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HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory
Open accessAbstract
Neuronal activity influences genes involved in circuit development and information processing. However, the molecular basis of this process remains poorly understood. We found that HDAC4, a histone deacetylase that shuttles between the nucleus and cytoplasm, controls a transcriptional program essential for synaptic plasticity and memory. The nuclear import of HDAC4 and its association with chromatin is negatively regulated by NMDA receptors. In the nucleus, HDAC4 represses genes encoding constituents of central synapses, thereby affecting synaptic architecture and strength. Furthermore, we show that a truncated form of HDAC4 encoded by an allele associated with mental retardation is a gain-of-function nuclear repressor that abolishes transcription and synaptic transmission despite the loss of the deacetylase domain. Accordingly, mice carrying a mutant that mimics this allele exhibit deficits in neurotransmission, spatial learning, and memory. These studies elucidate a mechanism of experience-dependent plasticity and define the biological role of HDAC4 in the brain.
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“Nuclear HDAC4 functions as a transcriptional repressor, downregulating the expression of numerous plasticity-related genes, that may mediate effects on learning and memory impairment in mice.143,144”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [143]
In the citing paper
“the amount of synaptic proteins is regulated by transcription 102 , splicing 103 , mRNA transport 104 , translation 105 and degradation 106”
From Progress toward treatments for synaptic defects in autism (2013) · cites this paper as [102]
In the citing paper
“The subcellular localization of HDAC4 is thought to be regulated by NMDA receptors, as application of the NMDA receptor antagonist AP5 induces nuclear accumulation of HDAC4.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [60]
In the citing paper
“In the brain, HDAC4 also negatively regulates transcription required for synaptic transmission and information processing.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [60]
In the citing paper
“Transgenic mice expressing mutant HDAC4 with constitutive nuclear localization showed reduced expression of genes essential for synaptic function, including Camk2a, Homer1, and Snap25.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [60]
In the citing paper
“These mice in which nuclear HDAC4 functions as a gain-of-function suppressor of transcription showed abnormal acquisition and retention of memory.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [60]
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Cites
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Haberland, M., Montgomery, R. L., & Olson, E. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2485 · Cited by 2,600
Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
Barnes, C. A. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077579 · Cited by 2,088
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002) · Science · doi:10.1126/science.1067081 · Cited by 1,992
The molecular basis of CaMKII function in synaptic and behavioural memory
Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn753 · Cited by 1,860
MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription
Chahrour, M., Jung, S. Y., Shaw, C., Zhou, X., Wong, S. T. C., Qin, J., & Zoghbi, H. Y. (2008) · Science · doi:10.1126/science.1153252 · Cited by 1,823
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644
HDAC2 negatively regulates memory formation and synaptic plasticity
Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
Chao, H.-T., Chen, H., Samaco, R. C., Xue, M., Chahrour, M., Yoo, J., Neul, J. L., Gong, S., Lu, H.-C., Heintz, N., et al. (2010) · Nature · doi:10.1038/nature09582 · Cited by 1,168
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
McKinsey, T. A., Zhang, C., Lu, J., & Olson, E. N. (2000) · Nature · doi:10.1038/35040593 · Cited by 1,051
Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy
Zhang, C. L., McKinsey, T. A., Chang, S., Antos, C. L., Hill, J. A., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00861-9 · Cited by 973
Flavell, S. W., & Greenberg, M. E. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125631 · Cited by 832
Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis
Vega, R. B., Matsuda, K., Oh, J., Barbosa, A. C. C., Yang, X., Meadows, E., McAnally, J., Pomajzl, C., Shelton, J. M., Richardson, J. A., et al. (2004) · Cell · doi:10.1016/j.cell.2004.10.024 · Cited by 805
Crawley, J. N. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01258-x · Cited by 772
Saura, C. A., Choi, S.-Y., Beglopoulos, V., Malkani, S., Zhang, D., Rao, B. S. S., Chattarji, S., Kelleher, R. J., Kandel, E. R., Duff, K., et al. (2004) · Neuron · doi:10.1016/s0896-6273(04)00182-5 · Cited by 757
RankProd: a bioconductor package for detecting differentially expressed genes in meta-analysis
Hong, F., Breitling, R., McEntee, C., Wittner, B. S., Nemhauser, J. L., & Chory, J. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl476 · Cited by 741
Hebb and homeostasis in neuronal plasticity
Turrigiano, G. G., & Nelson, S. B. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00091-x · Cited by 693
Neuronal MeCP2 Is Expressed at Near Histone-Octamer Levels and Globally Alters the Chromatin State
Skene, P. J., Illingworth, R. S., Webb, S., Kerr, A. R. W., James, K. D., Turner, D. J., Andrews, R., & Bird, A. P. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.030 · Cited by 688
MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice
Williams, A. H., Valdez, G., Moresi, V., Qi, X., McAnally, J., Elliott, J. L., Bassel-Duby, R., Sanes, J. R., & Olson, E. N. (2009) · Science · doi:10.1126/science.1181046 · Cited by 673
SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice
Schoch, S., Deák, F., Königstorfer, A., Mozhayeva, M. G., Sara, Y., Südhof, T. C., & Kavalali, E. T. (2001) · Science · doi:10.1126/science.1064335 · Cited by 664
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
Bantscheff, M., Hopf, C., Savitski, M. M., Dittmann, A., Grandi, P., Michon, A.-M., Schlegl, J., Abraham, Y., Becher, I., Bergamini, G., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1759 · Cited by 659
Regulation of gene expression and cocaine reward by CREB and ΔFosB
McClung, C. A., & Nestler, E. J. (2003) · Nature Neuroscience · doi:10.1038/nn1143 · Cited by 625
Chubykin, A. A., Atasoy, D., Etherton, M. R., Brose, N., Kavalali, E. T., Gibson, J. R., & Südhof, T. C. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.029 · Cited by 594
Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number
Flavell, S. W., Cowan, C. W., Kim, T.-K., Greer, P. L., Lin, Y., Paradis, S., Griffith, E. C., Hu, L. S., Chen, C., & Greenberg, M. E. (2006) · Science · doi:10.1126/science.1122511 · Cited by 573
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases
Lahm, A., Paolini, C., Pallaoro, M., Nardi, M. C., Jones, P., Neddermann, P., Sambucini, S., Bottomley, M. J., Lo Surdo, P., Carfı́, A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706487104 · Cited by 566
Mihaylova, M. M., Vasquez, D. S., Ravnskjaer, K., Denechaud, P.-D., Yu, R. T., Alvarez, J. G., Downes, M., Evans, R. M., Montminy, M., & Shaw, R. J. (2011) · Cell · doi:10.1016/j.cell.2011.03.043 · Cited by 533
MeCP2 Controls Excitatory Synaptic Strength by Regulating Glutamatergic Synapse Number
Chao, H.-T., Zoghbi, H. Y., & Rosenmund, C. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.018 · Cited by 511
Wojcik, S. M., Rhee, J. S., Herzog, É., Sigler, A., Jahn, R., Takamori, S., Brose, N., & Rosenmund, C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401764101 · Cited by 510
AMPA Receptor Incorporation into Synapses during LTP: The Role of Lateral Movement and Exocytosis
Makino, H., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.035 · Cited by 501
Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning
Nakashiba, T., Young, J. Z., McHugh, T. J., Buhl, D. L., & Tonegawa, S. (2008) · Science · doi:10.1126/science.1151120 · Cited by 492
Bach, M. E., Hawkins, R. D., Osman, M., Kandel, E. R., & Mayford, M. R. (1995) · Cell · doi:10.1016/0092-8674(95)90010-1 · Cited by 487
Dittgen, T., Nimmerjahn, A., Komai, S., Licznerski, P., Waters, J., Margrie, T. W., Helmchen, F., Denk, W., Brecht, M., & Osten, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407976101 · Cited by 485
Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes
Lunyak, V. V., Burgess, R., Prefontaine, G. G., Nelson, C., Sze, S.-H., Chenoweth, J., Schwartz, P., Pevzner, P. A., Glass, C., Mandel, G., et al. (2002) · Science · doi:10.1126/science.1076469 · Cited by 472
CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models
Benito, E., & Barco, Á. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.02.001 · Cited by 463
The many faces of REST oversee epigenetic programming of neuronal genes
Ballas, N., & Mandel, G. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.015 · Cited by 451
Flavell, S. W., Kim, T.-K., Gray, J. M., Harmin, D. A., Hemberg, M., Hong, E. J., Markenscoff-Papadimitriou, E., Bear, D. M., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.029 · Cited by 440
Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases
Sin, W. C., Haas, K. Z., Ruthazer, E. S., & Cline, H. T. (2002) · Nature · doi:10.1038/nature00987 · Cited by 433
Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23
Sørensen, J. B., Nagy, G., Varoqueaux, F., Nehring, R. B., Brose, N., Wilson, M. C., & Neher, E. (2003) · Cell · doi:10.1016/s0092-8674(03)00477-x · Cited by 364
The postsynaptic density proteins Homer and Shank form a polymeric network structure
Hayashi, M. K., Tang, C., Verpelli, C., Narayanan, R., Stearns, M. H., Xu, R.-M., Li, H., Sala, C., & Hayashi, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.050 · Cited by 356
V3 Spinal Neurons Establish a Robust and Balanced Locomotor Rhythm during Walking
Zhang, Y., Narayan, S., Geiman, E. J., Lanuza, G. M., Velasquez, T., Shanks, B., Akay, T., Dyck, J. R. B., Pearson, K. G., Gosgnach, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.027 · Cited by 350
Signaling from synapse to nucleus: the logic behind the mechanisms
Deisseroth, K. A., Mermelstein, P. G., Xia, H., & Tsien, R. W. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00076-x · Cited by 350
Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsy
Fukata, Y., Lovero, K. L., Iwanaga, T., Watanabe, A., Yokoi, N., Tabuchi, K., Shigemoto, R., Nicoll, R. A., & Fukata, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914537107 · Cited by 341
Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion
Maximov, A., Tang, J., Yang, X., Pang, Z. P., & Südhof, T. C. (2009) · Science · doi:10.1126/science.1166505 · Cited by 339
Self-citationSchenck, A., Bardoni, B., Langmann, C., Harden, N., Mandel, J.-L., & Giangrande, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00354-4 · Cited by 316
Gephyrin: where do we stand, where do we go?
Fritschy, J., Harvey, R., & Schwarz, G. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.02.006 · Cited by 315
Calcium/calmodulin-dependent protein kinase II and synaptic plasticity
Colbran, R. J., & Brown, A. M. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.05.008 · Cited by 311
Neuronal activity‐dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5
Chawla, S., Vanhoutte, P., Arnold, F. J. L., Huang, C. L.-H., & Bading, H. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01648.x · Cited by 304
Signaling from cAMP/PKA to MAPK and Synaptic Plasticity
Waltereit, R., & Weller, M. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:1:99 · Cited by 303
Williams, S. R., Aldred, M. A., Der Kaloustian, V. M., Halal, F., Gowans, G., McLeod, D. R., Zondag, S., Toriello, H. V., Magenis, R. E., & Elsea, S. H. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.07.011 · Cited by 302
Cohen, S., Gabel, H. W., Hemberg, M., Hutchinson, A. N., Sadacca, L. A., Ebert, D. H., Harmin, D. A., Greenberg, R. S., Verdine, V. K., Zhou, Z., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.022 · Cited by 298
Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins
Elias, G. M., & Nicoll, R. A. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.005 · Cited by 288
Identification of a Signal-Responsive Nuclear Export Sequence in Class II Histone Deacetylases
McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6312-6321.2001 · Cited by 287
Integration of biochemical signalling in spines
Kennedy, M. B., Beale, H. C., Carlisle, H. J., & Washburn, L. R. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1685 · Cited by 286
SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons
Rumbaugh, G., Adams, J. P., Kim, J. H., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600084103 · Cited by 260
Adult Neural Function Requires MeCP2
McGraw, C. M., Samaco, R. C., & Zoghbi, H. Y. (2011) · Science · doi:10.1126/science.1206593 · Cited by 255
Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome
Ronesi, J. A., Collins, K. A., Hays, S. A., Tsai, N.-P., Guo, W., Birnbaum, S. G., Hu, J.-H., Worley, P. F., Gibson, J. R., & Huber, K. M. (2012) · Nature Neuroscience · doi:10.1038/nn.3033 · Cited by 251
Paolo, G. D., Sankaranarayanan, S., Wenk, M. R., DANIELL, L. W., Perucco, E., Caldarone, B. J., Flavell, R. A., Picciotto, M. R., Ryan, T. A., Cremona, O., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00601-3 · Cited by 246
A Hormone-Dependent Module Regulating Energy Balance
Wang, B., Moya, N., Niessen, S., Hoover, H. S., Mihaylova, M. M., Shaw, R. J., Yates, J. R., Fischer, W. H., Thomas, J. B., & Montminy, M. (2011) · Cell · doi:10.1016/j.cell.2011.04.013 · Cited by 242
Self-citationTropea, D., Kreiman, G., Lyckman, A., Mukherjee, S., Yu, H., Horng, S., & Sur, M. (2006) · Nature Neuroscience · doi:10.1038/nn1689 · Cited by 226
Platel, J., Dave, K. A., Gordon, V., Lacar, B., Rubio, M. E., & Bordey, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.009 · Cited by 225
Distinct FGFs promote differentiation of excitatory and inhibitory synapses
Terauchi, A., Johnson‐Venkatesh, E., Toth, A. B., Javed, D., Sutton, M. A., & Umemori, H. (2010) · Nature · doi:10.1038/nature09041 · Cited by 214
Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia
Li, J., Chen, J., Ricupero, C. L., Hart, R. P., Schwartz, M. S., Kusnecov, A., & Herrup, K. (2012) · Nature Medicine · doi:10.1038/nm.2709 · Cited by 210
SynGAP regulates spine formation
Vazquez, L. E., Chen, H.-J., Sokolova, I., Knuesel, I., & Kennedy, M. B. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3213-04.2004 · Cited by 203
Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity
Schlüter, O. M., Basu, J., Südhof, T. C., & Rosenmund, C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3553-05.2006 · Cited by 199
HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas
Chen, B., & Cepko, C. L. (2009) · Science · doi:10.1126/science.1166226 · Cited by 192
Intracellular Trafficking of Histone Deacetylase 4 Regulates Neuronal Cell Death
Bolger, T. A., & Yao, T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1826-05.2005 · Cited by 190
Synaptic Roles of Cdk5: Implications in Higher Cognitive Functions and Neurodegenerative Diseases
Cheung, Z. H., Fu, A. K. Y., & Ip, N. Y. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.024 · Cited by 186
Ng, D., Pitcher, G. M., Szilard, R. K., Sertie, A. L., Kanisek, M., Clapcote, S. J., Lipina, T. V., Kalia, L. V., Joo, D. T., McKerlie, C., et al. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000041 · Cited by 185
Song, K., Backs, J., McAnally, J., Qi, X., Gerard, R. D., Richardson, J. A., Hill, J. A., Bassel‐Duby, R., & Olson, E. N. (2006) · Cell · doi:10.1016/j.cell.2006.02.048 · Cited by 179
SV2 Renders Primed Synaptic Vesicles Competent for Ca2+-Induced Exocytosis
Chang, W.-P., & Südhof, T. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4521-08.2009 · Cited by 176
Neurotransmission selectively regulates synapse formation in parallel circuits in vivo
Kerschensteiner, D., Morgan, J., Parker, E. D., Lewis, R. M., & Wong, R. (2009) · Nature · doi:10.1038/nature08236 · Cited by 175
A Neural Tetraspanin, Encoded by late bloomer , That Facilitates Synapse Formation
Kopczynski, C., Davis, G. W., & Goodman, C. S. (1996) · Science · doi:10.1126/science.271.5257.1867 · Cited by 169
Canzonetta, C., Mulligan, C., Deutsch, S., Ruf, S., O’Doherty, A., Lyle, R., Borel, C., Lin-Marq, N., Delom, F., Groet, J., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.08.012 · Cited by 165
Akhtar, M. W., Raingo, J., Nelson, E. D., Montgomery, R. L., Olson, E. N., Kavalali, E. T., & Monteggia, L. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0097-09.2009 · Cited by 159
Effects of visual experience on activity-dependent gene regulation in cortex
Majdan, M., & Shatz, C. J. (2006) · Nature Neuroscience · doi:10.1038/nn1674 · Cited by 159
Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory
Mansuy, I. M., & Shenolikar, S. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.10.004 · Cited by 157
Raiker, S. J., Lee, H., Baldwin, K. T., Duan, Y., Shrager, P. G., & Giger, R. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0895-10.2010 · Cited by 151
Haberland, M., Arnold, M., McAnally, J., Phan, D., Kim, Y., & Olson, E. N. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01415-06 · Cited by 150
Activity-Dependent IGF-1 Exocytosis is Controlled by the Ca2+-Sensor Synaptotagmin-10
Cao, P., Maximov, A., & Südhof, T. (2011) · Cell · doi:10.1016/j.cell.2011.03.034 · Cited by 149
Self-citationSelective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4
Backs, J., Worst, B. C., Lehmann, L., Patrick, D. M., Jebessa, Z. H., Kreußer, M. M., Sun, Q., Chen, L., Heft, C., Katus, H. A., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201105063 · Cited by 148
Colbran, R. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3602-04.2004 · Cited by 140
Activity-regulated genes as mediators of neural circuit plasticity
Leslie, J. H., & Nedivi, E. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.002 · Cited by 136
HDAC4 inhibits cell‐cycle progression and protects neurons from cell death
Majdzadeh, N., Wang, L., Morrison, B. E., Bassel‐Duby, R., Olson, E. N., & D’Mello, S. R. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20637 · Cited by 135
Activity-dependent synaptogenesis in the adult Mammalian cortex
Zito, K., & Svoboda, K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00903-0 · Cited by 134
Regulation of spine and synapse formation by activity-dependent intracellular signaling pathways
Saneyoshi, T., Fortin, D. A., & Soderling, T. R. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.09.013 · Cited by 133
A Calcium-Dependent Switch in a CREST-BRG1 Complex Regulates Activity-Dependent Gene Expression
Qiu, Z., & Ghosh, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.040 · Cited by 130
Smalla, K., Matthies, H. K., Langnäse, K., Shabir, S., Böckers, T. M., Wyneken, Ú., Staak, S., Krug, M., Beesley, P. W., & Gundelfinger, E. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080389297 · Cited by 124
Alfonso, J., Fernández, M. E., Cooper, B. H., Flügge, G., & Frasch, A. C. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504262102 · Cited by 120
cAMP Response Element-Binding Protein Is a Primary Hub of Activity-Driven Neuronal Gene Expression
Benito, E., Valor, L. M., Jimenez-Minchan, M., Huber, W. K., & Barco, Á. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4554-11.2011 · Cited by 119
IgLON cell adhesion molecules regulate synaptogenesis in hippocampal neurons
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Metadata
- Authors
- Sando, R., Gounko, N., Pieraut, S., Liao, L., Yates, J., & Maximov, A.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Maximov, Anton
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 151
- Issue
- 4
- Pages
- 821-834
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3496186
- OpenAlex
- W2031926951
- Cited by
- 274
- References
- 118
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 23 · 2023: 18 · 2022: 19 · 2021: 22 · 2020: 20 · 2019: 24 · 2018: 21 · 2017: 17 · 2016: 23 · 2015: 22 · 2014: 25 · 2013: 14
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Lirias (submittedVersion)
- Funders
- National Institute of Mental Health (MH085776, R01MH085776, R01MH067880, MH067880-09)
- National Institute of Neurological Disorders and Stroke (P30NS057096, NS057096)
- National Center for Research Resources (P41RR011823, RR011823)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- HDAC4, histone deacetylase, synaptic plasticity, memory, NMDA receptor, nuclear import, chromatin, transcriptional repression, central synapses, intellectual disability, neurotransmission, spatial learning, experience-dependent plasticity
- MeSH terms
- Animals, Brain, Histone Deacetylases, Memory, Neuronal Plasticity, Neurons, Synapses, Transcription Factors, Transcription, Genetic, Receptors, N-Methyl-D-Aspartate, Prosencephalon, Active Transport, Cell Nucleus, Mice
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