Cited by 24Amyotrophic Lateral Sclerosis ResearchSirtuins and Resveratrol in MedicineGenetic Neurodegenerative Diseases

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Could Sirtuin Activities Modify ALS Onset and Progression?

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Tang, Bor Luen·2017·Cellular and Molecular Neurobiology

DOI 10.1007/s10571-016-0452-2PMC PMC11482121

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Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a complex etiology. Sirtuins have been implicated as disease-modifying factors in several neurological disorders, and in the past decade, attempts have been made to check if manipulating Sirtuin activities and levels could confer benefit in terms of neuroprotection and survival in ALS models. The efforts have largely focused on mutant SOD1, and while limited in scope, the results were largely positive. Here, the body of work linking Sirtuins with ALS is reviewed, with discussions on how Sirtuins and their activities may impact on the major etiological mechanisms of ALS. Moving forward, it is important that the potentially beneficial effect of Sirtuins in ALS disease onset and progression are assessed in ALS models with TDP-43, FUS, and C9orf72 mutations.

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Authors: Tang, B. L.
Affiliations: National University of Singapore (SG)
Corresponding author: Tang, Bor Luen
ORCID: Tang, Bor Luen
Venue: Cellular and Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2016-12-10
Volume: 37
Issue: 7
Pages: 1147-1160
ISSN: 0272-4340 (ISSN-L)
1573-6830
DOI: 10.1007/s10571-016-0452-2
PMC: PMC11482121
OpenAlex: W2560651871
Cited by: 24
References: 201
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 4
FWCI: 0.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (unspecified)
Locations: Cellular and Molecular Neurobiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National University of Singapore (C-183-000-102-091)
Topics: Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
Keywords: amyotrophic lateral sclerosis, sirtuins, disease-modifying therapy, neuroprotection, SOD1 mutations, TDP-43, FUS, C9orf72
MeSH terms: Superoxide Dismutase-1, Amyotrophic Lateral Sclerosis, Animals, Humans, Motor Neurons, Disease Progression, Sirtuins

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Could Sirtuin Activities Modify ALS Onset and Progression?

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