Altered functional connectivity between medial prefrontal cortex and the inferior brainstem in major depression during appraisal of subjective emotional responses: a preliminary study
Abstract
Objective We tested the hypothesis that reduced rostral anterior cingulate cortex (rACC)-subcortical functional connectivity in depressed subjects might account for depression-related autonomic dysregulation.Methods Ten healthy and ten depressed subjects categorized their immediate subjective emotional responses to picture sets while undergoing functional magnetic resonance imaging and electrocardiography. Using an rACC cluster commonly activated in both groups by emotion categorization as a seed region, we then performed voxel-wise functional connectivity analyses to examine rACC connectivity across the brain in depressed and control subjects.Results rACC had significantly stronger connectivity with a region of the inferior pons in controls than in depressed subjects. Within-subjects differences in rACC-pons connectivity also significantly correlated with measures of both heart rate variability and depression severity.Conclusions These findings support the hypothesis that autonomic dysregulation in depression may be associated with a functional disconnection between rACC and autonomic brainstem nuclei.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A compromised body does not provide sufficient bodily information to allow the brain to predict complete safety.
“In neurobiological terms, a compromised body does not provide sufficient bodily information to allow the brain to predict complete safety (Smith et al., 2015).”
From Exposed to events that never happen: generalized unsafety, the default stress response, and prolonged autonomic activity (2017) · cites this paper as Smith et al., 2015
Cites
<i>The Brain's Default Network</i>: <i>Anatomy, Function, and Relevance to Disease</i>
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · see citing works
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 2× · see citing works
“As a secondary hypothesis, we also predicted that rACC connectivity with insula regions that register bodily feedback from visceral afferents (Craig, 2002, 2009) would be lower in depressed than control participants independent of attentional focus.”
BackgroundHow do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006 · see citing works
Whatever next? Predictive brains, situated agents, and the future of cognitive science
Clark, A. (2013) · Behavioral and Brain Sciences · doi:10.1017/s0140525x12000477 · Cited by 5,924 · see citing works
(2005) · CTIT technical reports series · Cited by 5,307 · see citing works
<i>Conn</i> : A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks
Whitfield-Gabrieli, S., & Nieto-Castanon, A. (2012) · Brain Connectivity · doi:10.1089/brain.2012.0073 · Cited by 4,885 · see citing works
The cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495 · see citing works
Porges, S. W. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2006.06.009 · Cited by 3,415 · see citing works
Thayer, J. F., Åhs, F., Fredrikson, M., Sollers, J. J., & Wager, T. D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.11.009 · Cited by 3,224 · see citing works
Self-citationA model of neurovisceral integration in emotion regulation and dysregulation
Thayer, J. F., & Lane, R. D. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00338-4 · Cited by 3,092 · see citing works
Self-citationEmotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059 · see citing works
Gusnard, D. A., Akbudak, E., Shulman, G. L., & Raichle, M. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071043098 · Cited by 2,997 · see citing works
Kirsch, I., Deacon, B. J., Huedo-Medina, T. B., Scoboria, A., Moore, T. J., & Johnson, B. T. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050045 · Cited by 2,442 · see citing works
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416 · see citing works
Salovey, P., Mayer, J. D., Goldman, S. L., Turvey, C., & Palfai, T. P. (1995) · Emotion, disclosure, & health. · doi:10.1037/10182-006 · Cited by 2,375 · see citing works
Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.020 · Cited by 2,214 · see citing works
Thayer, J. F., & Lane, R. D. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.004 · Cited by 2,040 · see citing works
Self-citationAntidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis
Fournier, J. C., DeRubeis, R. J., Hollon, S. D., Dimidjian, S., Amsterdam, J. D., Shelton, R. C., & Fawcett, J. (2010) · JAMA · doi:10.1001/jama.2009.1943 · Cited by 2,009 · see citing works
Hohwy, J. (2013) · doi:10.1093/acprof:oso/9780199682737.001.0001 · Cited by 1,914 · see citing works
Interoceptive inference, emotion, and the embodied self
Seth, A. K. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.09.007 · Cited by 1,816 · cited 2× · see citing works
“This prediction was based on previous evidence for rACC–insula connectivity abnormalities in depression (Horn et al., 2010), in conjunction with other work suggesting that autonomic control structures may implement predictive forward models (Critchley, 2005; Seth, 2013; Seth & Critchley, 2013).”
