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A genetic model for colorectal tumorigenesis
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“more than 50% of hypermutated tumors and more than 80% of non-hypermutated tumors have mutations in APC [1, 2].”
From Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells (2018) · cites this paper as [1]
In the citing paper
“APCmin/+ mice that harbored a point mutation in the APC gene, resulting in APC deletion and constitutive activation of Wnt signaling25”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [25]
In the citing paper
“We again focused on colorectal cancer which follows a relatively ordered mutational process55 and can be efficiently modeled through progressive loss of niche factors in ASC-derived colon organoids13,14.”
From One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids (2023) · cites this paper as [55]
In the citing paper
“GTP binding to KRAS shifts the active site from an open to a closed conformation, allowing multiple downstream effector pathways to interact and activate, including the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways [12, 13].”
From Targeting KRAS mutant cancers: from druggable therapy to drug resistance (2022) · cites this paper as [13]
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Metadata
- Authors
- Fearon, E. R., & Vogelstein, B.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1990-06
- Volume
- 61
- Issue
- 5
- Pages
- 759-767
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2001258296
- Cited by
- 12,132
- References
- 76
- Citations by year
- 2026: 199 · 2025: 247 · 2024: 300 · 2023: 321 · 2022: 367 · 2021: 387 · 2020: 320 · 2019: 339 · 2018: 358 · 2017: 394 · 2016: 374 · 2015: 392 · 2014: 411 · 2013: 395 · 2012: 376
- FWCI
- 48.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Keywords
- colorectal carcinogenesis, colorectal cancer, genetic models, tumor progression, colorectal adenoma
- MeSH terms
- Alleles, Chromosome Deletion, Heterozygote, Humans, Models, Genetic, Mutation, Oncogenes, Suppression, Genetic, Colorectal Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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