The DOI matches its Crossref record; 50 of the 53 references it cites were found in a registry or an index.
Intranasal Oxytocin Increases Positive Communication and Reduces Cortisol Levels During Couple Conflict
Open accessAbstract
Background In nonhuman mammals, the neuropeptide oxytocin has repeatedly been shown to increase social approach behavior and pair bonding. In particular, central nervous oxytocin reduces behavioral and neuroendocrine responses to social stress and is suggested to mediate the rewarding aspects of attachment in highly social species. However, to date there have been no studies investigating the effects of central oxytocin mechanisms on behavior and physiology in human couple interaction. Methods In a double-blind placebo-controlled design, 47 heterosexual couples (total n = 94) received oxytocin or placebo intranasally before a standard instructed couple conflict discussion in the laboratory. The conflict session was videotaped and coded for verbal and nonverbal interaction behavior (e.g., eye contact, nonverbal positive behavior, and self-disclosure). Salivary cortisol was repeatedly measured during the experiment. Results Oxytocin significantly increased positive communication behavior in relation to negative behavior during the couple conflict discussion (F = 4.18, p = .047) and significantly reduced salivary cortisol levels after the conflict compared with placebo (F = 7.14, p = .011). Conclusions These results are in line with animal studies indicating that central oxytocin facilitates approach and pair bonding behavior. Our findings imply an involvement of oxytocin in couple interaction and close relationships in humans.
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In the citing paper
“The hypothalamic peptide oxytocin (OXT) is released during partner contact (Grewen, Girdler, Amico, & Light, 2005) and contributes to the maintenance of long-term relationships (Ditzen et al., 2009;Kreuder et al., 2017;Scheele et al., 2013).”
From Oxytocin enhances the pain‐relieving effects of social support in romantic couples (2019) · cites this paper as Ditzen et al., 2009
In the citing paper
“Underlying human romantic attachment is a collection of interlocking brain systems that are hypothesized to have evolved to suit the reproductive needs of our ancestors.”
From The Medicalization of Love (2015) · cites this paper as [24]
In the citing paper
“Brain chemicals such as oxytocin, dopamine, testosterone, and many others seem to regulate our interpersonal drives and emotions, including the formation of romantic pair-bonds.”
From The Medicalization of Love (2015) · cites this paper as [24]
In the citing paper
“Although love is not simply reducible to these brain chemicals or pathways—and although there are many different theories of love, including how it should be defined—what is clear by now is that these underlying phenomena do much to shape (as well as to respond to) our higher-level romantic experiences, across a wide range of theoretical conceptions.”
From The Medicalization of Love (2015) · cites this paper as [24]
In the citing paper
“In one study, Swiss researchers showed that nasally inhaled oxytocin can reduce stress levels and promote more positive communication between couples engaged in an argument (Ditzen et al. 2009).”
From Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships (2012) · cites this paper as Ditzen et al. 2009
In the citing paper
“Acevedo et al. (2011) found higher activations among romantically attached individuals in regions implicated in pair-bonding in monogamous rodents, and OT administration has shown to increase couples’ positive communication (Ditzen et al., 2009).”
From Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity (2012) · cites this paper as Ditzen et al., 2009
In the citing paper
“Intranasal administration of OXT increases ratings of facial attractiveness (27), positive communication behavior during couple conflicts (28)”
From Oxytocin enhances brain reward system responses in men viewing the face of their female partner (2013) · cites this paper as [28]
In the citing paper
“Intranasal OT was also found to increase positive behavior during couple conflict in both male and female partners (Ditzen et al, 2009).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Ditzen et al, 2009
In the citing paper
“Also, Ditzen et al. (2009) showed that administering 40 IU of intranasal oxytocin increased positive communication during and decreased salivary cortisol after couple conflict in both men and women.”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Ditzen et al., 2009
In the citing paper
“reduce negative behavior during couple conflict (19,20)”
From Oxytocin and the development of parenting in humans (2010) · cites this paper as [20]
In the citing paper
“Interestingly, in a study involving couples engaged in a conflict discussion, salivary cortisol levels were also found to decrease following intranasal administration of 40 IU OT (Ditzen et al., 2009).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Ditzen et al., 2009
In the citing paper
“Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation and trust.”
From Acute intranasal oxytocin improves positive self-perceptions of personality (2012) · cites this paper as Ditzen et al., 2009
In the citing paper
“only scales related to social behavior were altered by the administration of intranasal oxytocin relative to a placebo, with the exception of openness to experiences.”