BackgroundResultEffects of Attention and Emotion on Face Processing in the Human Brain
Vuilleumier, P., Armony, J. L., Driver, J., & Dolan, R. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00328-2 · Cited by 1,664 · see citing works
Phillips, M. L., Ladouceur, C. D., & Drevets, W. C. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.65 · Cited by 1,383 · see citing works
Etkin, A., Egner, T., Peraza, D. M., Kandel, E. R., & Hirsch, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.029 · Cited by 1,360 · see citing works
Kemp, A. H., Quintana, D. S., Gray, M. A., Felmingham, K. L., Brown, K., & Gatt, J. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.012 · Cited by 1,286 · see citing works
Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., Dougherty, D. D., Iosifescu, D. V., Rauch, S. L., & Fava, M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081201 · Cited by 1,232 · see citing works
A unifying computational framework for motor control and social interaction
Wolpert, D. M., Doya, K., & Kawato, M. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1238 · Cited by 1,228 · see citing works
Neural mechanisms of autonomic, affective, and cognitive integration
Critchley, H. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20749 · Cited by 1,214 · see citing works
Sheline, Y. I., Barch, D. M., Donnelly, J. M., Ollinger, J. M., Snyder, A. Z., & Mintun, M. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01263-x · Cited by 1,191 · see citing works
Kober, H., Barrett, L. F., Joseph, J., Bliss-Moreau, E., Lindquist, K., & Wager, T. D. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.059 · Cited by 1,144 · see citing works
Cingulate function in depression: a potential predictor of treatment response
Mayberg, H. S., Brannan, S. K., Mahurin, R. K., Jerabek, P. A., Brickman, J. S., Tekell, J. L., Silva, J. A., McGinnis, S., Glass, T. G., Martin, C. C., et al. (1997) · NeuroReport · doi:10.1097/00001756-199703030-00048 · Cited by 1,029 · see citing works
Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression
Lozano, A. M., Mayberg, H. S., Giacobbe, P., Hamani, C., Craddock, R. C., & Kennedy, S. H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.034 · Cited by 1,024 · see citing works
Explicit and implicit emotion regulation: a dual-process framework.
Gyurak, A., Gross, J. J., & Etkin, A. (2011) · Cognition and Emotion · doi:10.1080/02699931.2010.544160 · Cited by 1,015 · see citing works
Koenigs, M., & Grafman, J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.004 · Cited by 956 · cited 1× · see citing works
“…subjects have also been found to have structural and/or functional abnormalities (Fales et al., 2009; Frodl et al., 2002; Kennedy et al., 2007; Koenigs & Grafman, 2009; Lozano et al., 2008; Mayberg et al., 1999; Pizzagalli, 2011; Sheline et al., 2001; Sprengelmeyer et al., 2011) as well as…”
BackgroundInteroception in anxiety and depression
Paulus, M. P., & Stein, M. B. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0258-9 · Cited by 952 · see citing works
Abnormalities in the awareness of action.
