The gut microbiome in psoriasis and psoriatic arthritis

Myers, Bridget; Brownstone, Nicholas; Reddy, Vidhatha; Chan, Stephanie; Thibodeaux, Quinn; Truong, Alexa; Bhutani, Tina; Chang, Hsin-Wen; Liao, Wilson

doi:10.1016/j.berh.2020.101494

Cited by 127Gut microbiota and healthSpondyloarthritis Studies and TreatmentsPsoriasis: Treatment and Pathogenesis

The gut microbiome in psoriasis and psoriatic arthritis

Myers, Bridget, Brownstone, Nicholas, Reddy, Vidhatha, Chan, Stephanie, Thibodeaux, Quinn, Truong, Alexa, Bhutani, Tina, Chang, Hsin-Wen +1 more·2019·Best Practice & Research Clinical Rheumatology

DOI 10.1016/j.berh.2020.101494

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Abstract

This review summarizes existing research on the gut microbiome composition and function in psoriasis and psoriatic arthritis, exploring potential roles in disease pathogenesis, progression, and management. A strong relationship between skin, joint, and gastrointestinal inflammation exists, as demonstrated by an increased prevalence of psoriasis, psoriatic arthritis, and inflammatory bowel disease co-occurring together; however, the link between them has not been fully elucidated. Studies analyzing the gut microbiome in psoriasis and psoriatic arthritis reveal a unique pattern of dysbiosis. With regard to the gut microbiome's role in psoriasis and psoriatic arthritis pathogenesis, we discuss several theories including intestinal permeability, altered immune homeostasis, and imbalance of short- and medium-chain fatty acid-producing bacteria. We also discuss how the gut microbiome affects patient risk of psoriatic arthritis and other serious comorbidities, and how fecal microbes could be used clinically as therapeutic targets or markers of disease.

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The abundance of Actinobacteria in the gut of patients with psoriasis was less than that of healthy controls.
“the abundance of Actinobacteria in the gut of patients with psoriasis was less than that of healthy controls.”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [101]

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D’Haens, G., & Jobin, C. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.04.053 · Cited by 98 · see citing works
Energy-restricted, n-3 polyunsaturated fatty acids-rich diet improves the clinical response to immuno-modulating drugs in obese patients with plaque-type psoriasis: a randomized control clinical trial
Guida, B., Napoleone, A., Trio, R., Nastasi, A., Balato, N., Laccetti, R., & Cataldi, M. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.09.010 · Cited by 96 · see citing works
Heterogeneity of Response to Biologic Treatment: Perspective for Psoriasis
Edson‐Heredia, E., Sterling, K. L., Alatorre, C., Carter, G. C., Paczkowski, R., Zarotsky, V., & Maeda‐Chubachi, T. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.326 · Cited by 85 · see citing works
The Microbiome and Psoriatic Arthritis
Eppinga, H., Konstantinov, S. R., Peppelenbosch, M. P., & Thio, H. B. (2014) · Current Rheumatology Reports · doi:10.1007/s11926-013-0407-2 · Cited by 84 · see citing works
Short, but Smart: SCFAs Train T Cells in the Gut to Fight Autoimmunity in the Brain
Bhutia, Y. D., & Ganapathy, V. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.014 · Cited by 79 · see citing works
Gut Microbiome in Psoriasis is Perturbed Differently During Secukinumab and Ustekinumab Therapy and Associated with Response to Treatment
Yeh, N.-L., Hsu, C.-Y., Tsai, T., & Chiu, H. (2019) · Clinical Drug Investigation · doi:10.1007/s40261-019-00849-7 · Cited by 79 · see citing works
Adverse effects of gluten ingestion and advantages of gluten withdrawal in nonceliac autoimmune disease
Lerner, A., Shoenfeld, Y., & Matthias, T. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux054 · Cited by 78 · see citing works
Biomarkers of Inflammation in Obesity-Psoriatic Patients