From Acute intranasal oxytocin improves positive self-perceptions of personality (2012) · cites this paper as Ditzen et al., 2009
In the citing paper
“While most studies examine the effects of oxytocin 45 minutes after administration (Ditzen et al., 2009; Kosfeld et al., 2005)”
From Acute intranasal oxytocin improves positive self-perceptions of personality (2012) · cites this paper as Ditzen et al., 2009
In the citing paper
“More recently, studies in humans have demonstrated that OXT administration increases pro-social behaviors like trust, empathy, and willingness to take social risks (Kosfeld et al, 2005), whereas dampening psychophysiological responses to stressors (Ditzen et al, 2009).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Ditzen et al, 2009
In the citing paper
“It has been shown, for example, that the peptide enhances positive communication in relation to negative behavior during couple conflicts and reduces cortisol saliva levels after the conflict (82).”
From Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships (2016) · cites this paper as [82]
In the citing paper
“positive communication between couples (24)”
From Oxytocin administration to parent enhances infant physiological and behavioral readiness for social engagement (2012) · cites this paper as [24]
In the citing paper
“Additionally, other researchers have reported reductions in stress hormones following oxytocin administration in stressful situations without reductions in subjective anxiety measures (Cardoso et al., in press; Ditzen et al., 2009; Linnen et al., 2012).”
From Effect of oxytocin on craving and stress response in marijuana-dependent individuals: A pilot study (2013) · cites this paper as Ditzen et al., 2009
In the citing paper
“IN-OT increases the rating of attractiveness of partners’ faces (Scheele et al. 2013), reduces conflict between couples (Ditzen et al. 2009), and enhances the distance between pair bonded men and unfamiliar attractive individuals (Scheele et al. 2012).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Ditzen et al. 2009
In the citing paper
“A more dominant theory of OT's effects on social cognition suggests that it increases approach toward and decreases avoidance of social stimuli [20], [18], [21], [22]”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [20]
In the citing paper
“Peripheral or nasal administration of OT facilitates social recognition and trust in healthy humans (Guastella et al., 2008a andb, 2009;Ditzen et al., 2009) and increases eye contact and recognition in autistic subjects (Hollander et al., 2007;Yamasue et al., 2009).”
From Two genetic variants of CD38 in subjects with autism spectrum disorder and controls (2010) · cites this paper as Ditzen et al., 2009
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In the paper
“Lerner, 2005, Facial expressions of emotion reveal neuroendocrine and cardiovascular stress responses, Biol Psychiatry, 58, 743, 10.1016/j.biopsych.2005.08.011”
Cited work 10.1016/j.biopsych.2005.08.011 · retracted 2007-01-12 · notice 10.1016/j.biopsych.2006.11.002 · this paper published 2009-05
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Lucht, M. J., Barnow, S., Sonnenfeld, C., Ulrich, I., Grabe, H. J., Schroeder, W., Völzke, H., Freyberger, H. J., John, U., Herrmann, F. H., et al. (2012) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2012.700731 · Cited by 67
The impact of oxytocin on stress: the role of sex
Love, T. M. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.06.018 · Cited by 56
EARP, B. D., SANDBERG, A., & SAVULESCU, J. (2015) · Cambridge Quarterly of Healthcare Ethics · doi:10.1017/s0963180114000206 · Cited by 63
Althaus, M., Groen, Y., Wijers, A. A., Noltes, H., Tucha, O., & Hoekstra, P. J. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.10.025 · Cited by 57
“…OXT administration has been shown in both animals (e.g., Febo et al., 2009) and humans (e.g., Heinrichs et al., 2003; Heinrichs and Domes, 2008; Ditzen et al., 2009), with OXT leading to diminished reactivity of both the HPA axis and the amygdala when responding to fearful and threatening…”
BackgroundRupp, H. A., James, T. W., Ketterson, E. D., Sengelaub, D. R., Ditzen, B., & Heiman, J. R. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.10.007 · Cited by 58
“Participants received an absolute dose of 24 IU, based on previous studies (Ditzen et al., 2009; Heinrichs et al., 2001; Kirsch et al., 2005; MacDonald et al., 2011).”
Self-citationOxytocin sharpens self-other perceptual boundary
Colonnello, V., Chen, F. S., Panksepp, J., & Heinrichs, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.08.010 · Cited by 58
“…reactivity to social stress (Heinrichs et al., 2003) and increased approach, trust, empathy, and attachment (Kosfeld et al., 2005; Baumgartner et al., 2008; Ditzen et al., 2008; Buchheim et al., 2009; Hurlemann et al., 2010), although these effects are strongly modulated by the social context.”
