An integrative view of microbiome-host interactions in inflammatory bowel diseases

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591 · see citing works

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T _reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works

Autophagy and Viruses: Adversaries or Allies?

Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,441 · see citing works

Ingestion of <i>Lactobacillus</i> strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works

Duodenal Infusion of Donor Feces for Recurrent <i>Clostridium difficile</i>

van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708 · see citing works

Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila

Moy, R. H., & Cherry, S. R. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,549 · see citing works

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · see citing works

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

Gevers, D., Kugathasan, S., Denson, L. A., Vázquez-Baeza, Y., Van Treuren, W., Ren, B., Schwager, E., Knights, D., Song, S. J., Yassour, M., et al. (2014) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2014.02.005 · Cited by 3,220 · see citing works

Human Genetics Shape the Gut Microbiome

Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164 · see citing works

An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System

Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910 · see citing works

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677 · see citing works

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476 · see citing works

A microbial symbiosis factor prevents intestinal inflammatory disease

Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340 · see citing works

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200 · see citing works

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

Scher, J. U., Sczesnak, A., Longman, R. S., Segata, N., Ubeda, C., Bielski, C., Rostron, T., Cerundolo, V., Pamer, E. G., Abramson, S. B., et al. (2013) · eLife · doi:10.7554/elife.01202 · Cited by 2,047 · see citing works

<i>Fusobacterium nucleatum</i> infection is prevalent in human colorectal carcinoma

Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043 · see citing works

The epidemiology of global micronutrient deficiencies

Bailey, R. L., West Jr., K. P., & Black, R. E. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000371618 · Cited by 2,035 · see citing works

Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity

Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025 · see citing works

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024 · see citing works

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1198719 · Cited by 1,988 · see citing works

Genomic analysis identifies association of <i>Fusobacterium</i> with colorectal carcinoma

Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., et al. (2012) · Genome Research · doi:10.1101/gr.126573.111 · Cited by 1,960 · see citing works

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921 · see citing works

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice

Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Hampe, J., Franke, A., Rosenstiel, P. C., Till, A., Teuber, M., Huse, K., Albrecht, M., Gabriele Mayr, B., Vega, F. M. D. L., Briggs, J. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1954 · Cited by 1,899 · see citing works

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

Buffie, C. G., Bucci, V., Stein, R. R., McKenney, P. T., Ling, L., Gobourne, A., No, D., Liu, H., Kinnebrew, M., Viale, A., et al. (2015) · Nature · doi:10.1038/nature13828 · Cited by 1,872 · see citing works

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770 · see citing works

Regional specialization within the intestinal immune system

Mowat, A. M., & Agace, W. W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3738 · Cited by 1,769 · see citing works

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769 · see citing works

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., Siebert, R., Baron, R. M., Kasper, D. L., et al. (2012) · Science · doi:10.1126/science.1219328 · Cited by 1,661 · see citing works

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

Macpherson, A. J., & Uhr, T. (2004) · Science · doi:10.1126/science.1091334 · Cited by 1,584 · see citing works

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

Cadwell, K., Liu, J. Y., Brown, S. L., Miyoshi, H., Loh, J., Lennerz, J. K., Kishi, C., Kc, W., Carrero, J. A., Hunt, S., et al. (2008) · Nature · doi:10.1038/nature07416 · Cited by 1,542 · see citing works

Symbiotic bacteria direct expression of an intestinal bactericidal lectin

Cash, H. L., Whitham, C. V., Behrendt, C. L., & Hooper, L. V. (2006) · Science · doi:10.1126/science.1127119 · Cited by 1,432 · see citing works

The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K., & Hooper, L. V. (2011) · Science · doi:10.1126/science.1209791 · Cited by 1,412 · see citing works

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

Palm, N. W., de Zoete, M. R., Cullen, T. W., Barry, N. A., Stefanowski, J., Hao, L., Degnan, P. H., Hu, J., Peter, I., Zhang, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.006 · Cited by 1,286 · see citing works

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.002 · Cited by 1,285 · see citing works

Sphingolipid metabolites in inflammatory disease

Maceyka, M. W., & Spiegel, S. (2014) · Nature · doi:10.1038/nature13475 · Cited by 1,284 · see citing works

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., et al. (2012) · Nature · doi:10.1038/nature11228 · Cited by 1,271 · see citing works

Measurement of gastrointestinal pH profiles in normal ambulant human subjects

Evans, D. F., Pye, G., Bramley, R., Clark, A. G., Dyson, T. J., & Hardcastle, J. D. (1988) · Gut · doi:10.1136/gut.29.8.1035 · Cited by 1,240 · see citing works

Viruses in the faecal microbiota of monozygotic twins and their mothers

Reyes, A., Haynes, M. R., Hanson, N., Angly, F. E., Heath, A. C., Rohwer, F. L., & Gordon, J. I. (2010) · Nature · doi:10.1038/nature09199 · Cited by 1,198 · see citing works

Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor

Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., et al. (2013) · Science · doi:10.1126/science.1229000 · Cited by 1,173 · see citing works

The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

Kostic, A. D., Gevers, D., Siljander, H., Vatanen, T., Hyötyläinen, T., Hämäläinen, A., Peet, A., Tillmann, V., Pöhö, P., Mattila, I. M., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.01.001 · Cited by 1,165 · see citing works

Enteric defensins are essential regulators of intestinal microbial ecology

Salzman, N. H., Hung, K., Haribhai, D., Chu, H., Karlsson-Sjöberg, J., Amir, E., Teggatz, P., Barman, M., Hayward, M., Eastwood, D., et al. (2010) · Nature Immunology · doi:10.1038/ni.1825 · Cited by 1,156 · see citing works

γ-Aminobutyric acid production by culturable bacteria from the human intestine

Barrett, E., Ross, R. P., O'Toole, P. W., Fitzgerald, G. F., & Stanton, C. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05344.x · Cited by 1,156 · see citing works

The indigenous gastrointestinal microflora

Berg, R. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10057-3 · Cited by 1,153 · see citing works

Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples

Segata, N., Haake, S. K., Mannon, P., Lemon, K. P., Waldron, L., Gevers, D., Huttenhower, C., & Izard, J. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r42 · Cited by 1,076 · see citing works

Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis

Iliev, I. D., Funari, V. A., Taylor, K. D., Nguyen, Q., Reyes, C. N., Strom, S. P., Brown, J., Becker, C. A., Fleshner, P. R., Dubinsky, M., et al. (2012) · Science · doi:10.1126/science.1221789 · Cited by 1,073 · see citing works

Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry

Ejsing, C. S., Sampaio, J. L., Surendranath, V., Duchoslav, E., Ekroos, K., Klemm, R. W., Simons, K., & Shevchenko, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811700106 · Cited by 1,071 · see citing works

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

Ng, K. M., Ferreyra, J. A., Higginbottom, S. K., Lynch, J. B., Kashyap, P. C., Gopinath, S., Naidu, N., Choudhury, B., Weimer, B. C., Monack, D. M., et al. (2013) · Nature · doi:10.1038/nature12503 · Cited by 1,035 · see citing works

Bacteria, Colonic Fermentation, and Gastrointestinal Health

Macfarlane, G. T., & Macfarlane, S. (2012) · Journal of AOAC INTERNATIONAL · doi:10.5740/jaoacint.sge_macfarlane · Cited by 970 · see citing works

Epithelial antimicrobial defence of the skin and intestine

Gallo, R. L., & Hooper, L. V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3228 · Cited by 959 · see citing works

Malnutrition and Infection: Complex Mechanisms and Global Impacts

Schaible, U. E., & Kaufmann, S. H. E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040115 · Cited by 958 · see citing works

Bacteriophage adhering to mucus provide a non–host-derived immunity

Barr, J. J., Auro, R., Furlan, M., Whiteson, K., Erb, M. L., Pogliano, J., Stotland, A. B., Wolkowicz, R., Cutting, A. S., Doran, K. S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305923110 · Cited by 944 · see citing works

The human gut virome: inter-individual variation and dynamic response to diet

Minot, S., Sinha, R., Chen, J., Li, H., Keilbaugh, S. A., Wu, G. D., Lewis, J. D., & Bushman, F. D. (2011) · Genome Research · doi:10.1101/gr.122705.111 · Cited by 935 · see citing works

