Poly(lactic acid) blends in biomedical applications

Stimuli-responsive nanocarriers for drug delivery

Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289

Can the pharmaceutical industry reduce attrition rates?

Kola, I., & Landis, J. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1470 · Cited by 4,167

A Literature Review of Poly(Lactic Acid)

Garlotta, D. (2001) · Journal of Polymers and the Environment · doi:10.1023/a:1020200822435 · Cited by 3,707

Biodegradable Long-Circulating Polymeric Nanospheres

Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V., Torchilin, V., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,920

Polymer blends and composites from renewable resources

Yu, L., Dean, K., & Li, L. (2006) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2006.03.002 · Cited by 2,107

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

Aggarwal, P., Hall, J. B., McLeland, C. B., Dobrovolskaia, M. A., & McNeil, S. E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.009 · Cited by 1,791

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

Kamaly, N., Xiao, Z., Valencia, P. M., Radovic-Moreno, A. F., & Farokhzad, O. C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15344k · Cited by 1,730

Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies

Mitragotri, S., Burke, P. A., & Langer, R. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4363 · Cited by 1,702

Polymer Data Handbook

Mark, J. E. (2009) · Cited by 1,658

Monomers, Polymers and Composites from Renewable Resources

(2008) · Elsevier eBooks · doi:10.1016/b978-0-08-045316-3.x0001-4 · Cited by 1,496

Properties of lactic acid based polymers and their correlation with composition

Södergård, A., & Stolt, M. (2002) · Progress in Polymer Science · doi:10.1016/s0079-6700(02)00012-6 · Cited by 1,461

An analysis of the attrition of drug candidates from four major pharmaceutical companies

Waring, M. J., Arrowsmith, J., Leach, A. R., Leeson, P. D., Mandrell, S., Owen, R. M., Pairaudeau, G., Pennie, W. D., Pickett, S. D., Wang, J., et al. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4609 · Cited by 1,450

Phase separation processes in polymer solutions in relation to membrane formation

van de Witte, P., Dijkstra, P. J., van den Berg, J. W. A., & Feijen, J. (1996) · Journal of Membrane Science · doi:10.1016/0376-7388(96)00088-9 · Cited by 1,393

Poly(lactide) Stereocomplexes: Formation, Structure, Properties, Degradation, and Applications

Tsuji, H. (2005) · Macromolecular Bioscience · doi:10.1002/mabi.200500062 · Cited by 1,366

Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend

Kenawy, E.-R., Bowlin, G. L., Mansfield, K., Layman, J., Simpson, D. G., Sanders, E. H., & Wnek, G. E. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00041-x · Cited by 1,311

Poly-lactic acid synthesis for application in biomedical devices — A review

Lasprilla, A. J. R., Martinez, G. A. R., Lunelli, B. H., Jardini, A. L., & Filho, R. M. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.06.019 · Cited by 1,174

Poly(Lactic Acid): Synthesis, Structures, Properties, Processing, and Applications

(2010) · Wiley eBooks · doi:10.1002/9780470649848 · Cited by 1,058

Poly(lactide) Stereocomplexes: Formation, Structure, Properties, Degradation, and Applications

Tsuji, H. (2007) · Macromolecular Bioscience · doi:10.1002/mabi.200700275 · Cited by 1,021

Study of Biodegradable Polylactide/Poly(butylene adipate-co-terephthalate) Blends

Jiang, L., Wolcott, M. P., & Zhang, J. (2006) · Biomacromolecules · doi:10.1021/bm050581q · Cited by 954

Biodegradable poly(lactic acid) polymers

Kulkarni, R. K., Moore, E. G., Hegyeli, A. F., & Leonard, F. (1971) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820050305 · Cited by 799

Properties and medical applications of polylactic acid: A review

Hamad, K., Kaseem, M., Yang, H. W., Deri, F., & Ko, Y. G. (2015) · Express Polymer Letters · doi:10.3144/expresspolymlett.2015.42 · Cited by 722

Lipid–polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review

Hadinoto, K., Sundaresan, A., & Cheow, W. S. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.07.002 · Cited by 702

Compatibilization in bio-based and biodegradable polymer blends

Imre, B., & Pukánszky, B. (2013) · European Polymer Journal · doi:10.1016/j.eurpolymj.2013.01.019 · Cited by 613

Diversity-oriented synthesis: Exploring the intersections between chemistry and biology

Tan, D. S. (2005) · Nature Chemical Biology · doi:10.1038/nchembio0705-74 · Cited by 605

Preparation and characterization of biodegradable PLA polymeric blends

Chen, C.-C., Chueh, J.-Y., Tseng, H., Huang, H.-M., & Lee, S.-Y. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00466-0 · Cited by 583

