Cited by 121Attention Deficit Hyperactivity DisorderNeural and Behavioral Psychology StudiesDevelopmental and Educational Neuropsychology

A meta-analytic study of event rate effects on Go/No-Go performance in attention-deficit/hyperactivity disorder

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Metin, Baris, Roeyers, Herbert, Wiersema, Jan R., van der Meere, Jaap, Sonuga-Barke, Edmund·2012·Biological Psychiatry

Abstract

Background According to the state regulation deficit model, event rate (ER) is an important determinant of performance of children with attention-deficit/hyperactivity disorder (ADHD). Fast ER is predicted to create overactivation and produce errors of commission, whereas slow ER is thought to create underactivation marked by slow and variable reaction times (RT) and errors of omission.Methods To test these predictions, we conducted a systematic search of the literature to identify all reports of comparisons of ADHD and control individuals' performance on Go/No-Go tasks published between 2000 and 2011. In one analysis, we included all trials with at least two event rates and calculated the difference between ER conditions. In a second analysis, we used metaregression to test for the moderating role of ER on ADHD versus control differences seen across Go/No-Go studies.Results There was a significant and disproportionate slowing of reaction time in ADHD relative to controls on trials with slow event rates in both meta-analyses. For commission errors, the effect sizes were larger on trials with fast event rates. No ER effects were seen for RT variability. There were also general effects of ADHD on performance for all variables that persisted after effects of ER were taken into account.Conclusions The results provide support for the state regulation deficit model of ADHD by showing the differential effects of fast and slow ER. The lack of an effect of ER on RT variability suggests that this behavioral characteristic may not be a marker of cognitive energetic effects in ADHD.

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Crossref · 10.1016/j.biopsych.2012.08.023

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  • The evidence of hypo-activation of the ANS during cognitive tasks described in this review is consistent with previous findings of greater RTV and response errors in ADHD, which are exacerbated when task stimuli are presented at a slower event rate.

    “The evidence of hypo-activation of the ANS during cognitive tasks described in this review is consistent with previous findings of greater RTV (Kofler et al., 2013) and response errors in ADHD, which are exacerbated when task stimuli are presented at a slower event rate (Metin et al., 2012).”

    From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Metin et al., 2012

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  • Increased intra-individual reaction time variability (RTV) is found across a range of experimental paradigms in ADHD, particularly during monotonous cognitive tasks.

    “Further support for this comes from evidence of increased intra-individual reaction time variability (RTV) across a range of experimental paradigms (see Kofler et al., 2013, for a metaanalysis), particularly during monotonous cognitive tasks (Metin et al., 2012).”

    From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Metin et al., 2012

    The within-subject results (page not supplied) show significantly greater reaction-time variability in ADHD at both slow and fast event rates on Go/No-Go tasks. They do not support the qualifier “particularly during monotonous cognitive tasks”: the Discussion reports no ADHD-specific effect of event rate on variability. The claim about a range of paradigms is cited separately to Kofler et al., not to Metin et al. (LLM, conf=0.88)

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  • The findings of ANS hypoarousal are consistent with evidence of poorer performance when cognitive tasks have a slow event rate and suggest that lower ANS activity may be one factor that contributes to poorer performance of people with ADHD when tasks require sustained attention and response regulation.

    “The findings of ANS hypoarousal are also consistent with evidence of poorer performance when cognitive tasks have a slow event rate (Metin et al., 2012;Wiersema et al., 2006) and suggest that lower ANS activity may be one factor that contributes to poorer performance of people with ADHD when tasks require sustained attention and response regulation.”

    From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Metin et al., 2012

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  • Several studies have directly tested the CEM performance pattern hypothesis and found their results to be supportive of the model predictions.

    “Several studies have directly tested this performance pattern hypothesis and found their results to be supportive to the model predictions (Wiersema et al., 2006; Metin et al., 2012).”

    From A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) (2019) · cites this paper as Metin et al., 2012

  • Performance-based incentives and optimal task pace help to offset impaired arousal regulation in ADHD.

    “suggest that these factors help to offset impaired arousal regulation in ADHD.”

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Authors
Metin, B., Roeyers, H., Wiersema, J. R., van der Meere, J., & Sonuga-Barke, E.
Affiliations
Ghent University (BE)
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2012-12
Volume
72
Issue
12
Pages
990-996
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2130750988
Cited by
121
References
57
Citations by year
2026: 6 · 2025: 10 · 2024: 10 · 2023: 10 · 2022: 10 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 4 · 2017: 6 · 2016: 12 · 2015: 8 · 2014: 12 · 2013: 3
FWCI
0.99
Type
journal article
Language
en
Open access
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders
Vlaamse regering
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
Keywords
attention deficit hyperactivity disorder, event rate, go/no-go task, reaction time, reaction time variability, commission errors, omission errors, children
MeSH terms
Algorithms, Attention Deficit Disorder with Hyperactivity, Choice Behavior, Humans, Psychomotor Performance, Reaction Time

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