BackgroundSelf-citationHormones as “difference makers” in cognitive and socioemotional aging processes
Ebner, N. C., Kamin, H. S., Diaz, V. G., Cohen, R. A., & MacDonald, K. S. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01595 · Cited by 59
“…intranasal oxytocin increased positive relative to negative behaviors during a laboratory couple conflict and reduced post-conflict and stress-elicited cortisol levels (Ditzen et al., 2009; Quirin et al., 2011; Cardoso et al., www.frontiersin.org January 2015 | Volume 5 | Article 1595 | 5 2013).”
BackgroundHormonal systems, human social bonding, and affiliation
Gangestad, S. W., & Grebe, N. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.08.005 · Cited by 55
“OT administration leads to more engaged, constructive communication about relationship conflicts (Ditzen et al., 2009), increased personal space between paired men and attractive strangers (Scheele et al., 2012) and more intense orgasms and greater contentment after intercourse with a partner…”
BackgroundSippel, L. M., Han, S., Watkins, L. E., Harpaz‐Rotem, I., Southwick, S. M., Krystal, J. H., Olff, M., Sherva, R., Farrer, L. A., Kranzler, H. R., et al. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.07.008 · Cited by 63
“Intranasal oxytocin has been found to increase trust (Kosfeld et al., 2005), positive communication (Ditzen et al., 2009), and empathy (Shamay-Tsoory, J Psychiatr Res.”
BackgroundFlanagan, J. C., Baker, N. L., McRae-Clark, A. L., Brady, K. T., & Moran-Santa Maria, M. M. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.07.064 · Cited by 56
Poulin, M. J., & Holman, E. A. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.01.004 · Cited by 63
“In humans, oxytocin promotes positive interactions with close others beyond offspring (Ditzen et al., 2008; Feldman, 2012) and facilitates prosociality more generally, including charitable giving, empathy, and compassion (e.”
BackgroundAttachment and its Vicissitudes in Borderline Personality Disorder
Levy, K. N., Beeney, J. E., & Temes, C. M. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0169-8 · Cited by 63
“A potential role of a disturbed oxytonergic system in BPD seems to be highlighted by the finding by Ditzen and colleagues [54] of a direct link between oxytocin and harmony in close relationships among healthy participants.”
BackgroundEngel, S., Laufer, S., Miller, R., Niemeyer, H., Knaevelsrud, C., & Schumacher, S. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100775 · Cited by 50
Ellenbogen, M. A., Linnen, A.-M., Cardoso, C., & Joober, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.06.016 · Cited by 53
“A number of studies in humans report that oxytocin facilitates positive interactions and trust in a variety of contexts (Kosfeld et al., 2005; Baumgartner et al., 2008; Ditzen et al., 2009; Mikolajczak et al., 2010; Naber et al., 2010).”
BackgroundEarp, B. D., Sandberg, A., & Savulescu, J. (2012) · Philosophy & Technology · doi:10.1007/s13347-012-0081-8 · Cited by 58
“In one study, Swiss researchers showed that nasally inhaled oxytocin can reduce stress levels and promote more positive communication between couples engaged in an argument (Ditzen et al. 2009).”
BackgroundDomes, G., Ower, N., von Dawans, B., Spengler, F. B., Dziobek, I., Bohus, M., Matthies, S., Philipsen, A., & Heinrichs, M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0658-4 · Cited by 61
Self-citationNeurobiological correlates of social anxiety disorder: an update
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“These results would support the hypothesis that, even in humans, OT would play a critical role in couple interaction and in the development of adult– adult pair bonds.(76) A recent double-blind study, using fMRI imaging to visualize amygdala activation by fear-inducing visual stimuli, showed that human amygdala functi…”
ResultOxytocin in health and disease
Tom, N., & Assinder, S. J. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.10.008 · Cited by 53
Oxytocin modulates selection of allies in intergroup conflict
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“IN-OT is also hypothesized to foster relationship maintenance and relational efficiency by improving emotion recognition (Domes, Heinrichs, Michel, Berger, & Herpertz, 2007), enhancing the recognition of familiar faces (Rimmele, Hediger, Heinrichs, & Klaver, 2009), improving constructive communication in couples (Ditz…”
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Wudarczyk, O. A., Earp, B. D., Guastella, A., & Savulescu, J. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283642e10 · Cited by 61
Oxytocin and social cognition in affective and psychotic disorders
Pérez-Rodríguez, M. M., Mahon, K., Russo, M., Ungar, A. K., & Burdick, K. E. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.07.012 · Cited by 58
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The endogenous oxytocin system in depressive disorders: A systematic review and meta-analysis
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“A more dominant theory of OT’s effects on social cognition suggests that it increases approach toward and decreases avoidance of social stimuli [20], [18], [21], [22] but this theory is yet to be directly tested in humans.”