Blakemore, S.-J., Wolpert, D. M., & Frith, C. D. (2002) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(02)01907-1 · Cited by 947 · see citing works
Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response
Pizzagalli, D. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.166 · Cited by 945 · see citing works
Ventromedial prefrontal–subcortical systems and the generation of affective meaning
Roy, M., Shohamy, D., & Wager, T. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.01.005 · Cited by 856 · see citing works
Ochsner, K. N., Knierim, K., Ludlow, D. H., Hanelin, J., Ramachandran, T., Glover, G., & Mackey, S. C. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/0898929042947829 · Cited by 850 · see citing works
Functional connectivity of the insula in the resting brain
Cauda, F., D'Agata, F., Sacco, K., Duca, S., Geminiani, G., & Vercelli, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.049 · Cited by 793 · see citing works
Zeng, L.-L., Shen, H., Liu, L., Wang, L., Li, B., Fang, P., Zhou, Z., Li, Y., & Hu, D. (2012) · Brain · doi:10.1093/brain/aws059 · Cited by 748 · see citing works
Limbic-frontal circuitry in major depression: a path modeling metanalysis
Seminowicz, D. A., Mayberg, H. S., McIntosh, A. R., Goldapple, K., Kennedy, S., Segal, Z., & Rafi-Tari, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.01.015 · Cited by 710 · see citing works
Emotion, Disclosure, and Health
Pennebaker, J. W. (1995) · Cited by 671 · see citing works
Salovey, P., Stroud, L. R., Woolery, A., & Epel, E. S. (2002) · Psychology and Health · doi:10.1080/08870440290025812 · Cited by 650 · see citing works
The Association of Comorbid Depression With Mortality in Patients With Type 2 Diabetes
Katon, W. J., Rutter, C., Simon, G., Lin, E. H. B., Ludman, E., Ciechanowski, P., Kinder, L., Young, B., & Von Korff, M. (2005) · Diabetes Care · doi:10.2337/diacare.28.11.2668 · Cited by 640 · see citing works
Pizzagalli, D., Pascual-Marqui, R. D., Nitschke, J. B., Oakes, T. R., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Koger, J. V., Benca, R. M., & Davidson, R. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.3.405 · Cited by 630 · see citing works
Neural activation during selective attention to subjective emotional responses
Lane, R. D., Fink, G. R., Chau, P. M.-L., & Dolan, R. J. (1997) · Neuroreport · doi:10.1097/00001756-199712220-00024 · Cited by 558 · see citing works
Self-citationNeumann, A., van Lier, P. A. C., Gratz, K. L., & Koot, H. M. (2010) · Assessment · doi:10.1177/1073191109349579 · Cited by 521 · see citing works
The many metrics of cardiac chronotropy: A pragmatic primer and a brief comparison of metrics
Allen, J. J. B., Chambers, A. S., & Towers, D. N. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2006.08.005 · Cited by 491 · see citing works
Self-citationLevels of emotional awareness and autism: an fMRI study
Silani, G., Bird, G., Brindley, R., Singer, T., Frith, C., & Frith, U. (2008) · Social Neuroscience · doi:10.1080/17470910701577020 · Cited by 485 · see citing works
Dimensions of intercultural effectiveness: An exploratory study
Hammer, M. R., Gudykunst, W. B., & Wiseman, R. L. (1978) · International Journal of Intercultural Relations · doi:10.1016/0147-1767(78)90036-6 · Cited by 447 · see citing works
Beyond threat: amygdala reactivity across multiple expressions of facial affect
Fitzgerald, D. A., Angstadt, M., Jelsone, L. M., Nathan, P. J., & Phan, K. L. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.11.003 · Cited by 427 · see citing works
Kennedy, S. H., Konarski, J. Z., Segal, Z. V., Lau, M. A., Bieling, P. J., McIntyre, R. S., & Mayberg, H. S. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.5.778 · Cited by 420 · see citing works
Prefrontal Cortical Networks Related to Visceral Function and Mood
Price, J. L. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09278.x · Cited by 397 · see citing works
Characteristics of emotion regulation in recovered depressed versus never depressed individuals
Ehring, T. W., Fischer, S., Schnülle, J., Bösterling, A., & Tuschen‐Caffier, B. (2008) · Personality and Individual Differences · doi:10.1016/j.paid.2008.01.013 · Cited by 328 · see citing works
