nerstedt, A., Lukas, C., Bártek, J., Lukas, J., & Mailand, N. (2009) · Nature Cell Biology · doi:10.1038/ncb2008 · Cited by 277
Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation
Zegerman, P., & Diffley, J. F. X. (2010) · Nature · doi:10.1038/nature09373 · Cited by 273
Sensing and responding to DNA damage
Lowndes, N. F., & Murguía, J. R. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00050-7 · Cited by 272
Self-citation
Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair
Spagnolo, L., Rivera-Calzada, Á., Pearl, L. H., & Llorca, Ó. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.013 · Cited by 270
BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.
Chen, Y., Farmer, A. A., Chen, C., Jones, D. C., Chen, P., & Lee, W. (1996) · PubMed · Cited by 267
Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression
Shimada, M., Niida, H., Zineldeen, D. H., Tagami, H., Tanaka, M., Saito, H., & Nakanishi, M. (2008) · Cell · doi:10.1016/j.cell.2007.12.013 · Cited by 263
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
Stracker, T. H., Usui, T., & Petrini, J. H. J. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.012 · Cited by 262
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
Chen, L., Gilkes, D. M., Pan, Y., Lane, W. S., & Chen, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600812 · Cited by 260
Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid.
Bennett, C. B., Lewis, A. L., Baldwin, K. K., & Resnick, M. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5613 · Cited by 258
Recruitment of Mec1 and Ddc1 Checkpoint Proteins to Double-Strand Breaks Through Distinct Mechanisms
Kondo, T., Wakayama, T., Naiki, T., Matsumoto, K., & Sugimoto, K. (2001) · Science · doi:10.1126/science.1063827 · Cited by 258
Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast.Preprint
Rhind, N., Furnari, B. A., & Russell, P. R. (1997) · Genes & Development · doi:10.1101/gad.11.4.504 · Cited by 256
Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint
Majka, J., & Burgers, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437148100 · Cited by 255
Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks
Nicolette, M. L., Lee, K., Guo, Z., Rani, M., Chow, J., Lee, S. E., & Paull, T. T. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1957 · Cited by 254
Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks
Shim, E. Y., Chung, W.-H., Nicolette, M. L., Zhang, Y., Davis, M., Zhu, Z., Paull, T. T., Ira, G., & Lee, S. E. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.219 · Cited by 254
Chk1‐deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
Zachos, G., Rainey, M. D., & Gillespie, D. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg060 · Cited by 247
The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeastPreprint
Paciotti, V., Clerici, M., Lucchini, G., & Longhese, M. P. (2000) · Genes & Development · doi:10.1101/gad.14.16.2046 · Cited by 246
Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1Preprint
Saka, Y., Esashi, F., Matsusaka, T., Mochida, S., & Yanagida, M. (1997) · Genes & Development · doi:10.1101/gad.11.24.3387 · Cited by 245
Human Claspin Is Required for Replication Checkpoint Control
Chini, C. C. S., & Chen, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301136200 · Cited by 244
MicroRNA‐mediated gene silencing modulates the UV‐induced DNA‐damage response
Pothof, J., Verkaik, N. S., van IJcken, W. F. J., Wiemer, E. A. C., Ta, V. T. B., van der Horst, G. T. J., Jaspers, N. G. J., van Gent, D. C., Hoeijmakers, J. H. J., & Persengiev, S. P. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.156 · Cited by 242
The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae
Charles, J. F., Jaspersen, S. L., Tinker-Kulberg, R. L., Hwang, L. H., Szidon, A., & Morgan, D. O. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70201-5 · Cited by 240
The ubiquitous role of ubiquitin in the DNA damage response
Al-Hakim, A., Escribano‐Diaz, C., Landry, M.-C., O’Donnell, L., Panier, S., Szilard, R. K., & Durocher, D. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.011 · Cited by 240
The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement
Ünsal-Kaçmaz, K., Chastain, P. D., Qu, P.-P., Minoo, P., Cordeiro-Stone, M., Sancar, A., & Kaufmann, W. K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02190-06 · Cited by 240
Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response
Bennetzen, M. V., Larsen, D. H., Bunkenborg, J., Bártek, J., Lukas, J., & Andersen, J. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900616-mcp200 · Cited by 240
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation
Sweeney, F. D., Yang, F., Chi, A., Shabanowitz, J., Hunt, D. F., & Durocher, D. (2005) · Current Biology · doi:10.1016/j.cub.2005.06.063 · Cited by 237
Cell-Cycle Control of Gene Expression in Budding and Fission Yeast
Bähler, J. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095808 · Cited by 235
Break dosage, cell cycle stage and DNA replication influence DNA double strand break response
Zierhut, C., & Diffley, J. F. X. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.111 · Cited by 234
ATM regulates ATR chromatin loading in response to DNA double-strand breaks
Cuadrado, M., Martinez-Pastor, B., Murga, M., Toledo, L. I., Gutierrez-Martinez, P., Lopez, E., & Fernandez-Capetillo, O. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051923 · Cited by 232