BackgroundHypnosis, Attachment, and Oxytocin:An Integrative Perspective1
Zelinka, V., Cojan, Y., & Desseilles, M. (2013) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207144.2013.841473 · Cited by 49
“For example, hypnotic suggestions as well as OT may influence the quality of relational interactions (Banyai, 1985; Ditzen et al., 2009), the level of trust (Alladin, 2007; Kosfeld, Heinrichs, Zak, Fischbacher, & Fehr, 2005), and the strength of collaborative alliances (Esch & Stefano, 2005a, 2005b; Ratner, Gross, Cas…”
BackgroundPrimary Process Affects and Brain Oxytocin
Panksepp, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.004 · Cited by 50
“[1]).”
ResultDitzen, B., Hahlweg, K., Fehm‐Wolfsdorf, G., & Baucom, D. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.019 · Cited by 51
“Most studies which interpreted group differences in cortisol — either following different treatments (e.g. Ditzen et al., 2009) or as a function of interaction styles (Fehm-Wolfsdorf et al., 1999; Malarkey et al., 1994) — did not find overall cortisol increases due to couple conflict.”
Self-citationUnderstanding the Biological Relationship between Migraine and Depression
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“For instance, it was reported that T administration increased positive communication and reduces alivary cortisol levels indicative of stress in couple conflict discusions (Ditzen et al., 2009).”
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“Three lines of evidence, however, support the observation of TL alteration in socially enriched females: (1) correlation between OT and social behaviours in females is stronger than males (Barraza and Zak, 2009); (2) both social experiences and OT hormone blunt HPA axis activity (Sippel et al., 2015; Ditzen et al., 20…”
Neuropeptide Regulation of Social Attachment: The Prairie Vole Model
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“For example, intranasal OT treatment in humans has been shown to increase the recognition of emotion, the memory of human faces, gaze and fixation to the eye region of faces, the attractiveness of faces, altruism, and positive communicative behavior (14,74,77,119,224,225,237,253).”
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The ties that bond: neurochemistry of attachment in voles
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“Furthermore, a structurally similar nonapeptide, OT, administered intra-nasally in human couples, significantly enhanced several dimensions of positive communication between one-another such as agreeableness, positive regard for the self and partner, consolation, and increased eye-contact during a simulated couple’s q…”
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“2005), and mediates the positive effects of social support (Ditzen et al. 2009).”
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“These findings suggest that oxytocin can reduce symptoms of anxiety which is likely, due in part, to attenuating the activity of the HPA axis [8].”
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“We chose a 30 UI dose of oxytocin because several recent studies used higher doses than the common 24 IU (Petrovic et al., 2008; Singer et al., 2008; Ditzen et al., 2009; Feifel et al., 2010; Mikolajczak et al., 2010) and because the original experiment that provided evidence that intranasally…”
Effects of Oxytocin and Prolactin on Stress-Induced Bladder Hypersensitivity in Female Rats
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“In light of the above inconsistent evidence (Ditzen et al., 2009; Hurlemann et al., 2010), we considered the possibility that OT might exert sexspecific effects on empathy and perspective taking and tested an equal number of women and men.”
BackgroundMcInnis, O. A., McQuaid, R. J., Matheson, K., & Anisman, H. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01133 · Cited by 44
Oxytocin treatment alleviates stress-aggravated colitis by a receptor-dependent mechanism
Çetınel, Ş., Hancıoğlu, S., Şener, T. E., Üner, C., Çil, M. K., Şener, G., & Yeğen, B. Ç. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.11.011 · Cited by 42
“Accordingly, intranasal OT was shown to suppress anxiety responses [40] and to mediate the stress-buffering effects of social support in humans [41], while chronic central oxytocin administrationwas shown to attenuate the pathological high anxiety state in rats [15].”
