Exploratory behavior models of anxiety in mice

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

Picciotto, M. R., Zoli, M., Léna, C., Bessis, A., Lallemand, Y., LeNovère, N., Vincent, P., Pich, E. M., Brûlet, P., & Changeux, J.-P. (1995) · Nature · doi:10.1038/374065a0 · Cited by 668

Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety

Likhtik, E., Stujenske, J. M., A Topiwala, M., Harris, A. Z., & Gordon, J. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3582 · Cited by 577

Mouse Behavioral Assays Relevant to the Symptoms of Autism*

Crawley, J. N. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00096.x · Cited by 541

Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions

Oury, F., Khrimian, L., Denny, C. A., Gardin, A., Chamouni, A., Goeden, N., Huang, Y.-Y., Lee, H., Srinivas, P., Gao, X.-B., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.042 · Cited by 484

Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty

Champagne, F. A., & Meaney, M. J. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.6.1353 · Cited by 381

Removing Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models

Markou, A., Chiamulera, C., Geyer, M. A., Tricklebank, M., & Steckler, T. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.173 · Cited by 328

Gpr158 mediates osteocalcin’s regulation of cognition

Khrimian, L., Obri, A., Ramos-Brossier, M., Rousseaud, A., Moriceau, S., Nicot, A.-S., Mera, P., Kosmidis, S., Karnavas, T., Saudou, F., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20171320 · Cited by 308

Transgenerational Epigenetic Programming of the Brain Transcriptome and Anxiety Behavior

Skinner, M. K., Anway, M. D., Savenkova, M. I., Gore, A. C., & Crews, D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003745 · Cited by 293

Context‐dependent effects of CB1 cannabinoid gene disruption on anxiety‐like and social behaviour in mice

Haller, J., Varga, B., Ledent, C., Barna, I., & Freund, T. F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03293.x · Cited by 284

Indole, a signaling molecule produced by the gut microbiota, negatively impacts emotional behaviors in rats

Jaglin, M., Rhimi, M., Philippe, C., Pons, N., Bruneau, A., Goustard, B., Daugé, V., Maguin, E., Naudon, L., & Rabot, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00216 · Cited by 269

Brain 5α-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation

Dong, E., Matsumoto, K., Uzunova, V., Sugaya, I., Takahata, H., Nomura, H., Watanabe, H., Costa, E., & Guidotti, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051628598 · Cited by 261

Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology

Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.022 · Cited by 255

Modeling fragile X syndrome in the Fmr1 knockout mouse

Kazdoba, T. M., Leach, P. T., Silverman, J. L., & Crawley, J. N. (2014) · Intractable & Rare Diseases Research · doi:10.5582/irdr.2014.01024 · Cited by 241

Oral treatment with Lactobacillus rhamnosus attenuates behavioural deficits and immune changes in chronic social stress

Bharwani, A., Mian, M. F., Surette, M. G., Bienenstock, J., & Forsythe, P. (2017) · BMC Medicine · doi:10.1186/s12916-016-0771-7 · Cited by 236

Defeat stress in rodents: from behavior to molecules

Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J.-P., Lesch, K.-P., Daskalakis, N. P., Steinbusch, H. W. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.006 · Cited by 230

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

Basso, A. M., Bratcher, N. A., Harris, R. R., Jarvis, M. F., Decker, M. W., & Rueter, L. E. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.018 · Cited by 224

Reproducibility and replicability of rodent phenotyping in preclinical studies

Kafkafi, N., Agassi, J., Chesler, E. J., Crabbe, J. C., Crusio, W. E., Eilam, D., Gerlai, R., Golani, I., Gomez-Marin, A., Heller, R., et al. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.01.003 · Cited by 215

Distributed circuits underlying anxiety

Adhikari, A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00112 · Cited by 204

Development of a mouse test for repetitive, restricted behaviors: Relevance to autism

Moy, S. S., Nadler, J. J., Poe, M. D., Nonneman, R. J., Young, N. B., Koller, B. H., Crawley, J. N., Duncan, G. E., & Bodfish, J. W. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.10.029 · Cited by 195

Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice

Curley, J. P. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.025.2009 · Cited by 184

Glucocorticoids Orchestrate Divergent Effects on Mood through Adult Neurogenesis

Lehmann, M. L., Brachman, R. A., Martinowich, K., Schloesser, R. J., & Herkenham, M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3878-12.2013 · Cited by 168

Social behavior, dominance, and social deprivation of rats determine drug choice

Wolffgramm, J., & Heyne, A. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90297-f · Cited by 155

Compulsive behavior in the 5-HT2C receptor knockout mouse

Chou-Green, J. M., Holscher, T. D., Dallman, M. F., & Akana, S. F. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00047-7 · Cited by 143

Lymphocytes from Chronically Stressed Mice Confer Antidepressant-Like Effects to Naive Mice

Brachman, R. A., Lehmann, M. L., Maric, D., & Herkenham, M. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2278-14.2015 · Cited by 130

Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain

Ryan, B. C., Young, N. B., Crawley, J. N., Bodfish, J. W., & Moy, S. S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.031 · Cited by 135

Rearrangement of the dendritic morphology in limbic regions and altered exploratory behavior in a rat model of autism spectrum disorder

Bringas, M. E., Carvajal-Flores, F. N., López-Ramírez, T. A., Atzori, M., & Flores, G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.03.030 · Cited by 114