The Interaction between Nutrition and Infection

Katona, P., & Katona‐Apte, J. (2008) · Clinical Infectious Diseases · doi:10.1086/587658 · Cited by 925 · see citing works

Gender Bias in Autoimmunity Is Influenced by Microbiota

Yurkovetskiy, L., Burrows, M. P., Khan, A. A., Graham, L., Volchkov, P., Becker, L., Antonopoulos, D. A., Umesaki, Y., & Chervonsky, A. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.013 · Cited by 912 · see citing works

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

Cadwell, K., Patel, K., Maloney, N. S., Liu, T., Ng, A., Storer, C. E., Head, R. D., Xavier, R. J., Stappenbeck, T. S., & Virgin, H. W. (2010) · Cell · doi:10.1016/j.cell.2010.05.009 · Cited by 897 · see citing works

Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota

Albenberg, L., Esipova, T. V., Judge, C. P., Bittinger, K., Chen, J., Laughlin, A., Grunberg, S., Baldassano, R. N., Lewis, J. D., Li, H., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.020 · Cited by 886 · see citing works

Metagenomic Analyses of an Uncultured Viral Community from Human Feces

Breitbart, M., Hewson, I., Felts, B., Mahaffy, J. M., Nulton, J., Salamon, P., & Rohwer, F. L. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.20.6220-6223.2003 · Cited by 828 · see citing works

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis

Mortha, A., Chudnovskiy, A., Hashimoto, D., Bogunovic, M., Spencer, S. P., Belkaid, Y., & Merad, M. (2014) · Science · doi:10.1126/science.1249288 · Cited by 820 · see citing works

Microbes, Microbiota, and Colon Cancer

Sears, C. L., & Garrett, W. S. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.007 · Cited by 820 · see citing works

Xenobiotics shape the physiology and gene expression of the active human gut microbiome

Maurice, C. F., Haiser, H. J., & Turnbaugh, P. J. (2013) · Cell · doi:10.1016/j.cell.2012.10.052 · Cited by 811 · see citing works

Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

Salzman, N. H., Ghosh, D., Huttner, K. M., Paterson, Y. Y. W., & Bevins, C. L. (2003) · Nature · doi:10.1038/nature01520 · Cited by 765 · see citing works

Effects of short chain fatty acids on gut morphology and function

Scheppach, W. (1994) · Gut · doi:10.1136/gut.35.1_suppl.s35 · Cited by 756 · see citing works

Intestinal Alkaline Phosphatase Detoxifies Lipopolysaccharide and Prevents Inflammation in Zebrafish in Response to the Gut Microbiota

Bates, J. M., Akerlund, J., Mittge, E., & Guillemin, K. J. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.10.010 · Cited by 752 · see citing works

Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation

Harig, J. M., Soergel, K. H., KOMOROWSKI, R. A., & Wood, C. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200105 · Cited by 748 · see citing works

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Donia, M. S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P. C., Fraser, J. S., & Fischbach, M. A. (2014) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2014.09.001 · Cited by 732 · see citing works

Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut

Petrof, E. O., Gloor, G. B., Vanner, S. J., Weese, S. J., Carter, D., Daigneault, M. C., Brown, E. M., Schroeter, K., & Allen-Vercoe, E. (2013) · Microbiome · doi:10.1186/2049-2618-1-3 · Cited by 731 · see citing works

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

Muller, P. A., Koscsó, B., Rajani, G. M., Stevanovic, K. D., Berres, M., Hashimoto, D., Mortha, A., Leboeuf, M., Li, X.-M., Mucida, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.050 · Cited by 727 · see citing works

The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates

Zoetendal, E. G., Raes, J., van den Bogert, B., Arumugam, M., Booijink, C. C. G. M., Troost, F. J., Bork, P., Wels, M., de Vos, W. M., & Kleerebezem, M. (2012) · The ISME Journal · doi:10.1038/ismej.2011.212 · Cited by 722 · see citing works

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

Wlodarska, M., Thaiss, C. A., Nowarski, R., Henao-Mejia, J., Zhang, J.-P., Brown, E. M., Frankel, G., Levy, M., Katz, M. N., Philbrick, W. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.026 · Cited by 708 · see citing works

Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium <i>Eggerthella lenta</i>

Haiser, H. J., Gootenberg, D. B., Chatman, K., Sirasani, G., Balskus, E. P., & Turnbaugh, P. J. (2013) · Science · doi:10.1126/science.1235872 · Cited by 704 · see citing works

New Insights on Classification, Identification, and Clinical Relevance ofBlastocystisspp

Tan, K. S. W. (2008) · Clinical Microbiology Reviews · doi:10.1128/cmr.00022-08 · Cited by 701 · see citing works

Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells.

Heller, F., Fuss, I., Nieuwenhuis, E., Blumberg, R., & Strober, W. (2002) · Immunity · doi:10.1016/s1074-7613(02)00453-3 · Cited by 648 · see citing works

Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells

An, D., Oh, S. F., Olszak, T., Neves, J. F., Avci, F. Y., Erturk-Hasdemir, D., Lu, X., Zeissig, S., Blumberg, R. S., & Kasper, D. L. (2014) · Cell · doi:10.1016/j.cell.2013.11.042 · Cited by 643 · see citing works

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

Shan, M., Gentile, M., Yeiser, J. R., Walland, A. C., Bornstein, V. U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., et al. (2013) · Science · doi:10.1126/science.1237910 · Cited by 642 · see citing works

Metagenomics and future perspectives in virus discovery

Mokili, J., Rohwer, F., & Dutilh, B. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.12.004 · Cited by 606 · see citing works

Rapid evolution of the human gut virome

Minot, S. S., Bryson, A. L., Chehoud, C., Wu, G. D., Lewis, J. D., & Bushman, F. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300833110 · Cited by 593 · see citing works

Invasive potential of gut mucosa-derived fusobacterium nucleatum positively correlates with IBD status of the host

Strauss, J., Kaplan, G. G., Beck, P. L., Rioux, K. P., Panaccione, R., DeVinney, R., Lynch, T., & Allen‐Vercoe, E. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21606 · Cited by 574 · see citing works

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

Goto, Y., Obata, T., Kunisawa, J., Sato, S., Ivanov, I. I., Lamichhane, A., Takeyama, N., Kamioka, M., Sakamoto, M., Matsuki, T., et al. (2014) · Science · doi:10.1126/science.1254009 · Cited by 568 · see citing works

Towards the Human Colorectal Cancer Microbiome

Marchesi, J. R., Dutilh, B. E., Hall, N., Peters, W. H. M., Roelofs, R., Boleij, A., & Tjalsma, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020447 · Cited by 552 · see citing works

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

Pickard, J. M., Maurice, C. F., Kinnebrew, M. A., Abt, M. C., Schenten, D., Golovkina, T. V., Bogatyrev, S. R., Ismagilov, R. F., Pamer, E. G., Turnbaugh, P. J., et al. (2014) · Nature · doi:10.1038/nature13823 · Cited by 535 · see citing works

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

Haberman, Y., Tickle, T. L., Dexheimer, P. J., Kim, M., Tang, D., Karns, R. A., Baldassano, R. N., Noe, J. D., Rosh, J. R., Markowitz, J. F., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75436 · Cited by 521 · see citing works

Focused specificity of intestinal TH17 cells towards commensal bacterial antigens

Yang, Y., Torchinsky, M. B., Gobert, M., Xiong, H., Xu, M., Linehan, J. L., Alonzo, F., Ng, C., Chen, A., Lin, X., et al. (2014) · Nature · doi:10.1038/nature13279 · Cited by 520 · see citing works

Fusobacterium Is Associated with Colorectal Adenomas

McCoy, A. N., Araújo-Pérez, F., Azcárate-Peril, M. A., Yeh, J. J., Sandler, R. S., & Keku, T. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053653 · Cited by 516 · see citing works

An enteric virus can replace the beneficial function of commensal bacteria

Kernbauer, E., Ding, Y., & Cadwell, K. (2014) · Nature · doi:10.1038/nature13960 · Cited by 513 · see citing works

Water, sanitation, and hygiene (WASH), environmental enteropathy, nutrition, and early child development: making the links