Rodríguez‐Cerdeira, C., Cordeiro-Rodríguez, M., Carnero-Gregorio, M., López-Bárcenas, A., Martínez-Herrera, E. O., Fabbrocini, G., Sinani, A., Arenas, R., & González-Cespón, J. L. (2019) · Mediators of Inflammation · doi:10.1155/2019/7353420 · Cited by 74 · see citing works
Psoriasis and inflammatory bowel disease: links and risks
Bassukas, I. D., Gaitanis, G., Katsanos, K., Christodoulou, D. K., Tsianos, E. V., & Vlachos, C. (2016) · Psoriasis Targets and Therapy · doi:10.2147/ptt.s85194 · Cited by 72 · see citing works
Early Psoriatic Arthritis
Gladman, D. D. (2012) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2012.05.005 · Cited by 69 · see citing works
Efficacy and safety of faecal microbiota transplantation in patients with psoriatic arthritis: protocol for a 6-month, double-blind, randomised, placebo-controlled trial
Kragsnæs, M. S., Kjeldsen, J., Horn, H. C., Munk, H. L., Pedersen, F. M., Holt, H. M., Stengaard‐Pedersen, K., Holm, D. K., Glerup, H., Andersen, V. C., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-019231 · Cited by 67 · see citing works
Rapid Regression of Psoriasis in a Coeliac Patient after Gluten-Free Diet
Addolorato, G., Parente, A., de Lorenzi, G., Paola, M. E. D. D., Abenavoli, L., Leggio, L., Capristo, E., SIMONE, C. D., Rotoli, M., Rapaccini, G. L., et al. (2003) · Digestion · doi:10.1159/000073220 · Cited by 62 · see citing works
Gut bacterial microbiota in psoriasis: A case control study
Doaa, M., Dalia, M., & Ahmed, F. S. (2016) · African Journal of Microbiology Research · doi:10.5897/ajmr2016.8046 · Cited by 56 · see citing works
How lifestyle factors and their associated pathogenetic mechanisms impact psoriasis
Madden, S. K., Flanagan, K. L., & Jones, G. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.05.006 · Cited by 54 · see citing works
A patient with osteomalacia as single presenting symptom of gluten‐sensitive enteropathy
de BOER, L. W. A., & Tytgat, G. N. J. (1992) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1992.tb00554.x · Cited by 52 · see citing works
Serum homocysteine, asymmetric dimethyl arginine (ADMA) and other arginine–NO pathway metabolite levels in patients with psoriasis
Bilgiç, Ö., Altinyazar, H. C., Baran, H., & Ünlü, A. (2015) · Archives of Dermatological Research · doi:10.1007/s00403-015-1553-3 · Cited by 41 · see citing works
The intestinal microbiome in human disease and how it relates to arthritis and spondyloarthritis
Costello, M., Robinson, P. C., Benham, H., & Brown, M. A. (2015) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2015.08.001 · Cited by 41 · see citing works
Antibiotic Exposure, Infection, and the Development of Pediatric Psoriasis
Horton, D. B., Scott, F. I., Haynes, K., Putt, M. E., Rosé, C. D., Lewis, J. D., & Strom, B. L. (2015) · JAMA Dermatology · doi:10.1001/jamadermatol.2015.3650 · Cited by 36 · see citing works
Evaluation of subclinical gut inflammation using faecal calprotectin levels and colonic mucosal biopsy in patients with psoriasis and psoriatic arthritis
Adarsh, M. B., Dogra, S., Vaiphei, K., Vaishnavi, C. V., Sinha, S. K., & Sharma, A. (2019) · British Journal of Dermatology · doi:10.1111/bjd.17745 · Cited by 36 · see citing works
Efficacy of erythromycin for psoriasis vulgaris
Polat, M., Lenk, N., Yalçın, B., Gür, G., Tamer, E., Artüz, F., & Allı, N. (2007) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2007.02370.x · Cited by 33 · see citing works
Psoriatic arthritis: tissue-directed inflammation?
Cafaro, G., & McInnes, I. B. (2018) · Clinical Rheumatology · doi:10.1007/s10067-018-4012-7 · Cited by 33 · see citing works
A review of antibiotics and psoriasis: induction, exacerbation, and amelioration
Tsai, Y., & Tsai, T. (2019) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2019.1665027 · Cited by 27 · see citing works
Frequency of Homocysteinemia in Young Ischemic Stroke Patients and Its Relationship with the Early Outcome of a Stroke
Niazi, F., Aslam, A., Khattak, S., & Waheed, S. (2019) · Cureus · doi:10.7759/cureus.5625 · Cited by 20 · see citing works
Osteomalacia associated with cutaneous psoriasis as the presenting feature of coeliac disease: a case report.