Orthopaedic applications for PLA‐PGA biodegradable polymers

Athanasiou, K., Agrawal, C., Barber, F., & Burkhart, S. (1998) · Arthroscopy · doi:10.1016/s0749-8063(98)70099-4 · Cited by 487

A holistic approach to targeting disease with polymeric nanoparticles

Cheng, C. J., Tietjen, G. T., Saucier-Sawyer, J. K., & Saltzman, W. M. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4503 · Cited by 480

Natural and Synthetic Biomedical Polymers

(2014) · Elsevier eBooks · doi:10.1016/c2011-0-07330-1 · Cited by 445

Recent advances in stimuli-responsive degradable block copolymer micelles: Synthesis and controlled drug delivery applications

Zhang, Q., Re Ko, N., & Kwon Oh, J. (2012) · Chemical Communications · doi:10.1039/c2cc32408c · Cited by 395

Safety assessment of polylactide (PLA) for use as a food-contact polymer

Conn, R. E., Kolstad, J. J., Borzelleca, J. F., Dixler, D. S., Filer, L. J., Ladu, B. N., & Pariza, M. W. (1995) · Food and Chemical Toxicology · doi:10.1016/0278-6915(94)00145-e · Cited by 344

PLA Nano‐ and Microparticles for Drug Delivery: An Overview of the Methods of Preparation

Lassalle, V., & Ferreira, M. L. (2007) · Macromolecular Bioscience · doi:10.1002/mabi.200700022 · Cited by 340

Fully Biodegradable and Biorenewable Ternary Blends from Polylactide, Poly(3-hydroxybutyrate-co-hydroxyvalerate) and Poly(butylene succinate) with Balanced Properties

Zhang, K., Mohanty, A. K., & Misra, M. (2012) · ACS Applied Materials & Interfaces · doi:10.1021/am3004522 · Cited by 335

Preparation and Properties of Plasticized Poly(lactic acid) Films

Ljungberg, N., & Wesslén, B. (2005) · Biomacromolecules · doi:10.1021/bm050098f · Cited by 331

Plasticization of Poly(l-lactide) with Poly(propylene glycol)

Kulinski, Z., Piorkowska, E., Gadzinowska, K., & Stasiak, M. (2006) · Biomacromolecules · doi:10.1021/bm060089m · Cited by 320

Characterization of thermoplastic polyurethane/polylactic acid (TPU/PLA) tissue engineering scaffolds fabricated by microcellular injection molding

Mi, H.-Y., Salick, M. R., Jing, X., Jacques, B. R., Crone, W. C., Peng, X.-F., & Turng, L.-S. (2013) · Materials Science and Engineering: C · doi:10.1016/j.msec.2013.07.037 · Cited by 308

Engineering biodegradable polyester particles with specific drug targeting and drug release properties

Mohamed, F., & van der Walle, C. F. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21082 · Cited by 299

Compatibilization strategies in poly(lactic acid)-based blends

Zeng, J.-B., Li, K.-A., & Du, A.-K. (2015) · RSC Advances · doi:10.1039/c5ra01655j · Cited by 290

Handbook of Plasticizers

(2012) · Elsevier eBooks · doi:10.1016/c2011-0-07408-2 · Cited by 278

Polylactic Acid: Synthesis, Properties and Applications

Avérous, L. (2008) · Monomers, Polymers and Composites from Renewable Resources · doi:10.1016/b978-0-08-045316-3.00021-1 · Cited by 258

Microencapsulation of protein drugs for drug delivery: Strategy, preparation, and applications

Ma, G. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.09.003 · Cited by 250

Biomedical Applications of Poly(Lactic Acid)

P. Pawar, R., U. Tekale, S., U. Shisodia, S., T. Totre, J., & J. Domb, A. (2014) · Recent Patents on Regenerative Medicine · doi:10.2174/2210296504666140402235024 · Cited by 248

Potential of Lignins as Antioxidant Additive in Active Biodegradable Packaging Materials

Domenek, S., Louaifi, A., Guinault, A., & Baumberger, S. (2013) · Journal of Polymers and the Environment · doi:10.1007/s10924-013-0570-6 · Cited by 238

Dynamically Vulcanized Biobased Polylactide/Natural Rubber Blend Material with Continuous Cross-Linked Rubber Phase

Chen, Y., Yuan, D., & Xu, C. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am5004766 · Cited by 233

Overcoming the Fundamental Challenges in Improving the Impact Strength and Crystallinity of PLA Biocomposites: Influence of Nucleating Agent and Mold Temperature

Nagarajan, V., Zhang, K., Misra, M., & Mohanty, A. K. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b01145 · Cited by 232

Mechanical, Thermal and Morphological Properties of Poly(lactic acid)/Epoxidized Palm Olein Blend