Ngure, F. M., Reid, B. M., Humphrey, J. H., Mbuya, M. N. N., Pelto, G. H., & Stoltzfus, R. J. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12330 · Cited by 502 · see citing works

Immunoproliferative Small Intestinal Disease Associated with Campylobacter jejuni

Lecuit, M., Abachin, É., Martin, A., Poyart, C., Pochart, P., Suárez, F., Bengoufa, D., Feuillard, J., Lavergne‐Slove, A., Gordon, J. I., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031887 · Cited by 461 · see citing works

Environmental enteropathy: critical implications of a poorly understood condition

Korpe, P. S., & Petri, W. A. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.04.007 · Cited by 449 · see citing works

Dysbiosis in inflammatory bowel diseases: the oxygen hypothesis

Rigottier‐Gois, L. (2013) · The ISME Journal · doi:10.1038/ismej.2013.80 · Cited by 437 · see citing works

Enteric Glia Regulate Intestinal Barrier Function and Inflammation Via Release of S-Nitrosoglutathione

Savidge, T., Newman, P., Pothoulakis, C., Rühl, A., Neunlist, M., Bourreille, A., Hurst, R. D., & Sofroniew, M. V. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.051 · Cited by 435 · see citing works

Immune Responses to the Microbiota at the Intestinal Mucosal Surface

Duerkop, B. A., Vaishnava, S., & Hooper, L. V. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.009 · Cited by 424 · see citing works

Complex host genetics influence the microbiome in inflammatory bowel disease

Knights, D., Silverberg, M. S., Weersma, R. K., Gevers, D., Dijkstra, G., Huang, H., Tyler, A. D., van Sommeren, S., Imhann, F., Stempak, J. M., et al. (2014) · Genome Medicine · doi:10.1186/s13073-014-0107-1 · Cited by 418 · see citing works

Intestinal absorption of water-soluble vitamins in health and disease

Said, H. M. (2011) · Biochemical Journal · doi:10.1042/bj20110326 · Cited by 416 · see citing works

Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid

Chyan, Y., Pöeggeler, B., Omar, R., Chain, D. G., Frangione, B., Ghiso, J. A., & Pappolla, M. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21937 · Cited by 409 · see citing works

Human interdigestive motility: variations in patterns from esophagus to colon.

Kellow, J., Borody, T., Phillips, S., Tucker, R., & Haddad, A. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90573-1 · Cited by 397 · see citing works

Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation

Cullen, T. W., Schofield, W. B., Barry, N. A., Putnam, E. E., Rundell, E. A., Trent, M. S., Degnan, P. H., Booth, C. J., Yu, H., & Goodman, A. L. (2015) · Science · doi:10.1126/science.1260580 · Cited by 395 · see citing works

Variable geographic distribution of Blastocystis subtypes and its potential implications

Alfellani, M. A., Stensvold, C. R., Vidal-Lapiedra, A., Onuoha, E. S. U., Fagbenro-Beyioku, A. F., & Clark, C. G. (2013) · Acta Tropica · doi:10.1016/j.actatropica.2012.12.011 · Cited by 390 · see citing works

Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging

He, G., Shankar, R. A., Chzhan, M., Samouilov, A., Kuppusamy, P., & Zweier, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4586 · Cited by 383 · see citing works

Immunoproliferative small intestinal disease associated with Campylobacter jejuni

Mesnard, B., Vroey, B. D., Maunoury, V., & Lecuit, M. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.03.020 · Cited by 382 · see citing works

Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition

Goldberg, R. F., Austen, W., Zhang, X.-B., Munene, G., Mostafa, G., Biswas, S., McCormack, M., Eberlin, K., Nguyen, J. T., Tatlıdede, H. S., et al. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0712140105 · Cited by 381 · see citing works

Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy

Kau, A. L., Planer, J. D., Liu, J., Rao, S. M., Yatsunenko, T., Trehan, I., MANARY, M. J., Liu, T., Stappenbeck, T. S., Maleta, K. M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa4877 · Cited by 373 · see citing works

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

Larsson, J. M. H., Karlsson, H., Crespo, J. G., Johansson, M., Eklund, L., Sjövall, H., & Hansson, G. C. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21625 · Cited by 361 · see citing works

Microbiota controls the homeostasis of glial cells in the gut lamina propria

Kabouridis, P. S., Lasrado, R., McCallum, S., Chng, S. H., Snippert, H. J., Clevers, H., Pettersson, S., & Pachnis, V. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.037 · Cited by 358 · see citing works

Household Environmental Conditions Are Associated with Enteropathy and Impaired Growth in Rural Bangladesh

Lin, A., Arnold, B. F., Afreen, S., Goto, R., Huda, T. M. N., Haque, R., Raqib, R., UNICOMB, L. E., Ahmed, T., Colford, J. M., et al. (2013) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.12-0629 · Cited by 347 · see citing works

The Multifaceted Role of the Intestinal Microbiota in Colon Cancer

Irrazábal, T., Belcheva, A., Girardin, S. E., Martín, A., & Philpott, D. J. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.039 · Cited by 345 · see citing works

Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease?

Cornet, A. M., Savidge, T., Cabarrocas, J., Deng, W., Colombel, J., Lassmann, H., Desreumaux, P., & Liblau, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231474098 · Cited by 321 · see citing works

Dietary modulation of the microbiome affects autoinflammatory disease

Lukens, J. R., Gurung, P., Vogel, P., Johnson, G. R., Carter, R. A., McGoldrick, D. J., Bandi, S. R., Calabrese, C. R., Walle, L. V., Lamkanfi, M., et al. (2014) · Nature · doi:10.1038/nature13788 · Cited by 314 · see citing works

Toll-Like Receptor 2 Regulates Intestinal Inflammation by Controlling Integrity of the Enteric Nervous System

Brun, P., Giron, M. C., Qesari, M., Porzionato, A., Caputi, V., Zoppellaro, C., Banzato, S., Grillo, A. R., Spagnol, L., De Caro, R., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.047 · Cited by 300 · see citing works

Environmental Enteric Dysfunction: Pathogenesis, Diagnosis, and Clinical Consequences

Keusch, G. T., Denno, D. M., Black, R. E., Duggan, C., Guerrant, R. L., Lavery, J. V., Nataro, J. P., Rosenberg, I. H., Ryan, E. T., Tarr, P. I., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu485 · Cited by 294 · see citing works

Contribution of Enteric Infection, Altered Intestinal Barrier Function, and Maternal Malnutrition to Infant Malnutrition in Bangladesh

Mondal, D., Minak, J., Alam, M., Liu, Y., Dai, J., Korpe, P. S., Liu, L., Haque, R., & Petri, W. A. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir807 · Cited by 277 · see citing works

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

Patel, K., Miyoshi, H., Beatty, W. L., Head, R. D., Malvin, N. P., Cadwell, K., Guan, J., Saitoh, T., Akira, S., Seglen, P. O., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.233 · Cited by 274 · see citing works

Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation

Moon, C., Baldridge, M. T., Wallace, M. A., Burnham, C.-A. D., Virgin, H. W., & Stappenbeck, T. S. (2015) · Nature · doi:10.1038/nature14139 · Cited by 268 · see citing works

Immunoproliferative small intestinal disease associated with Campylobacter jejuni

Lecuit, M. (2009) · Hematology Meeting Reports · doi:10.4081/hmr.v1i5.265 · Cited by 264 · see citing works

Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells

Blumberg, R. S., Terhorst, C., Bleicher, P. A., McDermott, F. V., Allan, C. H., Landau, S. B., Trier, J. S., & Balk, S. P. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.8.2518 · Cited by 263 · see citing works

The microbial eukaryote Blastocystis is a prevalent and diverse member of the healthy human gut microbiota

Scanlan, P. D., Stensvold, C. R., Rajilić-Stojanović, M. D., Heilig, H. G. H. J., de Vos, W. M., O’Toole, P. W., & Cotter, P. D. (2014) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12396 · Cited by 261 · see citing works

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota

Brown, L. C. W., Peñaranda, C., Kashyap, P., Williams, B. B., Clardy, J., Kronenberg, M., Sonnenburg, J. L., Comstock, L. E., Bluestone, J. A., & Fischbach, M. A. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001610 · Cited by 259 · see citing works

pH‐Profile and regional transit times of the normal gut measured by a radiotelemetry device

Fallingborg, J., Christensen, L. A., Ingeman‐Nielsen, M., Jacobsen, B. A., ABILDGAARD, K., & Rasmussen, H. H. (1989) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1989.tb00254.x · Cited by 243 · see citing works

On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae. 1929.