Frikha, F., Snoussi, M., & Bahloul, Z. (2012) · PubMed · doi:10.11604/pamj.2012.11.58.1613 · Cited by 10 · see citing works

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Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity
Wang, X., Zhang, P., & Zhang, X. (2021) · Molecules · doi:10.3390/molecules26196076 · Cited by 529 · see citing works
Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases
Mahmud, M. R., Akter, S., Tamanna, S. K., Mazumder, L., Esti, I. Z., Banerjee, S., Akter, S., Hasan, M. R., Acharjee, M., Hossain, M. S., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2096995 · Cited by 498 · see citing works
“Clostridium citroniae, Collinsella aerofaciens, Dorea formicigenerans, Parabacteroides distasonis, Prevotella copri, and Ruminococcus gnavus.(149,151) Technological advancements have opened up new possibilities for the selection and manufacture of monoclonal antibodies that target specific diseases.”
Background
Skin Barrier Dysregulation in Psoriasis
Orsmond, A., Bereza-Malcolm, L., Lynch, T., MARCH, L. M., & Xue, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910841 · Cited by 236 · see citing works
Psoriasis and Gut Microbiome—Current State of Art
Polak, K., Bergler-Czop, B. S., Szczepanek, M., Wojciechowska, K., Frątczak, A., & Kiss, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094529 · Cited by 127 · see citing works
“This may result in the restoration of the correct bacterial microbiota composition [33,68,81,82].”
Background
Exploring the Links between Obesity and Psoriasis: A Comprehensive Review
Barros, G., Durán, P., Vera, I., & Bermúdez, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147499 · Cited by 120 · see citing works
“These pathological changes in microbiota support the chronic inflammatory state hypothesis [29] based on lipoteichoic acid and lipopolysaccharides released into the bloodstream [39].”
BackgroundInfluential
Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases
Belvončíková, P., Marônek, M., & Gardlík, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810729 · Cited by 108 · see citing works
Ozone therapy for skin diseases: Cellular and molecular mechanisms
Liu, L., Zeng, L., Gao, L., Zeng, J., & Lu, J. (2022) · International Wound Journal · doi:10.1111/iwj.14060 · Cited by 105 · see citing works
Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases
Stec, A., Sikora, M., Maciejewska, M., Paralusz-Stec, K., Michalska, M. N., Sikorska, E., & Rudnicka, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043494 · Cited by 85 · see citing works
Immune responses and therapeutic options in psoriasis
Afonina, I. S., Nuffel, E. V., & Beyaert, R. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03726-1 · Cited by 79 · see citing works
Inflammatory bowel disease and psoriasis: modernizing the multidisciplinary approach
Hedin, C. R. H., Sonkoly, E., Eberhardson, M., & Ståhle, M. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13282 · Cited by 73 · see citing works
“…skin – joint axis has been proposed to explain the relationship between changes in the gut microbiota, increased intestinal permeability and altered immune homeostasis that may contribute to skin and joint inﬂammation; however, more evidence is needed to conﬁrm and explore these associations [56].”
