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Transcriptional Regulation and Its Misregulation in Disease
Open accessAbstract
The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.
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Metadata
- Authors
- Lee, T. I., & Young, R. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 152
- Issue
- 6
- Pages
- 1237-1251
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2137465688
- Cited by
- 1,620
- References
- 34
- FWCI
- 29.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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