Fleming, A. (2001) · PubMed Central · Cited by 242 · see citing works

Clinical features and diagnosis of celiac disease

Dewar, D. H., & Ciclitira, P. J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.010 · Cited by 213 · see citing works

Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms

Al‐Saleem, T., & Al-Mondhiry, H. A. B. (2004) · Blood · doi:10.1182/blood-2004-07-2755 · Cited by 207 · see citing works

Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine

Margolis, K. G., Stevanovic, K. D., Li, Z., Yang, Q., Oravecz, T., Zambrowicz, B., Jhaver, K. G., Diacou, A., & Gershon, M. D. (2013) · Gut · doi:10.1136/gutjnl-2013-304901 · Cited by 192 · see citing works

Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

Schutte, A. H., Ermund, A., Becker‐Pauly, C., Johansson, M., Rodríguez-Piñeiro, A. M., Bäckhed, F., Müller, S., Lottaz, D., Bond, J. S., & Hansson, G. C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407597111 · Cited by 190 · see citing works

Sphingolipids in Bacteria and Fungi

Olsen, I., & Jantzen, E. (2001) · Anaerobe · doi:10.1006/anae.2001.0376 · Cited by 186 · see citing works

Abundant and Diverse Fungal Microbiota in the Murine Intestine

Scupham, A. J., Presley, L. L., Wei, B., Bent, E., Griffith, N., McPherson, M., Zhu, F., Oluwadara, O., Rao, N. P., Braun, J. G., et al. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.1.793-801.2006 · Cited by 185 · see citing works

Communities of microbial eukaryotes in the mammalian gut within the context of environmental eukaryotic diversity

Parfrey, L. W., Walters, W. A., Lauber, C. L., Clemente, J. C., Berg-Lyons, D., Teiling, C., Kodira, C. D., Mohiuddin, M., Brunelle, J., Driscoll, M. D., et al. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00298 · Cited by 182 · see citing works

Short- and long-term therapeutic efficacy of nutritional therapy and corticosteroids in paediatric Crohn's disease

Canani, R. B., Terrin, G., Borrelli, O., Romano, M. T., Manguso, F., Coruzzo, A., D’Armiento, F. P., Romeo, E. F., & Cucchiara, S. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2005.10.005 · Cited by 178 · see citing works

Growth and host interaction of mouse segmented filamentous bacteria in vitro

Schnupf, P., Gaboriau‐Routhiau, V., Gros, M., Friedman, R. C., Moya‐Nilges, M., Nigro, G., Cerf–Bensussan, N., & Sansonetti, P. J. (2015) · Nature · doi:10.1038/nature14027 · Cited by 175 · see citing works

RESPONSES OF SMALL INTESTINAL ARCHITECTURE AND FUNCTION OVER TIME TO ENVIRONMENTAL FACTORS IN A TROPICAL POPULATION

Kelly, P. M., Menzies, I. S., Crane, R., Zulu, I., Nickols, C. D., Feakins, R. M., Mwansa, J. C. L., Mudenda, V. C., Katubulushi, M., GREENWALD, S., et al. (2004) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2004.70.412 · Cited by 157 · see citing works

Influence of Milk-Feeding Type and Genetic Risk of Developing Coeliac Disease on Intestinal Microbiota of Infants: The PROFICEL Study

Palma, G. D., Capilla, A., Nova, E., Castillejo, G., Varea, V., Pozo, T., Garrote, J. A., Polanco, I., López, A., Ribes‐Koninckx, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030791 · Cited by 150 · see citing works

Mucosal bacterial microflora and mucus layer thickness inadolescents with inflammatory bowel disease

Fyderek, K., Strus, M., Kowalska‐Duplaga, K., Gosiewski, T., Wędrychowicz, A., Jedynak‐Wąsowicz, U., Sładek, M., Pieczarkowski, S., Adamski, P., Kochan, P., et al. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5287 · Cited by 149 · see citing works

Norovirus Triggered Microbiota-driven Mucosal Inflammation in Interleukin 10-deficient Mice

Basic, M., Keubler, L. M., Büettner, M., Achard, M., Breves, G., Schröder, B., Smoczek, A., Jörns, A., Wedekind, D., Zschemisch, N., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000441346.86827.ed · Cited by 143 · see citing works

Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase.

Henthorn, P. S., Raducha, M. G., Edwards, Y. H., Weiss, M. J., Slaughter, C. A., Lafferty, M. A., & Harris, H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1234 · Cited by 137 · see citing works

Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate

Kajiya, M., Silva, M. J. B., Sato, K., Ouhara, K., & Kawai, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.117 · Cited by 127 · see citing works

GABA in the Mammalian Enteric Nervous System

Krantis, A. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.6.284 · Cited by 120 · see citing works

Commensal microbiota stimulate systemic neutrophil migration through induction of Serum amyloid A

Kanther, M., Tomkovich, S., Sun, X., Grosser, M. R., Koo, J. S., Flynn, E. J., Jobin, C., & Rawls, J. F. (2013) · Cellular Microbiology · doi:10.1111/cmi.12257 · Cited by 107 · see citing works

Abnormal Gut Integrity Is Associated With Reduced Linear Growth in Rural Malawian Children

Weisz, A. J., Manary, M. J., Stephenson, K. B., Agapova, S. E., Manary, F. G., Thakwalakwa, C. M., Shulman, R. J., & MANARY, M. J. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182650a4d · Cited by 105 · see citing works

A Multicenter, Randomized, Double-Blind Trial of Everolimus Versus Azathioprine and Placebo to Maintain Steroid-Induced Remission in Patients With Moderate-to-Severe Active Crohn's Disease

Reinisch, W., Panés, J., Lémann, M., Schreiber, S., Feagan, B. G., Schmidt, S. L., Sturniolo, G. C., Mikhailova, T. L., Alexeeva, O., Sanna, L., et al. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.02024.x · Cited by 102 · see citing works

Fecal Microbiota Transplantation in Inflammatory Bowel Disease

Ianiro, G., Bibbò, S., Scaldaferri, F., Gasbarrini, A., & Cammarota, G. (2014) · Medicine · doi:10.1097/md.0000000000000097 · Cited by 98 · see citing works

Active ulcerative colitis associated with low prevalence of Blastocystis and Dientamoeba fragilis infection

Petersen, A. M., Stensvold, C. R., Mirsepasi‐Lauridsen, H. C., Engberg, J., Friis‐Møller, A., Porsbo, L. J., Hammerum, A. M., Nordgaard-Lassen, I., Nielsen, H. V., & Krogfelt, K. A. (2013) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2013.780094 · Cited by 98 · see citing works

Jejunal microflora in malnourished Gambian children.

Heyworth, B., & Brown, J. L. (1975) · Archives of Disease in Childhood · doi:10.1136/adc.50.1.27 · Cited by 93 · see citing works

Bacterial, archaeal, and eukaryal diversity in the intestines of Korean people

Nam, Y., Chang, H.-W., Kim, K., Roh, S. W., Kim, M., Jung, M., Lee, S., Kim, J.-Y., Yoon, J., & Bae, J. (2008) · The Journal of Microbiology · doi:10.1007/s12275-008-0199-7 · Cited by 93 · see citing works

Impaired Nutrient Signaling and Body Weight Control in a Na+ Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse

Bröer, A., Juelich, T., Vanslambrouck, J. M., Tietze, N., Solomon, P. S., Holst, J., Bailey, C. G., Rasko, J. E. J., & Bröer, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.241323 · Cited by 88 · see citing works

The intestinal protozoa

Turkeltaub, J. A., McCarty, T. R., & Hotez, P. J. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000135 · Cited by 86 · see citing works

Crohn's disease: small bowel motility impairment correlates with inflammatory‐related markers C‐reactive protein and calprotectin

Bickelhaupt, S., Pazahr, S., Chuck, N. C., Blume, I. N., Froehlich, J. M., Cattin, R., Raible, S., Bouquet, H., Bill, U., Rogler, G., et al. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12088 · Cited by 77 · see citing works

Changes of faecal microbiota in patients with Crohn's disease treated with an elemental diet and total parenteral nutrition

Shiga, H., Kajiura, T., Shinozaki, J., Takagi, S., Kinouchi, Y., Takahashi, S., Negoro, K., Endo, K., Kakuta, Y., Suzuki, M., et al. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.04.014 · Cited by 76 · see citing works

Microbes and Inflammation in Colorectal Cancer

Kostic, A. D., Chun, E., Meyerson, M. M., & Garrett, W. S. (2013) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0101 · Cited by 71 · see citing works

Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease.