Potential Role of Probiotics in Ameliorating Psoriasis by Modulating Gut Microbiota in Imiquimod-Induced Psoriasis-Like Mice
Lu, W., Deng, Y., Fang, Z., Zhai, Q., Cui, S., Zhao, J., Chen, W., & Zhang, H. (2021) · Nutrients · doi:10.3390/nu13062010 · Cited by 64 · see citing works
“Nutrients 2021, 13, 2010 15 of 17 Abbreviations CCFM Culture Collection of Food Microorganisms EILISA Enzyme-linked Immunosorbent Assay IL Interleukin IMQ Imiquimod LDA Linear Discriminant Analysis MRS Man, Rogosa and Sharpe MTX Methotrexate OD Optical density PASI Psoriasis Area and Severity Index PCA Principal Compo…”
BackgroundInfluential
Oral antibiotic use and early-onset colorectal cancer: findings from a case-control study using a national clinical database
McDowell, R. D., Perrott, S. L., Murchie, P., Cardwell, C. R., Hughes, C. M., & Samuel, L. M. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01665-7 · Cited by 57 · see citing works
Association of Sarcopenia and Gut Microbiota Composition in Older Patients with Advanced Chronic Kidney Disease, Investigation of the Interactions with Uremic Toxins, Inflammation and Oxidative Stress
Margiotta, E., Caldiroli, L., Callegari, M. L., Miragoli, F., Zanoni, F., Armelloni, S., Rizzo, V., Messa, P., & Vettoretti, S. (2021) · Toxins · doi:10.3390/toxins13070472 · Cited by 53 · see citing works
“Verrucomicrobiaceae possess tryptophanase (an indole-producing enzyme, leading to increased IS production), while Micrococcaceae possess urease and uricase [18], which, through generation of high quantity of ammonia and ammonium hydroxide, play a key role in the development of uremic enterocolitis [19] and contribute…”
Background
Gut microbiota and psoriasis: pathogenesis, targeted therapy, and future directions
Zou, X., Zou, X., Gao, L., & Zhao, H. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1430586 · Cited by 49 · see citing works
“The antioxidant and anti-in ﬂ ammatory properties of polyphenols, polyunsaturated fatty acids, dietary ﬁ ber, and vitamins have been well established (Liu et al., 2019 2019; Liu et al., 2021; Zhang S. et al., 2021; Harwood, 2023; Kong et al., 2023; Tian et al., 2023).”
Background
The gut-retina axis: a new perspective in the prevention and treatment of diabetic retinopathy
Zhang, H., & Mo, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1205846 · Cited by 42 · see citing works
The gut microbiota profile in psoriasis: a Brazilian case-control study
Schade, L., Mesa, D., Faria, A. R., Santamaria, J. R., Xavier, C. A., Ribeiro, D., Hajar, F. N., & Azevedo, V. F. (2022) · Letters in Applied Microbiology · doi:10.1111/lam.13630 · Cited by 42 · see citing works
“Increasing evidence indicates that changes in the cutaneous and gut microbiota (dysbiosis) may induce activation of the Th17 pathway, leading to the development of psoriasis (Yan et al. 2017; Myers et al. 2019).”
Background
The Evolving Landscape of Fecal Microbial Transplantation
Shao, T., Hsu, R., Hacein-Bey, C., Zhang, W., Gao, L., Kurth, M. J., Zhao, H., Shuai, Z., & Leung, P. S. C. (2023) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-023-08958-0 · Cited by 42 · see citing works
A Novel E3 Probiotics Formula Restored Gut Dysbiosis and Remodelled Gut Microbial Network and Microbiome Dysbiosis Index (MDI) in Southern Chinese Adult Psoriasis Patients
Choy, C. T., Chan, U. K., Siu, P. L. K., Zhou, J., Wong, C. H., Lee, Y. W., Chan, H. W., Tsui, J. C. C., Loo, S. K. F., & Tsui, S. K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076571 · Cited by 39 · see citing works
“In general, gut dysbiosis with an altered abundance of Akkermansia muciniphila, Staphylococcus aureus, Streptococcus pyogenes, or Candida albicans was evidential and commonly reported in psoriasis patients [27,30,31].”
Background
Differences in gut microbiota between allergic rhinitis, atopic dermatitis, and skin urticaria
Su, Y., Luo, S., Hsu, C., & Kuo, H. (2021) · Medicine · doi:10.1097/md.0000000000025091 · Cited by 39 · see citing works
The obesity–inflammation axis in psoriatic disease: mechanisms and therapeutic strategies
Haberman, R. H., Ogdie, A., Merola, J. F., Scher, J. U., & Eder, L. (2025) · Nature Reviews Rheumatology · doi:10.1038/s41584-025-01326-6 · Cited by 39 · see citing works
“Specific microbial peptides might be presented by disease-associated HLA alleles (such as HLA-B27 or HLA-C06) potentially activating autoreactive T cells 132,139 .”
The Effectiveness and Safety of Probiotic Supplements for Psoriasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Preclinical Trials
Zeng, L., Yu, G., Wu, Y., Hao, W., & Chen, H. (2021) · Journal of Immunology Research · doi:10.1155/2021/7552546 · Cited by 39 · see citing works
Dietary Intake and Systemic Inflammation: Can We Use Food as Medicine?