Oxytocin and Anxiety Disorders: Translational and Therapeutic Aspects
Naja, W., & Aoun, M. P. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0819-1 · Cited by 42
Bienboire‐Frosini, C., Chabaud, C., Cozzi, A., Codecasa, E., & Pageat, P. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00524 · Cited by 44
“…has been described as being involved in positive social interactions in intra-species interactions (Grewen et al., 2005; Baumgartner et al., 2008; Ditzen et al., 2009; Dunbar, 2010; Smith and Wang, 2012; Romero et al., 2015; Numan and Young, 2016) and inter-species interactions, such as…”
BackgroundThe influence of oxytocin on volitional and emotional ambivalence
Preckel, K., Scheele, D., Eckstein, M., Maier, W., & Hurlemann, R. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu147 · Cited by 41
“OXT also increases positive communication and reduces cortisol levels during an instructed couple conflict (Ditzen et al., 2009).”
BackgroundAbraham, E., Hendler, T., Zagoory-Sharon, O., & Feldman, R. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.02.001 · Cited by 38
Gołyszny, M. J., Obuchowicz, E., & Zielinski, M. W. (2021) · Neuropeptides · doi:10.1016/j.npep.2021.102216 · Cited by 42
Common variant in OXTR predicts growth in positive emotions from loving-kindness training
Isgett, S. F., Algoe, S. B., Boulton, A. J., Way, B. M., & Fredrickson, B. L. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.010 · Cited by 41
Do we need oxytocin to treat schizophrenia? A randomized clinical trial
Dagani, J., Sisti, D., Abelli, M., Paolo, L. D., Pini, S., Raimondi, S., Rocchi, M., Saviotti, F. M., Scocco, P., Totaro, S., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.02.011 · Cited by 43
“This would have been one of themain targets for oxytocin treatment, given that in humans,when administered intranasally, it generally increases positive communication behavior and social interaction (Ditzen et al., 2009).”
BackgroundA precision medicine approach to oxytocin trials
Andari, E., Hurlemann, R., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_29 · Cited by 40
“2013), reduces conflict between couples (Ditzen et al. 2009), and enhances the distance between pair bonded men and unfamiliar attractive individuals (Scheele et al.”
BackgroundDonovan, M. L., Liu, Y., & Wang, Z. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.01.015 · Cited by 45
The human female orgasm: critical evaluations of proposed psychological sequelae
Prause, N. (2011) · Sexual & Relationship Therapy · doi:10.1080/14681994.2011.651452 · Cited by 40
“For example, oxytocin released at orgasm (Carmichael, Warburton, Dixen, & Davidson, 1994 ) does not contribute to uterine “upsuck” (Levin, 2012 ), but it might increase attention to positive relationship cues (Unkelbach, Guastella, & Forgas, 2008 ) and counteract couples' conflict (Ditzen et al, 2009 ).”
BackgroundKenna, G. A., Swift, R. M., Hillemacher, T., & Leggio, L. (2012) · Neuropsychology Review · doi:10.1007/s11065-012-9209-y · Cited by 38
“In couples who received either double-blind intranasal oxytocin or placebo before a standardized conflict discussion, oxytocin significantly increased positive communication during the conflict discussion and reduced post-conflict salivary cortisol (Ditzen et al. 2009).”
InfluentialCid-Jofré, V., Moreno, M., Reyes-Parada, M. I., & Renard, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222112077 · Cited by 40
“Clinical studies in healthy humans have shown that the administration of OT induces a decrease in the subjective perception of a stressful situation, which is accompanied by a decrease in salivary cortisol levels [148,149].”
BackgroundChu, C., Hammock, E. A. D., & Joiner, T. E. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.11.015 · Cited by 38
“Indeed, among socially excluded individuals, intranasal oxytocin administration promoted increased desires for connection (Ditzen et al., 2009).”