A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling
Cotta‐Ramusino, C., McDonald, E. R., Hurov, K. E., Sowa, M. E., Harper, J. W., & Elledge, S. J. (2011) · Science · doi:10.1126/science.1203430 · Cited by 229
The yeast Xrs2 complex functions in S phase checkpoint regulation
D'Amours, D., & Jackson, S. P. (2001) · Genes & Development · doi:10.1101/gad.208701 · Cited by 228
Rad9 Phosphorylation Sites Couple Rad53 to the Saccharomyces cerevisiae DNA Damage Checkpoint
Schwartz, M. F., Duong, J., Sun, Z., Morrow, J. S., Pradhan, D., & Stern, D. F. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00532-4 · Cited by 228
Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint‐blind DNA damage
Redon, C. E., Pilch, D. R., Rogakou, E. P., Orr, A. H., Lowndes, N. F., & Bonner, W. M. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor871 · Cited by 224
Self-citation
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks
Trenz, K., Smith, E., Smith, S. J., & Costanzo, V. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601045 · Cited by 219
MEC1-Dependent Phosphorylation of Rad9p in Response to DNA Damage
Emili, A. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80128-8 · Cited by 218
The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair
Lammens, K., Bemeleit, D., Möckel, C., Clausing, E., Schele, A., Hartung, S., Schiller, C., Lucas, M., Angermueller, C., Söding, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.038 · Cited by 216
Suppression of spontaneous mutagenesis in human cells by DNA base excision–repair
Lindahl, T. L. (2000) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(00)00024-7 · Cited by 214
Beyond ATM: The protein kinase landscape of the DNA damage response
Bensimon, A., Aebersold, R. H., & Shiloh, Y. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.013 · Cited by 214
Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response
Smits, V. A. J., Reaper, P. M., & Jackson, S. P. (2005) · Current Biology · doi:10.1016/j.cub.2005.11.066 · Cited by 212
Control of Sister Chromatid Recombination by Histone H2AX
Xie, A., Puget, N., Shim, I., Odate, S., Jarzyna, I., Bassing, C. H., Alt, F. W., & Scully, R. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.12.007 · Cited by 211
A novel Rad24 checkpoint protein complex closely related to replication factor C
Green, C., Erdjument‐Bromage, H., Tempst, P., & Lowndes, N. F. (2000) · Current Biology · doi:10.1016/s0960-9822(99)00263-8 · Cited by 208
Self-citation
Replication Protein A Directs Loading of the DNA Damage Checkpoint Clamp to 5′-DNA Junctions
Majka, J., Binz, S. K., Wold, M. S., & Burgers, P. M. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605176200 · Cited by 205 · cited 1×
“It is proposed that the 9-1-1 complex, which loads specifically onto 50 junctions [174, 175], signals replication stress on the lagging strand, while pol e and the leading strand factors Dpb11 and Sld2 detect replication perturbations on the leading strand, with both pathways independently leading to Mec1 activation […”
Background
Mrc1 and DNA Polymerase ɛ Function Together in Linking DNA Replication and the S Phase Checkpoint
Lou, H., Komata, M., Katou, Y., Guan, Z., Reis, C. C., Budd, M. E., Shirahige, K., & Campbell, J. L. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.020 · Cited by 204
Histone H2A Phosphorylation Controls Crb2 Recruitment at DNA Breaks, Maintains Checkpoint Arrest, and Influences DNA Repair in Fission Yeast
Nakamura, T., Du, L., Redon, C. E., & Russell, P. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.14.6215-6230.2004 · Cited by 201
Yeast Protein Serine/Threonine Phosphatases: Multiple Roles and Diverse Regulation
Stark, M. J. R. (1996) · Yeast · doi:10.1002/(sici)1097-0061(199612)12:16 · Cited by 201
Claspin, a Chk1-Regulatory Protein, Monitors DNA Replication on Chromatin Independently of RPA, ATR, and Rad17
Lee, J., Kumagai, A., & Dunphy, W. G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00045-5 · Cited by 199
Implications for Chk1 Regulation: The 1.7 Å Crystal Structure of Human Cell Cycle Checkpoint Kinase Chk1
Chen, P., Luo, C., Deng, Y., Ryan, K., Register, J., Margosiak, S. A., Tempczyk-Russell, A., Nguyen, B., Myers, P., Lundgren, K., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80704-7 · Cited by 199
Histone methyltransferase Dot1 and Rad9 inhibit single‐stranded DNA accumulation at DSBs and uncapped telomeres
Lazzaro, F., Sapountzi, V., Granata, M., Pellicioli, A., Vaze, M. B., Haber, J. E., Plevani, P., Lydall, D. A., & Muzi-Falconi, M. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.81 · Cited by 198
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
洪, 炫. (2012) · Medical Entomology and Zoology · Cited by 198
The Saccharomyces cerevisiae Sae2 Protein Promotes Resection and Bridging of Double Strand Break Ends
Clerici, M., Mantiero, D., Lucchini, G., & Longhese, M. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508339200 · Cited by 197
BRCA1 is a cell cycle-regulated nuclear phosphoprotein
Ruffner, H., & Verma, I. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7138 · Cited by 197
RAD9, RAD17, and RAD24 Are Required for S Phase Regulation in Saccharomyces cerevisiae in Response to DNA Damage
Paulovich, A. G., Margulies, R. U., Garvik, B. M., & Hartwell, L. H. (1997) · Genetics · doi:10.1093/genetics/145.1.45 · Cited by 196
RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae.