Molnár, K., Vannay, Á., Szebeni, B., Bánki, N. F., Sziksz, E., Cseh, Á., Győrffy, H., Lakatos, P. L., Papp, M., Arató, A., et al. (2012) · Europe PMC (PubMed Central) · doi:10.3748/wjg.v18.i25.3254 · Cited by 64 · see citing works

Butyrate enemas enhance both cholinergic and nitrergic phenotype of myenteric neurons and neuromuscular transmission in newborn rat colon

Suply, E., de Vries, P., Soret, R., Cossais, F., & Neunlist, M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00338.2011 · Cited by 62 · see citing works

Breath Hydrogen Test in the Diagnosis of Environmental Enteropathy in Children Living in an Urban Slum

dos Reis, J. C., de Morais, M. B., Oliva, C. A. G., & Fagundes‐Neto, U. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9288-9 · Cited by 60 · see citing works

Asymptomatic environmental enteropathy among slum-dwelling infants.

Neto, U. F., Martins, M. C., Lima, F. L., Patrı́cio, F. R. D. S., & Toledo, M. R. (1994) · Journal of the American College of Nutrition · doi:10.1080/07315724.1994.10718371 · Cited by 50 · see citing works

Serotonin receptor modulators in the treatment of irritable bowel syndrome

Lackner, J. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s140 · Cited by 47 · see citing works

Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine

Beuling, E., Kerkhof, I. M., Nicksa, G. A., Giuffrida, M. J., Haywood, J., de Kerk, D. J. A., Piaseckyj, C. M., Pu, W. T., Buchmiller, T. L., Dawson, P. A., et al. (2010) · Gut · doi:10.1136/gut.2009.204990 · Cited by 44 · see citing works

Upper Small Intestinal Microflora in Diarrhea and Malnutrition in Nigerian Children

Omoike, I. U., & Abiodun, P. O. (1989) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-198910000-00009 · Cited by 44 · see citing works

Rapamycin decreases leukocyte migration in vivo and effectively reduces experimentally induced chronic colitis

Farkas, S. A., Hornung, M., Sattler, C., Guba, M. O., Steinbauer, M. G. M., Anthuber, M., Herfarth, H. H., Schlitt, H. J., & Geissler, E. K. (2005) · International Journal of Colorectal Disease · doi:10.1007/s00384-005-0793-7 · Cited by 43 · see citing works

Conservation of Gene Cassettes among Diverse Viruses of the Human Gut

Minot, S. S., Wu, G. D., Lewis, J. D., & Bushman, F. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042342 · Cited by 37 · see citing works

Downregulation of CPI-17 contributes to dysfunctional motility in chronic intestinal inflammation model mice and ulcerative colitis patients

Ohama, T., Hori, M., Fujisawa, M., Kiyosue, M., Hashimoto, M., Ikenoue, Y., Jinno, Y., Miwa, H., Matsumoto, T., Murata, T., et al. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-008-2241-2 · Cited by 37 · see citing works

Epidemiology of Small Bowel Bacterial Overgrowth and Rice Carbohydrate Malabsorption in Burmese (Myanmar) Village Children

Khin-Maung-U, K.-M.-U., Bolin, T. D., Duncombe, V. M., Myo-Khin, Nyunt‐Nyunt‐Wai, Pereira, S. P., & Linklater, J. (1992) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1992.47.298 · Cited by 34 · see citing works

Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors

Murakami, I., Wakasa, Y., Yamashita, S., Kurihara, T., Zama, K., Kobayashi, N., Mizutani, Y., Mitsutake, S., Shigyo, T., & Igarashi, Y. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-150 · Cited by 29 · see citing works

Gut microbiome structure and metabolic activity in inflammatory bowel disease

Franzosa, E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H. J., Reinker, S., Vatanen, T., Hall, A. B., Mallick, H., McIver, L. J., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0306-4 · Cited by 1,995 · see citing works

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Baruch, E. N., Youngster, I., Ben-Betzalel, G., Ortenberg, R., Lahat, A., Katz, L., Adler, K., Dick-Necula, D., Raskin, S., Bloch, N., et al. (2021) · Science · doi:10.1126/science.abb5920 · Cited by 1,757 · see citing works

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

Gao, J., Xu, K., Liu, H., Liu, G., Bai, M., Peng, C., Li, T., & Yin, Y. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00013 · Cited by 1,313 · see citing works

The Human Gut Microbiome: From Association to Modulation

Schmidt, T. S. B., Raes, J., & Bork, P. (2018) · Cell · doi:10.1016/j.cell.2018.02.044 · Cited by 845 · see citing works

Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

Sartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808 · see citing works

Mechanisms and consequences of intestinal dysbiosis

Weiss, G. A., & Hennet, T. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2509-x · Cited by 775 · see citing works

Adhesion mechanisms mediated by probiotics and prebiotics and their potential impact on human health

Monteagudo-Mera, A., Rastall, R. A., Gibson, G. R., Charalampopoulos, D., & Chatzifragkou, A. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09978-7 · Cited by 743 · see citing works

Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals

Ormerod, K. L., Wood, D., Lachner, N., Gellatly, S. L., Daly, J. N., Parsons, J. D., Dal’Molin, C. G. D. O., Palfreyman, R. W., Nielsen, L. K., Cooper, M. A., et al. (2016) · Microbiome · doi:10.1186/s40168-016-0181-2 · Cited by 675 · see citing works

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

Chu, H., Khosravi, A., Kusumawardhani, I. P., Kwon, A. H. K., Vasconcelos, A. C., Cunha, L. D., Mayer, A. E., Shen, Y., Wu, W.-L., Kambal, A., et al. (2016) · Science · doi:10.1126/science.aad9948 · Cited by 647 · see citing works

Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis

Brown, E., Ke, X., Hitchcock, D. S., Jeanfavre, S., Ávila-Pacheco, J., Nakata, T., Arthur, T. D., Fornelos, N., Heim, C. E., Franzosa, E. A., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.04.002 · Cited by 539 · see citing works

Human genetic variation and the gut microbiome in disease

Hall, A. B., Tolonen, A. C., & Xavier, R. J. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.63 · Cited by 517 · see citing works

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works

Faecal microbiota study reveals specific dysbiosis in spondyloarthritis

Bréban, M., Tap, J., Leboime, A., Said‐Nahal, R., Langella, P., Chiocchia, G., Furet, J., & Sokol, H. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-211064 · Cited by 396 · see citing works

Holes in the Hologenome: Why Host-Microbe Symbioses Are Not Holobionts

Douglas, A. E., & Werren, J. H. (2016) · mBio · doi:10.1128/mbio.02099-15 · Cited by 366 · see citing works

Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease

Mirsepasi‐Lauridsen, H. C., Vallance, B. A., Krogfelt, K. A., & Petersen, A. M. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00060-18 · Cited by 374 · see citing works

Microbiome therapeutics — Advances and challenges

Mimee, M., Citorik, R. J., & Lu, T. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.032 · Cited by 317 · see citing works

Gut Microbiota Regulation of T Cells During Inflammation and Autoimmunity

Brown, E., Kenny, D. J., & Xavier, R. J. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041841 · Cited by 310 · see citing works

The role of the gut microbiota in development, function and disorders of the central nervous system and the enteric nervous system

Heiss, C. N., & Olofsson, L. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12684 · Cited by 304 · see citing works

Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course

Schirmer, M., Denson, L. A., Vlamakis, H. C., Franzosa, E. A., Thomas, S., Gotman, N., Rufo, P. A., Baker, S. S., Sauer, C. G., Markowitz, J. F., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.09.009 · Cited by 287 · see citing works