Graff, E., Vedantam, S., Parianos, M., Khakoo, N. S., Beiling, M., & Pearlman, M. Y. (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00458-z · Cited by 40 · see citing works
Microbiome and Metabolome Analyses Reveal Novel Interplay Between the Skin Microbiota and Plasma Metabolites in Psoriasis
Chen, D., He, J., Li, J., Zou, Q., Si, J., Guo, Y., Yu, J., Li, C., Wang, F., Chan, T., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.643449 · Cited by 36 · see citing works
Targeting dysbiosis in psoriasis, atopic dermatitis, and hidradenitis suppurativa: the gut-skin axis and microbiome-directed therapy
Aguwa, C. J., Enwereji, N., Santiago, S., Hine, A. M., Kels, G. G., McGee, J. S., & Lu, J. (2023) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2023.09.019 · Cited by 33 · see citing works
Curcumin alleviates imiquimod‐induced psoriasis‐like inflammation and regulates gut microbiota of mice
Cai, Z., Wang, W., Zhang, Y., & Zeng, Y. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.967 · Cited by 30 · see citing works
“Currently, increasing evidence had found that gut microbes were potentially involved in regulating the progression of a variety of diseases closely related to inflammation, such as psoriasis, psoriatic arthritis, inflammatory bowel diseases (IBD).(8,9) To further confirm our speculation, we found that curcumin could s…”
Background
Gut microbiota nexus: Exploring the interactions with the brain, heart, lungs, and skin axes and their effects on health
Chakraborty, P., Banerjee, D., Majumder, P., & Sarkar, J. (2024) · Medicine in Microecology · doi:10.1016/j.medmic.2024.100104 · Cited by 27 · see citing works
Inhibition of Phosphodiesterase-4 in Psoriatic Arthritis and Inflammatory Bowel Diseases
Diamanti, A. P., Spinelli, F. R., Rosado, M. M., Conti, F., & Laganà, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052638 · Cited by 25 · see citing works
Advances in the mechanism of action of short-chain fatty acids in psoriasis
Zhang, Q., Zhao, L., Li, Y., Wang, S., Lu, G., & Wang, H. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112928 · Cited by 24 · see citing works
Intestinal inflammation alters the antigen-specific immune response to a skin commensal
Merana, G. R., Dwyer, L. R., Dhariwala, M. O., Weckel, A., Gonzalez, J. R., Okoro, J. N., Cohen, J. N., Tamaki, C. M., Han, J., Tasoff, P., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110891 · Cited by 24 · see citing works
“While shared genetic features may increase the risk of simultaneous skin and gut disease (Marzano et al., 2014), there is evidence that gut microbiome perturbation can be closely tied to skin inflammation (Myers et al., 2019; Song et al., 2016).”
Assessing causal relationships between gut microbiota and psoriasis: evidence from two sample Mendelian randomization analysis
Li, Y., Chen, G., Hu, X., Bao, Y., Wu, C., Zeng, N., & Jiang, F. (2024) · Scientific Reports · doi:10.1038/s41598-024-59603-5 · Cited by 24 · see citing works
“The excessive release of these inflammatory mediators may exacerbate the inflammatory response of psoriasis, promoting abnormal proliferation of skin cells and inflammatory reactions 25 .”
Background
Physiological mechanisms of unexplained (functional) gastrointestinal disorders
Burns, G. L., Hoedt, E. C., Walker, M. M., Talley, N. J., & Keely, S. (2021) · The Journal of Physiology · doi:10.1113/jp281620 · Cited by 23 · see citing works
“Translocation of bacterial factors may then allow antigens to reach circulation and trigger responses at external sites, such as the skin and connective tissues (Myers et al. 2019; Walker et al. 2019).”