Siede, W., Friedberg, A. S., & Friedberg, E. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7985 · Cited by 195
Damage-induced phosphorylation of Sld3 is important to block late origin firing
López-Mosqueda, J., Maas, N. L., Jónsson, Z. O., Eli, L. D., Wohlschlegel, J. A., & Toczyski, D. P. (2010) · Nature · doi:10.1038/nature09377 · Cited by 194
Transient Stability of DNA Ends Allows Nonhomologous End Joining to Precede Homologous Recombination
Frank-Vaillant, M., & Marcand, S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00705-0 · Cited by 194
DNA end resection—Unraveling the tail
Mimitou, E. P., & Symington, L. S. (2011) · DNA repair · doi:10.1016/j.dnarep.2010.12.004 · Cited by 188
Phosphorylation of Threonine 68 Promotes Oligomerization and Autophosphorylation of the Chk2 Protein Kinase via the Forkhead-associated Domain
Ahn, J.-Y., Li, X., Davis, H. L., & Canman, C. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200822200 · Cited by 187
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
Majka, J., Niedziela-Majka, A., & Burgers, P. M. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.027 · Cited by 186
Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation
Chen, X., Niu, H., Chung, W.-H., Zhu, Z., Papusha, A., Shim, E. Y., Lee, S. E., Sung, P., & Ira, G. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2105 · Cited by 185
The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
Brush, G. S., Morrow, D. M., Hieter, P., & Kelly, T. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15075 · Cited by 185
Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex
Grenon, M., Gilbert, C., & Lowndes, N. F. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-844 · Cited by 184
Self-citation
A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival
Yamane, K., Wu, X., & Chen, J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.2.555-566.2002 · Cited by 184
Epigenetic Modifications in Double-Strand Break DNA Damage Signaling and Repair
Rossetto, D., Truman, A. W., Kron, S. J., & Côté, J. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0513 · Cited by 183
Lcd1p Recruits Mec1p to DNA Lesions In Vitro and In Vivo
Rouse, J. W., & Jackson, S. P. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00507-5 · Cited by 179
Identification of CDK2 substrates in human cell lysates
Chi, Y., Welcker, M., Hizli, A. A., Posakony, J., Aebersold, R. H., & Clurman, B. E. (2008) · Genome biology · doi:10.1186/gb-2008-9-10-r149 · Cited by 177
Chromatin dynamics and the repair of DNA double strand breaks
Xu, Y., & Price, B. D. (2011) · Cell Cycle · doi:10.4161/cc.10.2.14543 · Cited by 172
Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forksPreprint
Segurado, M., & Diffley, J. F. X. (2008) · Genes & Development · doi:10.1101/gad.477208 · Cited by 171
Differential Regulation of the Cellular Response to DNA Double-Strand Breaks in G1
Barlow, J. H., Lisby, M., & Rothstein, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.01.016 · Cited by 167
A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1
Blasius, M., Forment, J. V., Thakkar, N., Wagner, S., Choudhary, C., & Jackson, S. P. (2011) · Genome biology · doi:10.1186/gb-2011-12-8-r78 · Cited by 165
Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex
Adams, K. E., Medhurst, A. L., Dart, D. A., & Lakin, N. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209426 · Cited by 164
Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
Morin, I., Ngo, H., Greenall, A., Zubko, M. K., Morrice, N., & Lydall, D. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.171 · Cited by 164
RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast
Gardner, R. G., Putnam, C. W., & Weinert, T. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.3173 · Cited by 163
The G2 DNA damage checkpoint targets both Wee1 and Cdc25
Raleigh, J., & O’Connell, M. J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.10.1727 · Cited by 162
Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
Bonilla, C. Y., Melo, J. A., & Toczyski, D. P. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.023 · Cited by 161
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4 TOPBP1Preprint
Furuya, K., Poitelea, M., Guo, L., Caspari, T., & Carr, A. M. (2004) · Genes & Development · doi:10.1101/gad.291104 · Cited by 160
DNA Damage and Replication Checkpoints in Fission Yeast Require Nuclear Exclusion of the Cdc25 Phosphatase via 14-3-3 Binding
Zeng, Y., & Piwnica-Worms, H. M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7410 · Cited by 157
The Yku70–Yku80 complex contributes to regulate double‐strand break processing and checkpoint activation during the cell cycle
Clerici, M., Mantiero, D., Guerini, I., Lucchini, G., & Longhese, M. P. (2008) · EMBO Reports · doi:10.1038/embor.2008.121 · Cited by 155
The Rad50 hook domain is a critical determinant of Mre11 complex functions
Wiltzius, J. J. W., Hohl, M., Fleming, J. C., & Petrini, J. H. J. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb928 · Cited by 152
Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cyclePreprint
Ferreira, M. G., & Cooper, J. P. (2004) · Genes & Development · doi:10.1101/gad.315804 · Cited by 152
Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 andCLN2 transcription occur in response to DNA damage inSaccharomyces cerevisiaePreprint
Sidorova, J. M., & Breeden, L. L. (1997) · Genes & Development · doi:10.1101/gad.11.22.3032 · Cited by 150
Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast
Hammet, A., Magill, C. P., Heierhorst, J., & Jackson, S. P. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401036 · Cited by 150
Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae
Myung, K., & Kolodner, R. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062702199 · Cited by 148
53BP1 promotes ATM activity through direct interactions with the MRN complex
Lee, J., Goodarzi, A. A., Jeggo, P. A., & Paull, T. T. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.372 · Cited by 147
RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation
de la Torre‐Ruiz, M., Green, C. M., & Lowndes, N. F. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2687 · Cited by 147 · cited 1×
“The 9-1-1 complex promotes Mec1-dependent phosphorylation of its targets [162, 163, 178–180] and stimulates Mec1 kinase activity via a direct interaction with Ddc1 both in vitro and in vivo leading to activation of the G1 checkpoint [181].”
