Ambulatory emotional reactivity to negative daily life events predicts remission from major depressive disorder
Abstract
Major depressive disorder (MDD) is often associated with altered emotional reactivity. However, the functional significance of altered emotional reactivity in MDD is uncertain. This study was the first to examine the predictive relationship between intensely sampled ambulatory emotional reactivity and the clinical course of MDD. Forty-six outpatients who met criteria for MDD underwent six days of experience sampling of their ambulatory reactivity to everyday negative and positive life events. After experience sampling, all outpatients received pharmacotherapy with supportive psychotherapy and were followed clinically for 18 months. At one month, less emotional reactivity to negative and positive daily events predicted higher depressive symptom severity. Importantly, patients who exhibited less negative emotional reactivity to daily negative life events were less likely to recover from MDD over the 18 month follow-up. Relationships between ambulatory emotional reactivity and MDD course were not accounted for by the duration or the severity of initial MDD symptoms. Diminished ambulatory emotional reactivity appears to be functionally significant in depression. Intensive sampling of ambulatory emotions may have utility for predicting the clinical course of MDD.
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Larger positive affect increases and smaller negative affect decreases after positive events at baseline predicted lower clinician-rated depression scores after 1 month of treatment.
“Larger PA increases and smaller NA decreases after positive events at baseline predicted lower clinician-rated depression scores after 1 month of treatment, as did larger NA increases and smaller PA decreases after negative events at baseline (Peeters et al., 2010).”
From Mood Disorders in Everyday Life: A Systematic Review of Experience Sampling and Ecological Momentary Assessment Studies (2012) · cites this paper as Peeters et al., 2010
Baseline negative affect responsiveness to negative events predicted remission from MDD even after 18 months.
“Notably, baseline NA responsiveness to negative events predicted remission from MDD even after 18 months (Peeters et al., 2010).”
From Mood Disorders in Everyday Life: A Systematic Review of Experience Sampling and Ecological Momentary Assessment Studies (2012) · cites this paper as Peeters et al., 2010
Larger negative affect increases and smaller positive affect decreases after negative events at baseline predicted lower clinician-rated depression scores after 1 month of treatment.
“Larger PA increases and smaller NA decreases after positive events at baseline predicted lower clinician-rated depression scores after 1 month of treatment, as did larger NA increases and smaller PA decreases after negative events at baseline (Peeters et al., 2010).”
From Mood Disorders in Everyday Life: A Systematic Review of Experience Sampling and Ecological Momentary Assessment Studies (2012) · cites this paper as Peeters et al., 2010
MDD patients whose everyday affective responses are more normal before treatment are more likely to improve.
“according to Peeters and colleagues (Peeters et al., 2010; Wichers, Lothmann, et al., 2012), MDD patients whose everyday affective responses are more ' normal ' before treatment are more likely to improve.”
From Mood Disorders in Everyday Life: A Systematic Review of Experience Sampling and Ecological Momentary Assessment Studies (2012) · cites this paper as Peeters et al., 2010
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- Authors
- Peeters, F., Berkhof, J., Rottenberg, J., & Nicolson, N. A.
- Affiliations
- Maastricht University Medical Centre (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- University of South Florida (US)
- Maastricht University (NL)
- Corresponding author
- Peeters, Frenk
- Venue
- Behaviour Research and Therapy
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 48
- Issue
- 8
- Pages
- 754-760
- ISSN
- 0005-7967 (ISSN-L)
- OpenAlex
- W1978726913
- Cited by
- 84
- References
- 71
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 12 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 11 · 2014: 2 · 2013: 9 · 2012: 6
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behaviour Research and Therapy (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, emotional reactivity, daily life events, negative emotional reactivity, remission prediction, depression severity, pharmacotherapy, supportive therapy
- MeSH terms
- Activities of Daily Living, Adolescent, Adult, Aged, Antidepressive Agents, Major Depressive Disorder, Emotions, Female, Humans, Male, Middle Aged, Psychotherapy, Remission, Spontaneous, Monitoring, Ambulatory
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