Fabrication and characteristics of an implantable, polymer-based, intrafascicular electrode
Abstract
We describe new manufacturing techniques and physical properties of an improved polymer-based longitudinal intrafascicular electrode (polyLIFE). Modifications were made to correct: (1) poor metal film adhesion and fatigue resistance, (2) inconsistent insulation adhesion and control over recording/stimulation zone length, and (3) insufficient tensile strength for clinical use. Metal adhesion was significantly improved by both plasma treatment and fiber rotation (about the long axis) during metal deposition. Fatigue resistance was improved by reduction in sputtering energy (time x power) combined with long axis rotation, resulting in thin metal films that were 250 times more resistant to cyclic bending fatigue. Insulation adhesion was enhanced with the application of an adhesion-promoting silicone (MED2-4013, Nusil), while the recording/stimulation zone length was controlled to 1 +/- 0.2mm (mean +/- S.D.). The polyLIFE was made more robust by the inclusion of three individually metallized fibers, improving its tensile strength by a factor of 4 while producing minimal changes to its overall stiffness. However, the metallized fiber redundancy did not significantly affect fatigue resistance. The manufacturing changes described in this study enable the construction of more mechanically robust polyLIFEs, which should provide greater success when chronically implanted in peripheral nerves.
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When higher selectivity is required, interfaces tend to be more invasive.
“When higher selectivity is required, interfaces tend to be more invasive.”
From Realizing flexible bioelectronic medicines for accessing the peripheral nerves – technology considerations (2018) · cites this paper as Lawrence et al. 2003
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- Authors
- Lawrence, S. M., Dhillon, G. S., & Horch, K. W.
- Affiliations
- University of Utah (US)
- Corresponding author
- Horch, Kenneth W
- Venue
- Journal of Neuroscience Methods
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 131
- Issue
- 1-2
- Pages
- 9-26
- ISSN
- 0165-0270 (ISSN-L)
- OpenAlex
- W2046003207
- Semantic Scholar
- 826c76f761fa8f7a27250a5989d8ded173c1d7f8
- Cited by
- 93
- References
- 70
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 2
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Methods (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Keywords
- intrafascicular electrodes, peripheral nerve stimulation, chronic implantation, fatigue resistance, plasma treatment, silicone insulation, tensile strength, electrode fabrication
- MeSH terms
- Tissue Adhesions, Electrodes, Implanted, Gold, Materials Testing, Microelectrodes, Microscopy, Electron, Scanning, Peripheral Nerves, Platinum, Polymers, Surface Properties, Temperature, Time Factors, Titanium, Electric Impedance, Prostheses and Implants, Coated Materials, Biocompatible, Tissue Engineering
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