BackgroundSelf-citation
Combining Protein-Based IMAC, Peptide-Based IMAC, and MudPIT for Efficient Phosphoproteomic Analysis
Cantin, G. T., Yi, W., Lu, B., Park, S. K., Xu, T., Lee, J., & Yates, J. R. (2008) · Journal of Proteome Research · doi:10.1021/pr0705441 · Cited by 145
Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents.
Siede, W., Friedberg, A. S., Dianova, I. I., & Friedberg, E. C. (1994) · Genetics · doi:10.1093/genetics/138.2.271 · Cited by 145
Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint functionPreprint
Wang, H., Liu, D., Wang, Y., Qin, J., & Elledge, S. J. (2001) · Genes & Development · doi:10.1101/gad.893201 · Cited by 143
Mammalian TIMELESS and Tipin are Evolutionarily Conserved Replication Fork-associated Factors
Gotter, A. L., Suppa, C., & Emanuel, B. S. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.10.097 · Cited by 142
Mre11–Rad50–Nbs1‐dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
Jazayeri, A. R., Balestrini, A., Garner, E., Haber, J. E., & Costanzo, V. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.128 · Cited by 141
Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaksPreprint
Du, L.-L., Nakamura, T., & Russell, P. R. (2006) · Genes & Development · doi:10.1101/gad.1422606 · Cited by 141
Role of Dnl4–Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination
Zhang, Y., Hefferin, M. L., Chen, L., Shim, E. Y., Tseng, H.-M., Kwon, Y., Sung, P., Lee, S. E., & Tomkinson, A. E. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1261 · Cited by 140
Trans‐activation of the DNA‐damage signalling protein kinase Chk2 by T‐loop exchange
Oliver, A. W., Paul, A., Boxall, K. J., Barrie, S. E., Aherne, G. W., Garrett, M. D., Mittnacht, S., & Pearl, L. H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601209 · Cited by 136
Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p
Paciotti, V., Lucchini, G., Plevani, P., & Longhese, M. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.14.4199 · Cited by 132
The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling
Clerici, M., Mantiero, D., Lucchini, G., & Longhese, M. P. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400593 · Cited by 131
The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms
Navadgi, V. M., & Burgers, P. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.10.014 · Cited by 131
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress
Kemp, M. G., Akan, Z., Yilmaz, S., Grillo, M., Smith‐Roe, S. L., Kang, T., Cordeiro‐Stone, M., Kaufmann, W. K., Abraham, R. T., Sancar, A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.110304 · Cited by 129
DNA replication as a target of the DNA damage checkpoint
Zegerman, P., & Diffley, J. F. X. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.04.023 · Cited by 128
Recruitment and Dissociation of Nonhomologous End Joining Proteins at a DNA Double-Strand Break in Saccharomyces cerevisiae
Wu, D. L., Topper, L. M., & Wilson, T. E. (2008) · Genetics · doi:10.1534/genetics.107.083535 · Cited by 127
Tof1p Regulates DNA Damage Responses During S Phase in Saccharomyces cerevisiae
Foss, E. J. (2001) · Genetics · doi:10.1093/genetics/157.2.567 · Cited by 126
Choreography of recombination proteins during the DNA damage response
Lisby, M., & Rothstein, R. J. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.007 · Cited by 126
Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex—Implications for Clamp Loading and Regulation
Dore, A. S., Kilkenny, M. L., Rzechorzek, N. J., & Pearl, L. H. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.027 · Cited by 125
The role of DNA dependent protein kinase in synapsis of DNA ends
Weterings, E. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg889 · Cited by 125
The Functions of Budding Yeast Sae2 in the DNA Damage Response Require Mec1- and Tel1-Dependent Phosphorylation
Baroni, E., Viscardi, V., Cartagena‐Lirola, H., Lucchini, G., & Longhese, M. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4151-4165.2004 · Cited by 125
Recruitment of the Cell Cycle Checkpoint Kinase ATR to Chromatin during S-phase
Dart, D. A., Adams, K. E., Akerman, I., & Lakin, N. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314212200 · Cited by 124
Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation
Toh, G. W. ‐., O'Shaughnessy, A. M., Jimeno, S., Dobbie, I. M., Grenon, M., Maffini, S., O’Rorke, A., & Lowndes, N. F. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.03.005 · Cited by 123
Self-citation
NFBD1/MDC1 regulates ionizing radiation‐induced focus formation by DNA checkpoint signaling and repair factors
Xu, X., & Stern, D. F. (2003) · The FASEB Journal · doi:10.1096/fj.03-0310com · Cited by 121
Dpb11 activates the Mec1-Ddc2 complex
Mordes, D. A., Nam, E. A., & Cortez, D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806621105 · Cited by 121
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase
Navadgi-Patil, V. M., & Burgers, P. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807435200 · Cited by 121
Dpb11 coordinates Mec1 kinase activation with cell cycle‐regulated Rad9 recruitment
Pfander, B., & Diffley, J. F. X. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.345 · Cited by 120
Multiple Endonucleases Function to Repair Covalent Topoisomerase I Complexes in Saccharomyces cerevisiae
Deng, C., Brown, J. M., Dongqing, Y., & Brown, J. M. (2005) · Genetics · doi:10.1534/genetics.104.028795 · Cited by 119
Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double‐strand breaks
Mantiero, D., Clerici, M., Lucchini, G., & Longhese, M. P. (2007) · EMBO Reports · doi:10.1038/sj.embor.7400911 · Cited by 118
Mechanisms and regulation of DNA end resection