BackgroundThe Role of Intranasal Oxytocin in the Treatment of Patients with Schizophrenia: A Systematic Review
Berardis, D. D., Marini, S., Iasevoli, F., Tomasetti, C., de Bartolomeis, A., Mazza, M., Valchera, A., Fornaro, M., Cavuto, M., Srinivasan, V., et al. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312020012 · Cited by 39
Something to talk about: Gossip increases oxytocin levels in a near real-life situation
Brondino, N., Fusar‐Poli, L., & Politi, P. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.12.014 · Cited by 39
Oxytocin Signaling Pathway: From Cell Biology to Clinical Implications
Iovino, M., Messana, T., Tortora, A., Giusti, C., Lisco, G., Giagulli, V. A., Guastamacchia, E., Pergola, G. D., & Triggiani, V. (2020) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530320666200520093730 · Cited by 39
Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment
Bernhard, R. M., Chaponis, J., Siburian, R., Gallagher, P., Ransohoff, K. J., Wikler, D. I., Perlis, R. H., & Greene, J. D. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw103 · Cited by 41
“There has also been substantial research on the effect of exogenous oxytocin on pro-social behavior in humans (Ditzen et al., 2009; Heinrichs et al., 2009; Riem et al., 2013; Bartz et al., 2015; De Dreu and Kret, 2016).”
BackgroundTully, J., Gabay, A. S., Brown, D., Murphy, D., & Blackwood, N. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.11.017 · Cited by 39
“…(Heinrichs et al., 2003; Meinlschmidt and Heim, 2007; Saphire-Bernstein et al., 2011; Strathearn et al., 2009) physiological (Cardoso et al., 2013; Ditzen et al., 2009; Norman et al., 2012), and genetic (Feldman et al., 2013; Kim et al., 2010; Marsh et al., 2012; Rodrigues et al., 2009;…”
BackgroundCrosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction
Goh, K. K., Chen, C. Y.-A., Wu, T., Chen, C.-H., & Lu, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137092 · Cited by 41
“, cortisol) [194] and reduced the molecular responses of the hypothalamus–pituitary– adrenal axis, acting as hormonal protection from proinflammatory cytokines induced by glucocorticoids [178].”
BackgroundColaianni, G., Sun, L., Zaidi, M., & Zallone, A. Z. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00040.2014 · Cited by 41
“Nevertheless, encouraging results have been obtained by using intranasal oxytocin therapy in humans, in which OT has proved to be effective in increasing trusting behavior (36), positive communication (20), in-group favoritism (17), and reducing social stress reactivity (29).”
Attachment representation modulates oxytocin effects on the processing of own-child faces in fathers
Waller, C., Wittfoth, M., Fritzsche, K., Timm, L., Wittfoth, D., Rottler, E., Heinrichs, M., Buchheim, A., Kiefer, M., & Gündel, H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.07.003 · Cited by 38
Self-citationOxytocin improves compassion toward women among patients with PTSD
Palgi, S., Klein, E., & Shamay‐Tsoory, S. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.008 · Cited by 42
Social Interrelations in Aging
Hoppmann, C. A., & Gerstorf, D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411469-2.00014-5 · Cited by 37
Cardoso, C., Orlando, M. A., Brown, C. A., & Ellenbogen, M. A. (2014) · Social Neuroscience · doi:10.1080/17470919.2013.873079 · Cited by 38
“levels during interpersonal challenge (Ditzen et al., 2009; Linnen, Ellenbogen, Cardoso, & Joober, 2012).”
BackgroundResultInfluentialVizeli, P., & Liechti, M. E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199384 · Cited by 37
Oxytocin increases eye-gaze towards novel social and non-social stimuli
Eckstein, M., Bamert, V., Stephens, S. B. Z., Wallen, K., Young, L. J., Ehlert, U., & Ditzen, B. (2018) · Social Neuroscience · doi:10.1080/17470919.2018.1542341 · Cited by 36
“More specifically, OT enhanced social behavior to support parent-infant bonding (Weisman, Zagoory-Sharon, & Feldman, 2012) and improved positive behavior during an instructed couple interaction task (Ditzen et al., 2009, 2012).”
BackgroundSelf-citationSocial Support and Physical Health: Links and Mechanisms
Gruenewald, T. L., & Seeman, T. E. (2010) · Springer eBooks · doi:10.1007/978-0-387-09488-5_17 · Cited by 36
Brüne, M., Kolb, M., Ebert, A., Roser, P., & Edel, M.-A. (2015) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0000000000000240 · Cited by 35
“Another study reported that OT can improve communication between partners who have experienced couple conflict (Ditzen et al., 2009).”
BackgroundIntranasal administration of oxytocin increases compassion toward women
Palgi, S., Klein, E., & Shamay‐Tsoory, S. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu040 · Cited by 36
“Keywords: oxytocin; compassion; empathy; sex differences”
ResultAn evolutionary perspective on the behavioral consequences of exogenous oxytocin application
Ebitz, R. B., & Platt, M. L. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00225 · Cited by 35
“OT promotes resource sharing (Kosfeld et al., 2005), eye contact (Guastella et al., 2008a; Andari et al., 2010; Gamer et al., 2010), and positive social signals during conflict (Ditzen et al., 2009).”