Silverajah, V. S. G., Ibrahim, N. A., Zainuddin, N., Yunus, W. M. Z. W., & Hassan, H. A. (2012) · Molecules · doi:10.3390/molecules171011729 · Cited by 214

Processing and characterization of plasticized PLA/PHB blends for biodegradable multiphase systems

Armentano, I., Fortunati, E., Burgos, N., Dominici, F., Luzi, F., Fiori, S., Jimenez, A., Yoon, K., Ahn, J., Kang, S., et al. (2015) · Express Polymer Letters · doi:10.3144/expresspolymlett.2015.55 · Cited by 209

Polymeric worm micelles as nano-carriers for drug delivery

Kim, Y., Dalhaimer, P., Christian, D. A., & Discher, D. E. (2005) · Nanotechnology · doi:10.1088/0957-4484/16/7/024 · Cited by 207

Relevance of PEG in PLA-based blends for tissue engineering 3D-printed scaffolds

Serra, T., Ortiz-Hernandez, M., Engel, E., Planell, J. A., & Navarro, M. (2014) · Materials Science and Engineering: C · doi:10.1016/j.msec.2014.01.003 · Cited by 206

Miscibility and phase structure of binary blends of polylactide and poly(methyl methacrylate)

Zhang, G., Zhang, J., Wang, S., & Shen, D. (2003) · Journal of Polymer Science Part B: Polymer Physics · doi:10.1002/polb.10353 · Cited by 205

Properties of linear poly(lactic acid)/polyethylene glycol blends

Sungsanit, K., Kao, N., & Bhattacharya, S. N. (2012) · Polymer Engineering & Science · doi:10.1002/pen.22052 · Cited by 196

Characterization of Porous PLGA/PLA Microparticles as a Scaffold for Three Dimensional Growth of Breast Cancer Cells

Sahoo, S. K., Panda, A. K., & Labhasetwar, V. (2005) · Biomacromolecules · doi:10.1021/bm0492632 · Cited by 189

Development of biodegradable flexible films of starch and poly(lactic acid) plasticized with adipate or citrate esters

Shirai, M. A., Grossmann, M. V. E., Mali, S., Yamashita, F., Garcia, P. S., & Müller, C. M. O. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.09.038 · Cited by 189

Extrusion Foaming of Semi‐Crystalline PLA and PLA/Thermoplastic Starch Blends

Mihai, M., Huneault, M. A., Favis, B. D., & Li, H. (2007) · Macromolecular Bioscience · doi:10.1002/mabi.200700080 · Cited by 188

Targeted delivery of paclitaxel using folate-decorated poly(lactide)-vitamin E TPGS nanoparticles

Pan, J., & Feng, S.-S. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.02.020 · Cited by 187

A novel porous cells scaffold made of polylactide–dextran blend by combining phase-separation and particle-leaching techniques

Cai, Q., Yang, J., Bei, J., & Wang, S. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00168-0 · Cited by 186

Star-branched amphiphilic PLA-b-PDMAEMA copolymers for co-delivery of miR-21 inhibitor and doxorubicin to treat glioma

Qian, X., Long, L., Shi, Z., Liu, C., Qiu, M., Sheng, J., Pu, P., Yuan, X., Ren, Y., & Kang, C. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.039 · Cited by 186

Recent advances in high performance poly(lactide): from “green” plasticization to super-tough materials via (reactive) compounding

Kfoury, G., Raquez, J.-M., Hassouna, F., Odent, J., Toniazzo, V., Ruch, D., & Dubois, P. (2013) · Frontiers in Chemistry · doi:10.3389/fchem.2013.00032 · Cited by 182

Morphology and Properties of Soy Protein and Polylactide Blends

Zhang, J., Jiang, L., Zhu, L., Jane, J.-L., & Mungara, P. (2006) · Biomacromolecules · doi:10.1021/bm050888p · Cited by 176

Biomedical Science, Engineering and Technology

(2012) · InTech eBooks · doi:10.5772/1020 · Cited by 168

Handbook of biopolymers and biodegradable plastics : properties, processing and applications

Ebnesajjad, S. (2013) · Cited by 167

Supertough Polylactide Materials Prepared through In Situ Reactive Blending with PEG-Based Diacrylate Monomer

Fang, H., Jiang, F., Wu, Q., Ding, Y., & Wang, Z. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am502735q · Cited by 161

Morphology, miscibility and continuity development in poly(lactic acid)/poly(butylene adipate-co-terephthalate) blends

Jalali Dil, E., Carreau, P. J., & Favis, B. D. (2015) · Polymer · doi:10.1016/j.polymer.2015.05.012 · Cited by 158

