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Role of the Brain's Reward Circuitry in Depression
Open accessAbstract
Increasing evidence supports an important role for the brain's reward circuitry in controlling mood under normal conditions and contributing importantly to the pathophysiology and symptomatology of a range of mood disorders, such as depression. Here we focus on the nucleus accumbens (NAc), a critical component of the brain's reward circuitry, in depression and other stress-related disorders. The prominence of anhedonia, reduced motivation, and decreased energy level in most individuals with depression supports the involvement of the NAc in these conditions. We concentrate on several transcription factors (CREB, ΔFosB, SRF, NFκB, and β-catenin), which are altered in the NAc in rodent depression models--and in some cases in the NAc of depressed humans, and which produce robust depression- or antidepressant-like effects when manipulated in the NAc in animal models. These studies of the NAc have established novel approaches toward modeling key symptoms of depression in animals and could enable the development of antidepressant medications with fundamentally new mechanisms of action.
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“In rodent models of depression and depressive-like behaviors, multiple behavioral assays in addition to social interaction test, including sucrose preference, tail suspension, and forced swim tests are often used [7, 20, 29].”
From A nucleus accumbens-projecting prefrontal cortex circuit underlies chronic social stress-induced depression-like behaviors (2026) · cites this paper as [29]
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“It has been described that a number of brain regions, such as the frontal cortex and the hippocampus, provide glutamatergic input to the VTA and NAc (Nestler, 2015).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Nestler, 2015
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“Our results also expand on other previous work implicating mPFC dysfunction in depression [7, 9, 29, 30]”
From A nucleus accumbens-projecting prefrontal cortex circuit underlies chronic social stress-induced depression-like behaviors (2026) · cites this paper as [29]
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“The VC/VS is a central hub in the reward circuitry with dopaminergic inputs from the ventral tegmental area (VTA), and serving as a relay between prefrontal cortex (OFC, vmPFC, ACC), ventral striatum and the amygdala and hippocampus [55,56] (Fig. 4).”
From Deep brain stimulation for depression. (2022) · cites this paper as [55]
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Metadata
- Authors
- Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Nestler, Eric J.
- ORCID
- Nestler, Eric J.
- Venue
- International review of neurobiology
- Publisher
- Elsevier
- Published
- 2015
- Volume
- 124
- Pages
- 151-170
- ISSN
- 0074-7742 (ISSN-L)
- PMC
- PMC4690450
- OpenAlex
- W2410587014
- Cited by
- 108
- References
- 78
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 12 · 2023: 12 · 2022: 10 · 2021: 10 · 2020: 8 · 2019: 13 · 2018: 11 · 2017: 9 · 2016: 5
- FWCI
- 23.77
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International review of neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (P50MH096890, R01MH051399)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- depression, reward systems, nucleus accumbens, anhedonia, stress-related disorders, transcription factors, CREB, ΔFosB, SRF, NF-κB, β-catenin, antidepressant mechanism, animal models of depression, mood disorders
- MeSH terms
- Animals, Brain, Depression, Disease Models, Animal, Gene Expression Regulation, Humans, Neural Pathways, Reward, Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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