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

Matsuzawa, Y., Shono, Y., Gomez, L. E., Hubbard-Lucey, V. M., Cammer, M., Neil, J. A., Dewan, M. Z., Lieberman, S. R., Lazrak, A., Marinis, J. M., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170558 · Cited by 289 · see citing works

Dual Role of Indoles Derived From Intestinal Microbiota on Human Health

Ye, X., Li, H., Anjum, K., Zhong, X., Miao, S., Zheng, G., Liu, W., & Li, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.903526 · Cited by 282 · see citing works

Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic ( Allium sativum L.) Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis

Shao, X., Sun, C., Tang, X., Zhang, X., Han, D., Liang, S., Qu, R., Hui, X., Shan, Y., Hu, L., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04773 · Cited by 249 · see citing works

Mucosal Barrier Depletion and Loss of Bacterial Diversity are Primary Abnormalities in Paediatric Ulcerative Colitis

Alipour, M., Zaidi, D., Valcheva, R. S., Jovel, J., Martínez, I., Sergi, C. M., Walter, J., Mason, A. L., Wong, G. K., Dieleman, L. A., et al. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv223 · Cited by 248 · see citing works

A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers

Takahashi, M. K., Tan, X., Dy, A. J., Braff, D., Akana, R., Furuta, Y., Donghia, N. M., Ananthakrishnan, A. N., & Collins, J. J. (2018) · Nature Communications · doi:10.1038/s41467-018-05864-4 · Cited by 238 · see citing works

A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice

Chiaro, T. R., Soto, R., Stephens, W. Z., Kubinak, J. L., Petersen, C., Gogokhia, L., Bell, R. S., Delgado, J. C., Cox, J. E., Voth, W. P., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf9044 · Cited by 234 · see citing works

Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning

Staley, C. M., Kaiser, T., Beura, L. K., Hamilton, M. J., Weingarden, A. R., Bobr, A., Kang, J., Masopust, D., Sadowsky, M. J., & Khoruts, A. (2017) · Microbiome · doi:10.1186/s40168-017-0306-2 · Cited by 236 · see citing works

Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206 + macrophages IL-10 activation

Jia, D., Wang, Q.-W., Hu, Y., He, J., Ge, Q., Qi, Y., Chen, L.-Y., Zhang, Y., Fan, L., Lin, Y., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2145843 · Cited by 222 · see citing works

The Effects of Nutrition on the Gastrointestinal Microbiome of Cats and Dogs: Impact on Health and Disease

Wernimont, S. M., Radosevich, J., Jackson, M. I., Ephraim, E., Badri, D. V., MacLeay, J. M., Jewell, D. E., & Suchodolski, J. S. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01266 · Cited by 220 · see citing works

Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe

Lamichhane, S., Sen, P., Dickens, A. M., Orešič, M., & Bertram, H. C. (2018) · Methods · doi:10.1016/j.ymeth.2018.04.029 · Cited by 200 · see citing works

5-Aminosalicylic Acid Alters the Gut Bacterial Microbiota in Patients With Ulcerative Colitis

Xu, J., Chen, N., Wu, Z., Song, Y., Zhang, Y., Wu, N., Zhang, F., Ren, X., & Liu, Y. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01274 · Cited by 186 · see citing works

Polysaccharides, proteins, and their complex as microencapsulation carriers for delivery of probiotics: A review on carrier types and encapsulation techniques

Xie, A., Zhao, S., Liu, Z., Yue, X., Shao, J., Li, M., & Li, Z. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124784 · Cited by 180 · see citing works

A Review of Inflammatory Bowel Disease: A Model of Microbial, Immune and Neuropsychological Integration

Tavakoli, P., Vollmer-Conna, U. S., Hadzi-Pavlovic, D., & Grimm, M. (2021) · Public health reviews · doi:10.3389/phrs.2021.1603990 · Cited by 173 · see citing works

Determinants of IBD Heritability: Genes, Bugs, and More

Turpin, W., Goethel, A., Bedrani, L., & Croitoru, M. K. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy085 · Cited by 161 · see citing works

Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization

Yeung, F., Chen, Y.-H., Lin, J.-D., Leung, J. M., McCauley, C., Devlin, J. C., Hansen, C., Cronkite, A., Stephens, Z., Drake-Dunn, C., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.02.015 · Cited by 154 · see citing works

Alcohol, Inflammation, and Microbiota in Alcoholic Liver Disease

Dukić, M., Radonjić, T., Jovanović, I., Zdravkovic, M. D., Todorović, Z., Kraišnik, N., Aranđelović, B., Mandić, O., Popadić, V., Nikolić, N., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043735 · Cited by 155 · see citing works

Modulation of the microbiota-gut-brain axis by probiotics in a murine model of inflammatory bowel disease

Emge, J. R., Huynh, K., Miller, E. N., Kaur, M., Reardon, C., Barrett, K. E., & Gareau, M. G. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00086.2016 · Cited by 152 · see citing works

Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation

Chai, J. N., Peng, Y., Rengarajan, S., Solomon, B. D., Ai, T. L., Shen, Z., Perry, J. S. A., Knoop, K. A., Tanoue, T., Narushima, S., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aal5068 · Cited by 147 · see citing works

Attenuation of DSS induced colitis by Dictyophora indusiata polysaccharide (DIP) via modulation of gut microbiota and inflammatory related signaling pathways

Kanwal, S., Joseph, T. P., Aliya, S., Song, S., Saleem, M. Z., Nisar, M. A., Wang, Y., Meyiah, A., Ma, Y., & Xin, Y. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103641 · Cited by 149 · see citing works

Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications

Boyapati, R. K., Rossi, A. G., Satsangi, J., & Ho, G. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.14 · Cited by 148 · see citing works

Ursodeoxycholic Acid and Its Taurine- or Glycine-Conjugated Species Reduce Colitogenic Dysbiosis and Equally Suppress Experimental Colitis in Mice

den Bossche, L. V., Hindryckx, P., Devisscher, L., Devriese, S., Welden, S. V., Holvoet, T., Vilchez‐Vargas, R., Vital, M., Pieper, D. H., Bussche, J. V., et al. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.02766-16 · Cited by 146 · see citing works

Carcinogenesis and therapeutics: the microbiota perspective

Tsilimigras, M. C. B., Fodor, A., & Jobin, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.8 · Cited by 144 · see citing works

Camellia sinensis and Litsea coreana Ameliorate Intestinal Inflammation and Modulate Gut Microbiota in Dextran Sulfate Sodium‐Induced Colitis Mice

Liu, Y., Wang, X., Chen, Q., Luo, L., Ma, M., Xiao, B., & Zeng, L. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900943 · Cited by 135 · see citing works

Generation of axenic Aedes aegypti demonstrate live bacteria are not required for mosquito development

Correa, M. A., Matusovsky, B., Brackney, D. E., & Steven, B. T. (2018) · Nature Communications · doi:10.1038/s41467-018-07014-2 · Cited by 134 · see citing works

Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

Yamada, T., Hino, S., Iijima, H., Genda, T., Aoki, R., Nagata, R., Han, K., Hirota, M., Kinashi, Y., Oguchi, H., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.09.008 · Cited by 126 · see citing works

Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease

Moustafa, A. M., Li, W., Anderson, E. L., Wong, E., Dulai, P. S., Sandborn, W. J., Biggs, W., Yooseph, S., Jones, M. B., Venter, C. J., et al. (2018) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2017.58 · Cited by 116 · see citing works

Sesamol Supplementation Attenuates DSS-Induced Colitis via Mediating Gut Barrier Integrity, Inflammatory Responses, and Reshaping Gut Microbiome

Zhao, B., Xia, B., Li, X., Zhang, L., Liu, X., Shi, R., Kou, R.-W., Liu, Z., & Liu, X. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04370 · Cited by 116 · see citing works

The human gastrointestinal tract and oral microbiota in inflammatory bowel disease: a state of the science review

López, R. L., Burgos, M. J. G., Gálvez, A., & Pulido, R. P. (2016) · Apmis · doi:10.1111/apm.12609 · Cited by 116 · see citing works

Research Gaps in Diet and Nutrition in Inflammatory Bowel Disease. A Topical Review by D-ECCO Working Group [Dietitians of ECCO]