Longhese, M. P., Bonetti, D., Manfrini, N., & Clerici, M. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.165 · Cited by 117
MRN and the race to the break
Rupnik, A., Lowndes, N. F., & Grenon, M. (2009) · Chromosoma · doi:10.1007/s00412-009-0242-4 · Cited by 116
Self-citation
A role for DNA primase in coupling DNA replication to DNA damage response
Marini, F., Pellicioli, A., Paciotti, V., Lucchini, G., Plevani, P., Stern, D. F., & Foiani, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.3.639 · Cited by 116
The S‐phase checkpoint: targeting the replication fork
Segurado, M., & Tercero, J. A. (2009) · Biology of the Cell · doi:10.1042/bc20090053 · Cited by 115
Recruitment of ATM Protein to Double Strand DNA Irradiated with Ionizing Radiation
Suzuki, K., Kodama, S., & Watanabe, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25571 · Cited by 115
Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint
Puddu, F., Granata, M., Di Nola, L., Balestrini, A., Piergiovanni, G., Lazzaro, F., Giannattasio, M., Plevani, P., & Muzi-Falconi, M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00330-08 · Cited by 115
BRCA1 Is Phosphorylated at Serine 1497 In Vivo at a Cyclin-Dependent Kinase 2 Phosphorylation Site
Ruffner, H., Jiang, W. B., Craig, A. G., Hunter, T. R., & Verma, I. M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4843 · Cited by 115
Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells
Wu, X., Shell, S. M., & Zou, Y. (2005) · Oncogene · doi:10.1038/sj.onc.1208674 · Cited by 113 · cited 1×
“3e) and are required to initiate Mec1/ATR-dependent checkpoint signalling in both G1 and G2 phases [163, 166, 167, 169].”
Background
Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain
Grenon, M., Costelloe, T., Jimeno, S., O'Shaughnessy, A. M., Fitzgerald, J., Zgheib, O., Degerth, L., & Lowndes, N. F. (2007) · Yeast · doi:10.1002/yea.1441 · Cited by 110
Self-citation
The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2.
Haese, G. D., Walworth, N. C., Carr, A. M., & Gould, K. L. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.4.371 · Cited by 110
Chromatin dynamics coupled to DNA repair
Huertas, D., Sendra, R., & Muñoz, P. (2009) · Epigenetics · doi:10.4161/epi.4.1.7733 · Cited by 108
Cell Cycle Regulation of the Saccharomyces cerevisiae Polo-Like Kinase Cdc5p
Cheng, L., Hunke, L., & Hardy, C. F. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7360 · Cited by 108
Dif1 Is a DNA-Damage-Regulated Facilitator of Nuclear Import for Ribonucleotide Reductase
Lee, Y. D., Wang, J., Stubbe, J., & Elledge, S. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.018 · Cited by 107
Cyclins and the wiring of the yeast cell cycle.
Futcher, B. (1996) · PubMed · doi:10.1002/(sici)1097-0061(199612)12:16%3c1635::aid-yea83%3e3.0.co;2-o · Cited by 106
Two Distinct Pathways for Inhibiting Pds1 Ubiquitination in Response to DNA Damage
Agarwal, R., Tang, Z., Yu, H., & Cohen‐Fix, O. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306783200 · Cited by 103
The Chk1-mediated S-phase Checkpoint Targets Initiation Factor Cdc45 via a Cdc25A/Cdk2-independent Mechanism
Liu, P., Barkley, L. R., Day, T. A., Bi, X., Slater, D., Alexandrow, M. G., Nasheuer, H., & Vaziri, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602982200 · Cited by 102
Coping with DNA double strand breaks
Hiom, K. J. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.018 · Cited by 99
Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response
Brush, G. S. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.19.3725 · Cited by 98
TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint
Cescutti, R., Negrini, S., Kohzaki, M., & Halazonetis, T. D. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.238 · Cited by 97
The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast
Longhese, M. P. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.18.3533 · Cited by 96
A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1
Navadgi-Patil, V. M., & Burgers, P. M. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.03.011 · Cited by 93
An FHA domain–mediated protein interaction network of Rad53 reveals its role in polarized cell growth
Smolka, M. B., Chen, S., Maddox, P. S., Enserink, J. M., de Albuquerque, C. P., Wei, X. X., Desai, A. B., Kolodner, R. D., & Zhou, H. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200605081 · Cited by 91
Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity
Walker, M., Black, E. J., Oehler, V., Gillespie, D. A., & Scott, M. T. (2009) · Oncogene · doi:10.1038/onc.2009.102 · Cited by 90
MicroRNAs, the DNA damage response and cancer
Wouters, M. D., van Gent, D. C., Hoeijmakers, J. H. J., & Pothof, J. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.03.012 · Cited by 90
Mechanism of Dun1 Activation by Rad53 Phosphorylation in Saccharomyces cerevisiae
Chen, S., Smolka, M. B., & Zhou, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609322200 · Cited by 89
Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling
Javaheri, A., Wysocki, R., Jobin‐Robitaille, O., Altaf, M., Côté, J., & Kron, S. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511192103 · Cited by 89
Regulation of Chk1
Tapia-Alveal, C., Calonge, T. M., & O’Connell, M. J. (2009) · Cell Division · doi:10.1186/1747-1028-4-8 · Cited by 88
Chk1-Dependent S-M Checkpoint Delay in Vertebrate Cells Is Linked to Maintenance of Viable Replication Structures
Zachos, G., Rainey, M. D., & Gillespie, D. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.2.563-574.2005 · Cited by 88
Replication-dependent sister chromatid recombination in rad1 mutants of Saccharomyces cerevisiae.