Enlargement of the Amygdala in Patients with a First Episode of Major Depression
Frodl, T., Meisenzahl, E., Zetzsche, T., Bottlender, R., Born, C., Groll, C., Jäger, M., Leinsinger, G., Hahn, K., & Möller, H.-J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01359-2 · Cited by 316 · see citing works
Walter, M., Henning, A., Grimm, S., Schulte, R. F., Beck, J., Dydak, U., Schnepf, B., Boeker, H., Boesiger, P., & Northoff, G. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.39 · Cited by 306 · see citing works
Horn (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00033 · Cited by 276 · see citing works
Fales, C. L., Barch, D. M., Rundle, M. M., Mintun, M. A., Mathews, J., Snyder, A. Z., & Sheline, Y. I. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.027 · Cited by 266 · see citing works
Amygdalar activation associated with positive and negative facial expressions
Yang, T. T., Menon, V., D, S. E. M., Blasey, C. M., White, C. D., Reid, A. J., Gotlib, I. H., & Reiss, A. L. (2002) · Neuroreport · doi:10.1097/00001756-200210070-00009 · Cited by 265 · see citing works
Localized microstimulation of primate pregenual cingulate cortex induces negative decision-making
Amemori, K.-I., & Graybiel, A. M. (2012) · Nature Neuroscience · doi:10.1038/nn.3088 · Cited by 262 · see citing works
Reflections on Depression as a Cardiac Risk Factor
Frasure‐Smith, N., & Lespérance, F. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000162253.07959.db · Cited by 258 · see citing works
Amygdala–prefrontal dissociation of subliminal and supraliminal fear
Williams, L. M., Liddell, B. J., Kemp, A. H., Bryant, R. A., Meares, R. A., Peduto, A. S., & Gordon, E. (2006) · Human Brain Mapping · doi:10.1002/hbm.20208 · Cited by 257 · see citing works
Liverant, G. I., Brown, T. A., Barlow, D. H., & Roemer, L. (2008) · Behaviour Research and Therapy · doi:10.1016/j.brat.2008.08.001 · Cited by 253 · see citing works
Relation Between Structural and Functional Connectivity in Major Depressive Disorder
de Kwaasteniet, B., Ruhe, E., Caan, M., Rive, M., Olabarriaga, S., Groefsema, M., Heesink, L., van Wingen, G., & Denys, D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.024 · Cited by 229 · see citing works
Lane, R. D. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181647e44 · Cited by 223 · see citing works
Self-citationMitchell, D. G. V. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.030 · Cited by 219 · see citing works
Levels of appraisal: a medial prefrontal role in high-level appraisal of emotional material.
Kalisch, R., Wiech, K., Critchley, H. D., & Dolan, R. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.11.011 · Cited by 206 · see citing works
Onitilo, A., Nietert, P., & Egede, L. (2006) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2006.05.006 · Cited by 191 · see citing works
Identifying differences in biased affective information processing in major depression
Gollan, J. K., Pane, H. T., McCloskey, M. S., & Coccaro, E. F. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2007.06.011 · Cited by 189 · see citing works
The insular cortex and the neuroanatomy of major depression
Sprengelmeyer, R., Steele, J. D., Mwangi, B., Kumar, P., Christmas, D. M., Milders, M. M., & Matthews, K. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.04.004 · Cited by 176 · see citing works
Reduced caudate gray matter volume in women with major depressive disorder
Kim, M. J., Hamilton, J. P., & Gotlib, I. H. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.12.020 · Cited by 173 · see citing works
Extending predictive processing to the body: Emotion as interoceptive inference
Seth, A. K., & Critchley, H. D. (2013) · Behavioral and Brain Sciences · doi:10.1017/s0140525x12002270 · Cited by 164 · see citing works
Specificity of age differences in emotion regulation
Orgeta, V. (2009) · Aging & Mental Health · doi:10.1080/13607860902989661 · Cited by 161 · see citing works
Lane, R. D., Reiman, E. M., Ahern, G. L., & Thayer, J. F. (2001) · Brain and Cognition · Cited by 151 · see citing works
Self-citationImpaired attention in depressive states: a non-specific deficit?