Boneh, R. S., Levine, A., Lomer, M. C. E., Wierdsma, N., Allan, P., Fiorino, G., Gatti, S., Jonkers, D. M. A. E., Kierkuś, J., Katsanos, K. H., et al. (2017) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjx109 · Cited by 112 · see citing works

A correlation between intestinal microbiota dysbiosis and osteoarthritis

Szychlinska, M. A., Rosa, M. D., Castorina, A., Mobasheri, A., & Musumeci, G. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01134 · Cited by 111 · see citing works

Health benefits of edible mushroom polysaccharides and associated gut microbiota regulation

Ma, G., Du, H., Hu, Q., Yang, W., Pei, F., & Xiao, H. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1903385 · Cited by 113 · see citing works

Cellular stress and innate inflammation in organ‐specific autoimmunity: lessons learned from vitiligo

Harris, J. E. (2015) · Immunological Reviews · doi:10.1111/imr.12369 · Cited by 109 · see citing works

Role of Microbiota-Derived Metabolites in Alcoholic and Non-Alcoholic Fatty Liver Diseases

Park, J. W., Kim, S. E., Lee, N. Y., Kim, J. H., Jung, J.-H., Jang, M.-K., Park, S.-H., Lee, M.-S., Kim, D.-J., Kim, H.-S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010426 · Cited by 109 · see citing works

Deep Metaproteomics Approach for the Study of Human Microbiomes

Zhang, X., Chen, W., Ning, Z., Mayne, J., Mack, D. R., Stintzi, A. P., Tian, R., & Figeys, D. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b02224 · Cited by 103 · see citing works

Australian consensus statements for the regulation, production and use of faecal microbiota transplantation in clinical practice

Haifer, C., Kelly, C. R., Paramsothy, S., Andresen, D. N., Papanicolas, L. E., McKew, G. L., Borody, T. J., Kamm, M. A., Costello, S. P., Andrews, J. M., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-320260 · Cited by 106 · see citing works

Silk as a Biomaterial to Support Long-Term Three-Dimensional Tissue Cultures

Abbott, R. D., Kimmerling, E. P., Cairns, D. M., & Kaplan, D. L. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b12114 · Cited by 101 · see citing works

“I Am I and My Bacterial Circumstances”: Linking Gut Microbiome, Neurodevelopment, and Depression

Lima‐Ojeda, J. M., Rupprecht, R., & Baghai, T. C. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00153 · Cited by 99 · see citing works

Gut microbiota modulation and anti-inflammatory properties of mixed lactobacilli in dextran sodium sulfate-induced colitis in mice

Shi, J., Xie, Q., Yue, Y., Chen, Q., Zhao, L., Evivie, S. E., Li, B., & Huo, G. (2021) · Food & Function · doi:10.1039/d1fo00317h · Cited by 98 · see citing works

Intestinal Microbiota Mediates High-Fructose and High-Fat Diets to Induce Chronic Intestinal Inflammation

Tan, R., Dong, H., Chen, Z., Jin, M., Yin, J., Li, H., Shi, D., Shao, Y., Wang, H., Chen, T., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.654074 · Cited by 99 · see citing works

Microbiota and Autoimmunity: Exploring New Avenues

Yurkovetskiy, L., Pickard, J. M., & Chervonsky, A. V. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.010 · Cited by 95 · see citing works

Protective and pro-inflammatory roles of intestinal bacteria

Webb, C. R., Koboziev, I., Furr, K. L., & Grisham, M. B. (2016) · Pathophysiology · doi:10.1016/j.pathophys.2016.02.002 · Cited by 94 · see citing works

Absorption ofCodonopsis pilosulaSaponins by Coexisting Polysaccharides Alleviates Gut Microbial Dysbiosis with Dextran Sulfate Sodium-Induced Colitis in Model Mice

Jing, Y., Li, A., Liu, Z., Yang, P., Wei, J., Chen, X., Zhao, T., Bai, Y., Zha, L., & Zhang, C. (2018) · BioMed Research International · doi:10.1155/2018/1781036 · Cited by 91 · see citing works

Dietary Tangeretin Alleviated Dextran Sulfate Sodium-Induced Colitis in Mice via Inhibiting Inflammatory Response, Restoring Intestinal Barrier Function, and Modulating Gut Microbiota

Chen, B., Luo, J., Han, Y., Du, H., Liu, J., He, W., Zhu, J., Xiao, J., Wang, J., Cao, Y., et al. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c03046 · Cited by 91 · see citing works

Gut microbiome: a new player in gastrointestinal disease

Gorkiewicz, G., & Moschen, A. R. (2017) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-017-2277-x · Cited by 87 · see citing works

Enlisting commensal microbes to resist antibiotic-resistant pathogens

Keith, J. W., & Pamer, E. G. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180399 · Cited by 87 · see citing works

Metabolic Modeling of Human Gut Microbiota on a Genome Scale: An Overview

Sen, P., & Orešič, M. (2019) · Metabolites · doi:10.3390/metabo9020022 · Cited by 83 · see citing works

Synbiotics for Improved Human Health: Recent Developments, Challenges, and Opportunities

Krumbeck, J. A., Walter, J., & Hutkins, R. W. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012757 · Cited by 84 · see citing works

Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease

Gupta, S. K., Vyavahare, S. S., Blanes, I. L. D., Berger, F. G., Isales, C. M., & Fulzele, S. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112319 · Cited by 93 · see citing works

The Safety of Fecal Microbiota Transplantation for Crohn’s Disease: Findings from A Long-Term Study

Wang, H., Cui, B., Li, Q., Ding, X. L., Li, P., Zhang, T., Yang, X., Ji, G., & Zhang, F. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0800-3 · Cited by 86 · see citing works

Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition

Lin, J.-D., Devlin, J. C., Yeung, F., McCauley, C., Leung, J. M., Chen, Y.-H., Cronkite, A., Hansen, C., Drake-Dunn, C., Ruggles, K. V., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.03.001 · Cited by 82 · see citing works

Pediococcus pentosaceus LI05 alleviates DSS‐induced colitis by modulating immunological profiles, the gut microbiota and short‐chain fatty acid levels in a mouse model

Bian, X., Yang, L., Wu, W., Lv, L., Jiang, X., Wang, Q., Wu, J., Li, Y., Ye, J., Fang, D., et al. (2020) · Microbial Biotechnology · doi:10.1111/1751-7915.13583 · Cited by 84 · see citing works

Serum Metabolomics Identifies Altered Bioenergetics, Signaling Cascades in Parallel with Exposome Markers in Crohn’s Disease

Lai, Y., Xue, J., Liu, C., Gao, B., Chi, L., Tu, P., Lü, K., & Ru, H. (2019) · Molecules · doi:10.3390/molecules24030449 · Cited by 80 · see citing works

Effects of four food hydrocolloids on colitis and their regulatory effect on gut microbiota

Zhang, S., Sun, Y., Nie, Q., Hu, J., Li, Y., Shi, Z., Ji, H., Zhang, H., Zhao, M., Chen, C., et al. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.121368 · Cited by 79 · see citing works

The mouse gut microbiome revisited: From complex diversity to model ecosystems

Clavel, T., Lagkouvardos, I., Blaut, M., & Stecher, B. (2016) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2016.03.002 · Cited by 77 · see citing works

Interactions of tea catechins with intestinal microbiota and their implication for human health

Guo, T., Song, D., Cheng, L., & Zhang, X. (2019) · Food Science and Biotechnology · doi:10.1007/s10068-019-00656-y · Cited by 77 · see citing works

Gut-microbiota derived bioactive metabolites and their functions in host physiology

Debnath, N., Kumar, R., Kumar, A., Mehta, P. K., & Yadav, A. K. (2021) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2021.1989847 · Cited by 77 · see citing works

Gene Expression-Genotype Analysis ImplicatesGSDMA,GSDMB, andLRRC3Cas Contributors to Inflammatory Bowel Disease Susceptibility

Söderman, J., Berglind, L., & Almer, S. H. (2015) · BioMed Research International · doi:10.1155/2015/834805 · Cited by 76 · see citing works

Altered Gut Microbiota Composition Is Associated With Back Pain in Overweight and Obese Individuals