Background
The impact of diet on disease activity in spondyloarthritis: A systematic literature review
Ortolan, A., Felicetti, M., Lorenzin, M., Cozzi, G., Ometto, F., Striani, G., Favero, M., Doria, A., & Ramonda, R. (2022) · Joint Bone Spine · doi:10.1016/j.jbspin.2022.105476 · Cited by 23 · see citing works
The intestinal microbiota: Towards a multifactorial integrative model. Eubiosis and dysbiosis in morbid physical and psychological conditions
Giulio, P. (2021) · Archives of Clinical Gastroenterology · doi:10.17352/2455-2283.000094 · Cited by 22 · see citing works
“[51], asthma [52] and allergies [53] and food intolerances [54].”
Background
Alterations of gut microbiota for the onset and treatment of psoriasis: A systematic review
Xue, M., Deng, Q., Deng, L., Xun, T., Huang, T., Zhao, J., Wei, S., Zhao, C., Chen, X., Zhou, Y., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177521 · Cited by 24 · see citing works
The Causal Relationship between Psoriasis, Psoriatic Arthritis and Inflammatory Bowel Diseases
Sun, Y., Li, Y., Li, J., Xie, X., Gu, F., Sui, Z., Zhang, K., & 于铁成 (2022) · Scientific Reports · doi:10.1038/s41598-022-24872-5 · Cited by 21 · see citing works
Investigating the gut microbiota's influence on psoriasis and psoriatic arthritis risk: a Mendelian randomization analysis
Yu, N., Wang, J., Liu, Y., & Guo, Y. (2023) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbad023 · Cited by 21 · see citing works
“5 , 6 Se v er al hypotheses hav e been pr oposed to elucidate the role of the GM in the pathogenesis of Ps and PsA, encompassing factors such as intestinal permeability, perturbed immune homeostasis, and imbalances in specific bacteria producing short-and medium-chain fatty acids.”
Background
Evidence for the gut‐skin axis: Common genetic structures in inflammatory bowel disease and psoriasis
Guo, J., Luo, Q., Li, C., Hong, L., Cao, Q., Li, Z., Chen, G., & Yu, X. (2024) · Skin Research and Technology · doi:10.1111/srt.13611 · Cited by 20 · see citing works
“45 The gut microbiota also affects signaling pathways for epidermal differentiation, thereby altering skin homeostasis.”
Background
The efficacy and safety of probiotics in the adjuvant treatment of psoriasis: a systematic review and meta-analysis of randomized controlled trials
Zhu, Y., Xu, F., Chen, H., & Zheng, Q. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1448626 · Cited by 24 · see citing works
Altered Fecal Metabolomics and Potential Biomarkers of Psoriatic Arthritis Differing From Rheumatoid Arthritis
Wang, N., Yang, L., Shang, L., Liang, Z., Wang, Y., Feng, M., Yu, S., Li, X., Gao, C., Li, Z., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.812996 · Cited by 19 · see citing works
“In the recent years, there has been an increasing interest to the alteration of gut microbiota in the PsA research, which has been proved to have important significance in the pathogenesis of diseases (1, 7, 20, 31).”
Background
Two phenotypes of chronic recurrent multifocal osteomyelitis with different patterns of bone involvement
Cebecauerová, D., Malcová, H., Koukolská, V., Kvíčalová, Z., Souček, O., Wagenknecht, L., Bronský, J., Šumnı́k, Z., Kynčl, M., Cebecauer, M., et al. (2022) · Pediatric Rheumatology · doi:10.1186/s12969-022-00772-w · Cited by 18 · see citing works
Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes
Du, X., Yan, C., Kong, S., Che, D., Peng, B., Zhu, L., Geng, S., & Guo, K. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1227309 · Cited by 18 · see citing works
“Strikingly, several studies have emphasized the vital influence of the gut microbiota on the host immune homeostasis, dysbiosis of which is related to the development of several autoimmune diseases (Benhadou et al., 2018; Myers et al., 2019).”
Background
Sex Differences in the Effectiveness of First‐Line Tumor Necrosis Factor Inhibitors in Psoriatic Arthritis: Results From the European Spondyloarthritis Research Collaboration Network
Hellamand, P., van de Sande, M. G. H., Ørnbjerg, L. M., Klausch, T. L. T., Eklund, K. K., Relas, H., Santos, M. J., Vieira‐Sousa, E., Loft, A. G., Glintborg, B., et al. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42758 · Cited by 17 · see citing works
“45 These factors could signi ﬁ cantly impact disease severity and treatment response, emphasizing the need for further research to elucidate their interplay with PsA.”