Oxytocin receptor gene variation predicts subjective responses to MDMA
Bershad, A. K., Weafer, J. J., Kirkpatrick, M. G., Wardle, M. C., Miller, M. A., & de Wit, H. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1143026 · Cited by 35
“, 2011) and increased trust and positive communication (Ditzen et al., 2009; Kosfeld, Heinrichs, Zak, Fischbacher, & Fehr, 2005).”
BackgroundMercado, E., & Hibel, L. C. (2017) · Social and Personality Psychology Compass · doi:10.1111/spc3.12298 · Cited by 37
Oxytocin attenuates social and non-social avoidance: Re-thinking the social specificity of Oxytocin
Harari-Dahan, O., & Bernstein, A. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.04.005 · Cited by 34
“In the event that a potential female participant did not regularly take birth control pills, then she was eligible to participate in the study only during the week immediately before her next expected menses (during the mid-luteal phase of the cycle; e.g., Ditzen et al., 2009; Liu et al., 2012).”
Kim, S., & Strathearn, L. (2017) · The Psychoanalytic Study of the Child · doi:10.1080/00797308.2016.1277897 · Cited by 38
“communication in relationships (Ditzen et al. 2009), improve efficiency in recognizing and processing of socioemotional cues (Domes et al.”
BackgroundHopf, D., Eckstein, M., Aguilar‐Raab, C., Warth, M., & Ditzen, B. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12887 · Cited by 44
“Gerra et al (2003)88 Longitudinal: 3 time-points: 10 days (1), 40 days (2) and 6 months after stress-full life event DST administered Bereaved vs controls Parent (57) Son (14) Spouse (29) N = 28 n (bereaved) = 14 n (control) = 14 38 (17-75) None Degree of stress (Social Adjustment Scale) Blood cortisol blood ACTH DST…”
BackgroundMethodInfluentialSelf-citationSasaki, K., Ferdousi, F., Fukumitsu, S., Kuwata, H., & Isoda, H. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112291 · Cited by 37
Smith, T. W., Uchino, B. N., MacKenzie, J. J., Hicks, A. M., Campo, R., Reblin, M., Grewen, K., Amico, J. A., & Light, K. C. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.04.006 · Cited by 35
“Consistent with both perspectives, intranasal administration of oxytocin has been found to increase positive couple behavior, and to reduce cortisol responses during couple conflicts (Ditzen et al., 2009).”
BackgroundInfluentialQuantification of hormonal changes by effects of hippotherapy in the autistic population
Tabares, C., Vicente, F., Sánchez, S., Aparicio, A., Alejo, S., & Juánez, J. C. (2012) · Neurochemical Journal · doi:10.1134/s1819712412040125 · Cited by 36
Zinni, M., Colella, M., Novais, A. R. B., Baud, O., & Mairesse, J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00229 · Cited by 35
Samuel, S., Hayton, B. C., Gold, I., Feeley, N., Carter, C. S., & Zelkowitz, P. (2015) · Attachment & Human Development · doi:10.1080/14616734.2015.1029951 · Cited by 37
“…(HPA) axis (Carter, 1998; Neumann, 2002) and of the amygdala (Kirsch et al., 2005; Riem et al., 2011), and to decrease levels of cortisol (Ditzen et al., 2009; Heinrichs, Baumgartner, Kirschbaum, & Ehlert, 2003) and adrenocorticotropic hormone (Legros, 2001; Parker, Buckmaster,…”
BackgroundNew directions in the treatment of autism spectrum disorders from animal model research
Chadman, K. K., Guariglia, S. R., & Yoo, J. H. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.678828 · Cited by 33
“Studies have shown positive effects of intranasal oxytocin administration, which include enhancement of social behavior, memory and the ability to attend to social and verbal information [72,82-84].”
BackgroundOxytocin and vulnerable romantic relationships
Grebe, N. M., Kristoffersen, A. A., Grøntvedt, T. V., Emery Thompson, M., Kennair, L. E. O., & Gangestad, S. W. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.02.009 · Cited by 34
“, 2010); in humans, constructive communication between romantic couples during a conflict (Ditzen et al., 2009).”