Mialet, J., Pope, H. G., & Yurgelun-Todd, D. (1996) · Psychological Medicine · doi:10.1017/s0033291700035339 · Cited by 124 · see citing works
From affective value to decision‐making in the prefrontal cortex
Fabian Grabenhorst, B., Rolls, E. T., & Parris, B. A. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06489.x · Cited by 124 · see citing works
Reduced negative BOLD responses in the default-mode network and increased self-focus in depression
Grimm, S., Ernst, J., Boesiger, P., Schuepbach, D., Boeker, H., & Northoff, G. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.545145 · Cited by 119 · see citing works
Advances in functional magnetic resonance imaging of the human brainstem
Beißner, F., Schumann, A., Brunn, F., Eisenträger, D., & Bär, K. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.07.081 · Cited by 117 · see citing works
Rosnow, R. L., & Rosenthal, R. (2009) · Zeitschrift für Psychologie · doi:10.1027/0044-3409.217.1.6 · Cited by 83 · see citing works
Lane, R. D., Weidenbacher, H. J., Smith, R. S., Fort, C. L., Thayer, J. F., & Allen, J. J. B. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.02.005 · Cited by 77 · see citing works
Self-citationContemporary Psychological Approaches to Depression: "Theory, Research, And Treatment"
Ingram, R. E. (2011) · Medical Entomology and Zoology · Cited by 68 · see citing works
Depressive Realism and Nondepressive Optimistic Illusions: The Role of the Self
Alloy, L. B., Albright, J. S., Abramson, L. Y., & Dykman, B. M. (1990) · Springer eBooks · doi:10.1007/978-1-4613-0649-8_6 · Cited by 65 · see citing works
Conscious Perception of Emotional Stimuli
Mitchell, D. G. V., & Greening, S. G. (2011) · The Neuroscientist · doi:10.1177/1073858411416515 · Cited by 63 · see citing works
Detecting outliers in high-dimensional neuroimaging datasets with robust covariance estimators
Fritsch, V., Varoquaux, G. P., Thyreau, B., Poline, J., & Thirion, B. (2012) · Medical Image Analysis · doi:10.1016/j.media.2012.05.002 · Cited by 53 · see citing works
Worry, anhedonic depression, and emotional styles
Berenbaum, H., Bredemeier, K., Thompson, R. J., & Boden, M. T. (2012) · Cognitive Therapy and Research · doi:10.1007/s10608-010-9329-8 · Cited by 39 · see citing works
Smith, R., Fass, H., & Lane, R. (2014) · Consciousness and Cognition · doi:10.1016/j.concog.2014.08.002 · Cited by 34 · see citing works
Self-citationContemporary Psychological Approaches to Depression
Ingram, R. E. (1990) · Springer eBooks · doi:10.1007/978-1-4613-0649-8 · Cited by 33 · see citing works
Smith, R. S., Allen, J. J. B., Thayer, J. F., Fort, C. L., & Lane, R. D. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.08.015 · Cited by 30 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Heart rate variability as a transdiagnostic biomarker of psychopathology
Beauchaine, T. P., & Thayer, J. F. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.08.004 · Cited by 870 · see citing works
Self-citationFuture Directions in Emotion Dysregulation and Youth Psychopathology
Beauchaine, T. P. (2015) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2015.1038827 · Cited by 394 · see citing works
Brosschot, J. F., Verkuil, B., & Thayer, J. F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.019 · Cited by 178 · see citing works
Self-citationDisrupted prefrontal activity during emotion processing in complicated grief: An fMRI investigation
Arizmendi, B., Kaszniak, A. W., & O'Connor, M.-F. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.054 · Cited by 57 · see citing works
- Authors
- Smith, R., Allen, J. J. B., Thayer, J. F., & Lane, R. D.
- Affiliations
- University of Arizona (US)
- The Ohio State University (US)
- Corresponding author
- Smith, Ryan
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 108
- Pages
- 13-24
- ISSN
- 0301-0511 (ISSN-L)
- OpenAlex
- W1981153636
- Cited by
- 49
- References
- 88
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 4
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mental Health Research (2005-MF-116)
- Arizona Biomedical Research Commission (0728)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- major depressive disorder, rostral anterior cingulate cortex, functional connectivity, brainstem, autonomic dysfunction, heart rate variability, subjective emotional responses, emotion classification, depression severity
- MeSH terms
- Adult, Brain Stem, Major Depressive Disorder, Electrocardiography, Emotions, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Psychiatric Status Rating Scales, Psychomotor Performance, Reaction Time, Vagus Nerve, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