Background
Etiopathogenesis of Psoriasis: Integration of Proposed Theories
Hernandez-Nicols, B. F., Robledo-Pulido, J. J., & Alvarado‐Navarro, A. (2024) · Immunological Investigations · doi:10.1080/08820139.2024.2302823 · Cited by 17 · see citing works
Fecal microbiota transplantation in autoimmune diseases – An extensive paper on a pathogenetic therapy
Seida, I., Shawaf, M. A., & Mahroum, N. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103541 · Cited by 17 · see citing works
Effects of intestinal microbes on rheumatic diseases: A bibliometric analysis
Huang, R., Zhang, M., Lu, Y., Xu, D., Liu, Y., Jin, M., Xian, S., Wang, S., Tong, X., Lu, J., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1074003 · Cited by 15 · see citing works
“, 2018), psoriatic arthritis (PsA) (Myers et al., 2019), gout (Chu et al.”
Background
Psoriasis and gut microbes: research advances from mechanism to therapy
Chen, J., Sun, K., Zhang, X., Chen, X., Chu, Y., Geng, L., Bian, Z., Su, Y., Cong, X., & Wang, G. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1711288 · Cited by 16 · see citing works
Exploring the role of gut microbes in spondyloarthritis: Implications for pathogenesis and therapeutic strategies.
Furst, A., & Gill, T. (2024) · Baillière's Best Practice & Research : Clinical Rheumatology · doi:10.1016/j.berh.2024.101961 · Cited by 10 · see citing works
Benefits of Probiotics in Rheumatic Diseases
Oliviero, F., & Spinella, P. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00157 · Cited by 14 · see citing works
Impact of Gut Bacterial Metabolites on Psoriasis and Psoriatic Arthritis: Current Status and Future Perspectives
Lai, Y., Wu, X., Chao, E., Bloomstein, J. D., Wei, G., Hwang, S. T., & Shi, Z. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.05.012 · Cited by 13 · see citing works
New horizons in the treatment of psoriasis: Modulation of gut microbiome
Memariani, M., & Memariani, H. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e41672 · Cited by 14 · see citing works
Extremely small and incredibly close: Gut microbes as modulators of inflammation and targets for therapeutic intervention
Piazzesi, A., & Putignani, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.958346 · Cited by 12 · see citing works
“, 2021), psoriasis (Myers et al., 2019; Olejniczak-Staruch et al., 2021), metabolic diseases (Manco et al.”
Background
Evaluation of probiotics for inhibiting hyperproliferation and inflammation relevant to psoriasis in vitro
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Authors: Myers, B., Brownstone, N., Reddy, V., Chan, S., Thibodeaux, Q., Truong, A., Bhutani, T., Chang, H.-W., & Liao, W.
Affiliations: University of California, San Francisco (US)
University of California, Berkeley (US)
Corresponding author: Liao, Wilson
ORCID: Myers, Bridget
Brownstone, Nicholas
Reddy, Vidhatha
Chan, Stephanie
Thibodeaux, Quinn
Truong, Alexa
Bhutani, Tina
Chang, Hsin-Wen
Liao, Wilson
Venue: Best Practice & Research Clinical Rheumatology
Publisher: Elsevier BV
Published: 2019-12
Volume: 33
Issue: 6
Pages: 101494
ISSN: 1521-6942 (ISSN-L)
DOI: 10.1016/j.berh.2020.101494
OpenAlex: W3023269883
Cited by: 127
References: 98
Citations by year: 2026: 10 · 2025: 11 · 2024: 31 · 2023: 26 · 2022: 23 · 2021: 24 · 2020: 2
FWCI: 1.08
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Best Practice & Research Clinical Rheumatology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: gut microbiota, psoriasis, psoriatic arthritis, dysbiosis, intestinal permeability, immune homeostasis, short-chain fatty acids, medium-chain fatty acids, inflammatory bowel disease, comorbidities, pathogenesis, fecal microbiota transplantation, biomarkers, therapeutic target
MeSH terms: Gastrointestinal Microbiome, Humans, Psoriasis, Arthritis, Psoriatic, Microbiota, Dysbiosis

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