Kadyk, L. C., & Hartwell, L. H. (1993) · Genetics · doi:10.1093/genetics/133.3.469 · Cited by 88
Control of G2 delay by the RAD9 gene of Saccharomyces cerevisiae
Weinert, T. A., & Hartwell, L. H. (1989) · Journal of Cell Science · doi:10.1242/jcs.1989.supplement_12.12 · Cited by 87
PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks
Couto, C. A.-M., Wang, H.-Y., Green, J. C. A., Kiely, R., Siddaway, R., Borer, C., Pears, C. J., & Lakin, N. D. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201012132 · Cited by 84
Spindle Pole Body Separation in Saccharomyces cerevisiae Requires Dephosphorylation of the Tyrosine 19 Residue of Cdc28
Lim, H. H., Goh, P., & Surana, U. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6385 · Cited by 83
Impaired tRNA Nuclear Export Links DNA Damage and Cell-Cycle Checkpoint
Ghavidel, A., Kislinger, T., Pogoutse, O., Sopko, R., Jurišica, I., & Emili, A. (2007) · Cell · doi:10.1016/j.cell.2007.09.042 · Cited by 82
Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR
Jowsey, P. A., Morrice, N. A., Hastie, C. J., McLauchlan, H., Toth, R. L., & Rouse, J. W. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.04.011 · Cited by 82
Maintenance of the DNA-Damage Checkpoint Requires DNA-Damage-Induced Mediator Protein Oligomerization
Usui, T., Foster, S. S., & Petrini, J. H. J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.022 · Cited by 81
Crystal Structure of the Human Rad9–Hus1–Rad1 Clamp
Sohn, S. Y., & Cho, Y. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.05.028 · Cited by 81
mik1+ encodes a tyrosine kinase that phosphorylates p34cdc2 on tyrosine 15.
Lee, M. S., Enoch, T., & Piwnica-Worms, H. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43846-x · Cited by 80
Regulation of Intra-S Phase Checkpoint by Ionizing Radiation (IR)-dependent and IR-independent Phosphorylation of SMC3
Luo, H., Li, Y., Mu, J.-J., Zhang, J., Tonaka, T., Hamamori, Y., Jung, S. Y., Wáng, Y., & Qin, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802299200 · Cited by 80
Genetic and Physical Interactions Between DPB11 and DDC1 in the Yeast DNA Damage Response Pathway
Wang, H., & Elledge, S. J. (2002) · Genetics · doi:10.1093/genetics/160.4.1295 · Cited by 79
Regulation of Chk1 Kinase by Autoinhibition and ATR-mediated Phosphorylation
Katsuragi, Y., & Sagata, N. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-12-0874 · Cited by 78
Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1
Rappas, M., Oliver, A. W., & Pearl, L. H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq743 · Cited by 78
Dynamic Changes in Protein-Protein Interaction and Protein Phosphorylation Probed with Amine-reactive Isotope Tag
Smolka, M. B., de Albuquerque, C. P., Chen, S., Schmidt, K. H., Wei, X. X., Kolodner, R. D., & Zhou, H. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500115-mcp200 · Cited by 78
Yeast pip3/mec3 Mutants Fail To Delay Entry into S Phase and To Slow DNA Replication in Response to DNA Damage, and They Define a Functional Link between Mec3 and DNA Primase
Longhese, M. P., Fraschini, R., Plevani, P., & Lucchini, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3235 · Cited by 77
DNA damage checkpoint inactivation: Adaptation and recovery
Clémenson, C., & Marsolier‐Kergoat, M. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.008 · Cited by 75
RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1
Watanabe, K., Iwabuchi, K., Sun, J., Tsuji, Y., Tani, T., Tokunaga, K., Date, T., HASHIMOTO, M. W., Yamaizumi, M., & Tateishi, S. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp082 · Cited by 75
The S-phase checkpoint and its regulation in Saccharomyces cerevisiae
Longhese, M. P., Clerici, M., & Lucchini, G. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.009 · Cited by 74
Rad17 Plays a Central Role in Establishment of the Interaction between TopBP1 and the Rad9-Hus1-Rad1 Complex at Stalled Replication Forks
Lee, J., & Dunphy, W. G. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-11-0958 · Cited by 74
Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity
Granata, M., Lazzaro, F., Novarina, D., Panigada, D., Puddu, F., Abreu, C. M. C., Kumar, R., Grenon, M., Lowndes, N. F., Plevani, P., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001047 · Cited by 71
Self-citation
A domain of Rad9 specifically required for activation of Chk1 in budding yeast
Blankley, R. T., & Lydall, D. (2004) · Journal of Cell Science · doi:10.1242/jcs.00907 · Cited by 69
Editorial
Gannon, F. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor717 · Cited by 69
Di-methyl H4 Lysine 20 Targets the Checkpoint Protein Crb2 to Sites of DNA Damage
Greeson, N. T., Sengupta, R., Arida, A. R., Jenuwein, T., & Sanders, S. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806857200 · Cited by 65