BackgroundEvolutionary Science of Female Orgasm
Wheatley, J. R., & Puts, D. A. (2014) · Evolutionary psychology · doi:10.1007/978-3-319-09384-0_7 · Cited by 37
“Finally, couples given oxytocin prior to a conflict discussion exhibited more instances of positive communication compared to placebo-treated couples (Ditzen et al. 2009).”
ResultRoaldset, J. O., Bakken, A. M., & Bjørkly, S. K. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.07.029 · Cited by 34
Oxytocin and parenting behavior among impoverished mothers with low vs. high early life stress
Julian, M. M., Rosenblum, K. L., Doom, J. R., Leung, C. Y. Y., Lumeng, J. C., Cruz, M. G., Vázquez, D. M., & Miller, A. L. (2017) · Archives of Women s Mental Health · doi:10.1007/s00737-017-0798-6 · Cited by 34
“…spectrum disorders (Guastella et al. 2010), improve higherlevel social cognition in individuals with schizophrenia (Davis et al. 2013), improve trust toward one’s in-group (Van IJzendoorn and Bakermans-Kranenburg 2012), and improve positive communication during couple conflict (Ditzen et al. 2009).”
Humans Are People, Too: Nurturing an Appreciation for Nature in Communication Research
Floyd, K. (2014) · Review of Communication Research · doi:10.12840/issn.2255-4165.2014.02.01.001 · Cited by 35
“…has been shown to significantly increase spouses' positive communication behavior, and assuage cortisol increases, as compared to a placebo (Ditzen et al., 2009 ) various qualities of marital conf lict affect spouses' physiological health; and b) spouses' physiological reactivity to their…”
BackgroundXu, X., Yao, S., Xu, L., Geng, Y., Zhao, W., Ma, X., Kou, J., Luo, R., & Kendrick, K. M. (2017) · Scientific Reports · doi:10.1038/srep40589 · Cited by 33
“Previous studies have demonstrated that the hypothalamic neuropeptide oxytocin (OXT) plays a critical role in promoting social bonds and prosocial behaviors 13,14 and can also reduce social conflict 15 .”
Biobehavioral Pathways Underlying Spousal Health Dynamics: Its Nature, Correlates, and Consequences
Hoppmann, C. A., & Gerstorf, D. (2014) · Gerontology · doi:10.1159/000357671 · Cited by 33
Bhandari, R., Bakermans-Kranenburg, M. J., van der Veen, R., Parsons, C. E., Young, K. S., Grewen, K. M., Stein, A., Kringelbach, M. L., & van IJzendoorn, M. H. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.028 · Cited by 33
“The anxiolytic role of oxytocin [51,52] might explain why emotionally maltreated individuals ‘need’ more of it to cope with stressful events and situations, which may contribute to resilience in some individuals [53,54].”
Thomas, S. J., & Larkin, T. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00971 · Cited by 33
“There is evidence that oxytocin may reduce anxiety in response to stressors by downregulating HPA axis activity, reducing amygdala reactivity (6) and dampening stress responses (7, 29, 30).”
BackgroundOxytocin and social anxiety: Interactions with sex hormones
Schneider, E., Müller, L. E., Ditzen, B., Herpertz, S. C., & Bertsch, K. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105224 · Cited by 33
Self-citation
Metadata
- Authors
- Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., & Heinrichs, M.
- Affiliations
- Emory University (US)
- University of Fribourg (CH)
- University of Zurich (CH)
- Corresponding author
- Ditzen, Beate
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 65
- Issue
- 9
- Pages
- 728-731
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1977529793
- Cited by
- 805
- References
- 53
- Citations by year
- 2026: 33 · 2025: 30 · 2024: 23 · 2023: 35 · 2022: 28 · 2021: 45 · 2020: 46 · 2019: 51 · 2018: 57 · 2017: 68 · 2016: 45 · 2015: 62 · 2014: 65 · 2013: 55 · 2012: 54
- FWCI
- 15.08
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Digital Access to Libraries (submittedVersion)
- Zürcher Hochschule für Angewandte Wissenschaften digital collection (Zurich University of Applied Sciences) (submittedVersion, cc-by-nc-nd)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, couple conflict, positive communication, salivary cortisol, intranasal administration, close relationships, pair bonding, social stress, self-disclosure, eye contact, nonverbal behavior, attachment
- MeSH terms
- Administration, Intranasal, Adult, Communication, Conflict, Psychological, Double-Blind Method, Family Characteristics, Female, Humans, Hydrocortisone, Interpersonal Relations, Male, Middle Aged, Oxytocin, Placebos, Saliva
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