Nitert, M. D., Mousa, A., Barrett, H. L., Naderpoor, N., & de Courten, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00605 · Cited by 76 · see citing works

Lactobacillus plantarum HNU082-derived improvements in the intestinal microbiome prevent the development of hyperlipidaemia

Shao, Y., Huo, D., Peng, Q., Pan, Y., Jiang, S., Liu, B., & Zhang, J. (2017) · Food & Function · doi:10.1039/c7fo00902j · Cited by 72 · see citing works

Role of the microbiome in non-gastrointestinal cancers

Pevsner‐Fischer, M., Tuganbaev, T., Meijer, M. T., Zhang, S., Zeng, Z., Chen, M., & Elinav, E. (2016) · World Journal of Clinical Oncology · doi:10.5306/wjco.v7.i2.200 · Cited by 69 · see citing works

Indigo Naturalis Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulating the Intestinal Microbiota Community

Liang, Y.-N., Yu, J., Zhang, D.-B., Zhang, Z., Ren, L., Li, L., Wang, Z., & Tang, Z. (2019) · Molecules · doi:10.3390/molecules24224086 · Cited by 67 · see citing works

Role of gut microbiota in epigenetic regulation of colorectal Cancer

Zhao, Y., Wang, C., & Goel, A. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188490 · Cited by 68 · see citing works

Food contact materials and gut health: Implications for toxicity assessment and relevance of high molecular weight migrants

Groh, K. J., Geueke, B., & Muncke, J. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.08.023 · Cited by 66 · see citing works

The Potential Role of Phytonutrients Flavonoids Influencing Gut Microbiota in the Prophylaxis and Treatment of Inflammatory Bowel Disease

Wang, L., Gao, M., Kang, G., & Huang, H. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.798038 · Cited by 64 · see citing works

Microbial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation

Madella, A. M., van Bergenhenegouwen, J., Garssen, J., Masereeuw, R., & Overbeek, S. A. (2022) · Toxins · doi:10.3390/toxins14090645 · Cited by 66 · see citing works

Glucose modulates Drosophila longevity and immunity independent of the microbiota

Galenza, A., Hutchinson, J., Hazes, B., Campbell, S. D., & Foley, E. (2016) · Biology Open · doi:10.1242/bio.015016 · Cited by 62 · see citing works

Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic Injury

Leon‐Coria, A., Kumar, M., Workentine, M. L., Moreau, F., Surette, M. G., & Chadee, K. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.07.003 · Cited by 63 · see citing works

Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor

Dopkins, N., Becker, W., Miranda, K., Walla, M., Nagarkatti, P. S., & Nagarkatti, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.619265 · Cited by 65 · see citing works

Anti-inflammatory potential of ulvan

Flórez-Fernández, N., Rodríguez-Coello, A., Latire, T., Bourgougnon, N., Torres, M. D., Buján, M., Muíños, A., Muiños, A., Meijide-Faílde, R., Blanco, F. J., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126936 · Cited by 66 · see citing works

Differential Susceptibility to T Cell-Induced Colitis in Mice: Role of the Intestinal Microbiota

Webb, C. R., den Bakker, H., Koboziev, I., Jones‐Hall, Y., Kottapalli, K. R., Ostanin, D. V., Furr, K. L., Mu, Q., Luo, X., & Grisham, M. B. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izx014 · Cited by 64 · see citing works

Gut Microbiota Markers and Dietary Habits Associated with Extreme Longevity in Healthy Sardinian Centenarians

Palmas, V., Pisanu, S., Madau, V., Casula, E., Deledda, A., Cusano, R., Uva, P., Loviselli, A., Velluzzi, F., & Manzin, A. (2022) · Nutrients · doi:10.3390/nu14122436 · Cited by 67 · see citing works

Probiotics maintain the intestinal microbiome homeostasis of the sailors during a long sea voyage

Zhang, J., Zhao, J., Jin, H., Lv, R., Shi, H., De, G., Yang, B. K., Sun, Z., & Zhang, H. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1722054 · Cited by 63 · see citing works

A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival

Kattah, M. G., Shao, L., Rosli, Y. Y., Shimizu, H., Whang, M. I., Advincula, R., Achacoso, P., Shah, S. B., Duong, B. H., Onizawa, M., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180198 · Cited by 59 · see citing works

The Changes in the Frog Gut Microbiome and Its Putative Oxygen-Related Phenotypes Accompanying the Development of Gastrointestinal Complexity and Dietary Shift

Zhang, M., Chen, H., Liu, L., Xu, L., Wang, X., Chang, L., Chang, Q., Lu, G., Jiang, J., & Zhu, L. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00162 · Cited by 57 · see citing works

Potential application of immunotherapy for modulation of pulp inflammation: opportunities for Vital Pulp Treatment.

Arora, S., Cooper, P., Friedlander, L., Rizwan, S., Seo, B., Rich, A., & Hussaini, H. (2021) · International Endodontic Journal · doi:10.1111/iej.13524 · Cited by 49 · see citing works

The Contribution of Gut Microbiota and Endothelial Dysfunction in the Development of Arterial Hypertension in Animal Models and in Humans

Maiuolo, J., Carresi, C., Gliozzi, M., Mollace, R., Scarano, F., Scicchitano, M., Macrì, R., Nucera, S., Bosco, F., Oppedisano, F., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073698 · Cited by 57 · see citing works

Epithelial Sel1L is required for the maintenance of intestinal homeostasis

Sun, S., Lourie, R., Cohen, S. B., Ji, Y., Goodrich, J. K., Poole, A. C., Ley, R. E., Denkers, E., McGuckin, M. A., Long, Q., et al. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-10-0724 · Cited by 57 · see citing works

Gut Microbiota Serves as a Crucial Independent Biomarker in Inflammatory Bowel Disease (IBD)

Sharma, B., Agriantonis, G., Twelker, K., Ebelle, D., Kiernan, S., Siddiqui, M., Soni, A., Cheerasarn, S., Simon, W., Jiang, W., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062503 · Cited by 57 · see citing works

The COVID-19 Pandemic: Does Our Early Life Environment, Life Trajectory and Socioeconomic Status Determine Disease Susceptibility and Severity?

Holuka, C., Merz, M. P., Fernandes, S. B., Charalambous, E. G., Seal, S. V., Grova, N., & Turner, J. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145094 · Cited by 53 · see citing works

The Microbiota and Gut-Related Disorders: Insights from Animal Models

Kamareddine, L., Najjar, H., Sohail, M. U., Abdulkader, H. A., & Al‐Asmakh, M. (2020) · Cells · doi:10.3390/cells9112401 · Cited by 55 · see citing works

Lactobacillus plantarum strains attenuated DSS-induced colitis in mice by modulating the gut microbiota and immune response

KHAN, I. A., Wei, J., Li, A., Liu, Z., Yang, P., Jing, Y., Chen, X., Zhao, T., Bai, Y., Zha, L., et al. (2022) · International Microbiology · doi:10.1007/s10123-022-00243-y · Cited by 56 · see citing works

Die Interaktion zwischen Darmbakterien und Mensch als zentraler Faktor für die Darmgesundheit

Haller, D., & Hörmannsperger, G. (2015) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-014-2095-0 · Cited by 7 · see citing works

Microbiome and Mucosal Immunity in the Intestinal Tract

Ahrend, H., Buchholtz, A., & Stope, M. B. (2024) · In Vivo · doi:10.21873/invivo.13801 · Cited by 13 · see citing works

Role of the Gut Microbiota in Maintaining GI Health: Highlights on Inflammatory Bowel Disease

Gruber, L., & Haller, D. (2014) · Molecular and integrative toxicology · doi:10.1007/978-1-4471-6539-2_13 · Cited by 1 · see citing works

Editorial: Host-microbiota interactions in IBD: immune modulation and barrier function

Li, H., Nag, S., Pîrcălăbioru, G. G., & Weiskirchen, R. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1869268 · Cited by 1 · see citing works

Crosstalk Between the Intestinal Microbiota and the Innate Immune System in Intestinal Homeostasis and Inflammatory Bowel Disease

Dupaul-Chicoine, J., Dagenais, M., & Saleh, M. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e31828dcac7 · Cited by 67 · see citing works