Models of anxiety: Responses of rats to novelty in an open space and an enclosed space

Ennaceur, A., Michalikova, S., & Chazot, P. L. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.016 · Cited by 117

Characterization of benzodiazepine-sensitive behaviors in the A/J and C57BL/6J inbred strains of mice

Mathis, C., Paul, S. M., & Crawley, J. N. (1994) · Behavior Genetics · doi:10.1007/bf01067821 · Cited by 111

Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test

Boucher, A. A., Arnold, J. C., Hunt, G. E., Spiro, A., Spencer, J., Brown, C., McGregor, I. S., Bennett, M. R., & Kassiou, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.049 · Cited by 108

Effect of Y1 receptor deficiency on motor activity, exploration, and anxiety

Karl, T., Burne, T. H. J., & Herzog, H. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.08.019 · Cited by 95

Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis – related proteins in a rat model of post-traumatic stress disorder

Shafia, S., Vafaei, A. A., Samaei, S. A., Bandegi, A. R., Rafiei, A., Valadan, R., Hosseini-Khah, Z., Mohammadkhani, R., & Rashidy-Pour, A. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.01.009 · Cited by 89

Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood

Bilbo, S. D., Newsum, N. J., Sprunger, D. B., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.10.005 · Cited by 88

Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice

Lawson, M. A., McCusker, R. H., & Kelley, K. W. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-54 · Cited by 80

Hippocampal network oscillations at the interplay between innate anxiety and learned fear

Çalışkan, G., & Stork, O. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5109-z · Cited by 72

Long-term exposure to ceftriaxone sodium induces alteration of gut microbiota accompanied by abnormal behaviors in mice

Zhao, Z., Wang, B., Mu, L., Wang, H., Luo, J., Yang, Y., Yang, H., Li, M., Zhou, L., & Tao, C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00258 · Cited by 57

Reproducibility and relevance of future behavioral sciences should benefit from a cross fertilization of past recommendations and today's technology: “Back to the future”

Spruijt, B. M., Peters, S. M., de Heer, R. C., Pothuizen, H. H. J., & van der Harst, J. E. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.001 · Cited by 53

In utero exposure to fine particulate matter results in an altered neuroimmune phenotype in adult mice

Kulas, J. A., Hettwer, J. V., Sohrabi, M., Melvin, J. E., Manocha, G. D., Puig, K. L., Gorr, M. W., Tanwar, V., McDonald, M. P., Wold, L. E., et al. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.05.047 · Cited by 50

Gap Junctions in the Ventral Hippocampal-Medial Prefrontal Pathway Are Involved in Anxiety Regulation

Schoenfeld, T. J., Kloth, A. D., Hsueh, B., Runkle, M. B., Kane, G. A., Wang, S. S.-H., & Gould, E. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3234-13.2014 · Cited by 49

Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice

Desbonnet, L., Tighe, O., Karayiorgou, M., Gogos, J. A., Waddington, J. L., & O’Tuathaigh, C. M. P. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.014 · Cited by 38

Spatial memory formation requires netrin-1 expression by neurons in the adult mammalian brain

Wong, E. W., Glasgow, S. D., Trigiani, L. J., Chitsaz, D., Rymar, V., Sadikot, A., Ruthazer, E. S., Hamel, E., & Kennedy, T. E. (2019) · Learning & Memory · doi:10.1101/lm.049072.118 · Cited by 30

The Mouse Light–Dark Box Test

Hascoët, M., & Bourin, M. (2009) · Neuromethods · doi:10.1007/978-1-60761-303-9_11 · Cited by 26

Developmental exposure to a serotonin agonist produces subsequent behavioral and neurochemical changes in the adult male prairie vole

Martin, M. M., Liu, Y., & Wang, Z. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.09.015 · Cited by 26

mGlu5 Receptor Blockade Within the Nucleus Accumbens Shell Reduces Behavioral Indices of Alcohol Withdrawal-Induced Anxiety in Mice

Lee, K. M., Coelho, M. A., Class, M. A., Sern, K. R., Bocz, M. D., & Szumlinski, K. K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01306 · Cited by 24

Complex environmental rearing enhances social salience and affects hippocampal corticotropin releasing hormone receptor expression in a sex-specific manner.

Kentner, A. C., Lima, E., Migliore, M. M., Shin, J., & Scalia, S. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.035 · Cited by 23

Type 3 adenylyl cyclase in the main olfactory epithelium participates in depression-like and anxiety-like behaviours

Liu, X., Zhou, Y., Li, S., Yang, D., Jiao, M., Liu, X., & Wang, Z. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.02.041 · Cited by 21

Cognition as a cause, consequence, and component of welfare

Franks, B. (2018) · Advances in Agricultural Animal Welfare · doi:10.1016/b978-0-08-101215-4.00001-8 · Cited by 17

Exploration and Its Measurement: A Psychopharmacological Perspective

Kelley, A. E., Cador, M., & Stinus, L. (2003) · Psychopharmacology · doi:10.1385/0-89603-129-2:95 · Cited by 13

Polyethylene Glycol 3350 Changes Stool Consistency and the Microbiome but not Behavior of CD1 Mice

Salman, S. S., Williams, K. C., Marte‐Ortiz, P., Rumpf, W., Mashburn‐Warren, L., Lauber, C. L., Bailey, M. T., & Maltz, R. M. (2021) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000003222 · Cited by 11