Sexually dimorphic effects of a prenatal immune challenge on social play and vasopressin expression in juvenile rats
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BACKGROUND: Infectious diseases and inflammation during pregnancy increase the offspring's risk for behavioral disorders. However, how immune stress affects neural circuitry during development is not well known. We tested whether a prenatal immune challenge interferes with the development of social play and with neural circuits implicated in social behavior. METHODS: Pregnant rats were given intraperitoneal injections of the bacterial endotoxin lipopolysaccharide (LPS - 100 μg /kg) or saline on the 15th day of pregnancy. Offspring were tested for social play behaviors between postnatal days 26-40. Brains were harvested on postnatal day 45 and processed for arginine vasopressin (AVP) mRNA in situ hybridization. RESULTS: In males, LPS treatment reduced the frequency of juvenile play behavior and reduced AVP mRNA expression in the medial amygdala and bed nucleus of the stria terminalis. These effects were not found in females. LPS treatment did not change AVP mRNA expression in the suprachiasmatic nucleus, paraventricular nucleus, or supraoptic nucleus of either sex, nor did it affect the sex difference in the size of the sexually dimorphic nucleus of the preoptic area. CONCLUSIONS: Given AVP's central role in regulating social behavior, the sexually dimorphic effects of prenatal LPS treatment on male AVP mRNA expression may contribute to the sexually dimorphic effect of LPS on male social play and may, therefore, increase understanding of factors that contribute to sex differences in social psychopathology.
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Social play activities were found to be altered in juvenile male rats that were exposed to either maternal separation or prenatal immune stress.
“Likewise, social play activities were found to be altered in juvenile male rats that were exposed to either maternal separation (Veenema and Neumann, 2009) or prenatal immune stress (Taylor et al., 2012).”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Taylor et al., 2012
Prenatal exposure to an immune challenge, lipopolysaccharide (LPS), decreases both play and BNST AVP mRNA of juvenile male rats.
“prenatal exposure to an immune challenge, lipopolysaccharide (LPS), decreases both play and BNST AVP mRNA of juveniles male rats (Taylor et al., 2012).”
From Sexually dimorphic role for vasopressin in the development of social play (2014) · cites this paper as Taylor et al., 2012
A prenatal immune challenge reduced social play and AVP mRNA expression in the BNST and MeA in males only.
“For example, a prenatal immune challenge reduced social play as well as AVP mRNA expression in the BNST and MeA, but did so in males only (Taylor et al., 2012).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Taylor et al., 2012
Some reports show greater vasopressin mRNA density in the supraoptic nucleus of male rats and greater oxytocin production in female mice, but other studies show similar amounts of oxytocin and vasopressin in both sexes in the paraventricular/supraoptic nuclei of various rodent species, nonhuman primates, and humans.
“Some reports have shown that AVP messenger RNA (mRNA) density measurements in the SON of rats are greater in males (50), while, in mice, OXT production is greater in females (51); however, other studies have shown a similar amount of OXT and AVP in both sexes in the PVN/SON of various rodent species, nonhuman primates, and humans (49,52).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [50]
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- Authors
- Taylor, P. V., Veenema, A. H., Paul, M. J., Bredewold, R., Isaacs, S., & de Vries, G. J.
- Affiliations
- University of Massachusetts Amherst (US)
- Boston College (US)
- Venue
- Biology of Sex Differences
- Published
- 2012-06-14
- Volume
- 3
- Issue
- 1
- Pages
- 15-15
- ISSN
- 2042-6410 (ISSN-L)
- PMC
- PMC3420237
- OpenAlex
- W2151070308
- Cited by
- 86
- References
- 60
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 16 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 11 · 2013: 3 · 2012: 1
- FWCI
- 11.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Biology of Sex Differences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Archive @ GSU (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion, cc-by)
- Funders
- National Institute of Mental Health (R01MH047538)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- prenatal immune challenge, lipopolysaccharide, vasopressin, social play, sex differences, young rats, medial amygdala, bed nucleus of the stria terminalis, social behavior development, prenatal inflammation, sexually dimorphic nucleus of the preoptic area, social psychopathology
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