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Cited by 401Muscle Physiology and DisordersMuscle metabolism and nutritionNutrition and Health in Aging

The DOI matches its Crossref record; 125 of the 131 references it cites were found in a registry or an index.

Skeletal muscle atrophy during short-term disuse: Implications for age-related sarcopenia

Open access
Wall, Benjamin T., Dirks, Marlou L., van Loon, Luc J.C.·2013·Ageing Research Reviews
DOI 10.1016/j.arr.2013.07.003
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Abstract

Situations such as the recovery from injury and illness can lead to enforced periods of muscle disuse or unloading. Such circumstances lead to rapid skeletal muscle atrophy, loss of functional strength and a multitude of related negative health consequences. The elderly population is particularly vulnerable to the acute challenges of muscle disuse atrophy. Any loss of skeletal muscle mass must be underpinned by a chronic imbalance between muscle protein synthesis and breakdown rates. It is recognized that muscle atrophy during prolonged (>10 days) disuse is brought about primarily by declines in post-absorptive and post-prandial muscle protein synthesis rates, without a clear contribution from changes in muscle protein breakdown. Few data are available on the impact of short-term disuse (<10 days) on muscle protein turnover in humans. However, indirect evidence indicates that considerable muscle atrophy occurs during this early phase, and is likely attributed to a rapid increase in muscle protein breakdown accompanied by the characteristic decline in muscle protein synthesis. Short-term disuse atrophy is of particular relevance in the development of sarcopenia, as it has been suggested that successive short periods of muscle disuse, due to sickness or injury, accumulate throughout an individual's lifespan and contributes considerably to the net muscle loss observed with aging. Research is warranted to elucidate the physiological and molecular basis for rapid muscle loss during short periods of disuse. Such mechanistic insight will allow the characterization of nutritional, exercise and/or pharmacological interventions to prevent or attenuate muscle loss during periods of disuse and therefore aid in the treatment of age-related sarcopenia.

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Crossref · 10.1016/j.arr.2013.07.003

Cites

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Citations

Cites

Research works printed but not linked: 4

  1. Deitrick, 1948, The effect of immobilization on metabolic and physiological functions of normal men, Bull. N. Y. Acad. Med., 24, 364
  2. Gibson, 1987, Decrease in human quadriceps muscle protein turnover consequent upon leg immobilization, Clin. Sci. (Lond.), 72, 503, 10.1042/cs0720503 · DOI
  3. LeBlanc, 1992, Regional changes in muscle mass following 17 weeks of bed rest, J. Appl. Physiol., 73, 2172, 10.1152/jappl.1992.73.5.2172 · DOI · Paper page
  4. White, 1984, The effects of short-term voluntary immobilization on the contractile properties of the human triceps surae, Q. J. Exp. Physiol., 69, 685, 10.1113/expphysiol.1984.sp002860 · DOI

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Metadata

Authors
Wall, B. T., Dirks, M. L., & van Loon, L. J. C.
Affiliations
Maastricht University Medical Centre (NL)
ORCID
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2013-09
Volume
12
Issue
4
Pages
898-906
ISSN
1568-1637 (ISSN-L)
DOI
10.1016/j.arr.2013.07.003
OpenAlex
W2159802435
Cited by
400
References
131
Citations by year
2026: 27 · 2025: 25 · 2024: 33 · 2023: 37 · 2022: 37 · 2021: 45 · 2020: 38 · 2019: 27 · 2018: 34 · 2017: 31 · 2016: 29 · 2015: 19 · 2014: 12 · 2013: 6
FWCI
2.07
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion)
  • Research Bank (Australian Catholic University) (submittedVersion)
  • Socio-Environmental Systems Modeling (submittedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords
skeletal muscle atrophy, muscle disuse, age-related sarcopenia, muscle protein synthesis, muscle protein degradation, muscle protein turnover, muscle unloading, aging, sarcopenia prevention
MeSH terms
Aged, Aging, Humans, Muscular Atrophy, Muscle, Skeletal, Muscular Disorders, Atrophic, Sarcopenia

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