Structural and functional analysis of the Crb2–BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repairPreprint
Kilkenny, M. L., Doré, A. S., Roe, S. M., Nestoras, K., Ho, J. C.-Y., Watts, F. Z., & Pearl, L. H. (2008) · Genes & Development · doi:10.1101/gad.472808 · Cited by 62
CDC5 Inhibits the Hyperphosphorylation of the Checkpoint Kinase Rad53, Leading to Checkpoint Adaptation
Vidanes, G. M., Sweeney, F. D., Galicia, S., Cheung, S. K., Doyle, J. P., Durocher, D., & Toczyski, D. P. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000286 · Cited by 60
7 DNA-dependent protein kinase and related proteins
Smith, G. C. M., Divecha, N., Lakin, N. D., & Jackson, S. P. (1999) · Princeton University Press eBooks · doi:10.1515/9781400865048.91 · Cited by 59
Robust G1 checkpoint arrest in budding yeast: dependence on DNA damage signaling and repair
Gerald, J. N. F., Benjamin, J. M., & Kron, S. J. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.8.1749 · Cited by 54
Regulation of repair choice: Cdk1 suppresses recruitment of end joining factors at DNA breaks
Zhang, Y., Shim, E. Y., Davis, M., & Lee, S. E. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.07.007 · Cited by 54
The multiple facets of the intra-S checkpoint
Grallert, B., & Boye, E. (2008) · Cell Cycle · doi:10.4161/cc.6389 · Cited by 54
FHA Domain-Mediated DNA Checkpoint Regulation of Rad53
Schwartz, M. F., Lee, S.-J., Duong, J., Eminaga, S., & Stern, D. F. (2003) · Cell Cycle · doi:10.4161/cc.2.4.457 · Cited by 52
Rad53 Checkpoint Kinase Phosphorylation Site Preference Identified in the Swi6 Protein of Saccharomyces cerevisiae
Sidorova, J. M., & Breeden, L. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.10.3405-3416.2003 · Cited by 51
Elevated Levels of the Polo Kinase Cdc5 Override the Mec1/ATR Checkpoint in Budding Yeast by Acting at Different Steps of the Signaling Pathway
Donnianni, R. A., Ferrari, M., Lazzaro, F., Clerici, M., Nachimuthu, B. T., Plevani, P., Muzi-Falconi, M., & Pellicioli, A. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000763 · Cited by 50
Cytoplasmic Occurrence of the Chk1/Cdc25 Pathway and Regulation of Chk1 in Xenopus Oocytes
Oe, T., Nakajo, N., Katsuragi, Y., Okazaki, K., & Sagata, N. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9968 · Cited by 50
The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment
Siede, W., Allen, J. B., Elledge, S. J., & Friedberg, E. C. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.19.5841-5843.1996 · Cited by 50
Regulation of checkpoint kinases through dynamic interaction with Crb2
Mochida, S., Esashi, F., Aono, N., Tamai, K., O’Connell, M. J., & Yanagida, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600018 · Cited by 49
Knockdown of Dicer in MCF-7 human breast carcinoma cells results in G1 arrest and increased sensitivity to cisplatin
Zhao (1994) · Oncology Reports · doi:10.3892/or_00000183 · Cited by 49
Sensing of Replication Stress and Mec1 Activation Act through Two Independent Pathways Involving the 9-1-1 Complex and DNA Polymerase ε
Puddu, F., Piergiovanni, G., Plevani, P., & Muzi-Falconi, M. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002022 · Cited by 48
Destroying the ring: Freeing DNA from Ku with ubiquitin
Postow, L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.046 · Cited by 47
The metaphase-to-anaphase transition: avoiding a mid-life crisis
Cohen‐Fix, O., & Koshland, D. E. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80080-4 · Cited by 47
Reconstitution of Rad53 Activation by Mec1 through Adaptor Protein Mrc1
Chen, S., & Zhou, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018242 · Cited by 47
Casein kinase 2‐dependent phosphorylation of human Rad9 mediates the interaction between human Rad9‐Hus1‐Rad1 complex and TopBP1
Takeishi, Y., Ohashi, E., Ogawa, K., Masai, H., Obuse, C., & Tsurimoto, T. (2010) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01418.x · Cited by 44
NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway
Wilson, K. A., & Stern, D. F. (2008) · Cell Cycle · doi:10.4161/cc.7.22.7102 · Cited by 43
14-3-3 Proteins Regulate Exonuclease 1–Dependent Processing of Stalled Replication Forks
Engels, K., Giannattasio, M., Muzi-Falconi, M., Lopes, M., & Ferrari, S. M. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001367 · Cited by 43
DNA Damage Checkpoints Inhibit Mitotic Exit by Two Different Mechanisms
Liang, F., & Wang, Y. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00095-07 · Cited by 43
Chromatin modulation and the DNA damage response
Costelloe, T., Fitzgerald, J., Murphy, N., Flaus, A., & Lowndes, N. F. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.06.031 · Cited by 41
Self-citation