PEGylation strategies for active targeting of PLA/PLGA nanoparticles

Betancourt, T., Byrne, J. D., Sunaryo, N., Crowder, S. W., Kadapakkam, M., Patel, S., Casciato, S. L., & Brannon‐Peppas, L. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32247 · Cited by 155

Nanofibrous matrices of poly(lactic acid) and gelatin polymeric blends for the improvement of cellular responses

Kim, H., Yu, H., & Lee, H. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31677 · Cited by 155

Effect of Chain-Extenders on the Properties and Hydrolytic Degradation Behavior of the Poly(lactide)/ Poly(butylene adipate-co-terephthalate) Blends

Dong, W., Zou, B., Yan, Y., Ma, P., & Chen, M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020189 · Cited by 153

The morphology, properties, and shape memory behavior of polylactic acid/thermoplastic polyurethane blends

Jing, X., Mi, H., Peng, X., & Turng, L. (2014) · Polymer Engineering and Science · doi:10.1002/pen.23873 · Cited by 148

Poly(Lactic Acid)

Tsuji, H. (2013) · Wiley eBooks · doi:10.1002/9781118676646.ch8 · Cited by 146

Role of Specific Interfacial Area in Controlling Properties of Immiscible Blends of Biodegradable Polylactide and Poly[(butylene succinate)-co-adipate]

Ojijo, V. O., Ray, S. S., & Sadiku, E. R. (2012) · ACS Applied Materials & Interfaces · doi:10.1021/am301842e · Cited by 146

Effect of annealing on the mechanical properties of PLA/PCL and PLA/PCL/LTI polymer blends

Takayama, T., Todo, M., & Tsuji, H. (2010) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2010.10.003 · Cited by 145

Effect of miscibility on mechanical and thermal properties of poly(lactic acid)/polycaprolactone blends

Ferri, J. M., Fenollar, O., Jorda‐Vilaplana, A., García‐Sanoguera, D., & Balart, R. (2016) · Polymer International · doi:10.1002/pi.5079 · Cited by 141

Polylactide-graft-doxorubicin Nanoparticles with Precisely Controlled Drug Loading for pH-Triggered Drug Delivery

Yu, Y., Chen, C.-K., Law, W.-C., Weinheimer, E., Sengupta, S., Prasad, P. N., & Cheng, C. (2014) · Biomacromolecules · doi:10.1021/bm401471p · Cited by 134

An injection molding process for manufacturing highly porous and interconnected biodegradable polymer matrices for use as tissue engineering scaffolds

Kramschuster, A., & Turng, L. (2009) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.31523 · Cited by 131

New concepts in the design of drug-eluting coronary stents

Garg, S., Bourantas, C., & Serruys, P. W. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.13 · Cited by 125

Polyester-Grafted Cellulose Nanowhiskers: A New Approach for Tuning the Microstructure of Immiscible Polyester Blends

Goffin, A., Habibi, Y., Raquez, J., & Dúbois, P. (2012) · ACS Applied Materials & Interfaces · doi:10.1021/am3008196 · Cited by 125

Poly(lactic acid) Science and Technology: Processing, Properties, Additives and Applications

Royal Society of Chemistry (2014) · RSC polymer chemistry series · doi:10.1039/9781782624806 · Cited by 122

Biocompatible shape memory polymer actuators with high force capabilities

Song, J. J., Chang, H. H., & Naguib, H. E. (2015) · European Polymer Journal · doi:10.1016/j.eurpolymj.2015.03.067 · Cited by 120

Biomimetic poly(glycerol sebacate)/poly(l-lactic acid) blend scaffolds for adipose tissue engineering

Frydrych, M., Román, S., MacNeil, S., & Chen, B. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.03.004 · Cited by 111

Stereocomplexation of Polylactide Enhanced by Poly(methyl methacrylate): Improved Processability and Thermomechanical Properties of Stereocomplexable Polylactide-Based Materials

Samuel, C., Cayuela, J., Barakat, I., Müller, A. J., Raquez, J., & Dúbois, P. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am403443m · Cited by 110

Entanglement network formed in miscible PLA/PMMA blends and its role in rheological and thermo-mechanical properties of the blends

Hao, X., Kaschta, J., Liu, X., Pan, Y., & Schubert, D. W. (2015) · Polymer · doi:10.1016/j.polymer.2015.10.037 · Cited by 100

A new biodegradable blends prepared from polylactide and hyaluronic acid

Wu, C.-S., & Liao, H. (2005) · Polymer · doi:10.1016/j.polymer.2005.08.056 · Cited by 97

Compatible Ternary Blends of Chitosan/poly(vinyl alcohol)/poly(lactic acid) Produced by Oil-in-Water Emulsion Processing

Grande, R., & Carvalho, A. J. F. (2011) · Biomacromolecules · doi:10.1021/bm101227q · Cited by 97

The properties of antimicrobial films derived from poly(lactic acid)/starch/chitosan blended matrix

Bie, P., Liu, P., Yu, L. F., Li, X., Chen, L., & Xie, F. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.07.004 · Cited by 96

Long-acting delivery systems for narcotic antagonists. 1

Woodland, J. H. R., Yolles, S., Blake, D. A., Helrich, M., & Meyer, F. J. (1973) · Journal of Medicinal Chemistry · doi:10.1021/jm00266a007 · Cited by 95

Effect of annealing on the thermal properties of poly (lactic acid)/starch blends

Lv, S., Gu, J., Cao, J., Tan, H., & Zhang, Y. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.12.022 · Cited by 95

Thermoplastic PVA/PLA Blends with Improved Processability and Hydrophobicity

Li, H.-Z., Chen, S., & Wang, Y. (2014) · Industrial & Engineering Chemistry Research · doi:10.1021/ie502531w · Cited by 91

Bioreducible poly(2-ethyl-2-oxazoline)–PLA–PEI-SS triblock copolymer micelles for co-delivery of DNA minicircles and Doxorubicin

Gaspar, V. M., Baril, P., Costa, E. C., de Melo‐Diogo, D., Foucher, F., Queiroz, J. A., de Sousa, F. P., Pichon, C., & Correia, I. J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.011 · Cited by 88

Novel electrospun nanofibrous matrices prepared from poly(lactic acid)/poly(butylene adipate) blends for controlled release formulations of an anti-rheumatoid agent

Siafaka, P. I., Barmpalexis, P., & Bikiaris, D. Ν. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.03.021 · Cited by 85

Design and characterization of biocompatible shape memory polymer (SMP) blend foams with a dynamic porous structure

Song, J. J., Chang, H. H., & Naguib, H. E. (2014) · Polymer · doi:10.1016/j.polymer.2014.09.062 · Cited by 83

Electrospinning of hexanoyl chitosan/polylactide blends

Peesan, M., Rujiravanit, R., & Supaphol, P. (2006) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856206776986251 · Cited by 82

Nanoparticles of poly(D,L‐lactide)/methoxy poly(ethylene glycol)‐poly(D,L‐lactide) blends for controlled release of paclitaxel

Dong, Y., & Feng, S. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30684 · Cited by 81

Controlling Degradation Rate of Poly (lactic acid) for Its Biomedical Applications

Shasteen, C., & Choy, Y. B. (2011) · Biomedical Engineering Letters · doi:10.1007/s13534-011-0025-8 · Cited by 81

Evaluation of PHBHHx and PHBV/PLA fibers used as medical sutures

He, Y., Hu, Z., Ren, M., Ding, C., Chen, P., Gu, Q., & Wu, Q. (2013) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-013-5073-4 · Cited by 80

Preparation and characterization of starch/poly(l-lactic acid) hybrid foams

Preechawong, D., Peesan, M., Supaphol, P., & Rujiravanit, R. (2004) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2004.10.003 · Cited by 80

Disease, destination, dose and delivery aspects of ciclosporin: the state of the art

Italia, J. L., Bhardwaj, V., & Kumar, M. N. V. R. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.07.015 · Cited by 75

In vitro and in vivo testing of novel ultrathin PCL and PCL/PLA blend films as peripheral nerve conduit

Sun, M., Kingham, P. J., Reid, A. J., Armstrong, S. J., Terenghi, G., & Downes, S. (2009) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32681 · Cited by 73

Enzymatic synthesis of poly-l-lactide and poly-l-lactide-co-glycolide in an ionic liquid

Chanfreau, S., Mena, M., Porras-Domínguez, J. R., Ramírez-Gilly, M., Gimeno, M., Roquero, P., Tecante, A., & Bárzana, E. (2010) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-009-0388-8 · Cited by 72

Thermal and Mechanical Characterization of Electrospun Blends of Poly(lactic acid) and Poly(glycolic acid)

Ramdhanie, L. I., Aubuchon, S. R., Boland, E. D., Knapp, D. C., Barnes, C. P., Simpson, D. G., Wnek, G. E., & Bowlin, G. L. (2006) · Polymer Journal · doi:10.1295/polymj.pj2006062 · Cited by 72

Preparation and characterization of thermoplastic starches and their blends with poly(lactic acid)

Yang, Y., Tang, Z., Xiong, Z., & Zhu, J. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.03.053 · Cited by 71

Intranasal delivery of zidovudine by PLA and PLA–PEG blend nanoparticles

Mainardes, R. M., Khalil, N. M., & Gremião, M. P. D. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.05.020 · Cited by 70

Biodegradability study of polylactic acid/ thermoplastic polyurethane blends

Jašo, V., Glenn, G. M., Klamczynski, A. K., & Petrovìć, Z. S. (2015) · Polymer Testing · doi:10.1016/j.polymertesting.2015.07.011 · Cited by 69

Thermoplastic starch/polyester films: Effects of extrusion process and poly (lactic acid) addition

Shirai, M. A., Olivato, J. B., Garcia, P. S., Müller, C. M. O., Grossmann, M. V. E., & Yamashita, F. (2013) · Materials Science and Engineering: C · doi:10.1016/j.msec.2013.05.054 · Cited by 69

Aliphatic polyesters for medical imaging and theranostic applications

Nottelet, B., Darcos, V., & Coudane, J. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.06.023 · Cited by 68

Maleic Anhydride as a Compatibilizer and Plasticizer in TPS/PLA Blends

Clasen, S. H., Müller, C. M. O., & Pires, A. T. N. (2015) · Journal of the Brazilian Chemical Society · doi:10.5935/0103-5053.20150126 · Cited by 68

PLA/chain‐extended PEG blends with improved ductility

Park, B., Song, J. C., Park, D. H., & Yoon, K. (2011) · Journal of Applied Polymer Science · doi:10.1002/app.34823 · Cited by 67

The Future of Carbon Dioxide for Polymer Processing in Tissue Engineering

Bhamidipati, M., Scurto, A. M., & Detamore, M. S. (2013) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2012.0361 · Cited by 66

Controlled Protein Release from Polyethyleneimine-Coated Poly(L-lactic Acid)/Pluronic Blend Matrices

Park, T. G., Cohen, S., & Langer, R. (1992) · Pharmaceutical Research · doi:10.1023/a:1018971525301 · Cited by 63

Porous poly( dl -lactic acid) matrix film with antimicrobial activities for wound dressing application

Chitrattha, S., & Phaechamud, T. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.09.083 · Cited by 62

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Sankaran, K. K., Krishnan, U. M., & Sethuraman, S. (2014) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2014.950505 · Cited by 61

Quantitative control of targeting effect of anticancer drugs formulated by ligand-conjugated nanoparticles of biodegradable copolymer blend

Zhao, J., Mi, Y., Liu, Y., & Feng, S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.051 · Cited by 61

Processing and characterization of supercritical CO2batch foamed poly(lactic acid)/poly(ethylene glycol) scaffold for tissue engineering application

Zhang, W., Chen, B., Zhao, H., Yu, P., Fu, D., Wen, J., & Peng, X. (2013) · Journal of Applied Polymer Science · doi:10.1002/app.39523 · Cited by 60

Polylactide/Poly(ω-hydroxytetradecanoic acid) Reactive Blending: A Green Renewable Approach to Improving Polylactide Properties

Spinella, S., Cai, J., Samuel, C., Zhu, J., McCallum, S. A., Habibi, Y., Raquez, J., Dúbois, P., & Gross, R. A. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b00394 · Cited by 60

Fabrication of polylactic acid/polyethylene glycol ( PLA / PEG ) porous scaffold by supercritical CO 2 foaming and particle leaching

Chen, B., Jing, X., Mi, H., Zhao, H., Zhang, W., Peng, X., & Turng, L. (2015) · Polymer Engineering and Science · doi:10.1002/pen.24073 · Cited by 58

Long Acting Delivery Systems for Narcotic Antagonists II: Release Rates of Naltrexone from Poly(lactic Acid) Composites

Yolles, S., Leafe, T. D., Woodland, J. H. R., & Meyer, F. J. (1975) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600640239 · Cited by 58

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Haroosh, H. J., Dong, Y., & Lau, K.-T. (2014) · Journal of Materials Science · doi:10.1007/s10853-014-8352-7 · Cited by 58

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Hossain, K. M. Z., Hasan, M. S., Boyd, D., Rudd, C. D., Ahmed, I., & Thielemans, W. (2014) · Biomacromolecules · doi:10.1021/bm5001444 · Cited by 56

Poly(lactic acid)/chitosan hybrid nanoparticles for controlled release of anticancer drug

Wang, W., Chen, S., Zhang, L., Wu, X., Wang, J., Chen, J., & Le, Y. (2014) · Materials Science and Engineering C · doi:10.1016/j.msec.2014.10.048 · Cited by 56

Physical ageing and molecular mobility in PLA blends and composites

Müller, P., Imre, B., Bere, J., Móczó, J., & Pukánszky, B. (2015) · Journal of Thermal Analysis and Calorimetry · doi:10.1007/s10973-015-4831-6 · Cited by 55

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Sadiasa, A., Nguyen, H. T., & Lee, B. (2013) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2013.846633 · Cited by 53

Immiscibility–miscibility phase transitions in blends of poly( L ‐lactide) with poly(methyl methacrylate)

Li, S., & Woo, E. M. (2008) · Polymer International · doi:10.1002/pi.2469 · Cited by 52

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Gupta, K. K., Pal, N., Mishra, P. K., Srivastava, P., Mohanty, S., & Maiti, P. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34932 · Cited by 50

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Fu, C., Sun, X., Liu, D., Chen, Z., Lu, Z., & Zhang, N. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12021371 · Cited by 50

Phase morphology, physical properties, and biodegradation behavior of novel PLA/PHBHHx blends

Zhao, Q., Wang, S., Kong, M., Geng, W., Li, R. K. Y., Song, C., & Kong, D. (2012) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.31915 · Cited by 49

Preparation of hydrophilic poly(lactic acid) tissue engineering scaffold via (PLA)-(PLA-b-PEG)-(PEG) solution casting and thermal-induced surface structural transformation

Zhu, X., Zhong, T., Huang, R., & Wan, A. (2015) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2015.1088125 · Cited by 47

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Liu, X., Lei, L., Hou, J., Tang, M.-F., Guo, S., Wang, Z., & Chen, K. (2011) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-010-4213-3 · Cited by 47

Development of PEG–PLA/PLGA microparticles for pulmonary drug delivery prepared by a novel emulsification technique assisted with amphiphilic block copolymers

Takami, T., & Murakami, Y. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.06.004 · Cited by 46

Synthesis and characterization of poly(d,l-lactic acid) via enzymatic ring opening polymerization by using free and immobilized lipase

Omay, D., & Güvenilir, Y. (2013) · Biocatalysis and Biotransformation · doi:10.3109/10242422.2013.795148 · Cited by 45

In vitro study on the drug release behavior from Polylactide‐based blend matrices

Cai, Q., Bei, J., & Wang, S. (2002) · Polymers for Advanced Technologies · doi:10.1002/pat.222 · Cited by 42

Effect of blending conditions on mechanical, thermal, and rheological properties of plasticized poly(lactic acid)/maleated thermoplastic starch blends

Wootthikanokkhan, J., Wongta, N., Sombatsompop, N., Kositchaiyong, A., Wongon, J., Ayutthaya, S. I. N., & Kaabbuathong, N. (2011) · Journal of Applied Polymer Science · doi:10.1002/app.35142 · Cited by 41

Mechanical and thermal properties of conventional and microcellular injection molded poly (lactic acid)/poly (ε-caprolactone) blends

Zhao, H., & Zhao, G. (2015) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2015.08.002 · Cited by 40

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Yu, L. F., Petinakis, E., Dean, K., Liu, H., & Yuan, Q. (2010) · Journal of Applied Polymer Science · doi:10.1002/app.32949 · Cited by 40

Melt blending of polylactide and poly(methyl methacrylate): Thermal and mechanical properties and phase morphology characterization

Anakabe, J., Zaldua, A. M., Eceiza, A., & Arbelaiz, A. (2015) · Journal of Applied Polymer Science · doi:10.1002/app.42677 · Cited by 39

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Jia, Z., Tan, J., Han, C., Yang, Y., & Dong, L. (2009) · Journal of Applied Polymer Science · doi:10.1002/app.30638 · Cited by 38

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Adeosun, S. O., Lawal, G. I., & Gbenebor, O. P. (2014) · Journal of Minerals and Materials Characterization and Engineering · doi:10.4236/jmmce.2014.22013 · Cited by 37

Studies of in situ‐forming hydrogels by blending PLA‐PEG‐PLA copolymer with silk fibroin solution

Zhong, T., Deng, C., Gao, Y., Chen, M., & Zuo, B. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.33307 · Cited by 37

Synthesis, Morphological Structures, and Material Characterization of Electrospun PLA:PCL/Magnetic Nanoparticle Composites for Drug Delivery

Haroosh, H. J., Dong, Y., & Ingram, G. D. (2013) · Journal of Polymer Science Part B Polymer Physics · doi:10.1002/polb.23374 · Cited by 37

Fabrication of tissue engineering scaffolds through solid-state foaming of immiscible polymer blends

Zhou, C., Ma, L., Li, W., & Yao, D. (2011) · Biofabrication · doi:10.1088/1758-5082/3/4/045003 · Cited by 35

Endothelialization of electrospun polycaprolactone (PCL) small caliber vascular grafts spun from different polymer blends

Pfeiffer, D., Stefanitsch, C., Wankhammer, K., Müller, M., Dreyer, L., Krolitzki, B., Zernetsch, H., Glasmacher, B., Lindner, C., Lass, A., et al. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35123 · Cited by 35

Novel blends of polylactide with ethylene glycol derivatives of POSS

Zubrowska, A., Piórkowska, E., Kowalewska, A., & Cichorek, M. (2014) · Colloid & Polymer Science · doi:10.1007/s00396-014-3344-3 · Cited by 33

Properties of PLA/PCL particles as vehicles for oral delivery of the androgen hormone 17α-methyltestosterone

Sacchetin, P. S. C., Setti, R. F., Rosa, P. D. T. V. E., & Moraes, Â. M. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.09.071 · Cited by 30

Synthesis and reduction-responsive disassembly of PLA-based mono-cleavable micelles

Cunningham, A. J., Ko, N. R., & Oh, J. K. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.08.002 · Cited by 30

In vitro and in vivo testing of novel ultrathin PCL and PCL-PLA blend film as peripheral nerve conduits

Sun, M., Kingham, P. J., Aj, R., Armstrong, S. J., Terenghi, G., & Downes, S. (2010) · Cited by 30

SYNTHESIS AND PROPERTIES OF HIGH MOLECULAR WEIGHT POLY(LACTIC ACID) AND ITS RESULTANT FIBERS

Zhang, W., & Wang, Y.-Z. (2008) · Chinese Journal of Polymer Science · doi:10.1142/s0256767908003096 · Cited by 29

Characterization of biodegradable polymers by inverse gas chromatography. II. Blends of amylopectin and poly(ε‐caprolactone)

Al‐Ghamdi, A., Melibari, M., & Al‐Saigh, Z. Y. (2006) · Journal of Applied Polymer Science · doi:10.1002/app.24226 · Cited by 27

Modular polylactic acid microparticle‐based scaffolds prepared via microfluidic emulsion/solvent displacement process: Fabrication, characterization, andin vitromesenchymal stem cells interaction study

Salerno, A., Levato, R., Mateos‐Timoneda, M. A., Engel, E., Netti, P. A., & Planell, J. A. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34374 · Cited by 26

Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings

Conville, C. M., Major, I., Friend, D. R., Clark, M. R., Woolfson, A. D., & Malcolm, K. R. (2012) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.31919 · Cited by 25

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Boonkong, W., Petsom, A., & Thongchul, N. (2013) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-013-4864-y · Cited by 23

Preparation of poly(l-lactide) blends and biodegradation by Lentzea waywayandensis

Nair, N. R., Nampoothiri, K. M., & Pandey, A. (2012) · Biotechnology Letters · doi:10.1007/s10529-012-1005-5 · Cited by 23

Damage-induced hydrolyses modelling of biodegradable polymers for tendons and ligaments repair

Vieira, A. C., Guedes, R. M., & Tita, V. (2015) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2015.05.025 · Cited by 20

Miscibility and crystallization behaviors of stereocomplex-type poly(l- and d-lactide)/poly(methyl methacrylate) blends

Dong, Q., Bian, Y., Li, Y., Han, C., & Dong, L. (2014) · Journal of Thermal Analysis and Calorimetry · doi:10.1007/s10973-014-3966-1 · Cited by 20

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Liu, B., Jiang, L., & Zhang, J. (2010) · Journal of Polymers and the Environment · doi:10.1007/s10924-010-0274-0 · Cited by 18

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Pérez, E., Benito, M., Teijón, C., Olmo, R., Teijón, J. M., & Blanco, M. D. (2012) · Journal of Microencapsulation · doi:10.3109/02652048.2011.651496 · Cited by 15

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Xiong, X., Li, Q., Lu, J., Guo, Z., Sun, Z., & Yu, J. (2012) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/092050611x576981 · Cited by 15

Modification of PLA

Ren, J. (2010) · Springer eBooks · doi:10.1007/978-3-642-17596-1_4 · Cited by 11

Novel Thermoresponsive Biodegradable Nanocomposite Hydrogels for Dual Function in Biomedical Applications

Prabhakar, M. N., Sudhakara, P., Subha, M. C. S., Rao, K. C., & Song, J. I. (2015) · Polymer-Plastics Technology and Engineering · doi:10.1080/03602559.2015.1010212 · Cited by 10

Characterization of biodegradable polymers by inverse gas chromatography. III. Blends of amylopectin and poly( L ‐lactide)

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Nadeau, V., & Hildgen, P. (2005) · Molecules · doi:10.3390/10010105 · Cited by 8

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Hashim, N., Retenam, K., Somderam, S., & Yusoh, K. (2015) · Advanced materials research · doi:10.4028/www.scientific.net/amr.1134.185 · Cited by 7

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Zhao, X., Hu, H., Wang, X., Yu, X., Zhou, W., & Peng, S. (2020) · RSC Advances · doi:10.1039/d0ra01801e · Cited by 465

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Liu, J., Sun, L., Xu, W., Wang, Q., Yu, S., & Sun, J. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.11.077 · Cited by 428