Multiplicity of DNA end resection machineries in chromosome break repairPreprint
Niu, H., Raynard, S. J., & Sung, P. (2009) · Genes & Development · doi:10.1101/gad.1824209 · Cited by 40
Functional Specialization of Sensory Cilia by an RFX Transcription Factor Isoform
Wang, J., Schwartz, H. T., & Barr, M. M. (2010) · Genetics · doi:10.1534/genetics.110.122879 · Cited by 38
Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination
Germann, S. M., Oestergaard, V. H., Haas, C., Salis, P., Motegi, A., & Lisby, M. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.11.001 · Cited by 38
Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase
Navadgi, V. M., & Burgers, P. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390600 · Cited by 38
Activation of Protein Kinase Tel1 through Recognition of Protein-Bound DNA Ends
Fukunaga, K., Kwon, Y., Sung, P., & Sugimoto, K. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05157-11 · Cited by 37
DUN1 defines one branch downstream of RAD53 for transcription and DNA damage repair in Saccharomyces cerevisiae
de la Torre-Ruiz, M. Á., & Lowndes, N. F. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02198-0 · Cited by 31
Self-citation
The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNA
Lancelot, N., Charier, G., Couprie, J., Duband‐Goulet, I., Alpha‐Bazin, B., Quéméneur, É., Ma, É., Marsolier‐Kergoat, M., Ropars, V., Charbonnier, J., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm607 · Cited by 31
The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function
Gilbert, C. S., van den Bosch, M., Green, C., Vialard, J. E., Grenon, M., Erdjument‐Bromage, H., Tempst, P., & Lowndes, N. F. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor935 · Cited by 28
Self-citation
Cell cycle-dependent phosphorylation of Rad53 kinase by Cdc5 and Cdc28 modulates checkpoint adaptation
Schleker, T., Shimada, K., Sack, R., Pike, B. L., & Gasser, S. M. (2010) · Cell Cycle · doi:10.4161/cc.9.2.10448 · Cited by 28
Cooperative Control of Crb2 by ATM Family and Cdc2 Kinases Is Essential for the DNA Damage Checkpoint in Fission Yeast
Nakamura, T., Moser, B. A., Du, L.-L., & Russell, P. R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10721-10730.2005 · Cited by 27
Amino‐terminal domain of ATRIP contributes to intranuclear relocation of the ATR–ATRIP complex following DNA damage
Itakura, E., Takai, K., Umeda, K., Kimura, M., Ohsumi, M., Tamai, K., & Matsuura, A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.10.026 · Cited by 24
ATRMec1 Phosphorylation-independent Activation of Chk1 in Vivo
Chen, Y., Caldwell, J. M., Pereira, E., Baker, R. W., & Sánchez, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806530200 · Cited by 18
Probing ATR Activation with Model DNA Templates
Cimprich, K. A. (2007) · Cell Cycle · doi:10.4161/cc.6.19.4755 · Cited by 12

Sorted by citations

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Shiloh, Y., & Ziv, Y. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3546 · Cited by 1,649
Oxidative Stress and Programmed Cell Death in Yeast
Farrugia, G., & Balzan, R. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00064 · Cited by 323
Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress
Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247
FOXM1 (Forkhead box M1) in Tumorigenesis
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407190-2.00016-2 · Cited by 190
The Transcription Factor FOXM1 (Forkhead box M1)
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 180

See all 127

Authors: Finn, K., Lowndes, N. F., & Grenon, M.
Affiliations: Ollscoil na Gaillimhe – University of Galway (IE)
Corresponding author: Lowndes, Noel Francis
Grenon, Muriel
ORCID: Finn, Karen
Lowndes, Noel Francis
Grenon, Muriel
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2011-11-15
Volume: 69
Issue: 9
Pages: 1447-1473
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-011-0875-3
PMC: PMC11115150
OpenAlex: W1991917259
Cited by: 127
References: 399
Citations by year: 2026: 6 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 14 · 2018: 12 · 2017: 15 · 2016: 7 · 2015: 9 · 2014: 15 · 2013: 16 · 2012: 3
FWCI: 0.99
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: DNA damage checkpoint, DNA double-strand breaks, DNA damage response, genome stability, cell cycle arrest, DNA repair, Saccharomyces cerevisiae, genome rearrangement, cancer
MeSH terms: Checkpoint Kinase 1, Cell Cycle, DNA Damage, Humans, Models, Biological, Models, Genetic, Protein Kinases, Saccharomyces cerevisiae, Signal Transduction, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Saccharomyces cerevisiae Proteins, Genomic Instability, DNA Breaks, Double-Stranded, Eukaryota, Cell Cycle Checkpoints, Checkpoint Kinase 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks